Projects per year
Personal profile
Interests
Prof Danny McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast.
His major research area is the acute respiratory distress syndrome.
Research Statement
My major interest is the Acute Respiratory Distress Syndrome (ARDS). My research strategy in ARDS is to investigate potential novel therapeutic agents in ARDS in vitro, in vivo in a human LPS model of ARDS and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. My roles as the UK Intensive Care Society Co-Director of Research and the NICRN (Critical Care) clinical lead, mean I am well placed to develop the novel therapeutic targets into phase 3 clinical trials. I am currently investigating the role of statins, aspirin and extracorporeal carbon dioxide removal in ARDS.
I am also currently investigating MSCs, oncostatin M and anti-microbial peptides with a view to developing these agents as potential therapeutic agents for ARDS.
My other current research interests are nosocomial infection, sepsis diagnostics, delirium in critical illness and interventions to enhance recovery from critical illness.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R4903CEM: Mucoactive drugs for acute respiratory failure: A 2x2 factorial, randomised, controlled, allocation concealed, open-label, Phase 3, pragmatic, clinical and cost effectiveness trial with internal pilot
Connolly, B. (PI), Blackwood, B. (CoI), Bradley, J. (CoI), Clarke, M. (CoI), McAuley, D. (CoI) & Shyamsundar, M. (CoI)
24/07/2020 → …
Project: Research
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R4880CEM: ALPHA-2 Agonists for sedation to produce better outcomes from critical illness (A2B Trial)
Blackwood, B. (PI) & McAuley, D. (CoI)
28/01/2020 → …
Project: Research
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R1141CEM: The Role of Extracellular Proteasome in the acutely inflamed lung
Taggart, C. (PI), McAuley, D. (CoI), O'Kane, C. (CoI) & Weldon, S. (CoI)
02/01/2020 → …
Project: Research
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R4808CEM: Biomarker guided duration of antibiotic treatment in hospitalised patients with moderate to severe sepsis (ADAPT Sepsis)
McAuley, D. (PI) & McMullan, R. (CoI)
26/07/2017 → …
Project: Research
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R4794CEM: Antifungal stewardship opportunities with rapid tests for fungal infection in critically-ill patients (The A-Stop Study)
McMullan, R. (PI), Clarke, M. (CoI) & McAuley, D. (CoI)
09/03/2017 → …
Project: Research
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Beyond the cuff - characterising biofilm-forming microorganisms on endotracheal tubes in critically ill patients
Einarsson, G., Das, S., Silversides, J., Fundano, N., Lonsdale, E., McMullan, R., McAuley, D., Wylie, M., McCoy, C. & Sherrard, L., 03 Feb 2025.Research output: Contribution to conference › Abstract › peer-review
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Co-enrolment in critical care trials: a secondary analysis of the RECOVERY-RS trial
Eleftheriou, C., Ji, C., Lall, R., McAuley, D. F., Perkins, G. D. & Couper, K., 20 Nov 2025, In: Critical Care. 29, 3 p., 499.Research output: Contribution to journal › Letter › peer-review
Open AccessFile -
Development of a patient centred, structured, individually tailored, multi-component intervention to promote rehabilitation and recovery after critical illness: content, theory, and construction
O'Neill, B., McAuley, D., Clarke, R., Duncan, S., Firshman, P., Terblanche, E., Bruce, J., Costley, J., Connolly, B. & Bradley, J. M., 04 Aug 2025, In: NIHR Open Research. 5, 21 p., 64.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Dexmedetomidine- or clonidine-based sedation compared with propofol in critically ill patients: the A2B randomized clinical trial
