Personal profile
Interests
Inflammation, Metabolism, Cancer, Cell Signaling, Physiology, Membrane Trafficking, Quality Control in the Endoplasmic Reticulum
Research Statement
My lab is interested in understanding how trafficking and quality control processes in the secretory pathway regulate cell signaling during disease. We have a particular interest in the interplay between metabolism, inflammation and growth control in mammals. My lab uses a combination of cellular biochemistry and organismal physiology in our studies.
Achievements
MEETING ORGANIZATION:
-Co-Organizer of EMBO Workshop on Proteostasis: "From organelles to organisms", Portugal, 2019 http://meetings.embo.org/event/19-proteostasis
-Co-Organizer of EMBO Workshop on Proteostasis, Portugal, 2017 http://meetings.embo.org/event/17-proteostasis
EDITORIAL BOARD MEMBERSHIP:
-Editorial Board Member and Commissioning editor, the FEBS Journal.
-Editorial Board Member, Scientific Reports (2018-2019)
-Editorial Board Member, Cells Journal (2018)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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Collaborations and top research areas from the last five years
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Can the HB-EGF/EGFR pathway restore injured neurons?
Adrain, C. & Badenes, M., May 2024, In: The FEBS Journal. 291, 10, p. 2094-2097 4 p.Research output: Contribution to journal › Comment/debate › peer-review
2 Link opens in a new tab Citations (Scopus) -
Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity
Bläsius, K., Ludwig, L., Knapp, S., Flaßhove, C., Sonnabend, F., Keller, D., Tacken, N., Gao, X., Kahveci-Türköz, S., Grannemann, C., Babendreyer, A., Adrain, C., Huth, S., Baron, J. M., Ludwig, A. & Düsterhöft, S., 27 Feb 2024, In: Cellular and Molecular Life Sciences. 81, 102.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Link opens in a new tab Citations (Scopus)100 Downloads (Pure) -
RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling
Knopf, J. D., Steigleder, S. S., Korn, F., Kühnle, N., Badenes, M., Tauber, M., Theobald, S. J., Rybniker, J., Adrain, C. & Lemberg, M. K., 07 Mar 2024, (Early online date) In: Nature Communications. 15, 13 p., 1528.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Link opens in a new tab Citations (Scopus)31 Downloads (Pure) -
Ribosome quality control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
Chatterjee, S., Naeli, P., Onar, O., Simms, N., Garzia, A., Hackett, A., Coyle, K., Harris Snell, P., McGirr, T., Sawant, T. N., Dang, K., Stoichkova, Z. V., Azam, Y., Saunders, M. P., Braun, M., Alain, T., Tuschl, T., McDade, S. S., Longley, D. B. & Gkogkas, C. G. & 3 others, , 11 Nov 2024, In: Nucleic Acids Research. 52, 20, p. 12534-12548 15 p., gkae849.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Link opens in a new tab Citations (Scopus)120 Downloads (Pure) -
Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis
Amin, A., Badenes, M., Tüshaus, J., de Carvalho, É., Burbridge, E., Faísca, P., Trávníčková, K., Barros, A., Carobbio, S., Domingos, P. M., Vidal-Puig, A., Moita, L. F., Maguire, S., Stříšovský, K., Ortega, F. J., Fernández-Real, J. M., Lichtenthaler, S. F. & Adrain, C., Jul 2023, In: Molecular Metabolism. 73, 101731.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Link opens in a new tab Citations (Scopus)146 Downloads (Pure)