• Room 03.008 - CCRCB

    United Kingdom

19992020

Research output per year

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Research Output

2020

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
44 Downloads (Pure)

FLIP(L): the pseudo‐caspase

Smyth, P., Sessler, T., Scott, C. & Longley, D., 24 Feb 2020, In : FEBS journal.

Research output: Contribution to journalArticle

Open Access
File
8 Downloads (Pure)
3 Citations (Scopus)
Open Access
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6 Downloads (Pure)

The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

Roberts, J. Z., Holohan, C., Sessler, T., Fox, J., Crawford, N., Riley, J. S., Khawaja, H., Majkut, J., Evergren, E., Humphreys, L. M., Ferris, J., Higgins, C., Espona-Fiedler, M., Moynagh, P., McDade, S. S. & Longley, D. B., 20 Apr 2020, In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Open Access
File
12 Downloads (Pure)
2019

A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic

Salvucci, M., Rahman, A., Resler, A. J., Udupi, G. M., McNamara, D. A., Kay, E. W., Laurent-Puig, P., Longley, D. B., Johnston, P. G., Lawler, M., Wilson, R., Salto-Tellez, M., Van Schaeybroeck, S., Rafferty, M., Gallagher, W. M., Rehm, M. & Prehn, J. H. M., 17 Apr 2019, In : JCO Clinical Cancer Informatics. 17 p.

Research output: Contribution to journalArticle

Open Access
File
64 Downloads (Pure)

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform

Matveeva, A., Fichtner, M., McAllister, K., McCann, C., Sturrock, M., Longley, D. B. & Prehn, J. H. M., 25 Sep 2019, In : PLoS Computational Biology. 15, 9, 22 p., e1007374.

Research output: Contribution to journalArticle

Open Access
File
68 Downloads (Pure)

Repurposing of Cetuximab in antibody-directed chemotherapy-loaded nanoparticles in EGFR therapy-resistant pancreatic tumours

McDaid, W. J., Greene, M. K., Johnston, M. C., Pollheimer, E., Smyth, P., McLaughlin, K., Van Schaeybroeck, S., Straubinger, R. M., Longley, D. B. & Scott, C. J., 18 Oct 2019, In : Nanoscale. 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

Dunne, P. D., Coleman, H. G., Bankhead, P., Alderdice, M., Gray, R. T., McQuaid, S., Bingham, V., Loughrey, M. B., James, J. A., McCorry, A. M. B., Gilmore, A., Holohan, C., Klingbiel, D., Tejpar, S., Johnston, P. G., McArt, D. G., Nicolantonio, F. D., Longley, D. B. & Lawler, M., 13 Feb 2018, In : Oncotarget. 9, 17, p. 13834-13847 14 p.

Research output: Contribution to journalArticle

Open Access
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276 Downloads (Pure)
Open Access
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4 Citations (Scopus)
194 Downloads (Pure)

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

Cogo, F., Smyth, P., Burden, R., Longley, D. B., Williams, R., Johnston, M., Poreba, M., Rut, W., Groborz, K., Salvesen, G., Drag, M. & Scott, C. J., 13 Dec 2018, In : Nanoscale - Royal Society of Chemistry.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
62 Downloads (Pure)
Open Access
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5 Citations (Scopus)
159 Downloads (Pure)

FLIP as a therapeutic target in cancer

Humphreys, L., Espona-Fiedler, M. & Longley, D. B., Nov 2018, In : The FEBS Journal. 285, 22, p. 4104-4123 20 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)

Itch e3 ubiquitin ligase influences downstream receptor tyrosine kinase signalling in the oe33 cell line

Seeley, A., Cobbe, N., Turkington, R., Longley, D. & Evergren, E., 2018, Pharmacology 2017: British Pharmacological Society: Proceedings Annual Meeting.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711

Crawford, N., Salvucci, M., Hellwig, C. T., Lincoln, F. A., Mooney, R. E., O’Connor, C. L., Prehn, J. HM., Longley, D. B. & Rehm, M., 02 Mar 2018, In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
138 Downloads (Pure)

Transcriptional Subtyping and CD8 Immunohistochemistry Identifies Patients With Stage II and III Colorectal Cancer With Poor Prognosis Who Benefit From Adjuvant Chemotherapy

Allen, W., Dunne, P., McDade, S., Scanlon, E., Loughrey, M., Coleman, H., McCann, C., McLaughlin, K., Nemeth, Z., Syed, N. A., Jithesh, P. V., Arthur, K., Wilson, R., Coyle, V., McArt, D., Johnston, P., Murray, G. I., Samuel, L. M., Nuciforo, P., Jimenez, J. & 12 others, Argiles, G., Dienstmann, R., Picariello, L., Nobili, S., Mini, E., Sheahan, K., Ryan, E., Tabernero, J., Messerini, L., Van Schaeybroeck, S., Lawler, M. & Longley, D., 13 Jun 2018, In : JCO Precision Oncology. 2018, p. 1-15

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
273 Downloads (Pure)
2017

A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer

Salvucci, M., Würstle, M. L., Morgan, C., Curry, S., Cremona, M., Lindner, A. U., Bacon, O., Resler, A. J., Murphy, Á. C., O'Byrne, R., Flanagan, L., Dasgupta, S., Rice, N., Pilati, C., Zink, E., Schöller, L. M., Toomey, S., Lawler, M., Johnston, P. G., Wilson, R. & 10 others, Camilleri-Broët, S., Salto-Tellez, M., McNamara, D. A., Kay, E. W., Laurent-Puig, P., Van Schaeybroeck, S., Hennessy, B. T., Longley, D. B., Rehm, M. & Prehn, J. H. M., 01 Mar 2017, In : Clinical Cancer Research. 23, 5, p. 1200-1212 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

Dunne, P. D., Alderdice, M., O'Reilly, P. G., Roddy, A. C., McCorry, A. M. B., Richman, S., Maughan, T., McDade, S. S., Johnston, P. G., Longley, D. B., Kay, E., McArt, D. G. & Lawler, M., 31 May 2017, In : Nature Communications. 8, p. 15657 15657.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
328 Downloads (Pure)

IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer

Hutchinson, R. A., Coleman, H. G., Gately, K., Young, V., Nicholson, S., Cummins, R., Kay, E., Hynes, S. O., Dunne, P. D., Senevirathne, S., Hamilton, P. W., McArt, D. G. & Longley, D. B., 14 Aug 2017, In : Cell death discovery. 3, 17050.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
212 Downloads (Pure)

Itch, an E3 ubiquitin ligase, influences downstream receptor tyrosine kinase signalling in the colorectal cancer cell line, HCT116

Seeley, A., Longley, D. & Evergren, E., Feb 2017, 2017 Irish Association for Cancer Research: Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2016

Caspase modelling to predict personalised risk in stage III colorectal cancer (CRC) patients.

Salvucci, M., Wuerstle, M., Cremona, M., Curry, S., Morgan, C., Lindner, A. U., Bacon, O., Resler, AJ., Murphy, A., Longley, D., Wilson, R., Camilleri-Broët, S., Salto-Tellez, M., McNamara, D. A., Kay, E., Hennessy, B. T., Laurent-puig, P., Van Schaeybroeck, S., Rehm, M. & Prehn, J. H. M., 30 Jun 2016, In : Journal of Clinical Oncology. 34, (suppl, abstr 11592)

Research output: Contribution to journalMeeting abstract

Challenging the cancer molecular stratification dogma: Intratumoral heterogeneity undermines consensus molecular subtypes and potential diagnostic value in colorectal cancer

Dunne, P. D., McArt, D. G., Bradley, C. A., O'Reilly, P. G., Barrett, H. L., Cummins, R., O'Grady, A., Arthur, K., Loughrey, M. B., Moore, W. L., McDade, S. S., Waugh, D. J., Hamilton, P. W., Longley, D. B., Kay, E. W., Johnston, P. G., Lawler, M., Salto-Tellez, M. & Van Schaeybroeck, S., 15 Aug 2016, In : Clinical Cancer Research.

Research output: Contribution to journalArticle

Open Access
File
59 Citations (Scopus)
248 Downloads (Pure)

FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer

McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In : Molecular Cancer Therapeutics. p. 2432-2441 11 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
205 Downloads (Pure)
Open Access
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24 Citations (Scopus)
237 Downloads (Pure)

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy

Armstrong, C. W. D., Maxwell, P. J., Ong, C. W., Redmond, K. M., McCann, C., Neisen, J., Ward, G. A., Chessari, G., Johnson, C., Crawford, N. T., LaBonte, M. J., Prise, K. M., Robson, T., Salto-Tellez, M., Longley, D. B. & Waugh, D. J. J., 20 Jan 2016, In : Oncotarget.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
395 Downloads (Pure)
Open Access
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6 Citations (Scopus)
285 Downloads (Pure)
2015

DED or alive: assembly and regulation of the death effector domain complexes.