Walsh, T. S., Parker, R. A., Aitken, L. M., McKenzie, C. A., Emerson, L., Boyd, J., MacDonald, A., Beveridge, G., Giddings, A., Hope, D., Irvine, S., Tuck, S., Lone, N. I., Kydonaki, K., Norrie, J., Brealey, D., Antcliffe, D., Reay, M., Williams, A. & Bewley, J. & 12 others, , 19 May 2025, (Early online date) In: JAMA.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)38 Downloads (Pure) -
Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respiratory failure (MARCH): study protocol for a multi-centre 2x2 factorial, randomised, controlled, open-label, Phase 3, pragmatic, clinical and cost effectiveness trial with internal pilot
Connolly, B., Dickson, N., Agus, A., Blackwood, B., Borthwick, M., Bradley, J., Campbell, C., Chikhani, M., Clarke, M., Dark, P., Lall, R., McDowell, C., McFarland, M., McKelvey, M., O'Kane, C., O'Neill, B., Perkins, G., Shyamsundar, M., Sturmy, G. & Taggart, C. C. & 3 others, , 10 Apr 2025, In: NIHR Open Research. 5, 30.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Downloads (Pure)
Datasets
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Process evaluation of the sedation and weaning in children (SANDWICH) multicentre stepped wedge, cluster randomised controlled trial
Jordan, J. (Creator), Tume, L. N. (Creator), Clarke, M. (Creator), McAuley, D. (Creator), McDowell, C. (Creator), McIlmurray, L. (Creator), Morris, K. (Creator), Peters, M. J. (Creator), Walsh, T. S. (Creator) & Blackwood, B. (Creator), Queen's University Belfast, 31 Oct 2024
DOI: 10.17034/d6506ceb-396f-438d-a7ab-47fc0bc8988e
Dataset
Activities
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Eight Year Follow-up of an Observational Cohort of Postoperative Delirium in an Older Elective Arthroplasty Population – Preliminary Cognitive Outcomes
Sweeney, A. (Presenter), Passmore, P. (Contributor), Beverland, D. E. (Contributor), McGuinness, B. (Contributor), McAuley, D. (Contributor), Mawhinney, T. (Contributor), O’Brien, S. (Contributor), Schott, J. M. (Contributor), Zetterberg, H. (Advisor) & Cunningham, E. (Advisor)
Nov 2022Activity: Talk or presentation types › Oral presentation
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ANNE JOHNSON
Cole, A. (Host), Cunningham, E. (Host) & McAuley, D. (Host)
22 Jun 2022Activity: Hosting a visitor types › Hosting an academic visitor
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Follow-up of an Observational Cohort of Postoperative Delirium in an Older Elective Arthroplasty Population – Protocol and Recruitment Update
Sweeney, A. (Presenter), Passmore, P. (Contributor), Beverland, D. E. (Contributor), McGuinness, B. (Contributor), McAuley, D. (Contributor), Mawhinney, T. (Contributor), O’Brien, S. (Contributor), Schott, J. M. (Contributor), Zetterberg, H. (Contributor) & Cunningham, E. (Contributor)
17 Nov 2021Activity: Talk or presentation types › Oral presentation
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New England Journal of Medicine (Journal)
McAuley, D. (Peer reviewer)
16 Jul 2020Activity: Publication peer-review and editorial work types › Publication peer-review
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Lewis J Hurwitz Memorial Lecture: Howard Bauchner
Cole, A. (Organiser), McAuley, D. (Programme chair) & Cunningham, E. (Organiser)
15 Jan 2020Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Press/Media
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Biggest ever study on child ICU patients reveals major improvements with nurse centred care
Blackwood, B., McAuley, D., Clarke, M. & McIlmurray, L.
25/08/2021 → 26/08/2021
4 Media contributions
Press/Media: Research
Impacts
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Protocols that assist clinicians to wean critically ill patients from mechanical ventilation in the intensive care unit (ICU)
Blackwood, B. (Participant), Patterson, C. (Participant), Johnston, L. (Participant), Alderdice, F. (Participant), Cardwell, C. (Participant), O'Halloran, P. (Participant) & McAuley, D. (Participant)
Impact: Health Impact, Quality of Life Impact