• Room 03.002 - CCRCB

    United Kingdom

Accepting PhD Students

20002020

Research output per year

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Research Output

A bioavailable cathepsin S nitrile inhibitor abrogates tumor development

Wilkinson, R. D. A., Young, A., Burden, R. E., Williams, R. & Scott, C. J., 21 Apr 2016, In : Molecular Cancer. 15, 29, 11 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
258 Downloads (Pure)

Activity-based selection of a proteolytic species using ribosome display.

Quinn, D., Cunningham, S., Walker, B. & Scott, C., 23 May 2008, In : Biochemical and Biophysical Research Communications. 370(1), 1, p. 77-81 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications

Hill, M., Twigg, M., Sheridan, E. A., Hardy, J. G., Elborn, J. S., Taggart, C. C., Scott, C. J. & Migaud, M. E., 02 Aug 2019, In : Pharmaceutics. 11, 8, 12 p., 379.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
73 Downloads (Pure)

A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling.

McKeen, H., McAlpine, K., Valentine, A., Quinn, D., McClelland, K., Byrne, C., O'Rourke, M., Young, S., Scott, C., McCarthy, H., Hirst, D. & Robson, T., Nov 2008, In : Endocrinology. 149(11), 11, p. 5724-5734 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

A novel high throughput technique for identifying monoclonal antibodies capable of death receptor induced apoptosis

Kwok, H. F., Gormley, J. A., Scott, C., Johnston, J. A. & Olwill, S. A., 2009, In : journal of cell death. 2, p. 45-51 7 p.

Research output: Contribution to journalArticle

A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17

Jaworski, J., Govender, U., McFarlane, C., De La Vega, M., Greene, M. K., Rawlings, N. D., Johnston, J. A., Scott, C. J. & Burrows, J. F., 15 Jan 2014, In : Biochemical Journal. 457, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
219 Downloads (Pure)

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

Wilkinson, R., Burden, R., McDowell, S., McArt, D., McQuaid, S., Bingham, V., Williams, R., Cox, O., O'Connor, R., McCabe, N., Kennedy, R., Buckley, N. E. & Scott, C., 28 Jun 2019, In : Journal of Oncology.

Research output: Contribution to journalArticle

Open Access
File
78 Downloads (Pure)

Antibody conjugates and therapeutic strategies.

McCarron, P., Olwill, S. A., Marouf, W. M., Buick, R. J., Walker, B. & Scott, C., 01 Dec 2005, In : Molecular interventions. 5(6), 6, p. 368-380 13 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis

Burden, R. E., Gormley, J. A., Jaquin, T. J., Small, D., Quinn, D. J., Hegarty, S., Ward, C., Walker, B., Johnston, J. A., Olwill, S. A. & Scott, C. J., 01 Oct 2009, In : Clinical Cancer Research. 15, 19, p. 6042-6051 10 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Antibody-targeted nanoparticles for cancer therapy

Fay, F. & Scott, C., Mar 2011, In : Immunotherapy. 3, 3, p. 381-394 14 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells

McCarron, P. A., Marouf, W. M., Quinn, D. J., Fay, F., Burden, R. E., Olwill, S. A. & Scott, C. J., Aug 2008, In : Bioconjugate Chemistry. 19, 8, p. 1561-1569 9 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity

Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A. & 3 others, Scott, C. J., Johnston, J. A. & Olwill, S. A., 14 Dec 2011, In : Molecular Cancer. 10, 147.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF

Ward, C., Kuehn, D., Burden, R. E., Gormley, J. A., Jaquin, T. J., Gazdoiu, M., Small, D., Bicknell, R., Johnston, J. A., Scott, C. J. & Olwill, S. A., 2010, In : PLoS ONE. 5, 9, 8 p., e12543.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Antibody targeting of polymeric nanoparticles for cancer therapy

Scott, C. & Fay, F., Jun 2010, In : Drug Discovery Today. 15, p. 1087-1087 1 p.

