Projects per year
Personal profile
Interests
Prof Danny McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast.
He is Co-Director of Research for the Intensive Care Society. His major research area is the acute respiratory distress syndrome.
Research Statement
My major interest is the Acute Respiratory Distress Syndrome (ARDS). My research strategy in ARDS is to investigate potential novel therapeutic agents in ARDS in vitro, in vivo in a human LPS model of ARDS and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. My roles as the UK Intensive Care Society Co-Director of Research and the NICRN (Critical Care) clinical lead, mean I am well placed to develop the novel therapeutic targets into phase 3 clinical trials. I am currently investigating the role of statins, aspirin and extracorporeal carbon dioxide removal in ARDS.
I am also currently investigating MSCs, oncostatin M and anti-microbial peptides with a view to developing these agents as potential therapeutic agents for ARDS.
My other current research interests are nosocomial infection, sepsis diagnostics, delirium in critical illness and interventions to enhance recovery from critical illness.
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Projects
R1141CEM: The Role of Extracellular Proteasome in the acutely inflamed lung
Taggart, C., McAuley, D., O'Kane, C. & Weldon, S.
02/01/2020 → …
Project: Research
R1900CEM: Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for ARDS
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
13/04/2018 → …
Project: Research
Research Output
Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials
Sinha, P., Delucchi, K. L., McAuley, D., O'Kane, C., Matthay, M. & Calfee, C. S., 13 Jan 2020, In : The Lancet Respiratory Medicine. 11 p.Research output: Contribution to journal › Article
Fool’s gold? Why blinded trials are not always best
Anand, R., Bradley, J., Clarke, M., McAuley, D. & Norrie, J., 21 Jan 2020, In : The BMJ. 5 p.Research output: Contribution to journal › Article
Open Access
File
A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis a protocol for the CLEAR clinical trial
CLEAR study group, 19 Dec 2019, In : Trials. 20, 1, p. 747Research output: Contribution to journal › Article
Open Access
File
A Core Outcome Set for Critical Care Ventilation Trials
Blackwood, B., Ringrow, S., Clarke, M., Marshall, J. C., Connolly, B., Rose, L. & McAuley, D. F., 25 Jul 2019, In : Critical Care Medicine.Research output: Contribution to journal › Article
Open Access
File
1
Citation
(Scopus)
99
Downloads
(Pure)
A porcine ex vivo lung perfusion model to investigate bacterial pathogenesis
Dumigan, A., Fitzgerald, M., Santos, J. S. P. G., Hamid, U., O’kane, C. M., McAuley, D. F. & Bengoechea, J. A., 01 Nov 2019, In : mBio. 10, 6, e02802-19.Research output: Contribution to journal › Article
Open Access
File
Activities
Lewis J Hurwitz Memorial Lecture: Howard Bauchner
Aidan Cole (Organiser), Danny McAuley (Programme chair), Emma Cunningham (Organiser)15 Jan 2020
Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Clinical Academic Forum
Aidan Cole (Organiser), Danny McAuley (Chair), Emma Cunningham (Organiser), Richard Turkington (Participant), Cecilia O'Kane (Participant)15 Jan 2019
Activity: Participating in or organising an event types › Participation in workshop, seminar, course
UK Critical Care Research Forum
Cecilia O'Kane (Organiser), Murali Shyamsundar (Organiser), Bronagh Blackwood (Organiser), Danny McAuley (Organiser)07 Jun 2018 → 08 Jun 2018
Activity: Participating in or organising an event types › Participation in conference
Impact
Protocols that assist clinicians to wean critically ill patients from mechanical ventilation in the intensive care unit (ICU)
Bronagh Blackwood (Participant), Chris Patterson (Participant), Linda Johnston (Participant), Fiona Alderdice (Participant), Christopher Cardwell (Participant), Peter O'Halloran (Participant), Danny McAuley (Participant)
Impact: Health Impact, Quality of Life Impact
Thesis
The role of lipid A in the virulence of ESKAPE pathogens
Author: Bartholomew, T., 2019Supervisor: Bengoechea, J. (Supervisor), McAuley, D. (Supervisor) & Krasnodembskaya, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy