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Short Biography
David obtained his PhD in the field of molecular diagnostics of haematological malignancies in Salamanca, Spain. In 2004, he obtained a position at The Royal Marsden Hospital and The Institute of Cancer Research in London as a Clinical Scientist to lead the Molecular Diagnostics Laboratory. David has been involved in several translational research projects, particularly in the study of predictive and prognostics molecular biomarkers in haematological and solid tumours. He was one of the principal investigators on the CRUK stratified medicine programme, working in close collaboration with the pharmaceutical and biotech industry to deliver personalised medicine for cancer patients using genomics. In 2016 he was appointed Professor of Genomic Medicine at Queen’s University Belfast and leads the Genomics and Bioinformatics teams in the Precision Medicine Centre. His research is centred around developing and applying genomic stratification tools for precision medicine and to better classify and monitor disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R3005CNR: Establishing a Precision Medicine Catapult Centre of Excellence in Northern Ireland
Salto-Tellez, M. (PI), Gonzalez de Castro, D. (CoI), James, J. (CoI), Kennedy, R. (CoI), McArt, D. (CoI) & Waugh, D. (CoI)
01/12/2017 → …
Project: Research
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R1131CNR: KaryoSequencing: a novel and comprehensive approach for clinical diagnosis of genomic aberrations in myeloid disorders
10/01/2020 → 30/06/2022
Project: Research
Research output
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Correlation between P53 immunohistochemical staining and TP53 molecular testing in endometrial carcinomas: a detailed assessment of discrepant cases with implications for patient management
Machuca-Aguado, J., Catherwood, M., Gonzalez, D. & McCluggage, W. G., 31 Oct 2025, (Early online date) In: Histopathology. 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Initiation of molecular testing of endometrial carcinomas in a population‐based setting: practical considerations and pitfalls
Machuca‐Aguado, J., Catherwood, M., Houghton, O., Taylor, J., Shah, R., Ben‐Mussa, A., Gonzalez, D. & McCluggage, W. G., Mar 2025, In: Histopathology. 86, 4, p. 611-626 16 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Mutational profile dynamics in follicular lymphoma and large cell transformation
Hesius, E. A. M., Stevens, W. B. C., Stewart, J. P., Kroeze, L. I., Spek, E. V. D., Issa, D., Nooijen, P., Luijks, J., Gonzalez, D., Groenen, P. J. T. A., Blijlevens, N. M. A., Spriel, A. B. V. & Brand, M. V. D., 31 Jan 2025, (Early online date) In: Journal of Clinical Pathology.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Noninvasive genotyping and early disease dynamics demonstrate the efficacy of ibrutinib in combination with immunochemotherapy in patients with mantle cell lymphoma treated in the TRIANGLE trial
Khouja, M., Genuardi, E., Ferrero, S., Laqua, A., Alessandria, B., Verhagen, O. J. H. M., Homburg, C. H. E., Sanz, R. G., Medina Herrera, A., van der Velden, V. H. J., da Silva, M. G., Gameiro, P., Doorduijn, J., Giné, E., Visco, C., Brüggemann, M., Baldus, C. D., Ladetto, M., Schmidt, C. & Dreyling, M. & 9 others, , 03 Nov 2025, (Early online date) In: Leukemia. 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Comparison of results from two commercially available in-house tissue-based comprehensive genomic profiling solutions research-use only AVENIO tumor tissue comprehensive genomic profiling kit and TruSight oncology 500 Assay
Adams, H.-P., Hiemenz, M. C., Hertel, K., Fuhlbrück, F., Thomas, M., Oughton, J., Sorensen, H., Schlecht, U., Allen, J. M., Cantone, M., Osswald, S., Gonzalez, D., Pikarsky, E., De Vos, M., Schuuring, E. & Wieland, T., Nov 2024, In: Journal of Molecular Diagnostics. 26, 11, p. 1018-1033 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)149 Downloads (Pure)
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Behnoush Abedi-Ardekani
Craig, S. (Host), James, J. (Host), Salto-Tellez, M. (Host), McCombe, K. (Host), Albraikat, M. (Host), Graham, L. (Host), Maxwell, P. (Host), Gonzalez de Castro, D. (Host) & Lewis, C. (Host)
14 Sept 2023 → 15 Sept 2023Activity: Hosting a visitor types › Hosting an academic visitor
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Penny Wilson
James, J. (Host), Salto-Tellez, M. (Host) & Gonzalez de Castro, D. (Host)
14 Aug 2019Activity: Hosting a visitor types › Hosting of external, non-academic visitor
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Nick Chism
James, J. (Host) & Gonzalez de Castro, D. (Host)
05 Jul 2019Activity: Hosting a visitor types › Hosting of external, non-academic visitor