• Room 03.002 - CCRCB

    United Kingdom

Accepting PhD Students

20002020

Research output per year

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Research Output

2020

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
40 Downloads (Pure)

FLIP(L): the pseudo‐caspase

Smyth, P., Sessler, T., Scott, C. & Longley, D., 24 Feb 2020, In : FEBS journal.

Research output: Contribution to journalArticle

Open Access
File
3 Downloads (Pure)
Open Access
File
2019

Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications

Hill, M., Twigg, M., Sheridan, E. A., Hardy, J. G., Elborn, J. S., Taggart, C. C., Scott, C. J. & Migaud, M. E., 02 Aug 2019, In : Pharmaceutics. 11, 8, 12 p., 379.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
83 Downloads (Pure)

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

Wilkinson, R., Burden, R., McDowell, S., McArt, D., McQuaid, S., Bingham, V., Williams, R., Cox, O., O'Connor, R., McCabe, N., Kennedy, R., Buckley, N. E. & Scott, C., 28 Jun 2019, In : Journal of Oncology.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
90 Downloads (Pure)

Application of nanotechnology to target and exploit tumour associated proteases

Cogo, F., Williams, R., Burden, R. E. & Scott, C. J., 01 Nov 2019, In : Biochimie. 166, p. 112-131

Research output: Contribution to journalReview article

1 Citation (Scopus)

Identification and SAR exploration of a novel series of Legumain inhibitors

Eddie, S. L., Gregson, A., Graham, E., Burton, S., Harrison, T., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 15 Jun 2019, In : Bioorganic & Medicinal Chemistry Letters. 29, 12, p. 1546-1548 3 p.

Research output: Contribution to journalArticle

Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

Nogueira, J. C. F., Greene, M. K., Richards, D. A., Furby, A. O., Steven, J., Porter, A., Barelle, C., Scott, C. J. & Chudasama, V., 27 Jun 2019, In : Chemical Communications. 55, 53, p. 7671-7674

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
77 Downloads (Pure)

Repurposing of Cetuximab in antibody-directed chemotherapy-loaded nanoparticles in EGFR therapy-resistant pancreatic tumours

McDaid, W. J., Greene, M. K., Johnston, M. C., Pollheimer, E., Smyth, P., McLaughlin, K., Van Schaeybroeck, S., Straubinger, R. M., Longley, D. B. & Scott, C. J., 18 Oct 2019, In : Nanoscale. 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Star polymers with acid-labile diacetal-based cores synthesized by aqueous RAFT polymerization for intracellular DNA delivery

Gibson, T. J., Smyth, P., Semsarilar, M., McCann, A. P., McDaid, W. J., Johnston, M. C., Scott, C. J. & Themistou, E., 05 Jul 2019, In : Polymer Chemistry. 11, 2, p. 344-357 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease

Small, D. M., Brown, R. R., Doherty, D. F., Abladey, A., Zhou- Suckow, Z., Delaney, R. J., Kerrigan, L., Dougan, C. M., Borensztajn, K. S., Holsinger, L., Booth, R., Scott, C. J., Lopez Campos, G., Elborn, J. S., Mall, M. A., Weldon, S. & Taggart, C. C., 28 Mar 2019, In : European Respiratory Journal. 53, 3, 1801523.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2018
Open Access
File
6 Citations (Scopus)
211 Downloads (Pure)

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

Cogo, F., Smyth, P., Burden, R., Longley, D. B., Williams, R., Johnston, M., Poreba, M., Rut, W., Groborz, K., Salvesen, G., Drag, M. & Scott, C. J., 13 Dec 2018, In : Nanoscale - Royal Society of Chemistry.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
55 Downloads (Pure)
Open Access
File
252 Downloads (Pure)

Single-Domain Antibody-Functionalized pH-Responsive Amphiphilic Block Copolymer Nanoparticles for Epidermal Growth Factor Receptor Targeted Cancer Therapy

Gibson, T. J., Smyth, P., McDaid, W. J., Lavery, D., Thom, J., Cotton, G., Scott, C. J. & Themistou, E., 21 Aug 2018, In : ACS Macro Letters. 7, 8, p. 1010-1015

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
85 Downloads (Pure)

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F., 08 Nov 2018, In : Cell communication and signaling : CCS. 16, 1, p. 77

Research output: Contribution to journalArticle

Open Access
File
136 Downloads (Pure)
2017

Aspirin reduces lipopolysaccharide induced pulmonary inflammation in human models of ARDS

Hamid, U., Krasnodembskaya, A., Fitzgerald, M., Shyamsundar, M., Kissenpfennig, A., Scott, C., Lefrancais, E., Mark R, L., Verghis, R., Scott, J., Simpson, A. J., McNamee, J., McAuley, D. & O'Kane, C. M., 12 Jan 2017, In : Thorax. 72, p. 971-980 10 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
501 Downloads (Pure)

Generating Next-Generation Antibody-Nanoparticle Conjugates through the Oriented Installation of Non-Engineered Antibody Fragments

Greene, M. K., Richards, D. A., Nogueira, J. C. F., Campbell, K., Smyth, P., Fernańdez, M., Scott, C. J. & Chudasama, V., 14 Aug 2017, In : Chemical Science. 1, p. 79-87 9 p.

