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Danny McAuley

Professor

 https://orcid.org/0000-0002-3283-1947

  • Room 02.057 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Professor McAuley is open to PhD applications from candidates with a basic science or clinical background. His major interest is the Acute Respiratory Distress Syndrome (ARDS). My research strategy in ARDS is to investigate potential novel therapeutic agents in ARDS in vitro, in vivo in human models of ARDS and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. I am currently investigating the role of MSCs, statins and ECCO2R in ARDS. My other current research interests are patient stratification in ARDS, sepsis diagnostics and delirium. Previous research experience is desirable although not essential.

19972020

Research output per year

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Personal profile

Interests

Prof Danny McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast.

He is Co-Director of Research for the Intensive Care Society. His major research area is the acute respiratory distress syndrome.

Research Statement

My major interest is the Acute Respiratory Distress Syndrome (ARDS). My research strategy in ARDS is to investigate potential novel therapeutic agents in ARDS in vitro, in vivo in a human LPS model of ARDS and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. My roles as the UK Intensive Care Society Co-Director of Research and the NICRN (Critical Care) clinical lead, mean I am well placed to develop the novel therapeutic targets into phase 3 clinical trials. I am currently investigating the role of statins, aspirin and extracorporeal carbon dioxide removal in ARDS.

I am also currently investigating MSCs, oncostatin M and anti-microbial peptides with a view to developing these agents as potential therapeutic agents for ARDS.

My other current research interests are nosocomial infection, sepsis diagnostics, delirium in critical illness and interventions to enhance recovery from critical illness.

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Projects

R1141CEM: The Role of Extracellular Proteasome in the acutely inflamed lung

Taggart, C., McAuley, D., O'Kane, C. & Weldon, S.

02/01/2020 → …

Project: Research

R1002CEM: "The role of extracellular vesicle miRNAs in Mesenchymal Stem Cells’ effects on macrophage modulation in ARDS”

Krasnodembskaya, A., McAuley, D., O'Kane, C. & Simpson, D.

10/01/2019 → …

Project: Research

R1900CEM: Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for ARDS

Krasnodembskaya, A., McAuley, D. & O'Kane, C.

13/04/2018 → …

Project: Research

R4808CEM: Biomarker guided duration of antibiotic treatment in hospitalised patients with moderate to severe sepsis (ADAPT Sepsis)

McAuley, D. & McMullan, R.

26/07/2017 → …

Project: Research

R1744CEM: The role of Cathepsin S in PAR-1 mediated lung inflammation - a new paradigm for neutrophilic inflammation

Taggart, C., McAuley, D. & Weldon, S.

26/04/2017 → …

Project: Research

Research Output

A minimal common outcome measure set for COVID-19 clinical research

Marshall, J. C., Murthy, S., Diaz, J., Adhikari, N., Angus, D. C., Arabi, Y. M., Baillie, K., Bauer, M., Berry, S., Blackwood, B., Bonten, M., Bozza, F., Brunkhorst, F., Cheng, A., Clarke, M., Dat, V. Q., de Jong, M., Denholm, J., Derde, L., Dunning, J. & 41 others, Feng, X., Fletcher, T., Foster, N., Fowler, R., Gobat, N., Gomersall, C., Gordon, A., Glueck, T., Harhay, M., Hodgson, C., Horby, P., Kim, Y. J., Kojan, R., Kumar, B., Laffey, J., Malvey, D., Martin-Loeches, I., McArthur, C., McAuley, D., McBride, S., McGuinness, S., Merson, L., Morpeth, S., Needham, D., Netea, M., Oh, M. D., Phyu, S., Piva, S., Qiu, R., Salisu-Kabara, H., Shi, L., Shimizu, N., Sinclair, J., Tong, S., Turgeon, A., Uyeki, T., van de Veerdonk, F., Webb, S., Williamson, P., Wolf, T. & Zhang, J., 20 Jun 2020, In : The Lancet Infectious Diseases.

Research output: Contribution to journal › Review article

Open Access
File
    • 1 Citation (Scopus)

    Combined Mesenchymal Stromal Cell Therapy and ECMO in ARDS: A Controlled Experimental Study in Sheep

    Combining Extracorporeal Life Support and Cell Therapy in Critical Illness (CELTIC) investigators., 15 Apr 2020, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journal › Article

    • Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials

    Sinha, P., Delucchi, K. L., McAuley, D., O'Kane, C., Matthay, M. & Calfee, C. S., 13 Jan 2020, In : The Lancet Respiratory Medicine. 11 p.

    Research output: Contribution to journal › Article

    • 6 Citations (Scopus)

    Fluid management and deresuscitation practices: A survey of critical care physicians

    Silversides, J. A., McAuley, D. F., Blackwood, B., Fan, E., Ferguson, A. J. & Marshall, J. C., 01 May 2020, In : Journal of the Intensive Care Society. 21, 2, p. 111-118 8 p.

    Research output: Contribution to journal › Article

    • Fool’s gold? Why blinded trials are not always best: Why blinded trials are not always best

    Anand, R., Norrie, J., Bradley, J., McAuley, D. & Clarke, M., 21 Jan 2020, In : BMJ. 368, 5 p., l6228.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 4 Citations (Scopus)
    238 Downloads (Pure)

    Activities

    • 2 Participation in workshop, seminar, course
    • 1 Participation in conference

    Lewis J Hurwitz Memorial Lecture: Howard Bauchner

    Aidan Cole (Organiser), , Danny McAuley (Programme chair), & Emma Cunningham (Organiser)

    15 Jan 2020

    Activity: Participating in or organising an event types › Participation in workshop, seminar, course

    Clinical Academic Forum

    Aidan Cole (Organiser), , Danny McAuley (Chair), , Emma Cunningham (Organiser), , Richard Turkington (Participant), & Cecilia O'Kane (Participant)

    15 Jan 2019

    Activity: Participating in or organising an event types › Participation in workshop, seminar, course

    UK Critical Care Research Forum

    Cecilia O'Kane (Organiser), , Murali Shyamsundar (Organiser), , Bronagh Blackwood (Organiser), & Danny McAuley (Organiser)

    07 Jun 2018 → 08 Jun 2018

    Activity: Participating in or organising an event types › Participation in conference

    Impact

    Protocols that assist clinicians to wean critically ill patients from mechanical ventilation in the intensive care unit (ICU)

    Bronagh Blackwood (Participant), Christopher Patterson (Participant), Linda Johnston (Participant), Fiona Alderdice (Participant), Christopher Cardwell (Participant), Peter O'Halloran (Participant) & Danny McAuley (Participant)

    Impact: Health Impact, Quality of Life Impact

    Thesis

    The role of lipid A in the virulence of ESKAPE pathogens

    Author: Bartholomew, T., 2019

    Supervisor: Bengoechea, J. (Supervisor), McAuley, D. (Supervisor) & Krasnodembskaya, A. (Supervisor)

    Student thesis: Doctoral Thesis › Doctor of Philosophy