Accepting PhD Students

PhD projects

I will support research programs in all aspects of CF and bronchiectasis care, this could include clinical trials, pulmonary exacerbation exploration, microbiology and basic science mechanisms.

19992020

Research output per year

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Research Output

2020

Gram negative infections in cystic fibrosis: a review of preventative and treatment options

Addy, C., Caskey, S. & Downey, D., 29 Jan 2020, In : Expert Opinion on Orphan Drugs. 8, 1, p. 11-26 16 p.

Research output: Contribution to journalArticle

Staphylococcus Aureus Enterotoxins In People With Cystic Fibrosis (CF)

Wen, H., McCaughan, J., Schock, B. C., Reid, A., Rendall, J. C., Elborn, J. S., Downey, D. G., Ennis, M. & Moore, J. E., Jan 2020, In : The Ulster Medical Journal. 89, 1, p. 38-39 2 p.

Research output: Contribution to journalLetter

Who's at The Door? - Surface Contamination of Door Frames in a Single-Bedded In-Patient Adult Cystic Fibrosis (CF) Unit

Furukawa, M., McCaughan, J., Stirling, J., Millar, B. C., Addy, C., Caskey, S., Goldsmith, C. E., Rendall, J. C., Misawa, N., Downey, D. G. & Moore, J. E., Jan 2020, In : The Ulster Medical Journal. 89, 1, p. 17-20 4 p.

Research output: Contribution to journalArticle

Open Access
File
2 Downloads (Pure)

Who’s at the door? – surface contamination of door frames in a single-bedded in-patient adult cystic fibrosis (CF) unit

Furukawa, M., McCaughan, J., Stirling, J., Millar, B. C., Addy, C., Caskey, S., Goldsmith, C. E., Rendall, J. C., Misawa, N., Downey, D. G. & Moore, J. E., Jan 2020, In : Ulster Medical Journal. 89, 1, p. 17-20 4 p.

Research output: Contribution to journalArticle

Open Access
File
2 Downloads (Pure)
2019
Open Access
File
4 Citations (Scopus)
15 Downloads (Pure)

Community analysis and co-occurrence patterns in airway microbial communities during health and disease

Einarsson, G. G., Zhao, J., LiPuma, J. J., Downey, D. G., Tunney, M. M. & Elborn, J. S., 08 Jul 2019, In : ERJ Open. 5, 3, 11 p., 00128-2017.

Research output: Contribution to journalArticle

Open Access
File
79 Downloads (Pure)
35 Citations (Scopus)
Open Access

Improved culture detection of Staphylococcus aureus from sputum of patients with cystic fibrosis (CF)

Wen, H., Stirling, J., McCaughan, J., Schock, B., Downey, D. G., Ennis, M. & Moore, J. E., 13 Oct 2019, In : Journal of Clinical Pathology. jclinpath-2019-206059

Research output: Contribution to journalArticle

P112 Proton pump inhibitor use is associated with increased pulmonary exacerbations and hospital admissions in adult patients with cystic fibrosis

Ferguson, C., Mckeown, C., Hagan, C., Moore, J. E., McCaughan, J., Kirkwood, Z., Addy, C., Caskey, S. & Downey, D. G., 27 May 2019, In : Journal of Cystic Fibrosis. 18, p. S89

Research output: Contribution to journalMeeting abstract

P179 Detection of multi-drug resistant (MDR) Pseudomonas aeruginosa (PA) in people with cystic fibrosis

Sherrard, L., Allen, D., Barron, M., Einarsson, G., Johnston, E., O'Neill, K., McIlreavey, L., McGrath, S., Gilpin, D., Downey, D., Reid, A., McElvaney, N., Boucher, R. C., Muhlebach, M. S., Elborn, S. & Tunney, M., Jun 2019, In : Journal of Cystic Fibrosis. 18, S1, p. S108

Research output: Contribution to journalMeeting abstract

P206 Does adherence to DNase change following initiation of Orkambi for the treatment of cystic fibrosis?

McKeown, C., O'Neill, B., Addy, C., Caskey, S. & Downey, D. G., 27 May 2019, In : Journal of Cystic Fibrosis. 18, p. S115-S116

Research output: Contribution to journalMeeting abstract

P347 A survey of cardiovascular disease in UK cystic fibrosis centres

Downey, D. G., Bengoechea, J., Curtis, T., Grieve, D. & Harbinson, M., Jun 2019, In : Journal of Cystic Fibrosis. 18, p. S155-S156

Research output: Contribution to journalMeeting abstract

Poster abstract: Bacterial and fungal co-colonisation leads to poorer clinical outcomes in an adult cystic fibrosis population

Ferguson, C., Moore, J. E., McCaughan, J., Addy, C., Downey, D., Caskey, S. & Hagan, C., Jun 2019, In : Journal of Cystic Fibrosis. 18, Supplement 1, p. S105-S106 2 p., P170.

Research output: Contribution to journalMeeting abstract

Poster abstract: Use of the Fitbit Charge HR to monitor physical activity, sleep and heart rate during IV therapy for pulmonary exacerbations

Addy, C., Bradley, J. M., Elborn, J. S. & Downey, D. G., Jun 2019, In : Journal of Cystic Fibrosis. 18, Supplement 1, p. S126-S127 2 p., P247 .

Research output: Contribution to journalMeeting abstract

So You Want to be aClinical Research Fellow

Addy, C., Bradley, J., McGarvey, L., Elborn, J. S. & Downey, D., Jan 2019, In : The Ulster Medical Journal. 88, 1, p. 60-61 2 p.

Research output: Contribution to journalArticle

Open Access
File
59 Downloads (Pure)

Tackling bias in clinical trials

van Koningsbruggen-Rietschel, S. & Downey, D. G., 20 Jun 2019, In : Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 18, 4, p. 445-446 2 p.

Research output: Contribution to journalEditorial

WS06-1 Initial results evaluating combinations of the novel CFTR corrector PTI-801, potentiator PTI-808, and amplifier PTI-428 in cystic fibrosis subjects

Downey, D., Flume, P., Jain, M., Fajac, I., Schwarz, C., Pressler, T., Van Koningsbruggen-Rietschel, S., Taylor-Cousar, J., Horsley, A., Sutharsan, S., Miller, J., Poirier, G., Jiang, J., Inoue, T., Wilson, S., Lee, P-S. & Gilmartin, G., Jun 2019, In : Journal of Cystic Fibrosis. 18, Suppl 1, p. S10 1 p.

Research output: Contribution to journalMeeting abstract

2018

Airway infection, systemic inflammation and lung clearance index in children and adults with cystic fibrosis

O'Neill, K., Bradley, J., Reid, A., Downey, D., Rendall, J. C., McCaughan, J., Moore, J., Tunney, M. & Elborn, J., 31 Jan 2018, In : European Respiratory Journal. 51, 2, 4 p., 1701704.

Research output: Contribution to journalLetter

Open Access
File
5 Citations (Scopus)
96 Downloads (Pure)

Antimicrobial effect of dimethyl sulfoxide and N, N-Dimethylformamide on Mycobacterium abscessus: Implications for antimicrobial susceptibility testing

Kirkwood, Z. I., Millar, B. C., Downey, D. G. & Moore, J. E., 15 Jun 2018, In : International journal of mycobacteriology. 7, 2, p. 134-136 3 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
208 Downloads (Pure)

Antimycobacterial activity of nonantibiotics associated with the polypharmacy of cystic fibrosis (CF) against mycobacterium abscessus

Kirkwood, Z. I., Millar, B. C., Downey, D. G. & Moore, J. E., 05 Dec 2018, In : International journal of mycobacteriology. 7, 4, p. 358-360

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
125 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
134 Downloads (Pure)
Open Access
File
7 Downloads (Pure)

Failure to conceive in women with CF is associated with pancreatic insufficiency and advancing age

Shteinberg, M., Lulu, A. B., Downey, D. G., Blumenfeld, Z., Rousset-Jablonski, C., Perceval, M., Colombo, A., Stein, N., Livnat, G., Gur, M., Bentur, L., Mussaffi, H., Blau, H., Sarouk, I., Dagan, A., Kerem, E., Aviram, M., Picard, E., Aliberti, S., Álvarez, A. & 5 others, Miranda, J. P., Polverino, E., Durieu, I., Stuart Elborn, J. & Cohen-Cymberknoh, M., 23 Oct 2018, In : Journal of Cystic Fibrosis. p. 1-7

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
86 Downloads (Pure)

Increasing burden of antimicrobial resistance in pseudomonas aeruginosa from adult patients with cystic fibrosis (CF) in Northern Ireland: Then and now

Gramegna, A., Moore, J. E., McCaughan, J., Millar, B. C., Ewing, J., Elborn, J. S., Blasi, F. & Downey, D. G., May 2018, In : Ulster Medical Journal. 87, 2, p. 129-130 2 p.

