Damian Downey

2024

Bridging the gap: Challenging lung infections and clinical trial development in cystic fibrosis

Downey, D. G., Simmonds, N. J., van Koningsbruggen-Rietschel, S., Bend, J., Dunlevy, F., Hill, K. & Dupont, L., 23 Nov 2024, (Early online date) In: Journal of Cystic Fibrosis.

Research output: Contribution to journal › Article › peer-review

Open Access

Diminished airway host innate response in people with cystic fibrosis who experience frequent pulmonary exacerbations

Houston, C. J., Alkhatib, A., Einarsson, G. G., Tunney, M. M., Taggart, C. C. & Downey, D. G., 01 Feb 2024, In: European Respiratory Journal. 63, 2, 15 p., 2301228.

Research output: Contribution to journal › Article › peer-review

Open Access

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2 Citations (Scopus)

24 Downloads (Pure)

ECFS standards of care on CFTR-related disorders: identification and care of the disorders

Simmonds, N. J., Southern, K. W., De Wachter, E., De Boeck, K., Bodewes, F., Mainz, J. G., Middleton, P. G., Schwarz, C., Vloeberghs, V., Wilschanski, M., Bourrat, E., Chalmers, J. D., Ooi, C. Y., Debray, D., Downey, D. G., Eschenhagen, P., Girodon, E., Hickman, G., Koitschev, A. & Nazareth, D. & 9 others, Nick, J. A., Peckham, D., VanDevanter, D., Raynal, C., Scheers, I., Waller, M. D., Sermet-Gaudelus, I., Castellani, C. & ECFS Diagnostic Network Working Group, 19 Mar 2024, (Early online date) In: Journal of Cystic Fibrosis.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Genomic analysis and surveillance of respiratory syncytial virus using wastewater-based epidemiology

Allen, D. M., Reyne, M. I., Allingham, P., Levickas, A., Bell, S. H., Lock, J., Coey, J. D., Carson, S., Lee, A. J., McSparron, C., Nejad, B. F., McKenna, J., Shannon, M., Li, K., Curran, T., Broadbent, L. J., Downey, D. G., Power, U. F., Groves, H. E. & McKinley, J. M. & 3 others, McGrath, J. W., Bamford, C. G. G. & Gilpin, D. F., 15 Oct 2024, In: The Journal of Infectious Diseases. 230, 4, p. e895-e904 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2 Citations (Scopus)

39 Downloads (Pure)

Inhaled antimicrobial prescribing for Pseudomonas aeruginosa infections in Europe

Sloan, C. M., Sherrard, L. J., Einarsson, G. G., Dupont, L. J., van Koningsbruggen-Rietschel, S., Simmonds, N. J. & Downey, D. G., May 2024, In: Journal of Cystic Fibrosis. 23, 3, p. 499-505 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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4 Citations (Scopus)

28 Downloads (Pure)

Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment

Einarsson, G. G., Sherrard, L. J., Hatch, J. E., Zorn, B., Johnston, E., McGettigan, C., O'Neill, K., Gilpin, D. F., Downey, D. G., Murray, M., Lavelle, G., McElvaney, G., Wolfgang, M. C., Boucher, R., Muhlebach, M. S., Bradbury, I., Elborn, J. S. & Tunney, M. M., Mar 2024, In: Journal of Cystic Fibrosis. 23, 2, p. 252-261 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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4 Citations (Scopus)

42 Downloads (Pure)

Maternal and fetal outcomes in multiparous women with cystic fibrosis

Cohen-Cymberknoh, M., Ariel Dabby, M., Gindi Reiss, B., Melo Tanner, J., Pérez, G., Lechtzin, N., Polverino, E., Perez Miranda, J., Gramegna, A., Aliberti, S., Levine, H., Mussaffi, H., Blau, H., Prais, D., Mei-Zahav, M., Shteinberg, M., Livnat, G., Gur, M., Bentur, L. & Downey, D. G. & 12 others, Dagan, A., Golan-Tripto, I., Aviram, M., Mondejar-Lopez, P., Picard, E., Schwarz, C., Jakubec, P., Kazmerski, T. M., Amsalem, H., Hochner Celnikier, D., Kerem, E. & Reiter, J., Jul 2024, In: Respiratory Medicine. 228, 6 p., 107654.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Practical guidance for clinical microbiology laboratories: updated guidance for processing respiratory tract samples from people with cystic fibrosis

Saiman, L., Waters, V., LiPuma, J. J., Hoffman, L. R., Alby, K., Zhang, S. X., Yau, Y. C., Downey, D. G., Sermet-Gaudelus, I., Bouchara, J.-P., Kidd, T. J., Bell, S. C. & Brown, A. W., 2024, In: Clinical Microbiology Reviews. 37, 3, 40 p., e0021521.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Reversal of levofloxacin resistance in cystic fibrosis-associated Pseudomonas aeruginosa through dual inhibition of efflux pumps and DNA topoisomerases

Sloan, C. M., Sherrard, L. J., Einarsson, G. G., Tunney, M. M. & Downey, D. G., 07 Jun 2024, In: Journal of Cystic Fibrosis. 23, Supplement 1, p. S41 1 p., EPS3.04.

Research output: Contribution to journal › Meeting abstract › peer-review

SLPI deficiency alters airway protease activity and induces cell recruitment in a model of muco-obstructive lung disease

Brown, R., Dougan, C., Ferris, P., Delaney, R., Houston, C. J., Rodgers, A., Downey, D. G., Mall, M. A., Connolly, B., Small, D., Weldon, S. & Taggart, C. C., 05 Sept 2024, In: Frontiers in Immunology. 15, 9 p., 1433642.

Research output: Contribution to journal › Article › peer-review

Open Access

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15 Downloads (Pure)

Standards for the care of people with cystic fibrosis (CF); Planning for a longer life

Gramegna, A., Addy, C., Allen, L., Bakkeheim, E., Brown, C., Daniels, T., Davies, G., Davies, J. C., De Marie, K., Downey, D., Felton, I., Hafkemeyer, S., Hamouda, S., Kendall, V., Lindberg, U., Macek, M., Mayell, S., Pearlsman, O., Schechter, M. S. & Salvatori, L. & 20 others, Sands, D., Schwarz, C., Shteinberg, M., Taylor, J., Taylor-Cousar, J. L., Taylor-Robinson, D., Watkins, B., Verkleij, M., Bevan, A., Castellani, C., Drevinek, P., Gartner, S., Lammertyn, E., Landau, E. E. C., Middleton, P. G., Plant, B. J., Smyth, A. R., van Koningsbruggen-Rietschel, S., Burgel, P.-R. & Southern, K. W., 15 Jun 2024, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 23, 3, p. 375-387 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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2 Citations (Scopus)

43 Downloads (Pure)

Submission of comments on 'Reflection paper on establishing efficacy based on single arm trials submitted as pivotal evidence in a marketing authorisation' (EMA/CHMP/564424/2021)

Downey, D., Hill, K. & Dunlevy, F., 23 Sept 2024, 7 p. European Medicines Agency.

Research output: Other contribution

Open Access

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4 Downloads (Pure)

2023

Advancing the pipeline of cystic fibrosis clinical trials: a new roadmap with a global trial network perspective

Mayer-Hamblett, N., Clancy, J. P., Jain, R., Donaldson, S. H., Fajac, I., Goss, C. H., Polineni, D., Ratjen, F., Quon, B. S., Zemanick, E. T., Bell, S. C., Davies, J. C., Jain, M., Konstan, M. W., Kerper, N. R., LaRosa, T., Mall, M. A., McKone, E., Pearson, K. & Pilewski, J. M. & 6 others, Quittell, L., Rayment, J. H., Rowe, S. M., Taylor-Cousar, J. L., Retsch-Bogart, G. & Downey, D. G., Oct 2023, In: The Lancet. Respiratory medicine. 11, 10, p. 932-944

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

CFTR modulator therapy: transforming the landscape of clinical care in cystic fibrosis

Taylor-Cousar, J. L., Robinson, P. D., Shteinberg, M. & Downey, D. G., 30 Sept 2023, In: The Lancet. 402, 10408, p. 1171-1184

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Characterisation of the CF sputum proteome reveals that innate host defence proteins are depleted in frequent exacerbators

Houston, C., Alkhatib, A., Einarsson, G., Tunney, M., Taggart, C. & Downey, D., 09 Sept 2023, In: European Respiratory Journal. 62, suppl 67, OA1536.

Research output: Contribution to journal › Meeting abstract › peer-review

Development of levofloxacin resistance in clinical Pseudomonas aeruginosa isolates from people with cystic fibrosis in an in vitro variable exposure model

Sloan, C. M., Sherrard, L. J., Einarsson, G. G., Tunney, M. M. & Downey, D. G., 01 Jun 2023, In: Journal of Cystic Fibrosis. 22 , Supplement 2, p. S62 1 p., EPS9.06.

Research output: Contribution to journal › Meeting abstract › peer-review

ECFS Clinical Trials Network annual report 2022

Downey, D., Dunlevy, F., Hill, K., Bulteel, V., Verbrugge, A. & Sermet-Gaudelus, I., 08 Nov 2023, European Cystic Fibrosis Society. 39 p.

Research output: Book/Report › Other report

Open Access

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12 Downloads (Pure)

Future therapies for cystic fibrosis

Allen, L., Allen, L., Carr, S. B., Davies, G., Downey, D., Egan, M., Forton, J. T., Gray, R., Haworth, C., Horsley, A., Smyth, A. R., Southern, K. W. & Davies, J. C., 08 Feb 2023, In: Nature Communications. 14, 13 p., 693.

Research output: Contribution to journal › Review article › peer-review

Open Access

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52 Citations (Scopus)

113 Downloads (Pure)

Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial

Abdullah, A., Ahmad, M., Alderdice, D., Alexander, J., Alexander, P. D. G., Ali, S., Allen, K., Anderson, J., Anderson, S., Anderson, W., Baker, M., Barlow, R., Brady, C., Brown, A., Browne, D., Burns, A., Campbell, M., Carr, S., Chambers, E. & Chapman, K. & 151 others, Clark, P., Collins, E., Comer, D., Cooper, D., Craig, V., Cunningham, N., Curran, D., Davies, B., Davies, S., Dawson, E., Doherty, C., Donnelly, E., Donnelly, R., Downey, D., Drain, M., Evans, E., Evans, J., Evans, J., Ferguson, J., Fowler, S., Gallagher, W., Gordon, C., Gosling, R., Grant, D., Green, D., Griffiths, S., Hameed, M., Harrison, T., Hart, D., Heron, E., Hewitt, R., Hughes, S., Ibrahim, A., Jackson, A., Johnson, G., Johnson, M., Johnston, J., Jones, A., Jones, L., Jones, S., Jones, S., Jones, T., Keegan, B., Kelly, D., Kelly, D., Kelly, E., Kelly, M., Kelly, M., Kelly, S., Kerr, A., Khan, W., Kinnear, D. J., Kumar, S., Lee, S., Linden, D., Malone, E., Marshall, A., McCourt, P., McDermott, J., McElwaine, F., McGarvey, L., McGettigan, C., McGrath, B., McMahon, S., McManus, T., McMaster, P., McNally, H., Millar, J., Molloy, A., Moore, D. A. J., Moore, L., Morgan, P., Morris, P., Murray, C., Murray, L., Murray, T., Nguyen, Q., Nguyen, T. T. P., North, F., Nugent, A. M., O'Gorman, C., Orr, S., Patterson, R., Quinn, J., Regan, M., Rehman, A., Reid, A., Reid, J., Rice, M., Ritchie, J., Robinson, E., Robinson, M., Rogers, J., Rowan, S., Ryan, K., Saad, M., Scott, A., Scott, S., Shah, S., Shaw, C., Simms, R., Simpson, T., Simpson, K., Sloan, B., Smith, C., Smith, C., Smith, O., Smith, R., Smith, R., Smith, S., Smith, S., Smith, S., Smith, J., Sreenivasan, S., Stevenson, A., Stewart, C., Tan, W. T., Taylor, J., Taylor, S., Taylor, V., Thompson, C., Thompson, L., Thompson, L., Tinkler, M., Walsh, E., Walters, J., Walton, M., Wang, R., Ward, C., Ward, H., Ward, N., Ward, T., Watson, J. G. R., Watson, R., Webster, D., Webster, I., White, C., White, J., Williams, G., Williams, J., Williams, J., Williams, M., Williams, R., Williamson, J. D., Wilson, A., Wilson, A., Wilson, D., Wilson, M., Zhang, J., Zhao, X. & RECOVERY Collaborative Group, 06 May 2023, In: The Lancet. 401, 10387, p. 1499-1507 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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64 Citations (Scopus)

35 Downloads (Pure)

Improvement in lung clearance index and chest computed tomography scores with elexacaftor/tezacaftor/ivacaftor treatment in people with cystic fibrosis aged 12 years and older – The RECOVER Trial

McNally, P., Lester, K., Stone, G., Elnazir, B., Williamson, M., Cox, D., Linnane, B., Kirwan, L., Rea, D., O’Regan, P., Semple, T., Saunders, C., Tiddens, H. A. W. M., McKone, E., Davies, J. C., Lewis, C., Persaud, T., McQuaid, A., Twomey, E. & Lambe, A. & 9 others, McGrane, S., Dodd, J., Short, C., Downey, D., Keown, K., Broderick, B., Heffernan, C., Thornton, C. & RECOVER Study Group, 01 Nov 2023, In: American Journal of Respiratory and Critical Care Medicine. 208, 9, p. 917-929 13 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

In vitro evolution of levofloxacin resistance in lineages of clinical Pseudomonas aeruginosa isolates cultured at different stages of infection from people with cystic fibrosis

Sloan, C. M., Sherrard, L. J., Einarsson, G. G., Hoffman, L. R., Tunney, M. M. & Downey, D. G., 01 Jun 2023, In: Journal of Cystic Fibrosis. 22, Supplement 2, p. S135 1 p., P228.

Research output: Contribution to journal › Meeting abstract › peer-review

Optimisation of inhaled antibiotic prescribing for Pseudomonas aeruginosa infections in people with cystic fibrosis: further insights from principal investigators of the ECFS Clinical Trials Network

Sloan, C. M., Sherrard, L. J., Einarsson, G. G., Dupont, L. J., van Koningsbruggen-Rietschel, S., Simmonds, N. J. & Downey, D. G., 09 Jun 2023, In: Journal of Cystic Fibrosis. 22 , Supplement 2, p. S143 1 p., P253.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Understanding and addressing the needs of people with cystic fibrosis in the era of CFTR modulator therapy

Hisert, K. B., Birket, S. E., Clancy, J. P., Downey, D. G., Engelhardt, J. F., Fajac, I., Gray, R. D., Lachowicz-Scroggins, M. E., Mayer-Hamblett, N., Thibodeau, P., Tuggle, K. L., Wainwright, C. E. & De Boeck, K., 03 Oct 2023, In: The Lancet. Respiratory medicine. 11, 10, 916 p., 16.

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

2022

556 Evaluation of total bacterial 16S load and inflammation during intravenously treated pulmonary exacerbations in infrequent and frequent exacerbators

Houston, C., Tunney, M., Taggart, C. & Downey, D., 01 Oct 2022, In: Journal of Cystic Fibrosis. 21, Supplement 2, p. S309-S310 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Antimicrobial prescribing in people with cystic fibrosis: exploring inhaled antibiotic use for Pseudomonas aeruginosa infections across the ECFS-CTN

Sloan, C., Sherrard, L., Einarsson, G., Dupont, L. J., Simmonds, N., van Koningsbruggen-Rietschel, S. & Downey, D., 01 Jun 2022, In: Journal of Cystic Fibrosis. 21, Supplement 1, p. S107 1 p., P150.

Research output: Contribution to journal › Meeting abstract › peer-review

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Downey, D., Linden, D., McGarvey, L. & RECOVERY Collaborative Group, 08 Jan 2022, In: The Lancet. 399, 10320, p. 143-151 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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216 Citations (Scopus)

25 Downloads (Pure)

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis

Abdullah, A., Ahmad, M., Alderdice, D., Alexander, J., Alexander, P. D. G., Ali, S., Allen, K., Anderson, J., Anderson, S., Anderson, W., Baker, M., Barlow, R., Brady, C., Brown, A., Browne, D., Burns, A., Campbell, M., Carr, S., Chambers, E. & Chapman, K. & 147 others, Clark, P., Collins, E., Comer, D., Cooper, D., Craig, V., Cunningham, N., Curran, D., Davies, S., Dawson, E., Doherty, C., Donnelly, E., Donnelly, R., Downey, D., Drain, M., Evans, J., Evans, J., Ferguson, J., Fowler, S., Gallagher, W., Gordon, C., Gosling, R., Grant, D., Green, D., Griffiths, S., Hameed, M., Harrison, T., Hart, D., Heron, E., Hewitt, R., Hughes, S., Ibrahim, A., Jackson, A., Johnson, G., Johnson, M., Johnston, J., Jones, A., Jones, L., Jones, S., Jones, S., Jones, T., Keegan, B., Kelly, D., Kelly, D., Kelly, E., Kelly, M., Kelly, M., Kelly, S., Kerr, A., Khan, W., Kinnear, D. J., Kumar, S., Lee, S., Linden, D., Malone, E., Marshall, A., McCourt, P., McDermott, J., McElwaine, F., McGarvey, L., McGettigan, C., McGrath, B., McMahon, S., McManus, T., McNally, H., Millar, J., Molloy, A., Moore, D. A. J., Moore, L., Morgan, P., Morris, P., Murray, C., Murray, L., Murray, T., Nguyen, Q., North, F., Nugent, A. M., O'Gorman, C., Orr, S., Patterson, R., Quinn, J., Regan, M., Rehman, A., Reid, A., Reid, J., Rice, M., Ritchie, J., Robinson, E., Robinson, M., Rogers, J., Rowan, S., Ryan, K., Saad, M., Scott, A., Scott, S., Shah, S., Shaw, C., Simms, R., Simpson, T., Simpson, K., Sloan, B., Smith, C., Smith, C., Smith, O., Smith, R., Smith, R., Smith, S., Smith, S., Smith, S., Smith, J., Sreenivasan, S., Stevenson, A., Stewart, C., Tan, W. T., Taylor, J., Taylor, S., Taylor, V., Thompson, C., Thompson, L., Thompson, L., Tinkler, M., Walsh, E., Walters, J., Walton, M., Wang, R., Ward, C., Ward, H., Ward, N., Ward, T., Watson, J. G. R., Watson, R., Webster, D., Webster, I., White, C., White, J., Williams, G., Williams, J., Williams, J., Williams, M., Williams, R., Williamson, J. D., Wilson, A., Wilson, A., Wilson, D., Wilson, M., Zhang, J., Zhao, X. & RECOVERY Collaborative Group, 30 Jul 2022, In: The Lancet. 400, 10349, p. 359-368 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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186 Citations (Scopus)

17 Downloads (Pure)

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Downey, D., Linden, D., McGarvey, L. & RECOVERY Collaborative Group, 12 Feb 2022, In: The Lancet. 399, 10325, p. 665-676 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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247 Citations (Scopus)

62 Downloads (Pure)

Clinimetric properties of outcome measures in bronchiectasis

Bradley, J. M., Ferguson, K., Bailey, A., O'Neill, K., McLeese, R. H., Hill, A. T., Loebinger, M. R., Carroll, M., Chalmers, J. D., Gatheral , T., Johnson, C., De Soyza , A., Hurst, J. R., Downey, D. G. & Elborn, J. S., 22 Dec 2022, (Early online date) In: Annals of the American Thoracic Society.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

48 Downloads (Pure)

Diagnostic agreement among experts assessing adults presenting with possible cystic fibrosis: need for improvement and implications for patient care

Franciosi, A. N., Tanzler, A., Goodwin, J., Wilcox, P. G., Solomon, G. M., Faro, A., McElvaney, N. G., Downey, D. G. & Quon, B. S., 01 Oct 2022, In: ERJ Open Research. 8, 4, 00227-2022.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

28 Downloads (Pure)

ECFS Clinical Trials Network annual report 2021

Downey, D., Dunlevy, F., Hill, K., Bulteel, V., Verbrugge, A. & Sermet-Gaudelus, I., 31 Aug 2022, European Cystic Fibrosis Society. 20 p.

Research output: Book/Report › Other report

Open Access

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14 Downloads (Pure)

Induced levofloxacin resistance persists in evolved lineages of Pseudomonas aeruginosa isolates from people with cystic fibrosis after exposure to other inhaled antibiotics

Sloan, C. M., Sherrard, L. J., Einarsson, G. G., Tunney, M. M. & Downey, D. G., 01 Jun 2022, In: Journal of Cystic Fibrosis. 21, Supplement 1, p. S50 1 p., ePS3.05.

Research output: Contribution to journal › Meeting abstract › peer-review

Isolation, cultivation, and application of primary respiratory epithelial cells obtained by nasal brushing, polyp samples, or lung explants

Golec, A., Pranke, I., Scuderi, P., Hayes, K., Dreano, E., Dunlevy, F., Hatton, A., Downey, D. G., Galietta, L. & Sermet, I., 17 Jun 2022, In: STAR Protocols. 3, 2, 33 p., 101419.

Research output: Contribution to journal › Article › peer-review

Open Access

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7 Citations (Scopus)

129 Downloads (Pure)

P115 Comparison of total bacterial and Pseudomonas aeruginosa load during PEx between infrequent and frequent exacerbators

Houston, C., Tunney, M. M., Taggart, C. C. & Downey, D. G., 01 Jun 2022, In: Journal of Cystic Fibrosis. 21, Supplement 1, p. S96 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

POINT: In the Era of Cystic Fibrosis Transmembrane Regulator Protein Modulator Therapy, Are the Treatment Goals for Adults Now Different From Those for Children With Cystic Fibrosis? Yes

Downey, D. G., 01 Jan 2022, In: Chest. 161, 1, p. 18-20 3 p.

Research output: Contribution to journal › Editorial › peer-review

2 Citations (Scopus)

Rebuttal From Dr Downey

Downey, D. G., 01 Jan 2022, In: Chest. 161, 1, p. 24 1 p.

Research output: Contribution to journal › Article › peer-review

The Effect of CFTR Modulators on Airway Infection in Cystic Fibrosis

Harvey, C., Weldon, S., Elborn, S., Downey, D. G. & Taggart, C., 23 Mar 2022, In: International Journal of Molecular Sciences. 23, 7, 3513.

Research output: Contribution to journal › Review article › peer-review

Open Access

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32 Citations (Scopus)

101 Downloads (Pure)

2021

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Downey, D., Linden, D. & RECOVERY Collaborative Group, 13 Feb 2021, In: Lancet (London, England). 397, 10274, p. 605-612 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

220 Citations (Scopus)

29 Downloads (Pure)

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY) a randomised controlled, open-label, platform trial

Linden, D., McGarvey, L. & RECOVERY Collaborative Group, 29 May 2021, In: The Lancet. 397, 10289, p. 2049-2059 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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369 Citations (Scopus)

39 Downloads (Pure)

Discovery of inhibition of burkholderia cenocepacia, pseudomonas aeruginosa and stenotrophomonas maltophilia by the brown rot basidiomycete fungus, postia placenta

McIlroy, R., Nelson, D. W., Millar, B. C., Murphy, A., Rao, J. R., Downey, D. G. & Moore, J. E., 11 Sept 2021, In: Ulster Medical Journal. 90, 3, p. 168-174 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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30 Downloads (Pure)

Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial

VX18-445-109 study group, 20 Dec 2021, (Early online date) In: The Lancet. Respiratory medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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88 Citations (Scopus)

427 Downloads (Pure)

Empire-CF study: A phase 2 clinical trial of leukotriene A4 hydrolase inhibitor acebilustat in adult subjects with cystic fibrosis

EMPIRE-CF study group, 16 Sept 2021, (Early online date) In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Research output: Contribution to journal › Article › peer-review

Open Access

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10 Citations (Scopus)

103 Downloads (Pure)

Evolution of levofloxacin resistance and phenotypic characterisation of Pseudomonas aeruginosa clinical isolates from people with cystic fibrosis

Sloan, C. M., Sherrard, L. J., Einarsson, G. G., Tunney, M. M. & Downey, D. G., 01 Jun 2021, In: Journal of Cystic Fibrosis. 20, Supplement 1, p. S84-S85 P149.

Research output: Contribution to journal › Meeting abstract › peer-review

Factors for severe outcomes following SARS-CoV-2 infection in people with cystic fibrosis in Europe

Jung, A., Orenti, A., Dunlevy, F., Aleksejeva, E., Bakkeheim, E., Bobrovnichy, V., Carr, S. B., Colombo, C., Corvol, H., Cosgriff, R., Daneau, G., Dogru, D., Drevinek, P., Vukic, A. D., Fajac, I., Fox, A., Fustik, S., Gulmans, V., Harutyunyan, S. & Hatziagorou, E. & 27 others, Kasmi, I., Kayserová, H., Kondratyeva, E., Krivec, U., Makukh, H., Malakauskas, K., McKone, E. F., Mei-Zahav, M., de Monestrol, I., Olesen, H. V., Padoan, R., Parulava, T., Pastor-Vivero, M. D., Pereira, L., Petrova, G., Pfleger, A., Pop, L., van Rens, J. G., Rodic, M., Schlesser, M., Storms, V., Turcu, O., Woz Niacki, L., Yiallouros, P., Zolin, A., Downey, D. G. & Naehrlich, L., 27 Dec 2021, In: ERJ Open Research. 7, 4, 00411.

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Impact of the SARS-CoV-2 pandemic on clinical trials in the ECFS-CTN during 2020

van Koningsbruggen-Rietschel, S., Dunlevy, F., Bulteel, V., Hayes, K., Verbrugge, A. & Downey, D., 11 Jun 2021.

Research output: Contribution to conference › Abstract › peer-review

Inflammation biomarkers in sputum for clinical trials in cystic fibrosis: current understanding and gaps in knowledge

Lepissier, A., Addy, C., Hayes, K., Noel, S., Bui, S., Burgel, P.-R., Dupont, L., Eickmeier, O., Fayon, M., Leal, T., Lopes, C., Downey, D. & Sermet-Gaudelus, I., 10 Nov 2021, (Early online date) In: Journal of Cystic Fibrosis. 68 p.

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13 Citations (Scopus)

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Long-term safety and efficacy of tezacaftor–ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study

VX14-661-110 study group, 10 Feb 2021, (Early online date) In: The Lancet Respiratory Medicine.

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40 Citations (Scopus)

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P116 Clinical characteristics of frequent and infrequent pulmonary exacerbations

Houston, C., Taggart, C. C. & Downey, D. G., 01 Jan 2021, In: Journal of Cystic Fibrosis. 20, Supplement 1, p. S74 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Protecting Clinical Trials in Cystic Fibrosis; COVID-19 Mitigation Measures Crowd Sourced from the European Cystic Fibrosis Society Clinical Trials Network

van Koningsbruggen-Rietschel, S., Dunlevy, F., Bulteel, V., Hayes, K., Verbrugge, A., Janssens, H., Dufeu, N., Simmonds, N. J., Dupont, L. J. & Downey, D. G., 28 Aug 2021, (Early online date) In: Trials. p. 1 11 p.

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Protecting clinical trials in cystic fibrosis during the SARS-CoV-2 pandemic: risks and mitigation measures

van Koningsbruggen-Rietschel, S., Dunlevy, F., Bulteel, V., Hayes, K., Verbrugge, A., Janssens, H. M., Dufeu, N., Simmonds, N. J., Dupont, L. J. & Downey, D. G., 28 Aug 2021, In: Trials. 22, 578.

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6 Citations (Scopus)

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Damian Downey

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