Accepting PhD Students

PhD projects

I will support research programs in all aspects of CF and bronchiectasis care, this could include clinical trials, pulmonary exacerbation exploration, microbiology and basic science mechanisms.

19992020

Research output per year

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Research Output

1999

Phase II trial to assess the biochemical efficacy of transgenic alpha1-anti-trypsin as an effective treatment of cystic fibrosis

Martin, L., Downey, D., Elborn, J. S., Bilton, D., Keogan, M. T. & Edgar, J., 01 Dec 1999, In : Thorax. 54, SUPPL. 3

Research output: Contribution to journalArticle

1 Citation (Scopus)

The relationship of outcome to Burkholderia cepacia, lung function and inflammatory markers in stable patients with cystic fibrosis

Martin, L., Downey, D., Dempster, M., Keogan, M., Starcher, B., Edgar, J., Bilton, D. & Elborn, J., Dec 1999, p. S10-S10. 1 p.

Research output: Contribution to conferencePaper

1 Citation (Scopus)
2000

Nitric oxide, iNOS, and inflammation in cystic fibrosis.

Downey, D., Feb 2000, In : Journal of Pathology. 190, 2, p. 115-116 2 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Safety of sputum induction.

Downey, D., 2000, In : Chest. 118(1), p. 276 1 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Safety of sputum induction [3] (multiple letters)

Kelly, M. G., Downey, D. G., Ennis, M., Elborn, J. S., Castagnaro, A., Chetta, A. & Olivieri, D., 2000, In : Chest. 118, 1, p. 276 1 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)
2004

Biomedical Science in Brief

Moore, J. E., Shaw, A., Millar, B. C., Martin, S. L., Murphy, P. G., Downey, D. G., Ennis, M., Elborn, J. S., Xu, J., Moore, J. E., Murphy, P. G., Millar, B. C., Redmond, A. O. B., Elborn, J. S., Conroy, S., Morrish, N., Wassif, W. S., Mak, C. M., Pang, R. W. C., Tam, S. & 8 others, Windsor, J. S., Clark, C. G., Macfarlane, L., Abutaleb, A., Abed, E., Qasem, L., Memish, Z. A. & Hajeer, A. H., Jan 2004, In : British Journal of Biomedical Science. 61, 3, p. 146-147 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2005

Microbial ecology of the cystic fibrosis lung: does microflora type influence microbial loading?

Moore, J. E., Shaw, A., Millar, B. C., Downey, D. G., Murphy, P. G. & Elborn, J., 2005, In : British Journal of Biomedical Science. 62(4), 4, p. 175-178 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2006

Safety and efficacy of recombinant alpha(1)-antitrypsin therapy in cystic fibrosis.

Martin, L., Downey, D., Bilton, D., Keogan, M. T., Edgar, J. & Elborn, J., Feb 2006, In : Pediatric Pulmonology. 41, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Serine proteinase inhibitor therapy in alpha(1)-antitrypsin inhibitor deficiency and cystic fibrosis.

Martin, S. L., Downey, D., Bilton, D., Keogan, M. T., Edgar, J. & Elborn, J. S., 2006, In : Pediatric Pulmonology. 41, 2, p. 363-375 13 p.

Research output: Contribution to journalArticle

2007
7 Citations (Scopus)

The effect of treatment of cystic fibrosis pulmonary exacerbations on airways and systemic inflammation

Downey, D. G., Brockbank, S., Martin, L., Ennis, M. & Elborn, J., Aug 2007, In : Pediatric Pulmonology. 42, 8, p. 729-735 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
115 Downloads (Pure)
2009

Highlights of the North American Cystic Fibrosis Conference 2008.

Downey, D., 2009, In : Journal of the Royal Society of Medicine. 102 Suppl 1, SUPPL.1, p. 18-22 5 p.

Research output: Contribution to journalArticle

Neutrophils in cystic fibrosis

Downey, D., Jan 2009, In : Thorax. 64, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)
2010

Thoracic ultrasound for pleural effusion: delays and cost associated with departmental scanning.

Downey, D. G., Apr 2010, In : Respiratory Medicine. 104(4), 4, p. 612-614 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2012

Comparison of antibiotic susceptibility patterns in Pseudomonas aeruginosa isolated from adult patients with cystic fibrosis (CF) with invasive Pseudomonas aeruginosa from non-CF patients

Rao, P., McCaughan, J., McCalmont, M., Goldsmith, C. E., Hall, V., Millar, B. C., McCann, M-A., Downey, D. G., Rendall, J., Elborn, J. S. & Moore, J. E., Jul 2012, In : Journal of Cystic Fibrosis. 11, 4, p. 349-52 4 p.

