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Prof Danny McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast.
His major research area is the acute respiratory distress syndrome.
Research Statement
My major interest is the Acute Respiratory Distress Syndrome (ARDS). My research strategy in ARDS is to investigate potential novel therapeutic agents in ARDS in vitro, in vivo in a human LPS model of ARDS and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. My roles as the UK Intensive Care Society Co-Director of Research and the NICRN (Critical Care) clinical lead, mean I am well placed to develop the novel therapeutic targets into phase 3 clinical trials. I am currently investigating the role of statins, aspirin and extracorporeal carbon dioxide removal in ARDS.
I am also currently investigating MSCs, oncostatin M and anti-microbial peptides with a view to developing these agents as potential therapeutic agents for ARDS.
My other current research interests are nosocomial infection, sepsis diagnostics, delirium in critical illness and interventions to enhance recovery from critical illness.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R4903CEM: Mucoactive drugs for acute respiratory failure: A 2x2 factorial, randomised, controlled, allocation concealed, open-label, Phase 3, pragmatic, clinical and cost effectiveness trial with internal pilot
Connolly, B., Blackwood, B., Bradley, J., Clarke, M., McAuley, D. & Shyamsundar, M.
24/07/2020 → …
Project: Research
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R4880CEM: ALPHA-2 Agonists for sedation to produce better outcomes from critical illness (A2B Trial)
28/01/2020 → …
Project: Research
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R1141CEM: The Role of Extracellular Proteasome in the acutely inflamed lung
Taggart, C., McAuley, D., O'Kane, C. & Weldon, S.
02/01/2020 → …
Project: Research
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R4827CEM: Developong an early ICU swallowing inervention to improve outsomes following prolonged intubation
08/06/2018 → …
Project: Research
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Acute hypoxaemic respiratory failure after treatment with lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal: long-term outcomes from the REST randomised trial
Boyle, A. J., McDowell, C., Agus, A., Logan, D., Stewart, J. D., Jackson, C., Mills, J., McNamee, J. J. & McAuley, D. F., 01 Aug 2023, In: Thorax. 78, 8, p. 767-774 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Downloads (Pure) -
Advancing specificity in delirium: the delirium subtyping initiative
Bowman, E. M. L., Brummel, N. E., Caplan, G. A., Cunningham, C., Evered, L. A., Fiest, K. M., Girard, T. D., Jackson, T. A., LaHue, S. C., Lindroth, H. L., Maclullich, A. M. J., McAuley, D. F., Oh, E. S., Oldham, M. A., Page, V. J., Pandharipande, P. P., Potter, K. M., Sinha, P., Slooter, A. J. C., Sweeney, A. M., & 5 others, 31 Jul 2023, (Early online date) In: Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
A mechanistic analysis of the effect of valaciclovir for EBV suppression on airway inflammation and microbiome in COPD
Linden, D., Guo-Parke, H., Einarsson, G., Carson, S., Lee, A., Fairley, D., Singh, D., Tunney, M., Mcauley, D., Taggart, C. & Kidney, J., 19 May 2023, In: ERJ Open Research. 9, Suppl. 10, 1 p., 59.Research output: Contribution to journal › Meeting abstract › peer-review
Open Access -
A user evaluation of speech/phrase recognition software in critically ill patients: a DECIDE-AI feasibility study
Musalia, M., Lala, S., Cazalilla-Chica, L., Allan, J., Roach, L., Twamley, J., Nanda, S., Verlander, M., Williams, A., Kempe, I., Patel, II., Campbell-West, F., Blackwood, B. & McAuley, D. F., 10 Jul 2023, In: Critical Care. 27, 6 p., 277.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
biomArker-guided Duration of Antibiotic treatment in hospitalised Patients with suspecTed Sepsis (ADAPT-Sepsis): A protocol for a multicentre randomised controlled trial
Dark, P., Perkins, G. D., McMullan, R., McAuley, D., Gordon, A. C., Clayton, J., Mistry, D., Young, K., Regan, S., McGowan, N., Stevenson, M., Gates, S., Carlson, G. L., Walsh, T., Lone, N. I., Mouncey, P. R., Singer, M., Wilson, P., Felton, T., Marshall, K., & 2 others, 25 Apr 2023, (Early online date) In: Journal of the Intensive Care Society.Research output: Contribution to journal › Article › peer-review
Open Access
Activities
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Eight Year Follow-up of an Observational Cohort of Postoperative Delirium in an Older Elective Arthroplasty Population – Preliminary Cognitive Outcomes
Aoife Sweeney (Presenter), Peter Passmore (Contributor), D.E. Beverland (Contributor), Bernadette McGuinness (Contributor), Danny McAuley (Contributor), Tim Mawhinney (Contributor), Seamus O’Brien (Contributor), Jonathan M Schott (Contributor), Henrik Zetterberg (Advisor) & Emma Cunningham (Advisor)
Nov 2022Activity: Talk or presentation types › Oral presentation
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ANNE JOHNSON
Aidan Cole (Host), Emma Cunningham (Host) & Danny McAuley (Host)
22 Jun 2022Activity: Hosting a visitor types › Hosting an academic visitor
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Follow-up of an Observational Cohort of Postoperative Delirium in an Older Elective Arthroplasty Population – Protocol and Recruitment Update
Aoife Sweeney (Presenter), Peter Passmore (Contributor), D.E. Beverland (Contributor), Bernadette McGuinness (Contributor), Danny McAuley (Contributor), Tim Mawhinney (Contributor), Seamus O’Brien (Contributor), Jonathan M Schott (Contributor), Henrik Zetterberg (Contributor) & Emma Cunningham (Contributor)
17 Nov 2021Activity: Talk or presentation types › Oral presentation
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New England Journal of Medicine (Journal)
Danny McAuley (Peer reviewer)
16 Jul 2020Activity: Publication peer-review and editorial work types › Publication peer-review
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Lewis J Hurwitz Memorial Lecture: Howard Bauchner
Aidan Cole (Organiser), Danny McAuley (Programme chair) & Emma Cunningham (Organiser)
15 Jan 2020Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Press/Media
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Biggest ever study on child ICU patients reveals major improvements with nurse centred care
Bronagh Blackwood, Danny McAuley, Mike Clarke & Lisa McIlmurray
25/08/2021 → 26/08/2021
4 Media contributions
Press/Media: Research
Impact
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Protocols that assist clinicians to wean critically ill patients from mechanical ventilation in the intensive care unit (ICU)
Bronagh Blackwood (Participant), Christopher Patterson (Participant), Linda Johnston (Participant), Fiona Alderdice (Participant), Christopher Cardwell (Participant), Peter O'Halloran (Participant) & Danny McAuley (Participant)
Impact: Health Impact, Quality of Life Impact