Projects per year
Personal profile
Interests
Prof Danny McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast.
He is Co-Director of Research for the Intensive Care Society. His major research area is the acute respiratory distress syndrome.
Research Statement
My major interest is the Acute Respiratory Distress Syndrome (ARDS). My research strategy in ARDS is to investigate potential novel therapeutic agents in ARDS in vitro, in vivo in a human LPS model of ARDS and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. My roles as the UK Intensive Care Society Co-Director of Research and the NICRN (Critical Care) clinical lead, mean I am well placed to develop the novel therapeutic targets into phase 3 clinical trials. I am currently investigating the role of statins, aspirin and extracorporeal carbon dioxide removal in ARDS.
I am also currently investigating MSCs, oncostatin M and anti-microbial peptides with a view to developing these agents as potential therapeutic agents for ARDS.
My other current research interests are nosocomial infection, sepsis diagnostics, delirium in critical illness and interventions to enhance recovery from critical illness.
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Adult Respiratory Distress Syndrome
Medicine & Life Sciences
Critical Illness
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Randomized Controlled Trials
Medicine & Life Sciences
Acute Lung Injury
Medicine & Life Sciences
Intensive Care Units
Medicine & Life Sciences
Lung
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Artificial Respiration
Medicine & Life Sciences
Delirium
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2007 2019
R1900CEM: Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for ARDS
Krasnodembskaya, A., McAuley, D. & O'Kane, C.
13/04/2018 → …
Project: Research
R2353CEM: Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)
O'Kane, C., Krasnodembskaya, A. & McAuley, D.
25/01/2017 → …
Project: Research
Research Output 1997 2019
A Core Outcome Set for Critical Care Ventilation Trials
Blackwood, B., Ringrow, S., Clarke, M., Marshall, J. C., Connolly, B., Rose, L. & McAuley, D. F., 25 Jul 2019, In : Critical Care Medicine.Research output: Contribution to journal › Article
Open Access
File
Delphi Technique
Ventilation
Clinical Trials
Critical Care
Artificial Respiration
Cerebrospinal Fluid Spermidine, Glutamine and Putrescine Predict Postoperative Delirium Following Elective Orthopaedic Surgery
Pan, X., Cunningham, E. L., Passmore, A. P., McGuinness, B., McAuley, D. F., Beverland, D., O'Brien, S., Mawhinney, T., Schott, J. M., Zetterberg, H. & Green, B. D., 12 Mar 2019, In : Scientific Reports. 9, 1, 9 p., 4191.Research output: Contribution to journal › Article
Open Access
File
Putrescine
Spermidine
Delirium
Glutamine
Orthopedics
Development and Validation of Parsimonious Algorithms to Classify ARDS Phenotypes: Secondary Analyses of Randomised Controlled Trials
Sinha, P., Delucchi, K. L., McAuley, D., O'Kane, C., Matthay, M. & Calfee, C. S., 01 Aug 2019, (Accepted) In : The Lancet Respiratory Medicine.Research output: Contribution to journal › Article
Randomized Controlled Trials
Phenotype
Logistic Models
Bicarbonates
Protein C
Diabetic macular oedema and diode subthreshold micropulse laser (DIAMONDS): study protocol for a randomised controlled trial
DIAMONDS Study Group, 12 Feb 2019, In : Trials. 20, 11 p., 122.Research output: Contribution to journal › Article
Open Access
File
Macular Edema
Lasers
Randomized Controlled Trials
Cost-Benefit Analysis
Visual Acuity
Effectiveness of Multimodal imaging for the Evaluation of Retinal oedema And new vesseLs in Diabetic retinopathy (EMERALD)
EMERALD Study Group, 28 Jun 2019, In : BMJ Open. 9, 6, 8 p., e027795.Research output: Contribution to journal › Article
Open Access
File
Multimodal Imaging
Papilledema
Diabetic Retinopathy
Macular Edema
Cost-Benefit Analysis
Activities 2018 2018
- 1 Participation in conference
UK Critical Care Research Forum
Cecilia O'Kane (Organiser), Murali Shyamsundar (Organiser), Bronagh Blackwood (Organiser), Danny McAuley (Organiser)07 Jun 2018 → 08 Jun 2018
Activity: Participating in or organising an event types › Participation in conference
Impact
Protocols that assist clinicians to wean critically ill patients from mechanical ventilation in the intensive care unit (ICU)
Bronagh Blackwood (Participant), Chris Patterson (Participant), Linda Johnston (Participant), Fiona Alderdice (Participant), Christopher Cardwell (Participant), Peter O'Halloran (Participant), Danny McAuley (Participant)
Impact: Health Impact, Quality of Life Impact
Thesis
The role of lipid A in the virulence of ESKAPE pathogens
Author: Bartholomew, T., 2019Supervisor: Bengoechea, J. (Supervisor), McAuley, D. (Supervisor) & Krasnodembskaya, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy