Research output per year
Research output per year
- 50 - 100 out of 132 results
Search results
-
2019
Repurposing of Cetuximab in antibody-directed chemotherapy-loaded nanoparticles in EGFR therapy-resistant pancreatic tumours
McDaid, W. J., Greene, M. K., Johnston, M. C., Pollheimer, E., Smyth, P., McLaughlin, K., Van Schaeybroeck, S., Straubinger, R. M., Longley, D. B. & Scott, C. J., 18 Oct 2019, (Early online date) In: Nanoscale. 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)419 Downloads (Pure) -
2018
Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer
Dunne, P. D., Coleman, H. G., Bankhead, P., Alderdice, M., Gray, R. T., McQuaid, S., Bingham, V., Loughrey, M. B., James, J. A., McCorry, A. M. B., Gilmore, A., Holohan, C., Klingbiel, D., Tejpar, S., Johnston, P. G., McArt, D. G., Nicolantonio, F. D., Longley, D. B. & Lawler, M., 13 Feb 2018, In: Oncotarget. 9, 17, p. 13834-13847 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)402 Downloads (Pure) -
Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists
McCann, C., Crawford, N., Majkut, J., Holohan, C., Armstrong, C., Maxwell, P., Ong, C. W., LaBonte Wilson, M., McDade, S., Waugh, D. & Longley, D., 22 Oct 2018, In: Cell, Death & Disease. 9, 1081, 13 p., 1081.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)267 Downloads (Pure) -
Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe
Cogo, F., Smyth, P., Burden, R., Longley, D. B., Williams, R., Johnston, M., Poreba, M., Rut, W., Groborz, K., Salvesen, G., Drag, M. & Scott, C. J., 13 Dec 2018, (Early online date) In: Nanoscale - Royal Society of Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)286 Downloads (Pure) -
Epithelial-to-mesenchymal transition signature assessment in colorectal cancer quantifies tumour stromal content rather than true transition
McCorry, A. M. B., Loughrey, M. B., Longley, D. B., Lawler, M. & Dunne, P. D., Dec 2018, In: Journal of Pathology. 246, 4, p. 422-426 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)281 Downloads (Pure) -
Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711
Crawford, N., Salvucci, M., Hellwig, C. T., Lincoln, F. A., Mooney, R. E., O’Connor, C. L., Prehn, J. H., Longley, D. B. & Rehm, M., 02 Mar 2018, (Early online date) In: Cell Death and Differentiation. 25, p. 1952Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)261 Downloads (Pure) -
Transcriptional subtyping and CD8 immunohistochemistry identifies patients with stage II and III colorectal cancer with poor prognosis who benefit from adjuvant chemotherapy
Allen, W. L., Dunne, P. D., McDade, S., Scanlon, E., Loughrey, M., Coleman, H. G., McCann, C., McLaughlin, K., Nemeth, Z., Syed, N. A., Jithesh, P. V., Arthur, K., Wilson, R., Coyle, V. M., McArt, D., Johnston, P., Murray, G. I., Samuel, L. M., Nuciforo, P. & Jimenez, J. & 12 others, , 01 Nov 2018, In: JCO Precision Oncology. 2, 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile58 Citations (Scopus)380 Downloads (Pure) -
2017
A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer
Salvucci, M., Würstle, M. L., Morgan, C., Curry, S., Cremona, M., Lindner, A. U., Bacon, O., Resler, A. J., Murphy, Á. C., O'Byrne, R., Flanagan, L., Dasgupta, S., Rice, N., Pilati, C., Zink, E., Schöller, L. M., Toomey, S., Lawler, M., Johnston, P. G. & Wilson, R. & 10 others, , 01 Mar 2017, In: Clinical Cancer Research. 23, 5, p. 1200-1212 13 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification
Dunne, P. D., Alderdice, M., O'Reilly, P. G., Roddy, A. C., McCorry, A. M. B., Richman, S., Maughan, T., McDade, S. S., Johnston, P. G., Longley, D. B., Kay, E., McArt, D. G. & Lawler, M., 31 May 2017, In: Nature Communications. 8, p. 15657 15657.Research output: Contribution to journal › Article › peer-review
Open AccessFile70 Citations (Scopus)429 Downloads (Pure) -
IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer
Hutchinson, R. A., Coleman, H. G., Gately, K., Young, V., Nicholson, S., Cummins, R., Kay, E., Hynes, S. O., Dunne, P. D., Senevirathne, S., Hamilton, P. W., McArt, D. G. & Longley, D. B., 14 Aug 2017, (Early online date) In: Cell death discovery. 3, 17050.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)293 Downloads (Pure) -
2016
Challenging the cancer molecular stratification dogma: Intratumoral heterogeneity undermines consensus molecular subtypes and potential diagnostic value in colorectal cancer
Dunne, P. D., McArt, D. G., Bradley, C. A., O'Reilly, P. G., Barrett, H. L., Cummins, R., O'Grady, A., Arthur, K., Loughrey, M. B., Moore, W. L., McDade, S. S., Waugh, D. J., Hamilton, P. W., Longley, D. B., Kay, E. W., Johnston, P. G., Lawler, M., Salto-Tellez, M. & Van Schaeybroeck, S., 15 Aug 2016, In: Clinical Cancer Research. 22, 16, p. 4095Research output: Contribution to journal › Article › peer-review
Open AccessFile125 Citations (Scopus)424 Downloads (Pure) -
FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer
McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In: Molecular Cancer Therapeutics. p. 2432-2441 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)316 Downloads (Pure) -
Immune-derived PD-L1 gene expression defines a subgroup of stage II/III colorectal cancer patients with favorable prognosis that may be harmed by adjuvant chemotherapy
Dunne, P. D., McArt, D. G., O'Reilly, P. G., Coleman, H. G., Allen, W. L., Loughrey, M., Van Schaeybroeck, S., McDade, S., Salto-Tellez, M., Longley, D. B., Lawler, M. & Johnston, P. G., 13 May 2016, (Early online date) In: Cancer Immunology Research. 4, 7, p. 582Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Citations (Scopus)411 Downloads (Pure) -
PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy
Armstrong, C. W. D., Maxwell, P. J., Ong, C. W., Redmond, K. M., McCann, C., Neisen, J., Ward, G. A., Chessari, G., Johnson, C., Crawford, N. T., LaBonte, M. J., Prise, K. M., Robson, T., Salto-Tellez, M., Longley, D. B. & Waugh, D. J. J., 20 Jan 2016, In: Oncotarget. 7, p. 7855Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)468 Downloads (Pure) -
Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer
Dunne, P. D., O'Reilly, P. G., Coleman, H. G., Gray, R. T., Longley, D. B., Johnston, P. G., Salto-Tellez, M., Lawler, M. & McArt, D. G., 14 Jun 2016, In: Oncotarget. p. 36632-36644 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)351 Downloads (Pure) -
2015
DED or alive: assembly and regulation of the death effector domain complexes.
Riley, J., Malik, A., Holohan, C. & Longley, D., 27 Aug 2015, In: Cell, Death & Disease. 6, e1866, 16 p., e1866.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)324 Downloads (Pure) -
HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL
Carson, R., Celtikci, B., Fenning, C., Javadi, A., Crawford, N., Perez Carbonell, L., Lawler, M., Longley, D. B., Johnston, P. G. & Van Schaeybroeck, S., 15 Jul 2015, In: Clinical Cancer Research. 21, 14, p. 3230-3240 11 p.Research output: Contribution to journal › Article › peer-review
52 Citations (Scopus) -
2014
ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer
Van Schaeybroeck, S., Kalimutho, M., Dunne, P. D., Carson, R., Allen, W., Jithesh, P. V., Redmond, K. L., Sasazuki, T., Shirasawa, S., Blayney, J., Michieli, P., Fenning, C., Lenz, H.-J., Lawler, M., Longley, D. B. & Johnston, P. G., 26 Jun 2014, In: Cell Reports. 7, 6, p. 1940-1955 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile88 Citations (Scopus)439 Downloads (Pure) -
AXL Is a Key Regulator of Inherent and Chemotherapy-Induced Invasion and Predicts a Poor Clinical Outcome in Early-Stage Colon Cancer
Dunne, P. D., McArt, D. G., Blayney, J. K., Kalimutho, M., Greer, S., Wang, T., Srivastava, S., Ong, C. W., Arthur, K., Loughrey, M., Redmond, K., Longley, D. B., Salto-Tellez, M., Johnston, P. G. & Van Schaeybroeck, S., 01 Jan 2014, In: Clinical Cancer Research. 20, 1, p. 164-175 12 p.Research output: Contribution to journal › Article › peer-review
100 Citations (Scopus) -
Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly
Majkut, J., Sgobba, M., Holohan, C., Crawford, N., Logan, A. E., Kerr, E., Higgins, C. A., Redmond, K. L., Riley, J. S., Stasik, I., Fennell, D. A., Van Schaeybroeck, S., Haider, S., Johnston, P. G., Haigh, D. & Longley, D. B., 28 Feb 2014, In: Nature Communications. 5, 3350.Research output: Contribution to journal › Article › peer-review
68 Citations (Scopus) -
Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine
Schmid, D., Fay, F., Small, D. M., Jaworski, J., Riley, J. S., Tegazzini, D., Fenning, C., Jones, D. S., Johnston, P. G., Longley, D. B. & Scott, C. J., Dec 2014, In: Molecular therapy : the journal of the American Society of Gene Therapy. 22, 12, p. 2083-2092 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Citations (Scopus)410 Downloads (Pure) -
Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer
Turkington, R., Longley, D., Allen, W., Stevenson, L., McLaughlin, K., Dunne, P., Blayney, J., Salto-Tellez, M., Van Schaeybroeck, S. & Johnston, P., 06 Feb 2014, In: Cell, Death & Disease. 5, 11 p., e1046.Research output: Contribution to journal › Article › peer-review
Open AccessFile84 Citations (Scopus)368 Downloads (Pure) -
Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity
Schmid, D., Jarvis, G. E., Fay, F., Small, D. M., Greene, M. K., Majkut, J., Spence, S., McLaughlin, K. M., McCloskey, K. D., Johnston, P. G., Kissenpfennig, A., Longley, D. B. & Scott, C. J., 09 Oct 2014, In: Cell, Death & Disease. 5, 11 p., e1454.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Citations (Scopus)311 Downloads (Pure) -
2013
Cancer drug resistance: an evolving paradigm
Holohan, C., Van Schaeybroeck, S., Longley, D. B. & Johnston, P. G., Oct 2013, In: Nature Reviews. Cancer. 13, 10, p. 714-26Research output: Contribution to journal › Article › peer-review
3693 Citations (Scopus) -
Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles
Abdelghany, S. M., Schmid, D., Deacon, J., Jaworski, J., Fay, F., McLaughlin, K. M., Gormley, J. A., Burrows, J. F., Longley, D. B., Donnelly, R. F. & Scott, C. J., 11 Feb 2013, In: Biomacromolecules. 14, 2, p. 302-310Research output: Contribution to journal › Article › peer-review
80 Citations (Scopus) -
Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia
McLornan, D., Hay, J., McLaughlin, K., Holohan, C., Burnett, A. K., Hills, R. K., Johnston, P. G., Mills, K. I., McMullin, M. F. & Longley, D. B., Jan 2013, In: British Journal of Haematology. 160, 2, p. 188-98Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus) -
Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer
Riley, J. S., Hutchinson, R., McArt, D. G., Crawford, N., Holohan, C., Paul, I., Van Schaeybroeck, S., Salto-Tellez, M., Johnston, P., Fennell, D., Gately, K., O'Byrne, K., Cummins, R., Kay, E., Hamilton, P., Stasik, I. & Longley, D. B., Dec 2013, In: Cell, Death & Disease. 4, 12, p. e951 e951.Research output: Contribution to journal › Article › peer-review
Open AccessFile62 Citations (Scopus)206 Downloads (Pure) -
SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma
Crawford, N., Stasik, I., Holohan, C., Majkut, J., McGrath, M., Johnston, P., Chessari, G., Ward, G. A., Waugh, D. J., Fennell, D. A. & Longley, D. B., 18 Jul 2013, In: Cell, Death & Disease. 4, null, p. 1-11 11 p., e733.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)319 Downloads (Pure) -
2012
Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer
Paul, I., Chacko, A. D., Stasik, I., Busacca, S., Crawford, N., McCoy, F., McTavish, N., Wilson, B., Barr, M., O'Byrne, K. J., Longley, D. B. & Fennell, D. A., Dec 2012, In: Cell, Death & Disease. 3, null, p. 1-9 9 p., e449.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)234 Downloads (Pure) -