Research output: Contribution to journalLetter

Open Access
File
1 Citation (Scopus)
50 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
178 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
135 Downloads (Pure)

Microscopic Polyangitis secondary to Mycobacterium abscessus in a patient with Bronchiectasis: A case report

Addy, C., Doran, G., Jones, A. L., Wright, G., Caskey, S. & Downey, D., 19 Nov 2018, In : BMC Pulmonary Medicine. 18, 170

Research output: Contribution to journalArticle

Open Access
File
110 Downloads (Pure)

Pathogen eradication” and “Emerging pathogens”: Difficult definitions in cystic fibrosis

Gilligan, P. H., Downey, D. G., Elborn, J. S., Flume, P. A., Funk, S., Gilpin, D., Kidd, T. J., McCaughan, J., Millar, B. C., Murphy, P. G., Rendall, J. C., Tunney, M. M. & Moore, J. E., 06 Jun 2018, In : Journal of Clinical Microbiology. p. 1-23

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
57 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
131 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
221 Downloads (Pure)

The diagnosis and management of respiratory tract fungal infection in cystic fibrosis: A UK survey of current practice

Boyle, M., Moore, J. E., Whitehouse, J. L., Bilton, D. & Downey, D. G., 15 Mar 2018, In : Medical Mycology.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
1701 Downloads (Pure)

Theratyping in cystic fibrosis

Crawford, K. J. & Downey, D. G., 18 Aug 2018, In : Current Opinon in Pulmonary Medicine.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
298 Downloads (Pure)
2017

A treatment evaluator tool to monitor the real-world effectiveness of inhaled aztreonam lysine in cystic fibrosis

Plant, B. J., Downey, D. G., Eustace, J. A., Gunaratnam, C., Haworth, C. S., Jones, A. M., McKone, E. F., Peckham, D. G., Ketchell, R. I. & Bilton, D., 06 Apr 2017, In : Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 7 p.

Research output: Contribution to journalArticle

Open Access
File
297 Downloads (Pure)

Biomarkers to monitor exacerbations in cystic fibrosis

Gray, R. D., Downey, D. & Taggart, C. C., 03 Apr 2017, In : Expert review of respiratory medicine. 11, 4, p. 255-257 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
6 Citations (Scopus)

Efficacy of Pseudomonas aeruginosa eradication regimens in bronchiectasis

Vallières, E., Tumelty, K., Tunney, M. M., Hannah, R., Hewitt, O., Elborn, J. S. & Downey, D. G., 01 Apr 2017, In : European Respiratory Journal. 49, 4, 3 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
237 Downloads (Pure)

Immunodeficiency in Bronchiectasis

Coulter, T., Devlin, L., Downey, D., Elborn, J. & Edgar, D., 23 Dec 2017, Bronchiectasis The EMBARC Manual. Springer

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Lung function and disease severity in cystic fibrosis patients heterozygous for p.Arg117His

Shteinberg, M., Downey, D. G., Beattie, D., McCaughan, J., Reid, A., Stein, N. & Elborn, J. S., 01 Feb 2017, In : ERS Monograph. 3, 1, 00056-2016.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
1966 Downloads (Pure)

Relative resistance index (RRI) - a scoring system for antibiotic resistance in Pseudomonas aeruginosa

Ewing, J. C., McCaughan, J., Moore, J., Fairley, D., Sutherland, B., Reid, A. & Downey, D., 26 Jul 2017, In : British Journal of Biomedical Science. 5 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
3465 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
152 Downloads (Pure)
2016

A change in behaviour — getting the balance right for research and policy

O'Sullivan, M., Ryan, C., Downey, D. & Hughes, C. M., Oct 2016, In : International Journal of Clinical Pharmacy. 38, 5, p. 1027-31 5 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
154 Downloads (Pure)

Closed circuit rebreathing to achieve inert gas wash-in for multiple breath wash-out

Horsley, A. R., O'Neill, K., Downey, D. G., Elborn, J. S., Bell, N. J., Smith, J. & Owers-Bradley, J., 09 Feb 2016, In : ERJ Open. 2, 1, 8 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
237 Downloads (Pure)

Exploring the timing of Hypertonic Saline (HTS) and Airways Clearance Techniques (ACT) in Cystic Fibrosis (CF): a cross over study

Bradley, JM., O'Neill, K., Moran, F., Bradbury, I., Downey, DG., Rendall, JS., Tunney, MM. & Elborn, JS., 01 Dec 2016, In : Thorax. p. A134-A135 2 p.

Research output: Contribution to journalMeeting abstract

How specific are fluorogenic substrates designed to analyse active protease biomarkers of respiratory disease?

Robb, C., Ferguson, T., Moffitt, K., Downey, D., McCafferty, D., Ribeiro, D., Martin, L. & Walker, B., Dec 2016, In : Thorax. 71, Suppl 3, p. A79-A80 2 p.

Research output: Contribution to journalMeeting abstract

1 Citation (Scopus)