Projects per year
Prof Danny McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast.
His major research area is the acute respiratory distress syndrome.
My major interest is the Acute Respiratory Distress Syndrome (ARDS). My research strategy in ARDS is to investigate potential novel therapeutic agents in ARDS in vitro, in vivo in a human LPS model of ARDS and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. My roles as the UK Intensive Care Society Co-Director of Research and the NICRN (Critical Care) clinical lead, mean I am well placed to develop the novel therapeutic targets into phase 3 clinical trials. I am currently investigating the role of statins, aspirin and extracorporeal carbon dioxide removal in ARDS.
I am also currently investigating MSCs, oncostatin M and anti-microbial peptides with a view to developing these agents as potential therapeutic agents for ARDS.
My other current research interests are nosocomial infection, sepsis diagnostics, delirium in critical illness and interventions to enhance recovery from critical illness.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R4903CEM: Mucoactive drugs for acute respiratory failure: A 2x2 factorial, randomised, controlled, allocation concealed, open-label, Phase 3, pragmatic, clinical and cost effectiveness trial with internal pilot
24/07/2020 → …
R4880CEM: ALPHA-2 Agonists for sedation to produce better outcomes from critical illness (A2B Trial)
28/01/2020 → …
02/01/2020 → …
R4827CEM: Developong an early ICU swallowing inervention to improve outsomes following prolonged intubation
08/06/2018 → …
Acute hypoxaemic respiratory failure after treatment with lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal: long-term outcomes from the REST randomised trialBoyle, A. J., McDowell, C., Agus, A., Logan, D., Stewart, J. D., Jackson, C., Mills, J., McNamee, J. J. & McAuley, D. F., 01 Aug 2023, In: Thorax. 78, 8, p. 767-774 8 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile9 Downloads (Pure)
Bowman, E. M. L., Brummel, N. E., Caplan, G. A., Cunningham, C., Evered, L. A., Fiest, K. M., Girard, T. D., Jackson, T. A., LaHue, S. C., Lindroth, H. L., Maclullich, A. M. J., McAuley, D. F., Oh, E. S., Oldham, M. A., Page, V. J., Pandharipande, P. P., Potter, K. M., Sinha, P., Slooter, A. J. C., Sweeney, A. M., & 5 others, 31 Jul 2023, (Early online date) In: Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 12 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile5 Downloads (Pure)
A mechanistic analysis of the effect of valaciclovir for EBV suppression on airway inflammation and microbiome in COPDLinden, D., Guo-Parke, H., Einarsson, G., Carson, S., Lee, A., Fairley, D., Singh, D., Tunney, M., Mcauley, D., Taggart, C. & Kidney, J., 19 May 2023, In: ERJ Open Research. 9, Suppl. 10, 1 p., 59.
Research output: Contribution to journal › Meeting abstract › peer-reviewOpen Access
A user evaluation of speech/phrase recognition software in critically ill patients: a DECIDE-AI feasibility studyMusalia, M., Lala, S., Cazalilla-Chica, L., Allan, J., Roach, L., Twamley, J., Nanda, S., Verlander, M., Williams, A., Kempe, I., Patel, II., Campbell-West, F., Blackwood, B. & McAuley, D. F., 10 Jul 2023, In: Critical Care. 27, 6 p., 277.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
biomArker-guided Duration of Antibiotic treatment in hospitalised Patients with suspecTed Sepsis (ADAPT-Sepsis): A protocol for a multicentre randomised controlled trialDark, P., Perkins, G. D., McMullan, R., McAuley, D., Gordon, A. C., Clayton, J., Mistry, D., Young, K., Regan, S., McGowan, N., Stevenson, M., Gates, S., Carlson, G. L., Walsh, T., Lone, N. I., Mouncey, P. R., Singer, M., Wilson, P., Felton, T., Marshall, K., & 2 others, 25 Apr 2023, (Early online date) In: Journal of the Intensive Care Society.
Research output: Contribution to journal › Article › peer-reviewOpen Access
Eight Year Follow-up of an Observational Cohort of Postoperative Delirium in an Older Elective Arthroplasty Population – Preliminary Cognitive Outcomes
Aoife Sweeney (Presenter), Peter Passmore (Contributor), D.E. Beverland (Contributor), Bernadette McGuinness (Contributor), Danny McAuley (Contributor), Tim Mawhinney (Contributor), Seamus O’Brien (Contributor), Jonathan M Schott (Contributor), Henrik Zetterberg (Advisor) & Emma Cunningham (Advisor)Nov 2022
Activity: Talk or presentation types › Oral presentation
Follow-up of an Observational Cohort of Postoperative Delirium in an Older Elective Arthroplasty Population – Protocol and Recruitment Update
Aoife Sweeney (Presenter), Peter Passmore (Contributor), D.E. Beverland (Contributor), Bernadette McGuinness (Contributor), Danny McAuley (Contributor), Tim Mawhinney (Contributor), Seamus O’Brien (Contributor), Jonathan M Schott (Contributor), Henrik Zetterberg (Contributor) & Emma Cunningham (Contributor)17 Nov 2021
Activity: Talk or presentation types › Oral presentation
25/08/2021 → 26/08/2021
4 Media contributions
Protocols that assist clinicians to wean critically ill patients from mechanical ventilation in the intensive care unit (ICU)
Bronagh Blackwood (Participant), Christopher Patterson (Participant), Linda Johnston (Participant), Fiona Alderdice (Participant), Christopher Cardwell (Participant), Peter O'Halloran (Participant) & Danny McAuley (Participant)
Impact: Health Impact, Quality of Life Impact