• Room 02.020 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Professor Taggart is open to wide-ranging PhD applications from candidates with a basic science or clinical background. His fields of interest include: - acute and chronic lung disease eg. Cystic Fibrosis (CF), Acute Respiratory Distress Syndrome (ARDS) and Chronic Obstructive Pulmonary Disease (COPD) - Respiratory Innate Immunity - Protease and protease inhibitor function in lung disease Previous research experience is desirable although not essential.

1994 …2020

Research output per year

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Research Output

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Article
2020

Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics

Brown, R., Nath, S., Lora, A., Samaha, G., Elgamal, Z., Kaiser, R., Taggart, C., Weldon, S. & Geraghty, P., 12 May 2020, In : Respiratory Research.

Research output: Contribution to journalArticle

Open Access
File
9 Downloads (Pure)
2019

Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications

Hill, M., Twigg, M., Sheridan, E. A., Hardy, J. G., Elborn, J. S., Taggart, C. C., Scott, C. J. & Migaud, M. E., 02 Aug 2019, In : Pharmaceutics. 11, 8, 12 p., 379.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
89 Downloads (Pure)

Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease

Brown, R., Paulsen, M., Schmidt, S., Schaterrny, J., Frank, A., Hirtz, S., Delaney, R., Doherty, D., Hagner, M., Taggart, C., Weldon, S. & Mall, M. A., 09 Sep 2019, In : American Journal of Respiratory Cell and Molecular Biology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Protein Phosphatase 2A Reduces Cigarette Smoke-Induced Cathepsin S and Loss of Lung Function

Doherty, D. F., Nath, S., Poon, J., Foronjy, R. F., Ohlmeyer, M., Dabo, A. J., Salathe, M., Birrell, M., Belvisi, M., Baumlin, N., Kim, M. D., Weldon, S., Taggart, C. & Geraghty, P., 14 Jan 2019, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
315 Downloads (Pure)

Sea snake cathelicidin (Hc-cath) exerts a protective effect in mouse models of lung inflammation and infection

Carlile, S. R., Shiels, J., Kerrigan, L., Delaney, R., Megaw, J., Gilmore, B. F., Weldon, S., Dalton, J. P. & Taggart, C. C., 15 Apr 2019, In : Scientific Reports. 9, 9 p., 6071.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
91 Downloads (Pure)

Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease

Small, D. M., Brown, R. R., Doherty, D. F., Abladey, A., Zhou- Suckow, Z., Delaney, R. J., Kerrigan, L., Dougan, C. M., Borensztajn, K. S., Holsinger, L., Booth, R., Scott, C. J., Lopez Campos, G., Elborn, J. S., Mall, M. A., Weldon, S. & Taggart, C. C., 28 Mar 2019, In : European Respiratory Journal. 53, 3, 1801523.

Research output: Contribution to journalArticle

11 Citations (Scopus)
Open Access
File
4 Citations (Scopus)
129 Downloads (Pure)
2018
Open Access
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7 Citations (Scopus)
237 Downloads (Pure)

Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95)

Chen, Q., Soundara Pandi, S. P., Kerrigan, L., McElvaney, N. G., Greene, C. M., Elborn, J. S., Taggart, C. C. & Weldon, S., 01 Sep 2018, In : Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 17, 5, p. 616-623

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
134 Downloads (Pure)

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis

Dittrich, S., Kühbandner, I., Gehrig, S., Rickert-Zacharias, V., Twigg, M., Wege, S., Taggart, C., Herth, F., Schultz, C. & Mall, M., 15 Mar 2018, In : European Respiratory Journal. 51, 3

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
81 Downloads (Pure)
Open Access
File
262 Downloads (Pure)
4 Citations (Scopus)
64 Downloads (Pure)

The Parasitic 68-mer Peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma

Tanaka, A., Allam, V., Simpson, J., Tiberti, N., Shiels, J., To, J., Lund, M., Combes, V., Weldon, S., Taggart, C., Dalton, J., Phipps, S., Sukkar, M. & Donnelly, S., 01 Jun 2018, In : Journal of Allergy and Clinical Immunology. 141, 6, p. 2316-2319

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
171 Downloads (Pure)
2017
Open Access
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12 Citations (Scopus)
214 Downloads (Pure)

Biomarkers to monitor exacerbations in cystic fibrosis

Gray, R. D., Downey, D. & Taggart, C. C., 03 Apr 2017, In : Expert review of respiratory medicine. 11, 4, p. 255-257 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Characterisation of eppin function: expression and activity in the lung

Scott, A., Glasgow, A., Small, D., Carlile, S., McCrudden, M., McLean, D., Brown, R., Doherty, D., Lundy, F., Hamid, U., O'Kane, C., McAuley, D., Brodlie, M., Tunney, M., Elborn, J., Irwin, C., Timson, D., Taggart, C. & Weldon, S., 13 Jul 2017, In : European Respiratory Journal. 50, 1, 1601937.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
134 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
243 Downloads (Pure)

Protean proteases: At the cutting edge of lung diseases

Taggart, C., Mall, M. A., Lalmanach, G., Cataldo, D., Ludwig, A., Janciauskiene, S., Heath, N., Meiners, S., Overall, C. M., Schultz, C., Turk, B. & Borensztajn, K. S., 01 Feb 2017, In : European Respiratory Journal. 49, 2, 12 p., 1501200.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
148 Downloads (Pure)
2016

A Secretory Leukocyte Protease Inhibitor Variant with Improved Activity against Lung Infection

Camper, N., Glasgow, A. M. A., Osbourn, M., Quinn, D. J., Small, D. M., McLean, D. T., Lundy, F. T., Elborn, J. S., McNally, P., Ingram, R. J., Weldon, S. & Taggart, C. C., May 2016, In : Mucosal immunology. 9, 3, p. 669-676

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
272 Downloads (Pure)

Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium

Boxio, R., Wartelle, J., Nawrocki-Raby, B., Lagrange, B., Malleret, L., Hirche, T., Taggart, C., Pacheco, Y., Devouassoux, G. & Bentaher, A., 2016, In : Respiratory Research. 17, 15 p., 129.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
171 Downloads (Pure)
2015

A Functional Variant of Elafin With Improved Anti-inflammatory Activity for Pulmonary Inflammation

Small, D. M., Zani, M. L., Quinn, D. J., Dallet-Choisy, S., Glasgow, A. MA., O'Kane, C., Mcauley, D. F., Mcnally, P., Weldon, S., Moreau, T. & Taggart, C. C., 2015, In : Molecular therapy : the journal of the American Society of Gene Therapy. 23, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
127 Downloads (Pure)
Open Access
File
63 Citations (Scopus)
1310 Downloads (Pure)

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung

Glasgow, A. M. A., Small, D. M., Scott, A., McLean, D. T., Camper, N., Hamid, U., Hegarty, S., Parekh, D., O'Kane, C., Lundy, F. T., McNally, P., Elborn, J. S., McAuley, D. F., Weldon, S. & Taggart, C. C., May 2015, In : Thorax. 70, 5, p. 426-32

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
181 Downloads (Pure)

The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity

McGarry, N., Greene, C. M., McElvaney, N. G., Weldon, S. & Taggart, C. C., 2015, In : Journal of Immunology Research. 2015, 507315.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
192 Downloads (Pure)

Type-I interferons induce lung protease responses following respiratory syncytial virus infection via RIG-I-like receptors

Foronjy, R. F., Taggart, C. C., Dabo, A. J., Weldon, S., Cummins, N. & Geraghty, P., Jan 2015, In : Mucosal immunology. 8, 1, p. 161-175

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
214 Downloads (Pure)
2014

Keratinocyte Growth-Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury

Shyamsundar, M., McAuley, D. F., Ingram, R. J., Gibson, D. S., O'Kane, D., McKeown, S. T., Edwards, A., Taggart, C., Elborn, J. S., Calfee, C. S., Matthay, M. A. & O'Kane, C. M., 15 Jun 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 12, p. 1520-1529 10 p.

Research output: Contribution to journalArticle

Open Access
53 Citations (Scopus)

miR-31 Dysregulation in Cystic Fibrosis Airways Contributes to Increased Pulmonary Cathepsin S Production

Weldon, S., McNally, P., McAuley, D. F., Oglesby, I. K., Wohlford-Lenane, C. L., Bartlett, J. A., Scott, C. J., McElvaney, N. G., Greene, C. M., McCray, P. B. & Taggart, C. C., 15 Jul 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 2, p. 165-174

Research output: Contribution to journalArticle

44 Citations (Scopus)

Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice

Foronjy, R. F., Dabo, A. J., Taggart, C. C., Weldon, S. & Geraghty, P., 28 Feb 2014, In : PLoS ONE. 9, 2, e90567.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
268 Downloads (Pure)
2013

Proteolytic cleavage of elafin by 20S proteasome may contribute to inflammation in acute lung injury

Kerrin, A., Weldon, S., Chung, A. H-K., Craig, T., Simpson, A. J., O'Kane, C. M., McAuley, D. F. & Taggart, C. C., Apr 2013, In : Thorax. 68, 4, p. 315-321 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2012
Open Access
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89 Citations (Scopus)
377 Downloads (Pure)
2011

Altered Toll-like Receptor 2-mediated Endotoxin Tolerance Is Related to Diminished Interferon β Production

Zaric, S., Coulter, W., Shelburne, C. E., Fulton, C., Zaric, M., Scott, A., Lappin, M., Fitzgerald, D., Irwin, C. & Taggart, C., 26 Aug 2011, In : Journal of Biological Chemistry. 286, 34, p. 29492-29500 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.

Bulter, C. A., McQuaid, S., Taggart, C., Weldon, S., Carter, R., Skibinski, G., Warke, T., Choy, D. F., McGarvey, L., Bradding, P., Arron, J. R. & Heaney, L., 08 Dec 2011, In : Thorax. 67, 5, p. 392-398 7 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

High concentrations of pepsin in bronchoalveolar lavage from children with cystic fibrosis are associated with high interleukin-8

McNally, P., Ervine, E., Shields, M., Dimitrov, B. D., El Nazir, B., Taggart, C., Greene, C. M., McElvaney, N. G. & Greally, P., Feb 2011, In : Thorax. 66 (2), 2, p. 140-143 4 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

SLPI and elafin: multifunctional antiproteases of the WFDC family

Scott, A., Weldon, S. & Taggart, C. C., Oct 2011, In : Biochemical society transactions. 39, 5, p. 1437-40

Research output: Contribution to journalArticle

68 Citations (Scopus)

The Effect of Liposome Encapsulation on the Pharmacokinetics of Recombinant Secretory Leukocyte Protease Inhibitor (rSLPI) Therapy after Local Delivery to a Guinea Pig Asthma Model

Gibbons, A., Padilla-Carlin, D., Kelly, C., Hickey, A. J., Taggart, C., McElvaney, N. G. & Cryan, S. A., Sep 2011, In : Pharmaceutical Research. 28 (9), 9, p. 2233-2245 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The prevalence of alpha-1 antitrypsin deficiency in Ireland

Carroll, T. P., O'Connor, C. A., Floyd, O., McPartlin, J., Kelleher, D. P., O'Brien, G., Dimitrov, B. D., Morris, V. B., Taggart, C. & McElvaney, N. G., 13 Jul 2011, In : Respiratory Research. 12:91, 91.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis

McNally, P., Coughlan, C., Bergsson, G., Doyle, M., Taggart, C., Adorini, L., Uskokovic, M. R., El-Nazir, B., Murphy, P., Greally, P., Greene, C. M. & McElvaney, N. G., Jul 2011, In : Journal of Cystic Fibrosis. epub ahead of print, 6, p. 428-434 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2010

Anti-apoptotic effects of Z alpha-1 antitrypsin in human bronchial epithelial cells.

Green, C. M., Miller, S. D., Carroll, T. P., Oglesby, I. K., Ahmed, F., O'Mahony, M., Taggart, C., McElvaney, N. G. & O'Neill, S. J., May 2010, In : The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 35, 5, p. 000-000 1 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Biologic protease inhibitors as novel therapeutic agents.

Scott, C. & Taggart, C., Nov 2010, In : Biochimie. 92(11), 11, p. 1681-1688 8 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases

Guyot, N., Bergsson, G., Butler, M. W., Greene, C. M., Weldon, S., Kessler, E., Levine, R. L., O'Neill, S. J., Taggart, C. & McElvaney, N. G., Jun 2010, In : Biological Chemistry. 391, 6, p. 705-716

Research output: Contribution to journalArticle

22 Citations (Scopus)

Impaired Immune Tolerance to Porphyromonas gingivalis Lipopolysaccharide Promotes Neutrophil Migration and Decreased Apoptosis.

Zaric, S., Shelburne, C., Darveau, R., Quinn, D., Weldon, S., Taggart, C. & Coulter, W., Oct 2010, In : Infection and Immunity. 78(10), 10, p. 4151-4156 6 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2009

Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation

Weldon, S., McNally, P., McElvaney, N. G., Elborn, J. S., McAuley, D. F., Wartelle, J., Belaaouaj, A., Levine, R. L. & Taggart, C. C., 15 Dec 2009, In : Journal of Immunology. 183, 12, p. 8148-8156

Research output: Contribution to journalArticle

72 Citations (Scopus)

Neutrophil Elastase Increases Airway Epithelial Nonheme Iron Levels

Fischer, B. M., Domowicz, D. A. L., Zheng, S. O., Carter, J. L., McElvaney, N. G., Taggart, C., Lehmann, J. R., Voynow, J. A. & Ghio, A. J., Oct 2009, In : CTS-CLINICAL AND TRANSLATIONAL SCIENCE. 2, 5, p. 333-339 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers

Shyamsundar, M., McKeown, S., O'Kane, C., Craig, T., Brown, V., Thickett, D. R., Matthay, M. A., Taggart, C., Backman, J. T., Elborn, J. & McAuley, D., 15 Jun 2009, In : American Journal of Respiratory and Critical Care Medicine. 179, 12, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

169 Citations (Scopus)
2008

Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway

Bergin, D. A., Greene, C. M., Sterchi, E. E., Kenna, C., Geraghty, P., Belaaouaj, A., Taggart, C., O\'Neill, S. J. & McElvaney, N. G., 14 Nov 2008, In : Journal of Biological Chemistry. 283, 46, p. 31736-31744 9 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Alpha-1-antitrypsin aerosolized augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro

Geraghty, P., Rogan, M. P., Greene, C. M., Brantly, M. L., O'Neill, S. J., Taggart, C. & McElvaney, N. G., Jul 2008, In : Thorax. 63, 7, p. 621-626 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Alpha-1 antitrypsin deficiency: A conformational disease associated with lung and liver manifestations

Greene, C. M., Miller, S. D. W., Carroll, T., McLean, C., O'Mahony, M., Lawless, M. W., O'Neill, S. J., Taggart, C. C. & McElvaney, N. G., Feb 2008, In : Journal of Inherited Metabolic Disease. 31, 1, p. 21-34 14 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Elafin, an Elastase-specific Inhibitor, Is Cleaved by Its Cognate Enzyme Neutrophil Elastase in Sputum from Individuals with Cystic Fibrosis

Guyot, N., Butler, M. W., McNally, P., Weldon, S., Greene, C. M., Levine, R. L., O\'Neill, S. J., Taggart, C. & McElvaney, N. G., 21 Nov 2008, In : Journal of Biological Chemistry. 283, 47, p. 32377-32385

Research output: Contribution to journalArticle

59 Citations (Scopus)
2007

Alpha-1-antitrypsin deficiency: current concepts

Mulgrew, A., Taggart, C. & McElvaney, N. G., Aug 2007, In : Lung. 185(4), 4, p. 191-201 11 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)