Projects per year
Personal profile
Interests
Prof Danny McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast.
He is Co-Director of Research for the Intensive Care Society. His major research area is the acute respiratory distress syndrome.
Research Statement
My major interest is the Acute Respiratory Distress Syndrome (ARDS). My research strategy in ARDS is to investigate potential novel therapeutic agents in ARDS in vitro, in vivo in a human LPS model of ARDS and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. My roles as the UK Intensive Care Society Co-Director of Research and the NICRN (Critical Care) clinical lead, mean I am well placed to develop the novel therapeutic targets into phase 3 clinical trials. I am currently investigating the role of statins, aspirin and extracorporeal carbon dioxide removal in ARDS.
I am also currently investigating MSCs, oncostatin M and anti-microbial peptides with a view to developing these agents as potential therapeutic agents for ARDS.
My other current research interests are nosocomial infection, sepsis diagnostics, delirium in critical illness and interventions to enhance recovery from critical illness.
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Projects
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R1141CEM: The Role of Extracellular Proteasome in the acutely inflamed lung
Taggart, C., McAuley, D., O'Kane, C. & Weldon, S.
02/01/2020 → …
Project: Research
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R1900CEM: Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for ARDS
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
13/04/2018 → …
Project: Research
Research Output
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Airway clearance techniques and use of mucoactive agents for adult critically ill patients with acute respiratory failure: a qualitative study exploring UK physiotherapy practice
Connolly, B., Barclay, M., Blackwood, B., Bradley, J., Anand, R., Borthwick, M., Chikhani, M., Dark, P., Shyamsundar, M., Warburton, J., McAuley, D. F. & O'Neill, B., 01 Sep 2020, In : Physiotherapy (United Kingdom). 108, p. 78-87 10 p.Research output: Contribution to journal › Article › peer-review
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Airway Inflammation and Host Responses in the Era of CFTR Modulators
Keown, K., Brown, R., Doherty, D. F., Houston, C., McKelvey, M. C., Creane, S., Linden, D., McAuley, D. F., Kidney, J. C., Weldon, S., Downey, D. G. & Taggart, C. C., 02 Sep 2020, In : International journal of molecular sciences. 21, 17Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
A minimal common outcome measure set for COVID-19 clinical research
Marshall, J. C., Murthy, S., Diaz, J., Adhikari, N., Angus, D. C., Arabi, Y. M., Baillie, K., Bauer, M., Berry, S., Blackwood, B., Bonten, M., Bozza, F., Brunkhorst, F., Cheng, A., Clarke, M., Dat, V. Q., de Jong, M., Denholm, J., Derde, L., Dunning, J. & 41 others, , 20 Jun 2020, In : The Lancet Infectious Diseases.Research output: Contribution to journal › Review article › peer-review
Open AccessFile33 Citations (Scopus)182 Downloads (Pure) -
Combined Mesenchymal Stromal Cell Therapy and ECMO in ARDS: A Controlled Experimental Study in Sheep
Combining Extracorporeal Life Support and Cell Therapy in Critical Illness (CELTIC) investigators., 15 Apr 2020, In : American Journal of Respiratory and Critical Care Medicine.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Comparing regression and neural network techniques for personalized predictive analytics to promote lung protective ventilation in Intensive Care Units
Hagan, R., Gillan, C., Spence, I., McAuley, D. & Shyamsundar, M., 01 Nov 2020, In : Computers in Biology and Medicine. 126Research output: Contribution to journal › Article › peer-review
Activities
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Lewis J Hurwitz Memorial Lecture: Howard Bauchner
Aidan Cole (Organiser), Danny McAuley (Programme chair) & Emma Cunningham (Organiser)
15 Jan 2020Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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New England Journal of Medicine (Journal)
Danny McAuley (Peer reviewer)
16 Jul 2020Activity: Publication peer-review and editorial work types › Publication peer-review
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Clinical Academic Forum
Aidan Cole (Organiser), Danny McAuley (Chair), Emma Cunningham (Organiser), Richard Turkington (Participant) & Cecilia O'Kane (Participant)
15 Jan 2019Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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UK Critical Care Research Forum
Cecilia O'Kane (Organiser), Murali Shyamsundar (Organiser), Bronagh Blackwood (Organiser) & Danny McAuley (Organiser)
07 Jun 2018 → 08 Jun 2018Activity: Participating in or organising an event types › Participation in conference
Impact
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Protocols that assist clinicians to wean critically ill patients from mechanical ventilation in the intensive care unit (ICU)
Bronagh Blackwood (Participant), Christopher Patterson (Participant), Linda Johnston (Participant), Fiona Alderdice (Participant), Christopher Cardwell (Participant), Peter O'Halloran (Participant) & Danny McAuley (Participant)
Impact: Health Impact, Quality of Life Impact