Research output per year
Research output per year
- 1 - 50 out of 51 results
Search results
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2024
Can the HB-EGF/EGFR pathway restore injured neurons?
Adrain, C. & Badenes, M., May 2024, In: The FEBS Journal. 291, 10, p. 2094-2097 4 p.Research output: Contribution to journal › Comment/debate › peer-review
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Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity
Bläsius, K., Ludwig, L., Knapp, S., Flaßhove, C., Sonnabend, F., Keller, D., Tacken, N., Gao, X., Kahveci-Türköz, S., Grannemann, C., Babendreyer, A., Adrain, C., Huth, S., Baron, J. M., Ludwig, A. & Düsterhöft, S., 27 Feb 2024, In: Cellular and Molecular Life Sciences. 81, 102.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)24 Downloads (Pure) -
RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling
Knopf, J. D., Steigleder, S. S., Korn, F., Kühnle, N., Badenes, M., Tauber, M., Theobald, S. J., Rybniker, J., Adrain, C. & Lemberg, M. K., 07 Mar 2024, (Early online date) In: Nature Communications. 15, 13 p., 1528.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)16 Downloads (Pure) -
Ribosome quality control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
Chatterjee, S., Naeli, P., Onar, O., Simms, N., Garzia, A., Hackett, A., Coyle, K., Harris Snell, P., McGirr, T., Sawant, T. N., Dang, K., Stoichkova, Z. V., Azam, Y., Saunders, M. P., Braun, M., Alain, T., Tuschl, T., McDade, S. S., Longley, D. B. & Gkogkas, C. G. & 3 others, , 01 Oct 2024, (Early online date) In: Nucleic Acids Research. 15 p., gkae849.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Downloads (Pure) -
2023
Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis
Amin, A., Badenes, M., Tüshaus, J., de Carvalho, É., Burbridge, E., Faísca, P., Trávníčková, K., Barros, A., Carobbio, S., Domingos, P. M., Vidal-Puig, A., Moita, L. F., Maguire, S., Stříšovský, K., Ortega, F. J., Fernández-Real, J. M., Lichtenthaler, S. F. & Adrain, C., Jul 2023, In: Molecular Metabolism. 73, 101731.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)81 Downloads (Pure) -
The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth
Badenes, M., Burbridge, E., Oikonomidi, I., Amin, A., de Carvalho, É., Kosack, L., Mariano, C., Domingos, P., Faísca, P. & Adrain, C., Apr 2023, In: Life Science Alliance. 6, 4, e202201644.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)75 Downloads (Pure) -
Xport-A functions as a chaperone by stabilizing the first five transmembrane domains of rhodopsin-1
Gaspar, C. J., Gomes, T., Martins, J. C., Melo, M. N., Adrain, C., Cordeiro, T. N. & Domingos, P. M., 01 Dec 2023, In: iScience. 26, 12, 12 p., 108309.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Downloads (Pure) -
2022
EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel
Gaspar, C. J., Vieira, L. C., Santos, C. C., Christianson, J. C., Jakubec, D., Strisovsky, K., Adrain, C. & Domingos, P. M., 05 Jan 2022, In: EMBO Reports. 23, 1, 16 p., e53210.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Mitochondria shed their outer membrane in response to infection-induced stress
Li, X., Straub, J., Medeiros, T. C., Mehra, C., den Brave, F., Peker, E., Atanassov, I., Stillger, K., Michaelis, J. B., Burbridge, E., Adrain, C., Münch, C., Riemer, J., Becker, T. & Pernas, L. F., 14 Jan 2022, In: Science. 375, 6577, eabi4343.Research output: Contribution to journal › Article › peer-review
62 Citations (Scopus) -
Organelle homeostasis: from cellular mechanisms to disease
Burbridge, E. & Adrain, C., 15 Nov 2022, In: The FEBS Journal. 289, 22, p. 6822-6831Research output: Contribution to journal › Editorial › peer-review
9 Citations (Scopus) -
2021
Systemic and cellular metabolism: the cause of and remedy for disease?
Adrain, C., 21 Jun 2021, (Early online date) In: The FEBS Journal. 288, 12, p. 3624-3627 4 p.Research output: Contribution to journal › Editorial › peer-review
Open Access3 Citations (Scopus) -
2020
Pseudoenzymes: dead enzymes with a lively role in biology
Adrain, C., 07 Oct 2020, In: FEBS journal. 287, 19, p. 4102-4105 4 p.Research output: Contribution to journal › Editorial › peer-review
8 Citations (Scopus) -
The complex life of rhomboid pseudoproteases
Adrain, C. & Cavadas, M., 02 Oct 2020, In: FEBS journal. 287, 19, p. 4261-4283 23 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile12 Citations (Scopus)65 Downloads (Pure) -
2019
Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis
Badenes, M., Amin, A., Gonzalez-Garcia, I. & Adrain, C., 31 Oct 2019, In: Molecular Metabolism. 31, p. 67 16 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Citations (Scopus) -
iRhom2 and TNF: Partners or enemies?
Badenes, M. & Adrain, C., 29 Oct 2019, In: Science Signaling. 12, 605, 2 p., eaaz0444.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)436 Downloads (Pure) -
2018
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
Oikonomidi, I., Burbridge, E., Cavadas, M., Sullivan, G., Collis, B., Naegele, H., Clancy, D., Brezinova, J., Hu, T., Bileck, A., Gerner, C., Bolado, A., von Kriegsheim, A., Martin, S. J., Steinberg, F., Strisovsky, K. & Adrain, C., 13 Jun 2018, In: eLife. 7Research output: Contribution to journal › Article › peer-review
48 Citations (Scopus) -
Meeting Report - proteostasis in Ericeira
Adrain, C., Henis-Korenblit, S. & Domingos, P. M., 01 Mar 2018, In: Journal of Cell Science. 131, 5Research output: Contribution to journal › Review article › peer-review
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2017
Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE
Cavadas, M., Oikonomidi, I., Gaspar, C. J., Burbridge, E., Badenes, M., Félix, I., Bolado, A., Hu, T., Bileck, A., Gerner, C., Domingos, P. M., von Kriegsheim, A. & Adrain, C., 17 Oct 2017, In: Cell Reports. 21, 3, p. 745-757 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile85 Citations (Scopus)36 Downloads (Pure) -
Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery
Clemente, T., Vieira, N. J., Cerliani, J. P., Adrain, C., Luthi, A., Dominguez, M. R., Yon, M., Barrence, F. C., Riul, T. B., Cummings, R. D., Zorn, T. M., Amigorena, S., Dias-Baruffi, M., Rodrigues, M. M., Martin, S. J., Rabinovich, G. A. & Amarante-Mendes, G. P., 07 Dec 2017, In: Cell, Death & Disease. 8, 12, p. e3176Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis
Johnson, N., Březinová, J., Stephens, E., Burbridge, E., Freeman, M., Adrain, C. & Strisovsky, K., 04 Aug 2017, In: Scientific Reports. 7, 1, p. 7283Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
2016
Inactive rhomboid proteins: New mechanisms with implications in health and disease
Lemberg, M. K. & Adrain, C., 01 Dec 2016, In: Seminars in cell & developmental biology. 60, p. 29-37 9 p.Research output: Contribution to journal › Review article › peer-review
26 Citations (Scopus) -
Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα
Wunderle, L., Knopf, J. D., Kühnle, N., Morlé, A., Hehn, B., Adrain, C., Strisovsky, K., Freeman, M. & Lemberg, M. K., 06 Jun 2016, In: Scientific Reports. 6, p. 27342Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Citations (Scopus)58 Downloads (Pure) -
2014
Regulation of receptor tyrosine kinase ligand processing
Adrain, C. & Freeman, M., 01 Jan 2014, In: Cold Spring Harbor perspectives in biology. 6, 1Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus) -
2013
Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation
Christova, Y., Adrain, C., Bambrough, P., Ibrahim, A. & Freeman, M., Oct 2013, In: EMBO Reports. 14, 10, p. 884-90 7 p.Research output: Contribution to journal › Article › peer-review
111 Citations (Scopus) -
2012
New lives for old: evolution of pseudoenzyme function illustrated by iRhoms
Adrain, C. & Freeman, M., 11 Jul 2012, In: Biochemistry and cell biology = Biochimie et biologie cellulaire. 13, 8, p. 489-98 10 p.Research output: Contribution to journal › Review article › peer-review
130 Citations (Scopus) -
Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE
Adrain, C., Zettl, M., Christova, Y., Taylor, N. & Freeman, M., 13 Jan 2012, In: Science. 335, 6065, p. 225-8 4 p.Research output: Contribution to journal › Article › peer-review
335 Citations (Scopus) -
2011
Mammalian EGF receptor activation by the rhomboid protease RHBDL2
Adrain, C., Strisovsky, K., Zettl, M., Hu, L., Lemberg, M. K. & Freeman, M., May 2011, In: EMBO Reports. 12, 5, p. 421-7 7 p.Research output: Contribution to journal › Article › peer-review
95 Citations (Scopus) -
Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling
Zettl, M., Adrain, C., Strisovsky, K., Lastun, V. & Freeman, M., 01 Apr 2011, In: Cell. 145, 1, p. 79-91 13 p.Research output: Contribution to journal › Article › peer-review
136 Citations (Scopus) -
2009
Apoptosis: calling time on apoptosome activity
Adrain, C. & Martin, S. J., 06 Oct 2009, In: Science Signaling. 2, 91, p. pe62Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival
Creagh, E. M., Brumatti, G., Sheridan, C., Duriez, P. J., Taylor, R. C., Cullen, S. P., Adrain, C. & Martin, S. J., 2009, In: PLoS ONE. 4, 3, e5055.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
2008
Caspases: Agents of Defense and Destruction
Adrain, C. & Martin, S. J., 26 May 2008, Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts. John Wiley & Sons Ltd, Vol. 1. p. 259-281 23 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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2007
Human and murine granzyme B exhibit divergent substrate preferences
Cullen, S. P., Adrain, C., Lüthi, A. U., Duriez, P. J. & Martin, S. J., 12 Feb 2007, In: The Journal of cell biology. 176, 4, p. 435-44 10 p.Research output: Contribution to journal › Article › peer-review
108 Citations (Scopus) -
2006
Apoptosomes: protease activation platforms to die from
Adrain, C., Brumatti, G. & Martin, S. J., May 2006, In: Trends in Biochemical Sciences. 31, 5, p. 243-7 5 p.Research output: Contribution to journal › Review article › peer-review
22 Citations (Scopus) -
Cell biology. Double knockout blow for caspases
Adrain, C. & Martin, S. J., 10 Feb 2006, In: Science. 311, 5762, p. 785-6 2 p.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics
Delivani, P., Adrain, C., Taylor, R. C., Duriez, P. J. & Martin, S. J., 17 Mar 2006, In: Molecular Cell. 21, 6, p. 761-73 13 p.Research output: Contribution to journal › Article › peer-review
174 Citations (Scopus) -
The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics
Adrain, C., Duriez, P. J., Brumatti, G., Delivani, P. & Martin, S. J., 24 Mar 2006, In: The Journal of Biological Chemistry. 281, 12, p. 8118-25 8 p.Research output: Contribution to journal › Article › peer-review
74 Citations (Scopus) -
2005
Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B
Adrain, C., Murphy, B. M. & Martin, S. J., 11 Feb 2005, In: The Journal of Biological Chemistry. 280, 6, p. 4663-73 11 p.Research output: Contribution to journal › Article › peer-review
126 Citations (Scopus) -
Proteases, proteasomes and apoptosis: breaking Ub is hard to do
Taylor, R. C., Adrain, C. & Martin, S. J., Sept 2005, In: Cell Death and Differentiation. 12, 9, p. 1213-7 5 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
2004
Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes
Hill, M. M., Adrain, C., Duriez, P. J., Creagh, E. M. & Martin, S. J., 19 May 2004, In: The EMBO Journal. 23, 10, p. 2134-45 12 p.Research output: Contribution to journal › Article › peer-review
234 Citations (Scopus) -
Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man
Adrain, C., Creagh, E. M., Cullen, S. P. & Martin, S. J., 27 Aug 2004, In: The Journal of Biological Chemistry. 279, 35, p. 36923-30 8 p.Research output: Contribution to journal › Article › peer-review
61 Citations (Scopus) -
Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex
Twiddy, D., Brown, D. G., Adrain, C., Jukes, R., Martin, S. J., Cohen, G. M., MacFarlane, M. & Cain, K., 07 May 2004, In: The Journal of Biological Chemistry. 279, 19, p. 19665-82 18 p.Research output: Contribution to journal › Article › peer-review
102 Citations (Scopus) -
2003
Defying death: showing Bcl-2 the way home
Adrain, C., Creagh, E. M. & Martin, S. J., Jan 2003, In: Nature Cell Biology. 5, 1, p. 9-11 3 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Portrait of a killer: the mitochondrial apoptosome emerges from the shadows
Hill, M. M., Adrain, C. & Martin, S. J., Feb 2003, In: Molecular interventions. 3, 1, p. 19-26 8 p.Research output: Contribution to journal › Review article › peer-review
83 Citations (Scopus) -
The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome C
Murphy, B. M., O'Neill, A. J., Adrain, C., Watson, R. W. G. & Martin, S. J., 03 Mar 2003, In: Journal of Experimental Medicine. 197, 5, p. 625-32 8 p.Research output: Contribution to journal › Article › peer-review
93 Citations (Scopus) -
2001
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
Adrain, C., Creagh, E. M. & Martin, S. J., 03 Dec 2001, In: The EMBO Journal. 20, 23, p. 6627-36 10 p.Research output: Contribution to journal › Article › peer-review
376 Citations (Scopus) -
CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways
Bouchier-Hayes, L., Conroy, H., Egan, H., Adrain, C., Creagh, E. M., MacFarlane, M. & Martin, S. J., 23 Nov 2001, In: The Journal of Biological Chemistry. 276, 47, p. 44069-77 9 p.Research output: Contribution to journal › Article › peer-review
103 Citations (Scopus) -
Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis
Slee, E. A., Adrain, C. & Martin, S. J., 09 Mar 2001, In: The Journal of Biological Chemistry. 276, 10, p. 7320-6 7 p.Research output: Contribution to journal › Article › peer-review
921 Citations (Scopus) -
Search for Drosophila caspases bears fruit: STRICA enters the fray
Adrain, C. & Martin, S. J., Apr 2001, In: Cell Death and Differentiation. 8, 4, p. 319-23 5 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
The mitochondrial apoptosome: a killer unleashed by the cytochrome seas
Adrain, C. & Martin, S. J., Jun 2001, In: Trends in Biochemical Sciences. 26, 6, p. 390-7 8 p.Research output: Contribution to journal › Review article › peer-review
470 Citations (Scopus) -
1999
Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region
Adrain, C., Slee, E. A., Harte, M. T. & Martin, S. J., 23 Jul 1999, In: Journal of Biological Chemistry. 274, 30, p. 20855-60 6 p.Research output: Contribution to journal › Article › peer-review
99 Citations (Scopus)