Projects per year
Professor David Gonzalez de Castro was appointed as Professor of Genomic Medicine in May 2016. His research is centred around molecular biomarker analysis and developing genomic stratification tools for precision medicine with particular focus on developing biomarker strategies for immunotherapeutics and using circulating biomarkers to better classify and monitor disease. He is involved in several translational research projects identifying diagnostic, predictive and prognostics molecular biomarkers in haematological and solid tumours. Professor Gonzalez de Castro has been one of the principal investigators on the CRUK stratified medicines programme since 2011, working in close collaboration with clinicians and pharmaceutical and biotechnology industry. For the last 12 years he has been the Head of the Molecular Diagnostics department at the Royal Marsden and the Institute of Cancer Research in London, where he has been leading the implementation of genomic medicine-driven clinical trials in multiple cancer types, including leukaemias, soft-tissue sarcomas, gastric, colon, lung, skin, prostate, breast and other tumours. He joins CCRCB and the NI-MPL as a Consultant Clinical Scientist, where he aims to further develop genomic stratification protocols to improve patients’ outcomes.
Gonzalez, D. & Stenzinger, A., 10 Feb 2021, In: Genes, Chromosomes and Cancer.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile36 Downloads (Pure)
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancerGonzalez, D., Mateo, J., Stenzinger, A., Rojo, F., Shiller, M., Wyatt, A. W., Penault-Llorca, F., Gomella, L. G., Eeles, R. & Bjartell, A., 25 Feb 2021, In: The Journal of Pathology: Clinical Research.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile9 Downloads (Pure)
Stewart, P., Gazdova, J., Srivastava, S., Kim, C., Catherwood, M., Strobl, A., Flanagan, A. M., Oniscu, A., Kroeze, L. I., Groenen, P., Taniere, P., Salto-Tellez, M. & Gonzalez, D., 11 Feb 2020, In: Modern Pathology .
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile4 Citations (Scopus)36 Downloads (Pure)
Detection of Structural Variants in Circulating Cell-Free DNA from Sarcoma Patients Using Next Generation SequencingMc Connell, L., Gazdova, J., Beck, K., Srivastava, S., Harewood, L., Hübschmann, D., Stenzinger, A., Glimm, H., Heilig, C. E., Fröhling, S. & Gonzalez, D., 03 Dec 2020, In: Cancers. 12, 12, 9 p., 3627.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile28 Downloads (Pure)
Early circulating tumour DNA kinetics measured by ultra-deep next-generation sequencing during radical radiotherapy for non-small cell lung cancer: a feasibility studyWalls, G. M., McConnell, L., McAleese, J., Murray, P., Lynch, T. B., Savage, K., Hanna, G. G. & de Castro, D. G., 29 May 2020, In: Radiation oncology (London, England). 15, 1, p. 132
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)30 Downloads (Pure)