Projects per year
Personal profile
Research Statement
After being awarded a BSc honours degree by the University of Dundee in 1995, I completed a PhD on ‘The role of dietary lipoproteins in the initiation of atherosclerosis’ at The Royal Veterinary College, University of London, in 1998. I then worked as a post-doctoral researcher in the laboratory of Professor Ajay Shah in the Cardiovascular Division at King’s College London for almost 7 years. In 2005, I took up an academic position within the School of Medicine, Dentistry and Biomedical Sciences at Queen's University Belfast where I am now a full Professor with an established independent research programme. Notable achievements include receipt of the International Society for Heart Research Young Investigator Award (2003) and a prestigious Medical Research Council UK New Investigator Research Grant (2007), and election to the committee of the British Society for Cardiovascular Research (2008) on which I served as Honorary Secretary for 6 years (2014-2019). I am currently Associate Editor of Cardiovascular Drugs and Therapy (2020- ) and recently completed my term as Vice-Chair of the British Heart Foundation Projects Grants Committee (2017-2021). I have published >65 peer-reviewed papers in the cardiovascular field in high impact journals such as Circulation, Circulation Research, Journal of the American College of Cardiology and Proceedings of the National Academy of Sciences USA, with >4500 citations and an H-index of 31 (according to Scopus) and have been awarded >£5.5M in competitive research grant funding.
Research Interests
My research programme is mainly focussed on investigating mechanisms underlying cardiovascular remodelling and dysfunction, with a particular interest in the influence of oxidative stress, endothelial progenitor cells, and diabetes. My group employs a wide range of laboratory techniques, from in vivo physiology to molecular biology and tissue culture, to investigate mechanisms underlying the adaptive but ultimately detrimental changes that occur in various cardiovascular disease states and how these may be modulated for potential therapeutic benefit.
Teaching
I make a significant contribution to both undergraduate and postgraduate teaching across a range of modules:
Undergraduate
Postgraduate
SCM8110 - Cardiovascular Biology and Disease
SCM8111 - Translational Cardiovascular Medicine
PhD Supervision
26 students, 7 of whom are current
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R2200CEM: Influence of Nox4 on OEC function and their ability to promote Angiogenesis in tissue Ischaemia
Grieve, D., Margariti, A. & Medina, R.
13/02/2015 → …
Project: Research
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R2723CVS: GLP-1 in diabetic cardiomyopathy
Grieve, D., Green, B. & McDermott, B.
01/08/2010 → …
Project: Research
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R2330MSC: Role of glucagon-like peptide-1 in heart remodeling after myocardial infarction
01/08/2006 → …
Project: Research
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R1827MSC: Role of PPAR-alpha and NadPH oxidases in hypetensive cardiac remodeling
01/08/2006 → …
Project: Research
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PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia
Pun, S. H., O’Neill, K. M., Edgar, K. S., Gill, E. K., Moez, A., Naderi-Meshkin, H., Malla, S. B., Hookham, M. B., Alsaggaf, M., Madishetti, V. V., Botezatu, B., King, W., Brunssen, C., Morawietz, H., Dunne, P. D., Brazil, D. P., Medina, R. J., Watson, C. J. & Grieve, D. J., 06 Sep 2023, (Early online date) In: Cells. 12, 18, 2220.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Spatial gene expression changes in the mouse heart after base-targeted irradiation
Walls, G. M., Ghita, M., Queen, R., Edgar, K. S., Gill, E. K., Kuburas, R., Grieve, D. J., Watson, C. J., McWilliam, A., Van Herk, M., Williams, K. J., Cole, A. J., Jain, S. & Butterworth, K. T., 01 Feb 2023, In: International Journal of Radiation Oncology Biology Physics. 115, 2, p. 453-463 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Downloads (Pure) -
Targeted mobilisation of endogenous endothelial progenitor cells - an alternate approach to allogeneic therapy for ischaemic cardiovasular disease?
O'Neill, K. M. & Grieve, D. J., 03 May 2023, (Early online date) In: Cardiovascular Drugs and Therapy.Research output: Contribution to journal › Editorial › peer-review
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Who should be the corresponding author, what are their responsibilities, and what email address should they provide?
Birnbaum, Y., Kitakaze, M., Grieve, D. & Uretsky, B. F., 14 Jul 2023, (Early online date) In: Cardiovascular Drugs and Therapy.Research output: Contribution to journal › Editorial › peer-review
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Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats
O'Hare, M., Esquiva, G., McGahon, M. K., Hombrebueno, J. M. R., Augustine, J., Canning, P., Edgar, K. S., Barabas, P., Friedel, T., Cincolà, P., Henry, J., Mayne, K., Ferrin, H., Stitt, A. W., Lyons, T. J., Brazil, D. P., Grieve, D. J., McGeown, J. G. & Curtis, T. M., 22 Sep 2022, In: JCI insight. 7, 18, 18 p., e155128.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Downloads (Pure)
Prizes
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Best Oral Presentation Prize - Scottish Cardiovascular Forum
O'Neill, Karla (Recipient) & Grieve, David (Recipient), 05 Feb 2021
Prize: Prize (including medals and awards)
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Best Oral Presentation Prize - Scottish Cardiovascular Forum
O'Neill, Karla (Recipient) & Grieve, David (Recipient), 03 Feb 2018
Prize: Prize (including medals and awards)
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Best Poster Prize - 5th Annual REMERGE Meeting
O'Neill, Karla (Recipient) & Grieve, David (Recipient), 26 Jun 2017
Prize: Prize (including medals and awards)
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Best Poster Prize - Irish Association of Pharmacologists Annual Conference
Abudalo, Rawan (Recipient) & Grieve, David (Recipient), 30 Nov 2018
Prize: Prize (including medals and awards)
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Best Poster Prize - Scottish Cardiovascular Forum
Gill, Eleanor (Recipient) & Grieve, David (Recipient), 03 Feb 2018
Prize: Prize (including medals and awards)
Activities
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NI Science Festival: Lab View 360 - Biomedical Research in Action
David Grieve (Contributor)
19 Feb 2022Activity: Other activity types › Hosting a school group or open day
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Journal of Pharmacy and Pharmacology (Journal)
David Grieve (Peer reviewer)
30 Jan 2022 → …Activity: Publication peer-review and editorial work types › Publication peer-review
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European Commission (External organisation)
David Grieve (Reviewer)
06 Jan 2022 → …Activity: Membership types › Membership of public/government advisory/policy group or panel
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Pharmacology Research & Perspectives (Journal)
David Grieve (Peer reviewer)
17 Sep 2021 → …Activity: Publication peer-review and editorial work types › Publication peer-review
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Invited Speaker at International Society for Heart Research European Section Meeting
David Grieve (Invited speaker)
30 Jun 2021Activity: Talk or presentation types › Invited or keynote talk at national or international conference
Press/Media
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U105 interview - Heart failure research
28/07/2021
1 Media contribution
Press/Media: Public Engagement Activities
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Belfast Telegraph - Scientists getting to the heart of the matter
04/03/2021
1 Media contribution
Press/Media: Public Engagement Activities
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The Irish News - QUB heart failure scientist backs campaign to protect medical research
18/11/2020
1 Media contribution
Press/Media: Public Engagement Activities
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BBC NI interview - Covid-19 and cardiovascular research
17/11/2020
1 Media contribution
Press/Media: Public Engagement Activities
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BBC News website - Covid-19 has 'devastating' effect on medical research charities
17/11/2020
1 Media contribution
Press/Media: Public Engagement Activities