Riley, JS., Malik, A., Holohan, C. & Longley, DB., 27 Aug 2015, In : Cell, Death & Disease. 6, e1866, 16 p., e1866.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
258 Downloads (Pure)

HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL

Carson, R., Celtikci, B., Fenning, C., Javadi, A., Crawford, N., Perez Carbonell, L., Lawler, M., Longley, D. B., Johnston, P. G. & Van Schaeybroeck, S., 15 Jul 2015, In : Clinical Cancer Research. 21, 14, p. 3230-3240 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Molecular Classification of the invasive front in colorectal cancer

McArt, D., Dunne, P., Kay, E., O'Grady, A., Barrett, H., Arthur, K., Longley, D., Hamilton, P. W., Waugh, D. J., Lawler, M., Johnston, P. G., Salto-Tellez, M. & Van Schaeybroeck, S., 20 May 2015, In : Journal of Clinical Oncology. 33, Suppl 15, 3573.

Research output: Contribution to journalMeeting abstract

2014

ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer

Van Schaeybroeck, S., Kalimutho, M., Dunne, P. D., Carson, R., Allen, W., Jithesh, P. V., Redmond, K. L., Sasazuki, T., Shirasawa, S., Blayney, J., Michieli, P., Fenning, C., Lenz, H-J., Lawler, M., Longley, D. B. & Johnston, P. G., 26 Jun 2014, In : Cell Reports. 7, 6, p. 1940-1955 16 p.

Research output: Contribution to journalArticle

Open Access
File
52 Citations (Scopus)
327 Downloads (Pure)

AXL Is a Key Regulator of Inherent and Chemotherapy-Induced Invasion and Predicts a Poor Clinical Outcome in Early-Stage Colon Cancer

Dunne, P. D., McArt, D. G., Blayney, J. K., Kalimutho, M., Greer, S., Wang, T., Srivastava, S., Ong, C. W., Arthur, K., Loughrey, M., Redmond, K., Longley, D. B., Salto-Tellez, M., Johnston, P. G. & Van Schaeybroeck, S., 01 Jan 2014, In : Clinical Cancer Research. 20, 1, p. 164-175 12 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly

Majkut, J., Sgobba, M., Holohan, C., Crawford, N., Logan, A. E., Kerr, E., Higgins, C. A., Redmond, K. L., Riley, J. S., Stasik, I., Fennell, D. A., Van Schaeybroeck, S., Haider, S., Johnston, P. G., Haigh, D. & Longley, D. B., 28 Feb 2014, In : Nature Communications. 5, 3350.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine

Schmid, D., Fay, F., Small, D. M., Jaworski, J., Riley, J. S., Tegazzini, D., Fenning, C., Jones, D. S., Johnston, P. G., Longley, D. B. & Scott, C. J., Dec 2014, In : Molecular therapy : the journal of the American Society of Gene Therapy. 22, 12, p. 2083-2092 10 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
310 Downloads (Pure)
Open Access
File
48 Citations (Scopus)
278 Downloads (Pure)
Open Access
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27 Citations (Scopus)
223 Downloads (Pure)

Pro-inflammatory CXCL8 signalling potentiates survival of K-Ras mutant colorectal cancer cells

Campbell, L. M., Oladipo, O., Maxwell, P. J., Longley, D., Wilson, R. H. & Waugh, D. J. J., 01 Oct 2014, In : Cancer Research. 74, Suppl 19, 5267.

Research output: Contribution to journalMeeting abstract

Rational targeting of Inhibitor of Apoptosis Proteins (IAPs)for effective therapy of colorectal cancer

Crawford, N. T., Dunne, P. D., Johnston, P. G., Waugh, D. J. & Longley, D. B., 01 Oct 2014, In : Cancer Research. 74, Suppl 19, 2290.

Research output: Contribution to journalMeeting abstract

The role of the inflammatory microenvironment in regulating invasion, migration and drug responses in colorectal cancer

Redmond, K., Dunne, P., Forsythe, N., Longley, D., Johnston, P. & Van Schaeybroeck, S., Nov 2014, The role of the inflammatory microenvironment in regulating invasion, migration and drug responses in colorectal cancer. National Cancer Research Institute

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2013

AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early stage colon cancer

Dunne, P., McArt, D., Salto-Tellez, M., Longley, D., Johnston, P. & Van Schaeybroeck, S., Nov 2013, AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early stage colon cancer. National Cancer Research Institute

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cancer drug resistance: an evolving paradigm

Holohan, C., Van Schaeybroeck, S., Longley, D. B. & Johnston, P. G., Oct 2013, In : Nature Reviews. Cancer. 13, 10, p. 714-26

Research output: Contribution to journalArticle

1999 Citations (Scopus)

Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles

Abdelghany, S. M., Schmid, D., Deacon, J., Jaworski, J., Fay, F., McLaughlin, K. M., Gormley, J. A., Burrows, J. F., Longley, D. B., Donnelly, R. F. & Scott, C. J., 11 Feb 2013, In : Biomacromolecules. 14, 2, p. 302-310

Research output: Contribution to journalArticle

59 Citations (Scopus)

Oncogenic Kras and p53 mutational status control chemotherapy-induced growth factor shedding via activation of ADAM17 in colorectal cancer

Redmond, K., Dunne, P., McArt, D., Longley, D., Johnston, P. & Van Schaeybroeck, S., Nov 2013, Oncogenic Kras and p53 mutational status control chemotherapy-induced growth factor shedding via activation of ADAM17 in colorectal cancer. National Cancer Research Institute

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia

McLornan, D., Hay, J., McLaughlin, K., Holohan, C., Burnett, A. K., Hills, R. K., Johnston, P. G., Mills, K. I., McMullin, M. F. & Longley, D. B., Jan 2013, In : British Journal of Haematology. 160, 2, p. 188-98

Research output: Contribution to journalArticle

27 Citations (Scopus)

Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer

Riley, J. S., Hutchinson, R., McArt, D. G., Crawford, N., Holohan, C., Paul, I., Van Schaeybroeck, S., Salto-Tellez, M., Johnston, P., Fennell, D., Gately, K., O'Byrne, K., Cummins, R., Kay, E., Hamilton, P., Stasik, I. & Longley, D. B., Dec 2013, In : Cell, Death & Disease. 4, 12, p. e951 e951.

Research output: Contribution to journalArticle

Open Access
File
39 Citations (Scopus)
155 Downloads (Pure)

SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma

Crawford, N., Stasik, I., Holohan, C., Majkut, J., McGrath, M., Johnston, P., Chessari, G., Ward, G. A., Waugh, D. J., Fennell, D. A. & Longley, D. B., 18 Jul 2013, In : Cell, Death & Disease. 4, null, p. 1-11 11 p., e733.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
239 Downloads (Pure)

The c-MET-JAK1/2-STAT3 signalling axis is regulated by ADAM17 and is a key mediator of resistance to MEK inhibition in KRAS mutant colorectal cancer

Van Schaeybroeck, S., Kalimutho, M., Dunne, P., Moore, W., Jithesh, P., Fenning, C., Carson, R., Longley, D. & Johnston, P., Nov 2013, The c-MET-JAK1/2-STAT3 signalling axis is regulated by ADAM17 and is a key mediator of resistance to MEK inhibition in KRAS mutant colorectal cancer. Proffered paper sessions: National Cancer Research Institute

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2012

Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer

Paul, I., Chacko, A. D., Stasik, I., Busacca, S., Crawford, N., McCoy, F., McTavish, N., Wilson, B., Barr, M., O'Byrne, K. J., Longley, D. B. & Fennell, D. A., Dec 2012, In : Cell, Death & Disease. 3, null, p. 1-9 9 p., e449.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
144 Downloads (Pure)

A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer

Allen, W., Stevenson, L., Coyle, V., Jithesh, P., Proutski, I., Carson, G., Gordon, M. A., Lenz, H. J. D., Van Schaeybroeck, S., Longley, D. & Johnston, P., Jan 2012, In : Molecular Cancer Therapeutics. 11, 1, p. 119-131 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Constitutive and Treatment-Induced CXCL8-Signalling Selectively Modulates the Efficacy of Anti-Metabolite Therapeutics in Metastatic Prostate Cancer

Wilson, C., Maxwell, P. J., Longley, D. B., Wilson, R. H., Johnston, P. G. & Waugh, D. J. J., May 2012, In : PLoS ONE. 7, 5, 9 p., e36545.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
162 Downloads (Pure)