Research output: Contribution to journalArticle

Open Access
File
59 Citations (Scopus)
1275 Downloads (Pure)

Application of nanotechnology to target and exploit tumour associated proteases

Cogo, F., Williams, R., Burden, R. E. & Scott, C. J., 01 Nov 2019, In : Biochimie. 166, p. 112-131

Research output: Contribution to journalReview article

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

Research output: Contribution to journalArticle

Open Access
File
27 Downloads (Pure)

Aspirin reduces lipopolysaccharide induced pulmonary inflammation in human models of ARDS

Hamid, U., Krasnodembskaya, A., Fitzgerald, M., Shyamsundar, M., Kissenpfennig, A., Scott, C., Lefrancais, E., Mark R, L., Verghis, R., Scott, J., Simpson, A. J., McNamee, J., McAuley, D. & O'Kane, C. M., 12 Jan 2017, In : Thorax. 72, p. 971-980 10 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
457 Downloads (Pure)

Biologic protease inhibitors as novel therapeutic agents.

Scott, C. & Taggart, C., Nov 2010, In : Biochimie. 92(11), 11, p. 1681-1688 8 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Cathepsin S: therapeutic, diagnostic, and prognostic potential

Wilkinson, R. D. A., Williams, R., Scott, C. J. & Burden, R. E., Aug 2015, In : Biological Chemistry. 396, 8, p. 867-82 16 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Cathepsin S expression: An independent prognostic factor in glioblastoma tumours - A pilot Study

Scott, C., Flannery, T., McQuaid, S., McGoohan, C., McConnell, R. S., McGregor, G., Mirakhur, M., Hamilton, P., Diamond, J., Cran, G., Walker, B., Martin, L., Ellison, D., Patel, C., Nicholson, C., Mendelow, D., McCormick, D. & Johnston, P., 15 Aug 2006, In : International Journal of Cancer. 119, 4, p. 854-860 7 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
285 Downloads (Pure)

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

Wilkinson, R., Magorrian, S., Williams, R., Young, A., Small, D., Scott, C. & Burden, R., 22 Aug 2015, In : Oncotarget. p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
197 Downloads (Pure)

CD33 reponses are blocked by SOCS3 through accelerated proteasomal-mediated turnover

Scott, C., Orr, S. J., Johnston, J., Morgan, N. M., Elliott, J., Burrows, J. & McVickar, D. W., 01 Feb 2007, In : Blood. 109(3), 3, p. 1061-1068 8 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

CD74: a potential mediator of resistance in the treatment of Glioblastoma

Magorrian, S., Coulter, J., Flannery, T., Scott, C. & Burden, R., 01 Dec 2015, p. A40 . 1 p.

Research output: Contribution to conferenceAbstract

Characterisation of the functional domains of SEPT9

Scott, C., Mar 2006, p. 7A-7A.

Research output: Contribution to conferencePaper

2 Citations (Scopus)
Open Access
File
5 Citations (Scopus)
172 Downloads (Pure)

Comprehensive Inhibitor Profiling Of The Proteus Mirabilis Metalloprotease Virulence Factor Zapa (Mirabilysin)

Carson, L., Cathcart, G., Scott, C., Hollenberg, M. D., Walker, B., Ceri, H. & Gilmore, B., Aug 2011, In : Biochimie. 93, 10, p. 1824-1827 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Conatumumab (AMG 655) coated nanoparticles for targeted pro-apoptotic drug delivery

Fay, F., McLaughlin, K. M., Small, D. M., Fennell, D. A., Johnston, P. G., Longley, D. B. & Scott, C. J., Nov 2011, In : Biomaterials. 32, 33, p. 8645-8653 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Cysteine cathepsins in pulmonary diseases

Burden, R. & Scott, C., 2008, Mechanisms of Pulmonary Innate Immunity. Taggart C.C. Greene, C. M. (ed.). Research Signpost, p. 65-95 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Design, optimisation and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique.

Donnelly, R., Majithiya, R., Morrow, D., Garland, M., Thakur, R. S., Woolfson, D., Scott, C., Demir, Y., Gillen, D., Ryan, E. & Migalska, K., 2011, In : Pharmaceutical Research. 28, 1, p. 41-57 17 p.

Research output: Contribution to journalArticle

181 Citations (Scopus)

Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique

Donnelly, R. F., Majithiya, R., Singh, T. R. R., Morrow, D. I. J., Garland, M. J., Demir, Y. K., Migalska, K., Ryan, E., Gillen, D., Scott, C. J. & Woolfson, A. D., 2011, In : Pharmaceutical Research. 28, 1, p. 41-57 17 p.

Research output: Contribution to journalArticle

181 Citations (Scopus)

Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vivo.

Flannery, T., McConnell, R. S., McQuaid, S., McGregor, G., Mirakhur, M., Martin, L., Scott, C., Burden, R., Walker, B., McGoohan, C. & Johnston, P., Apr 2007, In : British Journal of Neurosurgery. 21, 2, p. 204-209 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Deubiquitylating enzymes in receptor endocytosis and trafficking

McCann, A. P., Scott, C. J., Van Schaeybroeck, S. & Burrows, J. F., 09 Dec 2016, In : Biochemical Journal. 473, 24, p. 4507-4525 19 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Development and targeting of nanoparticulate systems for site-specific drug delivery

McCarron, P., Scott, C. & Donnelly, R., Feb 2007, Encyclopedia of Nanoscience and Nanotechnology. Nalwa, H. S. (ed.). American Scientific Publishers, p. 1-20 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

Cogo, F., Smyth, P., Burden, R., Longley, D. B., Williams, R., Johnston, M., Poreba, M., Rut, W., Groborz, K., Salvesen, G., Drag, M. & Scott, C. J., 13 Dec 2018, In : Nanoscale - Royal Society of Chemistry.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
41 Downloads (Pure)

Development of a potent and selective cell penetrant Legumain inhibitor

Ness, K. A., Eddie, S. L., Higgins, C. A., Templeman, A., D'Costa, Z., Gaddale, K. K. D., Bouzzaoui, S., Jordan, L., Janssen, D., Harrison, T., Burkamp, F., Young, A., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 01 Dec 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 23, p. 5642-5645

Research output: Contribution to journalArticle

6 Citations (Scopus)

Dipeptide Proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha)

Gilmore, B., Lynas, J. F., Scott, C., McGoohan, C., Martin, L. & Walker, B., 28 Jul 2006, In : Biochemical and Biophysical Research Communications. 346(2), 2, p. 436-446 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Direct transcutaneous targeting of antigen to the specific skin dendritic cell subsets induces antigen specific CD4+and CD8+T cell responses

Zaric, M., Fay, F., Garland, M. J., Poux, C., Lyubomska, O., Scott, C., Donnelly, R. & Kissenpfennig, A., Dec 2011, p. 131-131. 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
45 Citations (Scopus)
332 Downloads (Pure)

Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine

Schmid, D., Fay, F., Small, D. M., Jaworski, J., Riley, J. S., Tegazzini, D., Fenning, C., Jones, D. S., Johnston, P. G., Longley, D. B. & Scott, C. J., Dec 2014, In : Molecular therapy : the journal of the American Society of Gene Therapy. 22, 12, p. 2083-2092 10 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
294 Downloads (Pure)

Encapsulation of the p38 MAPK inhibitor GSK 678361A in nanoparticles for inflammatory‐based disease states

Bains, B., Greene, M. K., McGirr, L., Dorman, J., Farrow, S. & Scott, C., 29 May 2016, In : Journal of Interdisciplinary Nanomedicine. 1, 3, p. 85-92

Research output: Contribution to journalArticle

Open Access
File
158 Downloads (Pure)

Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles

Abdelghany, S. M., Schmid, D., Deacon, J., Jaworski, J., Fay, F., McLaughlin, K. M., Gormley, J. A., Burrows, J. F., Longley, D. B., Donnelly, R. F. & Scott, C. J., 11 Feb 2013, In : Biomacromolecules. 14, 2, p. 302-310

Research output: Contribution to journalArticle

53 Citations (Scopus)
26 Citations (Scopus)

Expedited Solid-Phase Synthesis of Fluorescently Labeled and Biotinylated Aminoalkane Diphenyl Phosphonate Affinity Probes for Chymotrypsin- and Elastase-Like Serine Proteases

Gilmore, B. F., Quinn, D. J., Duff, T., Cathcart, G. R., Scott, C. J. & Walker, B., 18 Nov 2009, In : Bioconjugate Chemistry. 20, 11, p. 2098-2105 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Expression and purification of diagnostically sensitive mycobacterial (Mycobacterium bovis) antigens and profiling of their humoral immune response in a rabbit model.

Kwok, H. F., Scott, C., Snoddy, P., Buick, R. J., Johnston, J. A. & Olwill, S. A., Aug 2010, In : Research in Veterinary Science. 89(1), 1, p. 41-47 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B. F. & Scott, C. J., 23 Apr 2016, In : Particle and fibre toxicology. 13, 19, 13 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
248 Downloads (Pure)

FLIP(L): the pseudo‐caspase

Smyth, P., Sessler, T., Scott, C. & Longley, D., 24 Feb 2020, In : FEBS journal.

Research output: Contribution to journalArticle

Open Access