Accepting PhD Students

PhD projects

I will support research programs in all aspects of CF and bronchiectasis care, this could include clinical trials, pulmonary exacerbation exploration, microbiology and basic science mechanisms.

19992020

Research output per year

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Research Output

72 Potential for airborne bacterial contamination in an outpatient respiratory clinic

McElderry, J., O'Neill, K., Tunney, M. M., Downey, D. G., Rendall, J. C., Moore, J. E., Elborn, J. S. & Gilpin, D. F., Jun 2015, In : Journal of Cystic Fibrosis. 14, Supplement 1, p. S75 1 p.

Research output: Contribution to journalMeeting abstract

Open Access

A change in behaviour — getting the balance right for research and policy

O'Sullivan, M., Ryan, C., Downey, D. & Hughes, C. M., Oct 2016, In : International Journal of Clinical Pharmacy. 38, 5, p. 1027-31 5 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
160 Downloads (Pure)

Airborne bacteria and fungi concentrations in airtight contemporary dwellings

McGill, G., Moore, J., Sharpe, T., Downey, D. & Oyedele, L., 2015.

Research output: Working paper

Airborne Bacterial Contamination within an Outpatient Respiratory Clinic

J, M., O'Neill, K., Tunney, M., Downey, D., Rendall, J., Moore, J., Elborn, J. & Gilpin, D., 2015, p. S539-S540.

Research output: Contribution to conferenceAbstract

Airway infection, systemic inflammation and lung clearance index in children and adults with cystic fibrosis

O'Neill, K., Bradley, J., Reid, A., Downey, D., Rendall, J. C., McCaughan, J., Moore, J., Tunney, M. & Elborn, J., 31 Jan 2018, In : European Respiratory Journal. 51, 2, 4 p., 1701704.

Research output: Contribution to journalLetter

Open Access
File
5 Citations (Scopus)
100 Downloads (Pure)

Antimicrobial effect of dimethyl sulfoxide and N, N-Dimethylformamide on Mycobacterium abscessus: Implications for antimicrobial susceptibility testing

Kirkwood, Z. I., Millar, B. C., Downey, D. G. & Moore, J. E., 15 Jun 2018, In : International journal of mycobacteriology. 7, 2, p. 134-136 3 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
218 Downloads (Pure)

Antimycobacterial activity of nonantibiotics associated with the polypharmacy of cystic fibrosis (CF) against mycobacterium abscessus

Kirkwood, Z. I., Millar, B. C., Downey, D. G. & Moore, J. E., 05 Dec 2018, In : International journal of mycobacteriology. 7, 4, p. 358-360

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
132 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
27 Downloads (Pure)

A treatment evaluator tool to monitor the real-world effectiveness of inhaled aztreonam lysine in cystic fibrosis

Plant, B. J., Downey, D. G., Eustace, J. A., Gunaratnam, C., Haworth, C. S., Jones, A. M., McKone, E. F., Peckham, D. G., Ketchell, R. I. & Bilton, D., 06 Apr 2017, In : Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 7 p.

Research output: Contribution to journalArticle

Open Access
File
304 Downloads (Pure)

Biomarkers to monitor exacerbations in cystic fibrosis

Gray, R. D., Downey, D. & Taggart, C. C., 03 Apr 2017, In : Expert review of respiratory medicine. 11, 4, p. 255-257 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Biomedical Science in Brief

Moore, J. E., Shaw, A., Millar, B. C., Martin, S. L., Murphy, P. G., Downey, D. G., Ennis, M., Elborn, J. S., Xu, J., Moore, J. E., Murphy, P. G., Millar, B. C., Redmond, A. O. B., Elborn, J. S., Conroy, S., Morrish, N., Wassif, W. S., Mak, C. M., Pang, R. W. C., Tam, S. & 8 others, Windsor, J. S., Clark, C. G., Macfarlane, L., Abutaleb, A., Abed, E., Qasem, L., Memish, Z. A. & Hajeer, A. H., Jan 2004, In : British Journal of Biomedical Science. 61, 3, p. 146-147 2 p.

Research output: Contribution to journalArticle

Building global development strategies for cf therapeutics during a transitional cftr modulator era

Mayer-Hamblett, N., van Koningsbruggen-Rietschel, S., Nichols, D. P., VanDevanter, D. R., Davies, J. C., Lee, T., Durmowicz, A. G., Ratjen, F., Konstan, M. W., Pearson, K., Bell, S. C., Clancy, J. P., Taylor-Cousar, J. L., De Boeck, K., Donaldson, S. H., Downey, D. G., Flume, P. A., Drevinek, P., Goss, C. H., Fajac, I. & 5 others, Magaret, A. S., Quon, B. S., Singleton, S. M., VanDalfsen, J. M. & Retsch-Bogart, G. Z., 07 Jun 2020, In : Journal of Cystic Fibrosis.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Closed circuit rebreathing to achieve inert gas wash-in for multiple breath wash-out

Horsley, A. R., O'Neill, K., Downey, D. G., Elborn, J. S., Bell, N. J., Smith, J. & Owers-Bradley, J., 09 Feb 2016, In : ERJ Open. 2, 1, 8 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
241 Downloads (Pure)

Community analysis and co-occurrence patterns in airway microbial communities during health and disease

Einarsson, G. G., Zhao, J., LiPuma, J. J., Downey, D. G., Tunney, M. M. & Elborn, J. S., 08 Jul 2019, In : ERJ Open. 5, 3, 11 p., 00128-2017.

Research output: Contribution to journalArticle

Open Access
File
90 Downloads (Pure)

Comparison of antibiotic susceptibility patterns in Pseudomonas aeruginosa isolated from adult patients with cystic fibrosis (CF) with invasive Pseudomonas aeruginosa from non-CF patients

Rao, P., McCaughan, J., McCalmont, M., Goldsmith, C. E., Hall, V., Millar, B. C., McCann, M-A., Downey, D. G., Rendall, J., Elborn, J. S. & Moore, J. E., Jul 2012, In : Journal of Cystic Fibrosis. 11, 4, p. 349-52 4 p.

Research output: Contribution to journalLetter

11 Citations (Scopus)

Current pregnancy outcomes in women with cystic fibrosis

Burden, C., Ion, R., Chung, Y., Henry, A., Downey, D. G. & Trinder, J., Oct 2012, In : European Journal of Obstetrics, Gynaecology and Reproductive Biology. 164, 2, p. 142-145 4 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Current pregnancy outcomes in women with cystic fibrosis

Burden, C., Ion, R., Chung, Y., Henry, A., Downey, D. G. & Trinder, J., Feb 2013, In : Obstetrical and Gynecological Survey. 68, 2, p. 87-88 2 p.

Research output: Contribution to journalComment/debate

Development of a core outcome set for trials investigating the long-term management of bronchiectasis

Spargo, M., Ryan, C., Downey, D. & Hughes, C., 03 Oct 2018, In : Chronic Respiratory Disease. p. 1-9

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
137 Downloads (Pure)
Open Access
File
7 Downloads (Pure)

Do veterinary antibiotics have efficacy against highly resistant Gram-negative pathogens from patients with cystic fibrosis?

Moore, J. E., Alcorn, M., Ara, W., Millar, B. C., McCaughan, J., Rendall, J. C., McNeilly, J., Kuribayashi, T., Yamamoto, S., Matsuda, M., Goldsmith, C. E., Elborn, J. S. & Downey, D. G., Jan 2015, In : International Journal of Antimicrobial Agents. 45, 1, p. 93-95 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
53 Citations (Scopus)

Efficacy of Pseudomonas aeruginosa eradication regimens in bronchiectasis

Vallières, E., Tumelty, K., Tunney, M. M., Hannah, R., Hewitt, O., Elborn, J. S. & Downey, D. G., 01 Apr 2017, In : European Respiratory Journal. 49, 4, 3 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
243 Downloads (Pure)

Eradication of Pseudomonas aeruginosa in adults with cystic fibrosis

Kenny, S. L., Shaw, T. D., Downey, D. G., Moore, J. E., Rendall, J. C. & Elborn, J. S., Aug 2014, In : BMJ Open Respiratory Research. 1, p. 1-7 e000021.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
144 Downloads (Pure)

Exploring the timing of Hypertonic Saline (HTS) and Airways Clearance Techniques (ACT) in Cystic Fibrosis (CF): a cross over study

Bradley, JM., O'Neill, K., Moran, F., Bradbury, I., Downey, DG., Rendall, JS., Tunney, MM. & Elborn, JS., 01 Dec 2016, In : Thorax. p. A134-A135 2 p.

Research output: Contribution to journalMeeting abstract

Failure to conceive in women with CF is associated with pancreatic insufficiency and advancing age

Shteinberg, M., Lulu, A. B., Downey, D. G., Blumenfeld, Z., Rousset-Jablonski, C., Perceval, M., Colombo, A., Stein, N., Livnat, G., Gur, M., Bentur, L., Mussaffi, H., Blau, H., Sarouk, I., Dagan, A., Kerem, E., Aviram, M., Picard, E., Aliberti, S., Álvarez, A. & 5 others, Miranda, J. P., Polverino, E., Durieu, I., Stuart Elborn, J. & Cohen-Cymberknoh, M., 23 Oct 2018, In : Journal of Cystic Fibrosis. p. 1-7

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
96 Downloads (Pure)

Game changers: A new dawn for the treatment of cystic fibrosis

Doherty, P. & Downey, D. G., Sep 2015, In : Ulster Medical Journal. 84, 3, p. 218-219

Research output: Contribution to journalComment/debate

Open Access
File
47 Downloads (Pure)
7 Citations (Scopus)

Gram negative infections in cystic fibrosis: a review of preventative and treatment options

Addy, C., Caskey, S. & Downey, D., 29 Jan 2020, In : Expert Opinion on Orphan Drugs. 8, 1, p. 11-26 16 p.

