• Room 0G.007 - H.S.B

    United Kingdom


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Personal profile


Short Biography

Professor David Gonzalez de Castro was appointed as Professor of Genomic Medicine in May 2016.  His research is centred around molecular biomarker analysis and developing genomic stratification tools for precision medicine with particular focus on developing biomarker strategies for immunotherapeutics and using circulating biomarkers to better classify and monitor disease.  He is involved in several translational research projects identifying diagnostic, predictive and prognostics molecular biomarkers in haematological and solid tumours.  Professor Gonzalez de Castro has been one of the principal investigators on the CRUK stratified medicines programme since 2011, working in close collaboration with clinicians and pharmaceutical and biotechnology industry.  For the last 12 years he has been the Head of the Molecular Diagnostics department at the Royal Marsden and the Institute of Cancer Research in London, where he has been leading the implementation of genomic medicine-driven clinical trials in multiple cancer types, including leukaemias, soft-tissue sarcomas, gastric, colon, lung, skin, prostate, breast and other tumours. He joins CCRCB and the NI-MPL as a Consultant Clinical Scientist, where he aims to further develop genomic stratification protocols to improve patients’ outcomes.

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Research Output

A novel next generation sequencing approach to improve sarcoma diagnosis

McConnell, L., Houghton, O., Stewart, P., Gazdova, J., Srivastava, S., Kim, C., Catherwood, M., Strobl, A., Flanagan, A. M., Oniscu, A., Kroeze, L. I., Groenen, P., Taniere, P., Salto-Tellez, M. & Gonzalez, D., 11 Feb 2020, In : Modern Pathology .

Research output: Contribution to journalArticle

  • 1 Citation (Scopus)
    Open Access
  • 8 Downloads (Pure)

    Genomic landscape of platinum resistant and sensitive testicular cancers

    Loveday, C., Litchfield, K., Proszek, P. Z., Cornish, A. J., Santo, F., Levy, M., Macintyre, G., Holryod, A., Broderick, P., Dudakia, D., Benton, B., Bakir, M. A., Hiley, C., Grist, E., Swanton, C., Huddart, R., Powles, T., Chowdhury, S., Shipley, J., O'Connor, S. & 5 others, Brenton, J. D., Reid, A., de Castro, D. G., Houlston, R. S. & Turnbull, C., 04 May 2020, In : Nature Communications. 11, 1, p. 2189

    Research output: Contribution to journalArticle

    Open Access
  • 1 Citation (Scopus)
    3 Downloads (Pure)

    The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial

    Roider, T., Wang, X., Hüttl, K., Müller-Tidow, C., Klapper, W., Rosenwald, A., Stewart, J. P., Gonzalez de Castro, D., Dreger, P., Hermine, O., Kluin-Nelemans, H. C., Grabe, N., Dreyling, M., Pott, C., Ott, G., Hoster, E. & Dietrich, S., 07 Jul 2020, In : International Journal of Cancer.

    Research output: Contribution to journalArticle

  • Analysis of KRAS, NRAS, BRAF, PIK3CA and TP53 mutations in a large prospective series of locally advanced rectal cancer patients

    Sclafani, F., Hulkki Wilson, S., Cunningham, D., Gonzalez De Castro, D., Kalaitzaki, E., Begum, R., Wotherspoon, A., Capdevila, J., Glimelius, B., Roselló, S., Thomas, J., Tait, D., Brown, G., Oates, J. & Chau, I., 14 Jun 2019, In : International Journal of Cancer.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Citations (Scopus)
    19 Downloads (Pure)


    Targeted Next Generation Sequencing to improve solid tumour diagnosis using tissue-derived and cell-free DNA

    Author: McConnell, L., Jul 2020

    Supervisor: Gonzalez de Castro, D. (Supervisor) & Salto-Tellez, M. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy