• Room 01.012 - CCRCB Block 5 MBC Site

    United Kingdom

Accepting PhD Students

19992019
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Personal profile

Interests

Inflammation, Metabolism, Cancer, Cell Signaling, Physiology, Membrane Trafficking, Quality Control in the Endoplasmic Reticulum

Research Statement

My lab is interested in understanding how trafficking and quality control processes in the secretory pathway regulate cell signaling during disease. We have a particular interest in the interplay between metabolism, inflammation and growth control in mammals. My lab uses a combination of cellular biochemistry and organismal physiology in our studies.

Achievements

MEETING ORGANIZATION:

-Co-Organizer of EMBO Workshop on Proteostasis: "From organelles to organisms", Portugal, 2019 http://meetings.embo.org/event/19-proteostasis

-Co-Organizer of EMBO Workshop on Proteostasis, Portugal, 2017 http://meetings.embo.org/event/17-proteostasis

EDITORIAL BOARD MEMBERSHIP:

-Editorial Board Member and Commissioning editor, the FEBS Journal.

-Editorial Board Member, Scientific Reports (2018-2019)

-Editorial Board Member, Cells Journal (2018)

 

Fingerprint Dive into the research topics where Colin Adrain is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1999 2019

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis

Badenes, M., Amin, A., Gonzalez-Garcia, I. & Adrain, C., 31 Oct 2019, In : Molecular Metabolism. 16 p.

Research output: Contribution to journalArticle

Open Access
Thermogenesis
Obesity
Brown Adipocytes
Diet
Brown Adipose Tissue

iRhom2 and TNF: Partners or enemies?

Badenes, M. & Adrain, C., 29 Oct 2019, In : Science Signaling. 2 p., eaaz0444.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
Metalloproteases
Liver Cirrhosis
Liver
Necrosis
8 Citations (Scopus)

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

Oikonomidi, I., Burbridge, E., Cavadas, M., Sullivan, G., Collis, B., Naegele, H., Clancy, D., Brezinova, J., Hu, T., Bileck, A., Gerner, C., Bolado, A., von Kriegsheim, A., Martin, S. J., Steinberg, F., Strisovsky, K. & Adrain, C., 13 Jun 2018, In : eLife. 7

Research output: Contribution to journalArticle

Tail
Proteins
Inflammation
Biological Phenomena
Macrophages

Meeting Report - proteostasis in Ericeira

Adrain, C., Henis-Korenblit, S. & Domingos, P. M., 01 Mar 2018, In : Journal of Cell Science. 131, 5

Research output: Contribution to journalReview article

Portugal
Posters
Education
Proteolysis
Atlantic Ocean
21 Citations (Scopus)

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

Cavadas, M., Oikonomidi, I., Gaspar, C. J., Burbridge, E., Badenes, M., Félix, I., Bolado, A., Hu, T., Bileck, A., Gerner, C., Domingos, P. M., von Kriegsheim, A. & Adrain, C., 17 Oct 2017, In : Cell Reports. 21, 3, p. 745-757 13 p.

Research output: Contribution to journalArticle

Phosphorylation
Metalloproteases
Tissue homeostasis
14-3-3 Proteins
Secretory Pathway