Research output: Contribution to journalLetter

11 Citations (Scopus)

Current pregnancy outcomes in women with cystic fibrosis

Burden, C., Ion, R., Chung, Y., Henry, A., Downey, D. G. & Trinder, J., Oct 2012, In : European Journal of Obstetrics, Gynaecology and Reproductive Biology. 164, 2, p. 142-145 4 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2013

Current pregnancy outcomes in women with cystic fibrosis

Burden, C., Ion, R., Chung, Y., Henry, A., Downey, D. G. & Trinder, J., Feb 2013, In : Obstetrical and Gynecological Survey. 68, 2, p. 87-88 2 p.

Research output: Contribution to journalComment/debate

Increased susceptibility to antibiotics in Gram-negative and Gram-positive pathogens, including Pseudomonas aeruginosa, at lower temperature: is antibiotic resistance reversal possible?

Moore, J. E., Moore, P. J. A., Downey, D., Millar, B. C., Coulter, W. A. & Goldsmith, C. E., 2013, In : British Journal of Biomedical Science. 70, 4, p. 173-174 2 p.

Research output: Contribution to journalArticle

Overview of the Pharmacological Treatment of Cystic Fibrosis

Gilpin, D., Tunney, M., Downey, D. & Elborn, S., 2013, Hospital Pharmacy Journal.

Research output: Contribution to specialist publicationArticle

2014

Eradication of Pseudomonas aeruginosa in adults with cystic fibrosis

Kenny, S. L., Shaw, T. D., Downey, D. G., Moore, J. E., Rendall, J. C. & Elborn, J. S., Aug 2014, In : BMJ Open Respiratory Research. 1, p. 1-7 e000021.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
142 Downloads (Pure)
9 Citations (Scopus)
2015

72 Potential for airborne bacterial contamination in an outpatient respiratory clinic

McElderry, J., O'Neill, K., Tunney, M. M., Downey, D. G., Rendall, J. C., Moore, J. E., Elborn, J. S. & Gilpin, D. F., Jun 2015, In : Journal of Cystic Fibrosis. 14, Supplement 1, p. S75 1 p.

Research output: Contribution to journalMeeting abstract

Open Access

Airborne bacteria and fungi concentrations in airtight contemporary dwellings

McGill, G., Moore, J., Sharpe, T., Downey, D. & Oyedele, L., 2015.

Research output: Working paper

Airborne Bacterial Contamination within an Outpatient Respiratory Clinic

J, M., O'Neill, K., Tunney, M., Downey, D., Rendall, J., Moore, J., Elborn, J. & Gilpin, D., 2015, p. S539-S540.

Research output: Contribution to conferenceAbstract

Do veterinary antibiotics have efficacy against highly resistant Gram-negative pathogens from patients with cystic fibrosis?

Moore, J. E., Alcorn, M., Ara, W., Millar, B. C., McCaughan, J., Rendall, J. C., McNeilly, J., Kuribayashi, T., Yamamoto, S., Matsuda, M., Goldsmith, C. E., Elborn, J. S. & Downey, D. G., Jan 2015, In : International Journal of Antimicrobial Agents. 45, 1, p. 93-95 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Game changers: A new dawn for the treatment of cystic fibrosis

Doherty, P. & Downey, D. G., Sep 2015, In : Ulster Medical Journal. 84, 3, p. 218-219

Research output: Contribution to journalComment/debate

Open Access
File
47 Downloads (Pure)

How reliable are cough swabs for the detection of Pseudomonas aeruginosa in adult patients with cystic fibrosis?

Moore, J. E., McCaughan, J., McNeilly, J., Rendall, J. C. & Downey, D. G., 2015, In : British Journal of Biomedical Science. 72, 4, p. 206

Research output: Contribution to journalArticle

Lack of Association Between Haptoglobin Phenotype and Cystic Fibrosis Outcomes

Shteinberg, M., Rivlin, J., Gur, M., Konopnicki, M., Stein, N., Tunney, M. M., Elborn, J. S., Downey, D. G., Johnston, E., Shalom, H. & Levy, A., Dec 2015, In : Lung. 193, 6, p. 1017-1021 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Pseudomonas aeruginosa displays an altered phenotype in vitro when grown in the presence of mannitol

Moore, J. E., Rendall, J. C. & Downey, D. G., 2015, In : British Journal of Biomedical Science. 72, 3, p. 115-119

Research output: Contribution to journalArticle

3 Citations (Scopus)

Survival dynamics of cystic fibrosis-related gram-negative bacterial pathogens (Pseudomonas aeruginosa and Burkholderia cenocepacia) in Dead Sea and Atlantic Ocean waters

Shteinberg, M., Kis-Papo, T., Millar, B. C., Rendall, J. C., Downey, D. G., Elborn, J. S. & Moore, J. E., Sep 2015, In : Journal of Water and Health. 13, 3, p. 773-776

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

A change in behaviour — getting the balance right for research and policy

O'Sullivan, M., Ryan, C., Downey, D. & Hughes, C. M., Oct 2016, In : International Journal of Clinical Pharmacy. 38, 5, p. 1027-31 5 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
159 Downloads (Pure)

Closed circuit rebreathing to achieve inert gas wash-in for multiple breath wash-out

Horsley, A. R., O'Neill, K., Downey, D. G., Elborn, J. S., Bell, N. J., Smith, J. & Owers-Bradley, J., 09 Feb 2016, In : ERJ Open. 2, 1, 8 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
240 Downloads (Pure)

Exploring the timing of Hypertonic Saline (HTS) and Airways Clearance Techniques (ACT) in Cystic Fibrosis (CF): a cross over study

Bradley, JM., O'Neill, K., Moran, F., Bradbury, I., Downey, DG., Rendall, JS., Tunney, MM. & Elborn, JS., 01 Dec 2016, In : Thorax. p. A134-A135 2 p.

Research output: Contribution to journalMeeting abstract

How specific are fluorogenic substrates designed to analyse active protease biomarkers of respiratory disease?

Robb, C., Ferguson, T., Moffitt, K., Downey, D., McCafferty, D., Ribeiro, D., Martin, L. & Walker, B., Dec 2016, In : Thorax. 71, Suppl 3, p. A79-A80 2 p.

Research output: Contribution to journalMeeting abstract

1 Citation (Scopus)

Lung clearance index in adults and children with cystic fibrosis

O'Neill, K., Tunney, M. M., Johnston, E., Rowan, S., Downey, D. G., Rendall, J., Reid, A., Bradbury, I., Elborn, J. S. & Bradley, J. M., 06 Jul 2016, In : Chest. 150, 6, p. 1323-1332 10 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
338 Downloads (Pure)

MRSA eradication of newly acquired lower respiratory tract infection in cystic fibrosis

Vallières, E., Rendall, J. C., Moore, J. E., McCaughan, J., Hoeritzauer, A. I., Tunney, M. M., Elborn, J. S. & Downey, D. G., 31 Mar 2016, In : ERJ Open. 2, 1, 00064-2015.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
224 Downloads (Pure)

Pharmacists' perspectives on monitoring adherence to treatment in Cystic Fibrosis

Mooney, K., Ryan, C. & Downey, D. G., Apr 2016, In : International Journal of Clinical Pharmacy. 38, 2, p. 296-302 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

A treatment evaluator tool to monitor the real-world effectiveness of inhaled aztreonam lysine in cystic fibrosis

Plant, B. J., Downey, D. G., Eustace, J. A., Gunaratnam, C., Haworth, C. S., Jones, A. M., McKone, E. F., Peckham, D. G., Ketchell, R. I. & Bilton, D., 06 Apr 2017, In : Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 7 p.

Research output: Contribution to journalArticle

Open Access
File
303 Downloads (Pure)

Biomarkers to monitor exacerbations in cystic fibrosis

Gray, R. D., Downey, D. & Taggart, C. C., 03 Apr 2017, In : Expert review of respiratory medicine. 11, 4, p. 255-257 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
6 Citations (Scopus)

Efficacy of Pseudomonas aeruginosa eradication regimens in bronchiectasis

Vallières, E., Tumelty, K., Tunney, M. M., Hannah, R., Hewitt, O., Elborn, J. S. & Downey, D. G., 01 Apr 2017, In : European Respiratory Journal. 49, 4, 3 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
242 Downloads (Pure)

Immunodeficiency in Bronchiectasis

Coulter, T., Devlin, L., Downey, D., Elborn, J. & Edgar, D., 23 Dec 2017, Bronchiectasis The EMBARC Manual. Springer

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Lung function and disease severity in cystic fibrosis patients heterozygous for p.Arg117His

Shteinberg, M., Downey, D. G., Beattie, D., McCaughan, J., Reid, A., Stein, N. & Elborn, J. S., 01 Feb 2017, In : ERS Monograph. 3, 1, 00056-2016.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
1974 Downloads (Pure)

Relative resistance index (RRI) - a scoring system for antibiotic resistance in Pseudomonas aeruginosa

Ewing, J. C., McCaughan, J., Moore, J., Fairley, D., Sutherland, B., Reid, A. & Downey, D., 26 Jul 2017, In : British Journal of Biomedical Science. 5 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
3557 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
154 Downloads (Pure)
2018

Airway infection, systemic inflammation and lung clearance index in children and adults with cystic fibrosis

O'Neill, K., Bradley, J., Reid, A., Downey, D., Rendall, J. C., McCaughan, J., Moore, J., Tunney, M. & Elborn, J., 31 Jan 2018, In : European Respiratory Journal. 51, 2, 4 p., 1701704.

Research output: Contribution to journalLetter

Open Access
File
5 Citations (Scopus)
99 Downloads (Pure)