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20002020
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Research Output 2000 2020

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Article
2020
5 Downloads (Pure)

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

Research output: Contribution to journalArticle

Open Access
File
Death Domain Receptor Signaling Adaptor Proteins
CASP8 and FADD-Like Apoptosis Regulating Protein
Apoptosis
Caspase 8
Death Domain Receptors
Drug delivery
Encapsulation
Polyethylene glycols
attachment
delivery
2019
1 Citation (Scopus)
60 Downloads (Pure)

Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications

Hill, M., Twigg, M., Sheridan, E. A., Hardy, J. G., Elborn, J. S., Taggart, C. C., Scott, C. J. & Migaud, M. E., 02 Aug 2019, In : Pharmaceutics. 11, 8, 12 p., 379.

Research output: Contribution to journalArticle

Open Access
File
Tobramycin
Chitosan
Mucus
Drug Delivery Systems
Cystic Fibrosis
61 Downloads (Pure)

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

Wilkinson, R., Burden, R., McDowell, S., McArt, D., McQuaid, S., Bingham, V., Williams, R., Cox, O., O'Connor, R., McCabe, N., Kennedy, R., Buckley, N. E. & Scott, C., 28 Jun 2019, In : Journal of Oncology.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Triple Negative Breast Neoplasms
Biomarkers
Neoplasms
DNA Repair

Identification and SAR exploration of a novel series of Legumain inhibitors

Eddie, S. L., Gregson, A., Graham, E., Burton, S., Harrison, T., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 15 Jun 2019, In : Bioorganic & Medicinal Chemistry Letters. 29, 12, p. 1546-1548 3 p.

Research output: Contribution to journalArticle

asparaginylendopeptidase
Dipeptides
Molecules
Research
Experiments
2 Citations (Scopus)
50 Downloads (Pure)

Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

Nogueira, J. C. F., Greene, M. K., Richards, D. A., Furby, A. O., Steven, J., Porter, A., Barelle, C., Scott, C. J. & Chudasama, V., 27 Jun 2019, In : Chemical Communications. 55, 53, p. 7671-7674

Research output: Contribution to journalArticle

Open Access
File
glycolic acid
Nanoconjugates
Antigen Receptors
Lactic acid
Antigens
1 Citation (Scopus)

Repurposing of Cetuximab in antibody-directed chemotherapy-loaded nanoparticles in EGFR therapy-resistant pancreatic tumours

McDaid, W. J., Greene, M. K., Johnston, M. C., Pollheimer, E., Smyth, P., McLaughlin, K., Van Schaeybroeck, S., Straubinger, R. M., Longley, D. B. & Scott, C. J., 18 Oct 2019, In : Nanoscale. 13 p.

Research output: Contribution to journalArticle

Chemotherapy
Epidermal Growth Factor Receptor
Antibodies
Tumors
Nanoparticles
1 Citation (Scopus)

Star polymers with acid-labile diacetal-based cores synthesized by aqueous RAFT polymerization for intracellular DNA delivery

Gibson, T. J., Smyth, P., Semsarilar, M., McCann, A. P., McDaid, W. J., Johnston, M. C., Scott, C. J. & Themistou, E., 05 Jul 2019, In : Polymer Chemistry. 11, 2, p. 344-357 14 p.

Research output: Contribution to journalArticle

Polymerization
Stars
Polymers
DNA
Acids
2 Citations (Scopus)

Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease

Small, D. M., Brown, R. R., Doherty, D. F., Abladey, A., Zhou- Suckow, Z., Delaney, R. J., Kerrigan, L., Dougan, C. M., Borensztajn, K. S., Holsinger, L., Booth, R., Scott, C. J., Lopez Campos, G., Elborn, J. S., Mall, M. A., Weldon, S. & Taggart, C. C., 28 Mar 2019, In : European Respiratory Journal. 53, 3, 1801523.

Research output: Contribution to journalArticle

cathepsin S
Cystic Fibrosis
Lung Diseases
Cats
Epithelial Sodium Channels
2018
4 Citations (Scopus)
144 Downloads (Pure)
Open Access
File
Klebsiella Infections
Klebsiella pneumoniae
Gentamicins
Nanoparticles
Microbial Viability
1 Citation (Scopus)
25 Downloads (Pure)

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

Cogo, F., Smyth, P., Burden, R., Longley, D. B., Williams, R., Johnston, M., Poreba, M., Rut, W., Groborz, K., Salvesen, G., Drag, M. & Scott, C. J., 13 Dec 2018, In : Nanoscale - Royal Society of Chemistry.

Research output: Contribution to journalArticle

Open Access
File
Caspase 3
Labels
Labeling
Tumors
Pharmacodynamics
220 Downloads (Pure)
Open Access
File
Bacterial Infections
Anti-Bacterial Agents
Staphylococcal Pneumonia
Nanomedicine
Acinetobacter baumannii
3 Citations (Scopus)
57 Downloads (Pure)

Single-Domain Antibody-Functionalized pH-Responsive Amphiphilic Block Copolymer Nanoparticles for Epidermal Growth Factor Receptor Targeted Cancer Therapy

Gibson, T. J., Smyth, P., McDaid, W. J., Lavery, D., Thom, J., Cotton, G., Scott, C. J. & Themistou, E., 21 Aug 2018, In : ACS Macro Letters. 7, 8, p. 1010-1015

Research output: Contribution to journalArticle

Open Access
File
Single-Domain Antibodies
Nanoconjugates
Epidermal Growth Factor Receptor
Antibodies
Block copolymers
105 Downloads (Pure)

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F., 08 Nov 2018, In : Cell communication and signaling : CCS. 16, 1, p. 77

Research output: Contribution to journalArticle

Open Access
File
Clathrin
Protein-Tyrosine Kinases
Exons
Chemical activation
Apoptosis
2017
15 Citations (Scopus)
420 Downloads (Pure)

Aspirin reduces lipopolysaccharide induced pulmonary inflammation in human models of ARDS

Hamid, U., Krasnodembskaya, A., Fitzgerald, M., Shyamsundar, M., Kissenpfennig, A., Scott, C., Lefrancais, E., Mark R, L., Verghis, R., Scott, J., Simpson, A. J., McNamee, J., McAuley, D. & O'Kane, C. M., 12 Jan 2017, In : Thorax. 72, p. 971-980 10 p.

Research output: Contribution to journalArticle

Open Access
File
Adult Respiratory Distress Syndrome
Aspirin
Lipopolysaccharides
Pneumonia
Bronchoalveolar Lavage
24 Citations (Scopus)
233 Downloads (Pure)

Generating Next-Generation Antibody-Nanoparticle Conjugates through the Oriented Installation of Non-Engineered Antibody Fragments

Greene, M. K., Richards, D. A., Nogueira, J. C. F., Campbell, K., Smyth, P., Fernańdez, M., Scott, C. J. & Chudasama, V., 14 Aug 2017, In : Chemical Science. 1, p. 79-87 9 p.

Research output: Contribution to journalArticle

Open Access
File
Immunoglobulin Fragments
Nanoparticles
Antibodies
Antibody Binding Sites
Ligands
7 Citations (Scopus)
63 Downloads (Pure)
Open Access
File
Salt mines
Transaminases
Amines
Enzymes
Ketones
2016
12 Citations (Scopus)
242 Downloads (Pure)

A bioavailable cathepsin S nitrile inhibitor abrogates tumor development

Wilkinson, R. D. A., Young, A., Burden, R. E., Williams, R. & Scott, C. J., 21 Apr 2016, In : Molecular Cancer. 15, 29, 11 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Nitriles
Neoplasms
MCF-7 Cells
Apoptosis
7 Citations (Scopus)

Deubiquitylating enzymes in receptor endocytosis and trafficking

McCann, A. P., Scott, C. J., Van Schaeybroeck, S. & Burrows, J. F., 09 Dec 2016, In : Biochemical Journal. 473, 24, p. 4507-4525 19 p.

Research output: Contribution to journalArticle

Ubiquitin
Endocytosis
Enzymes
Degradation
Cell membranes
140 Downloads (Pure)

Encapsulation of the p38 MAPK inhibitor GSK 678361A in nanoparticles for inflammatory‐based disease states

Bains, B., Greene, M. K., McGirr, L., Dorman, J., Farrow, S. & Scott, C., 29 May 2016, In : Journal of Interdisciplinary Nanomedicine. 1, 3, p. 85-92

Research output: Contribution to journalArticle

Open Access
File
p38 Mitogen-Activated Protein Kinases
Protein Kinase Inhibitors
Nanoparticles
Anti-Inflammatory Agents
Macrophages
16 Citations (Scopus)
230 Downloads (Pure)

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B. F. & Scott, C. J., 23 Apr 2016, In : Particle and fibre toxicology. 13, 19, 13 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Caspase 1
Macrophages
Biomarkers
Interleukin-1
27 Citations (Scopus)

IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination

Oleszycka, E., Moran, H. B. T., Tynan, G. A., Hearnden, C. H., Coutts, G., Campbell, M., Allan, S. M., Scott, C. J. & Lavelle, E. C., 11 Jan 2016, In : FEBS journal. 283, 1, p. 9-24 16 p.

Research output: Contribution to journalArticle

Inflammasomes
Neutrophil Infiltration
Interleukin-1
Infiltration
Vaccination
20 Citations (Scopus)

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

Hamon, Y., Legowska, M., Hervé, V., Dallet-Choisy, S., Marchand-Adam, S., Vanderlynden, L., Demonte, M., Williams, R., Scott, C. J., Si-Tahar, M., Heuzé-Vourc'h, N., Lalmanach, G., Jenne, D. E., Lesner, A., Gauthier, F. & Korkmaz, B., 15 Apr 2016, In : The Journal of biological chemistry. 291, 16, p. 8486-99 14 p.

Research output: Contribution to journalArticle

Cathepsin C
Pulmonary diseases
Lung Diseases
Serine Proteases
Cats
7 Citations (Scopus)

Strategies for detection and quantification of cysteine cathepsins-evolution from bench to bedside

Hughes, C. S., Burden, R. E., Gilmore, B. F. & Scott, C. J., Mar 2016, In : Biochimie. 122, p. 48-61 14 p.

Research output: Contribution to journalArticle

Cathepsins
Cysteine
Peptide Hydrolases
Sulfhydryl Compounds
Labeling
2 Citations (Scopus)
cathepsin S
Cathepsins
Cysteine
Biotin
Click Chemistry
2015
58 Citations (Scopus)
1246 Downloads (Pure)
Open Access
File
Pseudomonas Infections
Tobramycin
Cystic Fibrosis
Nanoparticles
Pseudomonas aeruginosa
63 Citations (Scopus)

Cathepsin S: therapeutic, diagnostic, and prognostic potential

Wilkinson, R. D. A., Williams, R., Scott, C. J. & Burden, R. E., Aug 2015, In : Biological Chemistry. 396, 8, p. 867-82 16 p.

Research output: Contribution to journalArticle

cathepsin S
Cathepsins
Cysteine
Peptide Hydrolases
Therapeutics
16 Citations (Scopus)
185 Downloads (Pure)

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

Wilkinson, R., Magorrian, S., Williams, R., Young, A., Small, D., Scott, C. & Burden, R., 22 Aug 2015, In : Oncotarget. p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
protease S
Neoplasms
Tumor Microenvironment
45 Citations (Scopus)
312 Downloads (Pure)
Open Access
File
Cross-Priming
Immunization
Langerhans Cells
Nanoparticles
Skin
20 Citations (Scopus)

Laser-engineered dissolving microneedle arrays for protein delivery: potential for enhanced intradermal vaccination

McCrudden, M. T. C., Torrisi, B. M., Al-Zahrani, S., McCrudden, C. M., Zaric, M., Scott, C. J., Kissenpfennig, A., McCarthy, H. O. & Donnelly, R. F., Mar 2015, In : Journal of Pharmacy and Pharmacology. 67, 3, p. 409-425 17 p.

Research output: Contribution to journalArticle

Protein Array Analysis
Ovalbumin
Vaccination
Lasers
Interleukin-4
48 Citations (Scopus)
673 Downloads (Pure)

Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation

Spence, S., Greene, M. K., Fay, F., Hams, E., Saunders, S. P., Hamid, U., Fitzgerald, M., Beck, J., Bains, B. K., Smyth, P., Themistou, E., Small, D. M., Schmid, D., O'Kane, C. M., Fitzgerald, D. C., Abdelghany, S. M., Johnston, J. A., Fallon, P. G., Burrows, J. F., McAuley, D. F. & 2 others, Kissenpfennig, A. & Scott, C. J., 02 Sep 2015, In : Science Translational Medicine. 7, 303, 12 p., 140.

Research output: Contribution to journalArticle

Open Access
File
Sialic Acid Binding Immunoglobulin-like Lectins
N-Acetylneuraminic Acid
Nanoparticles
Inflammation
Sepsis
2014
10 Citations (Scopus)
203 Downloads (Pure)

A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17

Jaworski, J., Govender, U., McFarlane, C., De La Vega, M., Greene, M. K., Rawlings, N. D., Johnston, J. A., Scott, C. J. & Burrows, J. F., 15 Jan 2014, In : Biochemical Journal. 457, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Specific Proteases
Cell membranes
Protein Isoforms
Cell Membrane
Enzymes
19 Citations (Scopus)
271 Downloads (Pure)

Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine

Schmid, D., Fay, F., Small, D. M., Jaworski, J., Riley, J. S., Tegazzini, D., Fenning, C., Jones, D. S., Johnston, P. G., Longley, D. B. & Scott, C. J., Dec 2014, In : Molecular therapy : the journal of the American Society of Gene Therapy. 22, 12, p. 2083-2092 10 p.

Research output: Contribution to journalArticle

Open Access
File
TNF-Related Apoptosis-Inducing Ligand Receptors
Nanomedicine
Colorectal Neoplasms
Apoptosis
Pharmaceutical Preparations
39 Citations (Scopus)

miR-31 Dysregulation in Cystic Fibrosis Airways Contributes to Increased Pulmonary Cathepsin S Production

Weldon, S., McNally, P., McAuley, D. F., Oglesby, I. K., Wohlford-Lenane, C. L., Bartlett, J. A., Scott, C. J., McElvaney, N. G., Greene, C. M., McCray, P. B. & Taggart, C. C., 15 Jul 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 2, p. 165-174

Research output: Contribution to journalArticle

cathepsin S
Cystic Fibrosis
Lung
Epithelial Cells
Interferon Regulatory Factor-1
23 Citations (Scopus)
181 Downloads (Pure)

Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity

Schmid, D., Jarvis, G. E., Fay, F., Small, D. M., Greene, M. K., Majkut, J., Spence, S., McLaughlin, K. M., McCloskey, K. D., Johnston, P. G., Kissenpfennig, A., Longley, D. B. & Scott, C. J., 09 Oct 2014, In : Cell, Death & Disease. 5, 11 p., e1454.

Research output: Contribution to journalArticle

Open Access
File
Camptothecin
Nanoparticles
Topoisomerase I Inhibitors
Leukopenia
Therapeutic Uses
4 Citations (Scopus)

P3 SAR exploration of biphenyl carbamate based Legumain inhibitors

Higgins, C., Bouazzaoui, S., Gaddale Devanna, K., D'Costa, Z., Templeman, A., O'Rourke, M., Young, A., Scott, C., Harrison, T., Mullan, P. & Williams, R., 01 Jun 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 11, p. 2521-2524

Research output: Contribution to journalArticle

asparaginylendopeptidase
Carbamates
Enzymes
diphenyl
23 Citations (Scopus)
194 Downloads (Pure)

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.

D'Costa, Z. C., Higgins, C., Ong, C. W., Irwin, G. W., Boyle, D., McArt, D. G., McCloskey, K., Buckley, N. E., Crawford, N. T., Thiagarajan, L., Murray, J. T., Kennedy, R. D., Mulligan, K. A., Harkin, D. P., Waugh, D. J. J., Scott, C. J., Salto-Tellez, M., Williams, R. & Mullan, P. B., 08 Feb 2014, In : Oncotarget. 5, 6, p. 1609-1620 12 p.

Research output: Contribution to journalArticle

Open Access
File
asparaginylendopeptidase
Cystatin M
Breast Neoplasms
Neoplasms
Cathepsins
6 Citations (Scopus)
288 Downloads (Pure)

USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor

Jaworski, J., de la Vega, M., Fletcher, S. J., McFarlane, C., Greene, M. K., Smyth, A. W., Van Schaeybroeck, S., Johnston, J. A., Scott, C. J., Rappoport, J. Z. & Burrows, J. F., 30 Aug 2014, In : Oncotarget. 5, 16, p. 6964-6975 12 p.

Research output: Contribution to journalArticle

Open Access
File
Clathrin
Endocytosis
Epidermal Growth Factor Receptor
Transferrin
Amino Acid Motifs
2013
48 Citations (Scopus)
273 Downloads (Pure)

Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Growth
Neoplasms
53 Citations (Scopus)

Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles

Abdelghany, S. M., Schmid, D., Deacon, J., Jaworski, J., Fay, F., McLaughlin, K. M., Gormley, J. A., Burrows, J. F., Longley, D. B., Donnelly, R. F. & Scott, C. J., 11 Feb 2013, In : Biomacromolecules. 14, 2, p. 302-310

Research output: Contribution to journalArticle

Thymidine Monophosphate
Photosensitizing Agents
Photosensitizers
Alginate
Chitosan
94 Citations (Scopus)
1 Downloads (Pure)

Skin Dendritic Cell Targeting via Microneedle Arrays Laden with Antigen-Encapsulated Poly-D, L-lactide-co-Glycolide Nanoparticles Induces Efficient Antitumor and Antiviral Immune Responses

Zaric, M., Lyubomska, O., Touzelet, O., Poux, C., Al-Zahrani, S., Fay, F., Wallace, L., Terhorst, D., Malissen, B., Henri, S., Power, U. F., Scott, C. J., Donnelly, R. F. & Kissenpfennig, A., 26 Mar 2013, In : ACS Nano. 7, 3, p. 2042-2055 14 p.

Research output: Contribution to journalArticle

antigens
Antigens
Antiviral Agents
Skin
Nanoparticles
2012
84 Citations (Scopus)
336 Downloads (Pure)
Open Access
File
Pseudomonas Infections
Gentamicins
Nanoparticles
Pseudomonas aeruginosa
Hydrophilicity
28 Citations (Scopus)

Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.

Burden, R. E., Gormley, J. A., Kuehn, D., Ward, C., Kwok, H. F., Gazdoiu, M., McClurg, A., Jaquin, T. J., Johnston, J. A., Scott, C. J. & Olwill, S. A., Feb 2012, In : Biochimie. 94, 2, p. 487-493 7 p.

Research output: Contribution to journalArticle

cathepsin S
irinotecan
Chemotherapy
Colorectal Neoplasms
Tumors
2011
102 Citations (Scopus)

Antibody-targeted nanoparticles for cancer therapy

Fay, F. & Scott, C., Mar 2011, In : Immunotherapy. 3, 3, p. 381-394 14 p.

Research output: Contribution to journalArticle

Nanoparticles
Antibodies
Neoplasms
Cell Surface Receptors
Therapeutics
11 Citations (Scopus)

Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity

Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A. & 3 others, Scott, C. J., Johnston, J. A. & Olwill, S. A., 14 Dec 2011, In : Molecular Cancer. 10, 147.

Research output: Contribution to journalArticle

cathepsin S
Antibodies
Neoplasms
Colorectal Neoplasms
Cellular Microenvironment
4 Citations (Scopus)

Comprehensive Inhibitor Profiling Of The Proteus Mirabilis Metalloprotease Virulence Factor Zapa (Mirabilysin)

Carson, L., Cathcart, G., Scott, C., Hollenberg, M. D., Walker, B., Ceri, H. & Gilmore, B., Aug 2011, In : Biochimie. 93, 10, p. 1824-1827 4 p.

Research output: Contribution to journalArticle

Proteus mirabilis
Metalloproteases
Virulence Factors
Libraries
Dipeptides
34 Citations (Scopus)

Conatumumab (AMG 655) coated nanoparticles for targeted pro-apoptotic drug delivery

Fay, F., McLaughlin, K. M., Small, D. M., Fennell, D. A., Johnston, P. G., Longley, D. B. & Scott, C. J., Nov 2011, In : Biomaterials. 32, 33, p. 8645-8653 9 p.

Research output: Contribution to journalArticle

Prodrugs
Drug delivery
Nanoparticles
Antibodies
Cell death
180 Citations (Scopus)

Design, optimisation and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique.

Donnelly, R., Majithiya, R., Morrow, D., Garland, M., Thakur, R. S., Woolfson, D., Scott, C., Demir, Y., Gillen, D., Ryan, E. & Migalska, K., 2011, In : Pharmaceutical Research. 28, 1, p. 41-57 17 p.

Research output: Contribution to journalArticle

Skin
Lasers
Optical tomography
Optical Coherence Tomography
Geometry
180 Citations (Scopus)

Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique

Donnelly, R. F., Majithiya, R., Singh, T. R. R., Morrow, D. I. J., Garland, M. J., Demir, Y. K., Migalska, K., Ryan, E., Gillen, D., Scott, C. J. & Woolfson, A. D., 2011, In : Pharmaceutical Research. 28, 1, p. 41-57 17 p.

Research output: Contribution to journalArticle

Lasers
Equipment and Supplies
Geometry
Polymers
Chemical analysis
36 Citations (Scopus)

The Deubiquitinating Enzyme USP17 is Essential for GTPase Subcellular localization and Cell Motility

de la Vega, M., Kelvin, A. A., Dunican, D. J., McFarlane, C., Burrows, J. F., Jaworski, J., Stevenson, N. J., Dib, K., Rappoport, J. Z., Scott, C. J., Long, A. & Johnston, J. A., Mar 2011, In : Nature Communications. 2, 1, 259.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
protease
locomotion
GTP Phosphohydrolases
Cell Movement