A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Allen, W., Stevenson, L., Coyle, V., Jithesh, P., Proutski, I., Carson, G., Gordon, M. A., Lenz, H. J. D., Van Schaeybroeck, S., Longley, D. & Johnston, P., Jan 2012, In: Molecular Cancer Therapeutics. 11, 1, p. 119-131 13 p.Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus) -
Constitutive and Treatment-Induced CXCL8-Signalling Selectively Modulates the Efficacy of Anti-Metabolite Therapeutics in Metastatic Prostate Cancer
Wilson, C., Maxwell, P. J., Longley, D. B., Wilson, R. H., Johnston, P. G. & Waugh, D. J. J., May 2012, In: PLoS ONE. 7, 5, 9 p., e36545.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)223 Downloads (Pure) -
Evaluation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy
McCourt, C., Maxwell, P., Mazzucchelli, R., Scarpelli, M., Salto-Tellez, M., O'Sullivan, J., Longley, D. & Waugh, D., May 2012, In: Clinical Cancer Research. 18, 14, p. 3822-3833 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)271 Downloads (Pure) -
Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis
Kerr, E., Holohan, C., McLaughlin, K., Majkut, J., Dolan, S., Redmond, K., Riley, J., McLaughlin, K., Stasik, I., Crudden, M., Van Schaeybroeck, S., Fenning, C., O'Connor, R., Kiely, P., Sgobba, M., Haigh, D., Johnston, P. & Longley, D., Aug 2012, In: Cell Death and Differentiation. 19, 8, p. 1317-1327 11 p., e1745.Research output: Contribution to journal › Article › peer-review
94 Citations (Scopus) -
Identification of Galanin and Its Receptor GalR1 as Novel Determinants of Resistance to Chemotherapy and Potential Biomarkers in Colorectal Cancer
Stevenson, L., Allen, W. L., Turkington, R., Jithesh, P. V., Proutski, I., Stewart, G., Lenz, H.-J., Van Schaeybroeck, S., Longley, D. B. & Johnston, P. G., 01 Oct 2012, In: Clinical Cancer Research. 18, 19, p. 5412-5426 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Citations (Scopus)283 Downloads (Pure) -
Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells.
Allen, W., Turkington, R., Stevenson, L., Carson, G., Coyle, V., Hector, S., Dunne, P., Van Schaeybroeck, S., Longley, D. & Johnston, P., Aug 2012, In: Clinical Cancer Research. 11, 8, p. 1724-34 11 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent.
Hurwitz, J., Stasik, I., Kerr, E., Holohan, C., Johnston, P., Fennell, D. & Longley, D., May 2012, In: European Journal of Cancer. 48, 7, p. 1096-107 12 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression
Barbone, D., Cheung, P., Battula, S., Busacca, S., Gray, S. G., Longley, D. B., Bueno, R., Sugarbaker, D. J., Fennell, D. A. & Broaddus, V. C., 29 Dec 2012, In: PLoS ONE. 7, 12, e52753.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
2011
Calbindin 2 (CALB2) Regulates 5-Fluorouracil Sensitivity in Colorectal Cancer by Modulating the Intrinsic Apoptotic Pathway
Stevenson, L., Allen, W. L., Proutski, I., Stewart, G., Johnston, L., McCloskey, K., Wilson, P. M., Longley, D. & Johnston, P., 2011, In: PLoS ONE. 6, 5, e20276.Research output: Contribution to journal › Article › peer-review
35 Citations (Scopus) -
Conatumumab (AMG 655) coated nanoparticles for targeted pro-apoptotic drug delivery
Fay, F., McLaughlin, K. M., Small, D. M., Fennell, D. A., Johnston, P. G., Longley, D. B. & Scott, C. J., Nov 2011, In: Biomaterials. 32, 33, p. 8645-8653 9 p.Research output: Contribution to journal › Article › peer-review
63 Citations (Scopus) -
Development and independent validation of a prognostic assay for stage ii colon cancer using formalin-fixed paraffin-embedded tissue
Kennedy, R., Bylesjo, M., Kerr, D., Davison, T., Black, J. M., Kay, E. W., Holt, R. J., Proutski, V., Ahdesmaki, M., Farztdinov, V., Goffard, N., Hey, P., McDyer, F., Mulligan, K., Mussen, J., O'Brien, E., Oliver, G., Walker, S. M., Mulligan, J. & Wilson, C. & 22 others, , 10 Dec 2011, In: Journal of Clinical Oncology. 29, 35, p. 4620-4626 7 p.Research output: Contribution to journal › Article › peer-review
176 Citations (Scopus) -
Oncogenic Kras Promotes Chemotherapy-Induced Growth Factor Shedding via ADAM17.
Van Schaeybroeck, S., Kyula, J., Fenton, A., Fenning, C., Sasazuki, T., Shirasawa, S., Longley, D. & Johnston, P., 01 Jan 2011, In: Cancer Research. 25, 3, p. 1071-1080 10 p.Research output: Contribution to journal › Article › peer-review
44 Citations (Scopus) -
Platinum resistant cancer cells conserve sensitivity to BH3 domains and obatoclax induced mitochondrial apoptosis
Crawford, N., Chacko, A. D., Savage, K. I., McCoy, F., Redmond, K., Longley, D. B. & Fennell, D. A., Mar 2011, In: Apoptosis. 16, 3, p. 311-320 10 p.Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus) -
2010
Chemotherapy-Induced Activation of ADAM-17: A Novel Mechanism of Drug Resistance in Colorectal Cancer
Kyula, J., Van Schaeybroeck, S., Doherty, J., Fenning, C., Longley, D. & Johnston, P., 01 Jul 2010, In: Clinical Cancer Research. 16, 13, p. 3378-3389 12 p.Research output: Contribution to journal › Article › peer-review
89 Citations (Scopus) -
In vitro and in vivo characterisation of a novel c-FLIP-targeted antisense phosphorothioate oligonucleotide.
Logan, A. E., Wilson, T. R., Fenning, C., Cummins, R., Kay, E., Johnston, P. G. & Longley, D., Aug 2010, In: Apoptosis. epub, 12, p. 1-10 10 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK
McCoy, F., Hurwitz, J., McTavish, N., Paul, I., Barnes, C., O'Hagan, B., Odrzywol, K., Murray, J., Longley, D., McKerr, G. & Fennell, D., Dec 2010, In: Cell death and disease. 1, 12, p. e108 1 p., e108.Research output: Contribution to journal › Article › peer-review
85 Citations (Scopus) -
Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer
McLornan, D. P., Barrett, H. L., Cummins, R., McDermott, U., McDowell, C., Conlon, S. J., Coyle, V. M., Van Schaeybroeck, S., Wilson, R., Kay, E. W., Longley, D. B. & Johnston, P. G., 01 Jul 2010, In: Clinical Cancer Research. 16, 13, p. 3442-3451 10 p.Research output: Contribution to journal › Article › peer-review
70 Citations (Scopus) -
The Colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information
Allen, W., Jithesh, P., Oliver, G. R., Proutski, I., Longley, D., Lenz, H. J., Proutski, V., Harkin, P. & Johnston, P., 20 Dec 2010, In: BMC Cancer. 10, p. 687 687.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8.
Chako, A. D., Liberante, F., Paul, I., Longley, D. & Fennel, D. A., 20 Jul 2010, In: BMC Cancer. 10, p. 380-388 9 p., 380.Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus) -
2009
Anti-apoptotic mechanisms of drug resistance in cancer.
Wilson, T. R., Johnston, P. G. & Longley, D., May 2009, In: Current cancer drug targets. 9(3), 3, p. 307-319 13 p.Research output: Contribution to journal › Article › peer-review
167 Citations (Scopus) -
Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells.
Wilson, T., McEwan, M., McLaughlin, K., Le Clorennec, C., Allen, W., Fennell, D., Johnston, P. & Longley, D., 08 Jan 2009, In: Oncogene. 28, 1, p. 63-72 10 p.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus)