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Prof Danny McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast.
He is Co-Director of Research for the Intensive Care Society. His major research area is the acute respiratory distress syndrome.
My major interest is the Acute Respiratory Distress Syndrome (ARDS). My research strategy in ARDS is to investigate potential novel therapeutic agents in ARDS in vitro, in vivo in a human LPS model of ARDS and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. My roles as the UK Intensive Care Society Co-Director of Research and the NICRN (Critical Care) clinical lead, mean I am well placed to develop the novel therapeutic targets into phase 3 clinical trials. I am currently investigating the role of statins, aspirin and extracorporeal carbon dioxide removal in ARDS.
I am also currently investigating MSCs, oncostatin M and anti-microbial peptides with a view to developing these agents as potential therapeutic agents for ARDS.
My other current research interests are nosocomial infection, sepsis diagnostics, delirium in critical illness and interventions to enhance recovery from critical illness.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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R4903CEM: Mucoactive drugs for acute respiratory failure: A 2x2 factorial, randomised, controlled, allocation concealed, open-label, Phase 3, pragmatic, clinical and cost effectiveness trial with internal pilot
24/07/2020 → …
R4880CEM: ALPHA-2 Agonists for sedation to produce better outcomes from critical illness (A2B Trial)
28/01/2020 → …
02/01/2020 → …
R4827CEM: Developong an early ICU swallowing inervention to improve outsomes following prolonged intubation
08/06/2018 → …
A randomised trial of the effects on recruitment and retention of including a wet-ink signature and photograph in the patient invitation letter for a clinical trial: results from a Study Within a Trial (SWAT 3 and SWAT 53) [version 1; peer review: awaiting peer review]Anand, R., Bradley, J., O'Neill, B., McAuley, D. F. & Clarke, M., 11 Feb 2022, In: F1000Research.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile12 Downloads (Pure)
Decision support system to evaluate ventilation in the acute respiratory distress syndrome (DeVENT study)-trial protocolPatel, B., Mumby, S., Johnson, N., Falaschetti, E., Hansen, J., Adcock, I., McAuley, D., Takata, M., Karbing, D. S., Jabaudon, M., Schellengowski, P. & Rees, S. E., 17 Jan 2022, In: Trials. 23, 1, 18 p., 47.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile6 Downloads (Pure)
Effect of Antiplatelet Therapy on Survival and Organ Support Free Days in Critically Ill Patients with COVID-19: A Randomized Clinical Trial: REMAP-CAP COVID-19 Antiplatelet Domain RCTMcAuley, D., 31 Mar 2022.
Research output: Working paper
Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical TrialRECOVERY-RS Collaborators, 24 Jan 2022, (Early online date) In: JAMA : the journal of the American Medical Association.
Research output: Contribution to journal › Article › peer-review
Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation Effect on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure-ReplyMcNamee, J. J., Brodie, D. & McAuley, D. F., 04 Jan 2022, In: JAMA : the journal of the American Medical Association. 327, 1, p. 84-85
Research output: Contribution to journal › Comment/debate › peer-review
Protocols that assist clinicians to wean critically ill patients from mechanical ventilation in the intensive care unit (ICU)
Bronagh Blackwood (Participant), Christopher Patterson (Participant), Linda Johnston (Participant), Fiona Alderdice (Participant), Christopher Cardwell (Participant), Peter O'Halloran (Participant) & Danny McAuley (Participant)
Impact: Health Impact, Quality of Life Impact