Research output: Contribution to journalArticle

Open Access
File
30 Citations (Scopus)
263 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
88 Downloads (Pure)

Method and Kit for Detection of Bacterial Infection

Taggart, C., Weldon, S. & Scott, C., 2017, Patent No. 1509564.9, 06 Feb 2015

Research output: Patent

Microneedles in Nanomedicine Delivery

Tekko, I., Larrañeta, E., Rodgers, A., Scott, C., Kissenpfennig, A. & Donnelly, R., 31 Oct 2017, Nanotechnologies in Preventive and Regenerative Medicine. Elsevier, p. 131 163 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

1 Citation (Scopus)
2016

A bioavailable cathepsin S nitrile inhibitor abrogates tumor development

Wilkinson, R. D. A., Young, A., Burden, R. E., Williams, R. & Scott, C. J., 21 Apr 2016, In : Molecular Cancer. 15, 29, 11 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
270 Downloads (Pure)

Deubiquitylating enzymes in receptor endocytosis and trafficking

McCann, A. P., Scott, C. J., Van Schaeybroeck, S. & Burrows, J. F., 09 Dec 2016, In : Biochemical Journal. 473, 24, p. 4507-4525 19 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Encapsulation of the p38 MAPK inhibitor GSK 678361A in nanoparticles for inflammatory‐based disease states

Bains, B., Greene, M. K., McGirr, L., Dorman, J., Farrow, S. & Scott, C., 29 May 2016, In : Journal of Interdisciplinary Nanomedicine. 1, 3, p. 85-92

Research output: Contribution to journalArticle

Open Access
File
170 Downloads (Pure)

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B. F. & Scott, C. J., 23 Apr 2016, In : Particle and fibre toxicology. 13, 19, 13 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
260 Downloads (Pure)

IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination

Oleszycka, E., Moran, H. B. T., Tynan, G. A., Hearnden, C. H., Coutts, G., Campbell, M., Allan, S. M., Scott, C. J. & Lavelle, E. C., 11 Jan 2016, In : FEBS journal. 283, 1, p. 9-24 16 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

Hamon, Y., Legowska, M., Hervé, V., Dallet-Choisy, S., Marchand-Adam, S., Vanderlynden, L., Demonte, M., Williams, R., Scott, C. J., Si-Tahar, M., Heuzé-Vourc'h, N., Lalmanach, G., Jenne, D. E., Lesner, A., Gauthier, F. & Korkmaz, B., 15 Apr 2016, In : The Journal of biological chemistry. 291, 16, p. 8486-99 14 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Strategies for detection and quantification of cysteine cathepsins-evolution from bench to bedside

Hughes, C. S., Burden, R. E., Gilmore, B. F. & Scott, C. J., Mar 2016, In : Biochimie. 122, p. 48-61 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2 Citations (Scopus)
2015
Open Access
File
62 Citations (Scopus)
1296 Downloads (Pure)

Cathepsin S: therapeutic, diagnostic, and prognostic potential

Wilkinson, R. D. A., Williams, R., Scott, C. J. & Burden, R. E., Aug 2015, In : Biological Chemistry. 396, 8, p. 867-82 16 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

Wilkinson, R., Magorrian, S., Williams, R., Young, A., Small, D., Scott, C. & Burden, R., 22 Aug 2015, In : Oncotarget. p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
203 Downloads (Pure)

CD74: a potential mediator of resistance in the treatment of Glioblastoma

Magorrian, S., Coulter, J., Flannery, T., Scott, C. & Burden, R., 01 Dec 2015, p. A40 . 1 p.

Research output: Contribution to conferenceAbstract

Development of a potent and selective cell penetrant Legumain inhibitor

Ness, K. A., Eddie, S. L., Higgins, C. A., Templeman, A., D'Costa, Z., Gaddale, K. K. D., Bouzzaoui, S., Jordan, L., Janssen, D., Harrison, T., Burkamp, F., Young, A., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 01 Dec 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 23, p. 5642-5645

Research output: Contribution to journalArticle

6 Citations (Scopus)
Open Access
File
45 Citations (Scopus)
348 Downloads (Pure)

Laser-engineered dissolving microneedle arrays for protein delivery: potential for enhanced intradermal vaccination

McCrudden, M. T. C., Torrisi, B. M., Al-Zahrani, S., McCrudden, C. M., Zaric, M., Scott, C. J., Kissenpfennig, A., McCarthy, H. O. & Donnelly, R. F., Mar 2015, In : Journal of Pharmacy and Pharmacology. 67, 3, p. 409-425 17 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation

Spence, S., Greene, M. K., Fay, F., Hams, E., Saunders, S. P., Hamid, U., Fitzgerald, M., Beck, J., Bains, B. K., Smyth, P., Themistou, E., Small, D. M., Schmid, D., O'Kane, C. M., Fitzgerald, D. C., Abdelghany, S. M., Johnston, J. A., Fallon, P. G., Burrows, J. F., McAuley, D. F. & 2 others, Kissenpfennig, A. & Scott, C. J., 02 Sep 2015, In : Science Translational Medicine. 7, 303, 12 p., 140.

Research output: Contribution to journalArticle

Open Access
File
50 Citations (Scopus)
740 Downloads (Pure)

The utility of animal models in developing immunosuppressive agents

McDaid, J., Scott, C. J., Kissenpfennig, A., Chen, H. & Martins, P. N., 15 Jul 2015, In : European Journal of Pharmacology. 759, p. 295-302 8 p.

Research output: Contribution to journalReview article

File
6 Citations (Scopus)
737 Downloads (Pure)
2014

A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17

Jaworski, J., Govender, U., McFarlane, C., De La Vega, M., Greene, M. K., Rawlings, N. D., Johnston, J. A., Scott, C. J. & Burrows, J. F., 15 Jan 2014, In : Biochemical Journal. 457, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
233 Downloads (Pure)

Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine

Schmid, D., Fay, F., Small, D. M., Jaworski, J., Riley, J. S., Tegazzini, D., Fenning, C., Jones, D. S., Johnston, P. G., Longley, D. B. & Scott, C. J., Dec 2014, In : Molecular therapy : the journal of the American Society of Gene Therapy. 22, 12, p. 2083-2092 10 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
303 Downloads (Pure)

miR-31 Dysregulation in Cystic Fibrosis Airways Contributes to Increased Pulmonary Cathepsin S Production

Weldon, S., McNally, P., McAuley, D. F., Oglesby, I. K., Wohlford-Lenane, C. L., Bartlett, J. A., Scott, C. J., McElvaney, N. G., Greene, C. M., McCray, P. B. & Taggart, C. C., 15 Jul 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 2, p. 165-174

Research output: Contribution to journalArticle

41 Citations (Scopus)
Open Access
File
24 Citations (Scopus)
219 Downloads (Pure)

P3 SAR exploration of biphenyl carbamate based Legumain inhibitors

Higgins, C., Bouazzaoui, S., Gaddale Devanna, K., D'Costa, Z., Templeman, A., O'Rourke, M., Young, A., Scott, C., Harrison, T., Mullan, P. & Williams, R., 01 Jun 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 11, p. 2521-2524

Research output: Contribution to journalArticle

4 Citations (Scopus)

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.

D'Costa, Z. C., Higgins, C., Ong, C. W., Irwin, G. W., Boyle, D., McArt, D. G., McCloskey, K., Buckley, N. E., Crawford, N. T., Thiagarajan, L., Murray, J. T., Kennedy, R. D., Mulligan, K. A., Harkin, D. P., Waugh, D. J. J., Scott, C. J., Salto-Tellez, M., Williams, R. & Mullan, P. B., 08 Feb 2014, In : Oncotarget. 5, 6, p. 1609-1620 12 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
221 Downloads (Pure)

USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor

Jaworski, J., de la Vega, M., Fletcher, S. J., McFarlane, C., Greene, M. K., Smyth, A. W., Van Schaeybroeck, S., Johnston, J. A., Scott, C. J., Rappoport, J. Z. & Burrows, J. F., 30 Aug 2014, In : Oncotarget. 5, 16, p. 6964-6975 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
313 Downloads (Pure)
2013

Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

Research output: Contribution to journalArticle

Open Access
File
51 Citations (Scopus)
300 Downloads (Pure)

Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles

Abdelghany, S. M., Schmid, D., Deacon, J., Jaworski, J., Fay, F., McLaughlin, K. M., Gormley, J. A., Burrows, J. F., Longley, D. B., Donnelly, R. F. & Scott, C. J., 11 Feb 2013, In : Biomacromolecules. 14, 2, p. 302-310

Research output: Contribution to journalArticle

54 Citations (Scopus)

Microneedles for vaccine delivery

Donnelly, R., Alzahrani, S., Zaric, M., McCrudden, C., Scott, C. & Kissenpfennig, A., 2013, (Accepted) Encyclopedia of Pharmaceutical Science and Technology. Swarbrick, J. (ed.). 4th ed. informa

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)