Projects per year
Personal profile
Research Statement
After being awarded a BSc honours degree by the University of Dundee in 1995, I completed a PhD on ‘The role of dietary lipoproteins in the initiation of atherosclerosis’ at The Royal Veterinary College, University of London, in 1998. I then worked as a post-doctoral researcher in the laboratory of Professor Ajay Shah in the Cardiovascular Division at King’s College London for almost 7 years. In 2005, I took up an academic position within the School of Medicine, Dentistry and Biomedical Sciences at Queen's University Belfast where I am now a Professor with an established independent research programme. Notable achievements include receipt of the International Society for Heart Research Young Investigator Award (2003) and a prestigious Medical Research Council UK New Investigator Research Grant (2007), and election to the committee of the British Society for Cardiovascular Research (2008) on which I served as Honorary Secretary from 2014-2019. I am also currently Vice-Chair of the British Heart Foundation Projects Grants Committee and Associate Editor of Cardiovascular Drugs and Therapy. To date, I have published 57 peer-reviewed papers in the cardiovascular field in high impact journals such as Circulation, Circulation Research, Journal of the American College of Cardiology and Proceedings of the National Academy of Sciences USA, with >3900 citations and an H-index of 27 (according to Scopus) and have been awarded >£4.1M in competitive research grant funding.
Research Interests
My research programme is mainly focussed on investigating mechanisms underlying cardiovascular remodelling and dysfunction, with a particular interest in the role of oxidative stress, novel peptide hormones, endothelial progenitor cells, and the influence of diabetes. My group employs a wide range of laboratory techniques, from in vivo physiology to molecular biology and tissue culture, to investigate mechanisms underlying the adaptive but ultimately detrimental changes that occur in various cardiovascular disease states and how these may be modulated for potential therapeutic benefit.
Teaching
I make a significant contribution to both undergraduate and postgraduate teaching across a range of modules:
Undergraduate
Medicine
Laboratory Projects Supervised:
40 BSc, Masters and Summer Students
40 BSc, Masters and Summer Students
Postgraduate
MSc Experimental Medicine
SCM8110 - Diabetes and Cardiovascular Disease (Module Co-ordinator)
SCM8110 - Diabetes and Cardiovascular Disease (Module Co-ordinator)
SMDBS Postgraduate Training Programme (Co-ordinator)
PhD Supervision
22 students, 11 of whom are current
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Projects
R2200CEM: Influence of Nox4 on OEC function and their ability to promote Angiogenesis in tissue Ischaemia
Grieve, D., Margariti, A. & Medina, R.
13/02/2015 → …
Project: Research
R2723CVS: GLP-1 in diabetic cardiomyopathy
Grieve, D., Green, B. & McDermott, B.
01/08/2010 → …
Project: Research
R1827MSC: Role of PPAR-alpha and NadPH oxidases in hypetensive cardiac remodeling
01/08/2006 → 17/12/2019
Project: Research
Research Output
The influence of vestibular stimulation on metabolism and body composition
McKeown, J., McGeoch, P. D. & Grieve, D. J., 01 Jan 2020, In : Diabetic Medicine. 37, 1, p. 20-28 9 p.Research output: Contribution to journal › Article
1
Citation
(Scopus)
British Society for Cardiovascular Research (Special Issue): Introduction
Grieve, D. J., 20 Mar 2019, In : Cardiovascular Drugs and Therapy. 33, 201, p. 1Research output: Contribution to journal › Editorial
Open Access
NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation
O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., O'Neill, C. L., Dellett, M., Hargey, C. J., Abudalo, R. A., O'Hare, M., Doyle, P., Toh, T., Khoo, J., Wong, J., McCrudden, C. M., Meloni, M., Brunssen, C., Morawietz, H., Yoder, M. C. & 6 others, , 01 Apr 2019, In : Cardiovascular Research.Research output: Contribution to journal › Article
Open Access
File
P347 A survey of cardiovascular disease in UK cystic fibrosis centres
Downey, D. G., Bengoechea, J., Curtis, T., Grieve, D. & Harbinson, M., Jun 2019, In : Journal of Cystic Fibrosis. 18, p. S155-S156Research output: Contribution to journal › Meeting abstract
The RNA-binding protein QKI controls alternative splicing in vascular cells, producing an effective model for therapy
Caines, R., Cochrane, A., Kelaini, S., Gonzalez, M. V., Yang, C., Eleftheriadou, M., Moez, A., Stitt, A. W., Zeng, L., Grieve, D. J. & Margariti, A., 15 Aug 2019, In : Journal of Cell Science.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Prizes
Best Poster Prize - 5th Annual REMERGE Meeting
Karla O'Neill (Recipient) & David Grieve (Recipient), 26 Jun 2017
Prize: Prize (including medals and awards)
Best Poster Prize - Irish Association of Pharmacologists Annual Conference
Rawan Abudalo (Recipient) & David Grieve (Recipient), 30 Nov 2018
Prize: Prize (including medals and awards)
British Heart Foundation Heart Heroes Award
David Grieve (Recipient), 05 Oct 2018
Prize: Prize (including medals and awards)
British Heart Foundation Heart Heroes Award
David Grieve (Recipient), 29 Jun 2017
Prize: Prize (including medals and awards)
British Heart Foundation Project Grants Committee
David Grieve (Recipient), 23 Jan 2017
Prize: Appointment
Activities
Cardiovascular Drugs and Therapy (Journal)
David Grieve (Associate editor)13 Jan 2020 → …
Activity: Publication peer-review and editorial work types › Editorial activity
Invited Speaker at International Society for Heart Research European Section Meeting
David Grieve (Invited speaker)30 Jun 2020 → 03 Jul 2020
Activity: Talk or presentation types › Invited or keynote talk at national or international conference
King's College London (External organisation)
David Grieve (Reviewer)13 Jan 2020
Activity: Membership types › Membership of peer review panel or committee
British Heart Foundation NI Annual Supporters Conference 2019
David Grieve (Organiser)24 Sep 2019
Activity: Other activity types › Other
Invited Seminar at Shenyang Pharmaceutical University
David Grieve (Invited speaker)18 Nov 2019
Activity: Talk or presentation types › Invited talk
Press / Media
It’s not just heart research that’s important in Northern Ireland…
17/03/2018
1 Media contribution
Press/Media: Public Engagement Activities
Half of heart attack patients delay seeking medical help
12/04/2016
1 Media contribution
Press/Media: Expert Comment
Warning over number of people ignoring heart attack symptoms
12/04/2016
1 Media contribution
Press/Media: Expert Comment
How mentoring is helping us develop the research stars of the future
01/10/2015
1 Media contribution
Press/Media: Public Engagement Activities
Thesis
The role of FKBPL in diabetes and associated cardiovascular health
Author: Alqudah, A., Dec 2019Supervisor: Grieve, D. (Supervisor), Lyons, T. (Supervisor) & McClements, L. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy