My research focuses on evaluating mechanisms of excessive inflammation in lung disease and how this may predispose to infection in the lung. My primary disease interests are Cystic Fibrosis, Chronic Obstructive Pulmonary Disease and Acute Respiratory Distress Syndrome. I am interested in how the innate immune response becomes dysregulated during excessive inflammation as a result of elevated protease activity. Findings from our group have been published in high-ranking Respiratory journals including the American Journal of Respiratory and Critical Care Medicine and the European Respiratory Journal. My research brings me in to contact with Pharma and Diagnostics companies, from whom I receive funding for translational studies. I have also been funded by the Medical Research Council, the Engineering and Physical Sciences Research Council, EU H2020, EU FP7, Innovate UK and the Cystic Fibrosis Foundation. I am actively involved in the European Respiratory Society (ERS) as a member of Assembly 3. In addition, I was previously the Chair and Secretary of the Airway Cell Biology group of ERS (2011-17) and currently serve as a member of the ERS College of Experts.

Respiratory Disease

Inflammation

Innate Immunity