• Room 02.008 - CCRCB

    United Kingdom

Accepting PhD Students

20052020

Research output per year

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Personal profile

Research Statement

My lab's focus is on the role of the organ-specific microvasculature in the development of metastatic disease.

Over 90% of cancer-associated mortality is due to cancer dissemination from its primary origin to distant sites.

We have demonstrated in models of breast cancer metastasis to the lung that changes in endothelial cell behaviour alone can significantly change disease outcome. 

We wish to understand not only how the microvasculature interacts with cancer cells themselves, but also how endothelial cells mediate organ predisposition and vulnerability (or resistance) to metastatic colonization.

We use a combination of animal models and primary endothelial cells to assess physiological, cellular, molecular and metabolic parameters that can influence vascular function and tissue remodeling during cancer progression and treatment. 

Fingerprint Dive into the research topics where Cristina Branco is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Research Output

  • 21 Article
  • 1 Comment/debate
  • 1 Short survey
  • 1 Other contribution

Acute and chronic hypoxia differentially predispose lungs for metastases

Reiterer, M., Colaço, R., Emrouznejad, P., Jensen, A., Rundqvist, H., Johnson, R. S. & Branco, C., 15 Jul 2019, In : Scientific Reports. 9, 15 p., 10246.

Research output: Contribution to journalArticle

Open Access
File
  • 2 Citations (Scopus)
    130 Downloads (Pure)
    Open Access
    File
  • 40 Downloads (Pure)

    Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis

    Evans, C. E., Palazon, A., Sim, J., Tyrakis, P. A., Prodger, A., Lu, X., Chan, S., Bendahl, P-O., Belting, M., Von Euler, L., Rundqvist, H., Johnson, R. S. & Branco, C., 15 May 2017, In : Open biology. 6, 5, p. 688-697 10 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 7 Citations (Scopus)
    143 Downloads (Pure)

    Diverse roles of cell-specific hypoxia-inducible factor 1 in cancer-Associated hypercoagulation

    Evans, C. E., Bendahl, P. O., Belting, M., Branco, C. & Johnson, R. S., 10 Mar 2016, In : Blood. 127, 10, p. 1355-1360

    Research output: Contribution to journalArticle

  • 13 Citations (Scopus)

    Autocrine VEGF Isoforms Differentially Regulate Endothelial Cell Behavior

    Yamamoto, H., Rundqvist, H., Branco, C. & Johnson, R. S., 21 Sep 2016, In : Frontiers in Cell and Developmental Biology. 4, p. 1-12

    Research output: Contribution to journalArticle

    Open Access
    File
  • 7 Citations (Scopus)
    119 Downloads (Pure)

    Activities

    • 3 Invited talk
    • 1 Participation in workshop, seminar, course

    Endothelial cell contribution to organ microenvironment and metastatic disease

    Cristina Branco (Advisor)

    07 Nov 2019

    Activity: Talk or presentation typesInvited talk

    Early Career Researchers Forum Inaugural

    Aidan Cole (Organiser), , Cristina Branco (Chair), , Seyed Mehdi Jafarnejad (Organiser), , Emma Allott (Organiser), , Stephen McMahon (Participant), , Karl Butterworth (Participant), , Emma Kerr (Participant), , Philip Dunne (Participant), , Adone Tielenius Kruythoff-Mohd Sarip (Participant), & Melissa LaBonte Wilson (Participant)

    25 Nov 2019

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

    Challenges and risks of treating cancer: pre-empting/preventing metastasis

    Cristina Branco (Advisor)

    19 Sep 2018

    Activity: Talk or presentation typesInvited talk

    Endothelial cell contribution to organ microenvironment and metastatic disease

    Cristina Branco (Advisor)

    11 Oct 2018

    Activity: Talk or presentation typesInvited talk