Projects per year
Personal profile
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Prof Danny McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast.
His major research area is the acute respiratory distress syndrome.
Research Statement
My major interest is the Acute Respiratory Distress Syndrome (ARDS). My research strategy in ARDS is to investigate potential novel therapeutic agents in ARDS in vitro, in vivo in a human LPS model of ARDS and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. My roles as the UK Intensive Care Society Co-Director of Research and the NICRN (Critical Care) clinical lead, mean I am well placed to develop the novel therapeutic targets into phase 3 clinical trials. I am currently investigating the role of statins, aspirin and extracorporeal carbon dioxide removal in ARDS.
I am also currently investigating MSCs, oncostatin M and anti-microbial peptides with a view to developing these agents as potential therapeutic agents for ARDS.
My other current research interests are nosocomial infection, sepsis diagnostics, delirium in critical illness and interventions to enhance recovery from critical illness.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R4903CEM: Mucoactive drugs for acute respiratory failure: A 2x2 factorial, randomised, controlled, allocation concealed, open-label, Phase 3, pragmatic, clinical and cost effectiveness trial with internal pilot
Connolly, B. (PI), Blackwood, B. (CoI), Bradley, J. (CoI), Clarke, M. (CoI), McAuley, D. (CoI) & Shyamsundar, M. (CoI)
24/07/2020 → …
Project: Research
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R4880CEM: ALPHA-2 Agonists for sedation to produce better outcomes from critical illness (A2B Trial)
Blackwood, B. (PI) & McAuley, D. (CoI)
28/01/2020 → …
Project: Research
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R1141CEM: The Role of Extracellular Proteasome in the acutely inflamed lung
Taggart, C. (PI), McAuley, D. (CoI), O'Kane, C. (CoI) & Weldon, S. (CoI)
02/01/2020 → …
Project: Research
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R4827CEM: Developong an early ICU swallowing inervention to improve outsomes following prolonged intubation
Blackwood, B. (PI) & McAuley, D. (CoI)
08/06/2018 → …
Project: Research
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R4808CEM: Biomarker guided duration of antibiotic treatment in hospitalised patients with moderate to severe sepsis (ADAPT Sepsis)
McAuley, D. (PI) & McMullan, R. (CoI)
26/07/2017 → …
Project: Research
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An international survey of the management of atrial fibrillation in critically unwell patients
Johnston, B. W., Udy, A. A., McAuley, D. F., Mogk, M., Welters, I. D. & Sibley, S., 01 Apr 2024, In: Critical Care Explorations. 6, 4, 10 p., e1069.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)23 Downloads (Pure) -
A randomized control trial evaluating the advice of a physiological-model/digital twin-based decision support system on mechanical ventilation in patients with acute respiratory distress syndrome
Patel, B. V., Mumby, S., Johnson, N., Handslip, R., Patel, S., Lee, T., Andersen, M. S., Falaschetti, E., Adcock, I. M., McAuley, D. F., Takata, M., Staudinger, T., Karbing, D. S., Jabaudon, M., Schellongowski, P., Rees, S. E. & DeVENT Study Group, 30 Oct 2024, In: Frontiers in Medicine. 11, 1473629.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Assessment and report of individual symptoms in studies of delirium in postoperative populations: a systematic review
Bowman, E. M. L., Sweeney, A. M., McAuley, D. F., Cardwell, C., Kane, J., Badawi, N., Jahan, N., Iqbal, H. K., Mitchell, C., Ballantyne, J. A. & Cunningham, E. L., Apr 2024, In: Age and Ageing. 53, 4, 14 p., afae077.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)50 Downloads (Pure) -
Cell-based therapies for ARDS - Where are we now?
Curley, G. F., O'Kane, C. M., McAuley, D. F., Matthay, M. A. & Laffey, J. G., 07 Feb 2024, (Early online date) In: American Journal of Respiratory and Critical Care Medicine. 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)85 Downloads (Pure) -
Cohort profile: post-hospitalisation COVID-19 (PHOSP-COVID) study
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L.-P., Marks, M., Poinasamy, K., Raman, B., Shikotra, A., Singapuri, A., Sereno, M., Heaney, L. G., McGarvey, L., Baillie, J. K., Siddiqui, S., Beggs, M., Wilkinson, D., Armour, C. & McAuley, D. F. & 10 others, , Feb 2024, In: International Journal of Epidemiology. 53, 1, 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)30 Downloads (Pure)
Datasets
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Process evaluation of the sedation and weaning in children (SANDWICH) multicentre stepped wedge, cluster randomised controlled trial
Jordan, J. (Creator), Tume, L. N. (Creator), Clarke, M. (Creator), McAuley, D. (Creator), McDowell, C. (Creator), McIlmurray, L. (Creator), Morris, K. (Creator), Peters, M. J. (Creator), Walsh, T. S. (Creator) & Blackwood, B. (Creator), Queen's University Belfast, 31 Oct 2024
DOI: 10.17034/d6506ceb-396f-438d-a7ab-47fc0bc8988e
Dataset
Activities
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Eight Year Follow-up of an Observational Cohort of Postoperative Delirium in an Older Elective Arthroplasty Population – Preliminary Cognitive Outcomes
Sweeney, A. (Presenter), Passmore, P. (Contributor), Beverland, D. E. (Contributor), McGuinness, B. (Contributor), McAuley, D. (Contributor), Mawhinney, T. (Contributor), O’Brien, S. (Contributor), Schott, J. M. (Contributor), Zetterberg, H. (Advisor) & Cunningham, E. (Advisor)
Nov 2022Activity: Talk or presentation types › Oral presentation
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ANNE JOHNSON
Cole, A. (Host), Cunningham, E. (Host) & McAuley, D. (Host)
22 Jun 2022Activity: Hosting a visitor types › Hosting an academic visitor
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Follow-up of an Observational Cohort of Postoperative Delirium in an Older Elective Arthroplasty Population – Protocol and Recruitment Update
Sweeney, A. (Presenter), Passmore, P. (Contributor), Beverland, D. E. (Contributor), McGuinness, B. (Contributor), McAuley, D. (Contributor), Mawhinney, T. (Contributor), O’Brien, S. (Contributor), Schott, J. M. (Contributor), Zetterberg, H. (Contributor) & Cunningham, E. (Contributor)
17 Nov 2021Activity: Talk or presentation types › Oral presentation
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New England Journal of Medicine (Journal)
McAuley, D. (Peer reviewer)
16 Jul 2020Activity: Publication peer-review and editorial work types › Publication peer-review
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Lewis J Hurwitz Memorial Lecture: Howard Bauchner
Cole, A. (Organiser), McAuley, D. (Programme chair) & Cunningham, E. (Organiser)
15 Jan 2020Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Press/Media
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Biggest ever study on child ICU patients reveals major improvements with nurse centred care
Blackwood, B., McAuley, D., Clarke, M. & McIlmurray, L.
25/08/2021 → 26/08/2021
4 Media contributions
Press/Media: Research
Impacts
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Protocols that assist clinicians to wean critically ill patients from mechanical ventilation in the intensive care unit (ICU)
Blackwood, B. (Participant), Patterson, C. (Participant), Johnston, L. (Participant), Alderdice, F. (Participant), Cardwell, C. (Participant), O'Halloran, P. (Participant) & McAuley, D. (Participant)
Impact: Health Impact, Quality of Life Impact