• Room 01.012 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr. Adrain encourages PhD applications from candidates from a basic science or clinical background. Work in the Adrain lab combines cellular biochemistry, cell biology and mutant mouse models. His lab’s interests include: -Organismal and cellular metabolism -Organismal biology and pathophysiology -Inflammatory signaling -Growth factor signaling -Proteolysis -Protein biogenesis/protein quality control -Protein trafficking in the secretory pathway


Research output per year

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Personal profile


Inflammation, Metabolism, Cancer, Cell Signaling, Physiology, Membrane Trafficking, Quality Control in the Endoplasmic Reticulum

Research Statement

My lab is interested in understanding how trafficking and quality control processes in the secretory pathway regulate cell signaling during disease. We have a particular interest in the interplay between metabolism, inflammation and growth control in mammals. My lab uses a combination of cellular biochemistry and organismal physiology in our studies.



-Co-Organizer of EMBO Workshop on Proteostasis: "From organelles to organisms", Portugal, 2019 http://meetings.embo.org/event/19-proteostasis

-Co-Organizer of EMBO Workshop on Proteostasis, Portugal, 2017 http://meetings.embo.org/event/17-proteostasis


-Editorial Board Member and Commissioning editor, the FEBS Journal.

-Editorial Board Member, Scientific Reports (2018-2019)

-Editorial Board Member, Cells Journal (2018)


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Research Output

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis

Badenes, M., Amin, A., Gonzalez-Garcia, I. & Adrain, C., 31 Oct 2019, In : Molecular Metabolism. 16 p.

Research output: Contribution to journalArticle

Open Access
  • iRhom2 and TNF: Partners or enemies?

    Badenes, M. & Adrain, C., 29 Oct 2019, In : Science Signaling. 12, 605, 2 p., eaaz0444.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Citation (Scopus)
    56 Downloads (Pure)

    iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

    Oikonomidi, I., Burbridge, E., Cavadas, M., Sullivan, G., Collis, B., Naegele, H., Clancy, D., Brezinova, J., Hu, T., Bileck, A., Gerner, C., Bolado, A., von Kriegsheim, A., Martin, S. J., Steinberg, F., Strisovsky, K. & Adrain, C., 13 Jun 2018, In : eLife. 7

    Research output: Contribution to journalArticle

  • 8 Citations (Scopus)

    Meeting Report - proteostasis in Ericeira

    Adrain, C., Henis-Korenblit, S. & Domingos, P. M., 01 Mar 2018, In : Journal of Cell Science. 131, 5

    Research output: Contribution to journalReview article

  • Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

    Cavadas, M., Oikonomidi, I., Gaspar, C. J., Burbridge, E., Badenes, M., Félix, I., Bolado, A., Hu, T., Bileck, A., Gerner, C., Domingos, P. M., von Kriegsheim, A. & Adrain, C., 17 Oct 2017, In : Cell Reports. 21, 3, p. 745-757 13 p.

    Research output: Contribution to journalArticle

  • 25 Citations (Scopus)