Research output: Contribution to journalArticle

Highlights of the North American Cystic Fibrosis Conference 2008.

Downey, D., 2009, In : Journal of the Royal Society of Medicine. 102 Suppl 1, SUPPL.1, p. 18-22 5 p.

Research output: Contribution to journalArticle

How reliable are cough swabs for the detection of Pseudomonas aeruginosa in adult patients with cystic fibrosis?

Moore, J. E., McCaughan, J., McNeilly, J., Rendall, J. C. & Downey, D. G., 2015, In : British Journal of Biomedical Science. 72, 4, p. 206

Research output: Contribution to journalArticle

How specific are fluorogenic substrates designed to analyse active protease biomarkers of respiratory disease?

Robb, C., Ferguson, T., Moffitt, K., Downey, D., McCafferty, D., Ribeiro, D., Martin, L. & Walker, B., Dec 2016, In : Thorax. 71, Suppl 3, p. A79-A80 2 p.

Research output: Contribution to journalMeeting abstract

Immunodeficiency in Bronchiectasis

Coulter, T., Devlin, L., Downey, D., Elborn, J. & Edgar, D., 23 Dec 2017, Bronchiectasis The EMBARC Manual. Springer

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Open Access

Improved culture detection of Staphylococcus aureus from sputum of patients with cystic fibrosis (CF)

Wen, H., Stirling, J., McCaughan, J., Schock, B., Downey, D. G., Ennis, M. & Moore, J. E., 13 Oct 2019, In : Journal of Clinical Pathology. jclinpath-2019-206059

Research output: Contribution to journalArticle

1 Citation (Scopus)

Increased susceptibility to antibiotics in Gram-negative and Gram-positive pathogens, including Pseudomonas aeruginosa, at lower temperature: is antibiotic resistance reversal possible?

Moore, J. E., Moore, P. J. A., Downey, D., Millar, B. C., Coulter, W. A. & Goldsmith, C. E., 2013, In : British Journal of Biomedical Science. 70, 4, p. 173-174 2 p.

Research output: Contribution to journalArticle

Increasing burden of antimicrobial resistance in pseudomonas aeruginosa from adult patients with cystic fibrosis (CF) in Northern Ireland: Then and now

Gramegna, A., Moore, J. E., McCaughan, J., Millar, B. C., Ewing, J., Elborn, J. S., Blasi, F. & Downey, D. G., May 2018, In : Ulster Medical Journal. 87, 2, p. 129-130 2 p.

Research output: Contribution to journalLetter

Open Access
File
1 Citation (Scopus)
50 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
188 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
140 Downloads (Pure)

Lack of Association Between Haptoglobin Phenotype and Cystic Fibrosis Outcomes

Shteinberg, M., Rivlin, J., Gur, M., Konopnicki, M., Stein, N., Tunney, M. M., Elborn, J. S., Downey, D. G., Johnston, E., Shalom, H. & Levy, A., Dec 2015, In : Lung. 193, 6, p. 1017-1021 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Lung clearance index in adults and children with cystic fibrosis

O'Neill, K., Tunney, M. M., Johnston, E., Rowan, S., Downey, D. G., Rendall, J., Reid, A., Bradbury, I., Elborn, J. S. & Bradley, J. M., 06 Jul 2016, In : Chest. 150, 6, p. 1323-1332 10 p.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
343 Downloads (Pure)

Lung function and disease severity in cystic fibrosis patients heterozygous for p.Arg117His

Shteinberg, M., Downey, D. G., Beattie, D., McCaughan, J., Reid, A., Stein, N. & Elborn, J. S., 01 Feb 2017, In : ERS Monograph. 3, 1, 00056-2016.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
1976 Downloads (Pure)

Microbial ecology of the cystic fibrosis lung: does microflora type influence microbial loading?

Moore, J. E., Shaw, A., Millar, B. C., Downey, D. G., Murphy, P. G. & Elborn, J., 2005, In : British Journal of Biomedical Science. 62(4), 4, p. 175-178 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Microscopic Polyangitis secondary to Mycobacterium abscessus in a patient with Bronchiectasis: A case report

Addy, C., Doran, G., Jones, A. L., Wright, G., Caskey, S. & Downey, D., 19 Nov 2018, In : BMC Pulmonary Medicine. 18, 170

Research output: Contribution to journalArticle

Open Access
File
114 Downloads (Pure)

MRSA eradication of newly acquired lower respiratory tract infection in cystic fibrosis

Vallières, E., Rendall, J. C., Moore, J. E., McCaughan, J., Hoeritzauer, A. I., Tunney, M. M., Elborn, J. S. & Downey, D. G., 31 Mar 2016, In : ERJ Open. 2, 1, 00064-2015.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
224 Downloads (Pure)