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Short Biography
David obtained his PhD in the field of molecular diagnostics of haematological malignancies in Salamanca, Spain. In 2004, he obtained a position at The Royal Marsden Hospital and The Institute of Cancer Research in London as a Clinical Scientist to lead the Molecular Diagnostics Laboratory. David has been involved in several translational research projects, particularly in the study of predictive and prognostics molecular biomarkers in haematological and solid tumours. He was one of the principal investigators on the CRUK stratified medicine programme, working in close collaboration with the pharmaceutical and biotech industry to deliver personalised medicine for cancer patients using genomics. In 2016 he was appointed Professor of Genomic Medicine at Queen’s University Belfast and leads the Genomics and Bioinformatics teams in the Precision Medicine Centre. He also works as a Consultant Clinical Scientist and Lead Scientist for Molecular Diagnostics at the Belfast Health and Social Care Trust. His research is centred around developing and applying genomic stratification tools for precision medicine and to better classify and monitor disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R3005CNR: Establishing a Precision Medicine Catapult Centre of Excellence in Northern Ireland
Salto-Tellez, M., Gonzalez de Castro, D., James, J., Kennedy, R., McArt, D. & Waugh, D.
01/12/2017 → …
Project: Research
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R1131CNR: KaryoSequencing: a novel and comprehensive approach for clinical diagnosis of genomic aberrations in myeloid disorders
10/01/2020 → 30/06/2022
Project: Research
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A novel next-generation sequencing capture-based strategy to report somatic hypermutation status using genomic regions downstream to immunoglobulin rearrangements
McCafferty, N., Stewart, J. P., Darzentas, N., Gazdova, J., Catherwood, M., Stamatopoulos, K., Langerak, A. W. & Gonzalez, D., 29 Dec 2022, (Early online date) In: HAEMATOLOGICA.Research output: Contribution to journal › Article › peer-review
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Immunoglobulin/T Cell Receptor Capture Strategy for Comprehensive Immunogenetics
Stewart, J. P., Gazdova, J., Srivastava, S., Revolta, J., Harewood, L., Maurya, M., Darzentas, N. & Gonzalez, D., 28 May 2022, Immunogenetics. Methods and Protocols . Langerak, A. W. (ed.). Springer, p. 133-152 20 p. (Methods in molecular biology (Clifton, N.J.); vol. 2453).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
Open AccessFile15 Downloads (Pure) -
TP53 Mutations Identified Using NGS Comprise the Overwhelming Majority of TP53 Disruptions in CLL: Results From a Multicentre Study
Catherwood, M. A., Wren, D., Chiecchio, L., Cavalieri, D., Donaldson, D., Lawless, S., ElHassadi, E., Hayat, A., Cahill, M. R., O’Shea, D., Sargent, J., Stewart, P., Maurya, M., Quinn, J., Murphy, P., de Castro, D. G., Mills, K., Cross, N. C. P., Forconi, F., Iyengar, S. & 2 others, , 28 Jun 2022, (Early online date) In: Frontiers in Oncology. 12, 909615.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Downloads (Pure) -
FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas
Milton, C. I., Selfe, J., Aladowicz, E., Man, Y. K. S., Bernauer, C., Missiaglia, E., Walters, Z. S., Gatz, S. A., Kelsey, A., Generali, M., Box, G., Valenti, M., Haven‐Brandon, A., Galiwango, D., Hayes, A., Clarke, M., Izquierdo, E., Gonzalez De Castro, D., Raynaud, F. I., Kirkin, V. & 1 others, , 30 Nov 2021, (Early online date) In: Molecular oncology.Research output: Contribution to journal › Article › peer-review
Open AccessFile74 Downloads (Pure) -
Homologous recombination repair deficiency (HRD): From biology to clinical exploitation
Gonzalez, D. & Stenzinger, A., 10 Feb 2021, (Early online date) In: Genes, Chromosomes and Cancer.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)210 Downloads (Pure)
Activities
- 2 Hosting of external, non-academic visitor
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Penny Wilson
Jacqueline James (Host), Manuel Salto-Tellez (Host) & David Gonzalez de Castro (Host)
14 Aug 2019Activity: Hosting a visitor types › Hosting of external, non-academic visitor
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Nick Chism
Jacqueline James (Host) & David Gonzalez de Castro (Host)
05 Jul 2019Activity: Hosting a visitor types › Hosting of external, non-academic visitor