• Room 01.063 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Professor Grieve is open to wide-ranging PhD applications from candidates with a basic science or clinical background. His fields of interest include: - cardiovascular biology - pathophysiology - pharmacology Previous research experience is desirable although not essential.

20032020

Research output per year

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Personal profile

Research Statement

After being awarded a BSc honours degree by the University of Dundee in 1995, I completed a PhD on ‘The role of dietary lipoproteins in the initiation of atherosclerosis’ at The Royal Veterinary College, University of London, in 1998. I then worked as a post-doctoral researcher in the laboratory of Professor Ajay Shah in the Cardiovascular Division at King’s College London for almost 7 years. In 2005, I took up an academic position within the School of Medicine, Dentistry and Biomedical Sciences at Queen's University Belfast where I am now a Professor with an established independent research programme. Notable achievements include receipt of the International Society for Heart Research Young Investigator Award (2003) and a prestigious Medical Research Council UK New Investigator Research Grant (2007), and election to the committee of the British Society for Cardiovascular Research (2008) on which I served as Honorary Secretary from 2014-2019. I am also currently Vice-Chair of  the British Heart Foundation Projects Grants Committee and Associate Editor of Cardiovascular Drugs and Therapy. To date, I have published 61 peer-reviewed papers in the cardiovascular field in high impact journals such as Circulation, Circulation Research, Journal of the American College of Cardiology and Proceedings of the National Academy of Sciences USA, with >4000 citations and an H-index of 28 (according to Scopus) and have been awarded >£4.1M in competitive research grant funding.

Research Interests

My research programme is mainly focussed on investigating mechanisms underlying cardiovascular remodelling and dysfunction, with a particular interest in the role of oxidative stress, novel peptide hormones, endothelial progenitor cells, and the influence of diabetes. My group employs a wide range of laboratory techniques, from in vivo physiology to molecular biology and tissue culture, to investigate mechanisms underlying the adaptive but ultimately detrimental changes that occur in various cardiovascular disease states and how these may be modulated for potential therapeutic benefit.

Dr Grieve's laboratory page

 

Teaching

I make a significant contribution to both undergraduate and postgraduate teaching across a range of modules:

Undergraduate

MED1017 - Physiological Basis of Clinical Practice
MED2013 - Physiological Basis of Clinical Practice
MED3013 - Student-Selected Component

Biomedical Sciences
BMS2027 - Physiological Sciences
BMS3013 - Sports and Exercise Physiology

Postgraduate

Fingerprint Dive into the research topics where David Grieve is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Projects

Research Output

Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart

Ghita, M., Gill, E., Walls, G., Edgar, K., McMahon, S., Vasquez Osorio, E., Bergom, C., Grieve, D., Watson, C., McWilliam, A., Aznar, M., van herk, M., Williams, K. J. & Butterworth, K., 11 Jul 2020, In : Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology. DOI: 10.1016/j.radonc.2020.07.016 .

Research output: Contribution to journalArticle

  • NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation

    O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., O'Neill, C. L., Dellett, M., Hargey, C. J., Abudalo, R. A., O'Hare, M., Doyle, P., Toh, T., Khoo, J., Wong, J., McCrudden, C. M., Meloni, M., Brunssen, C., Morawietz, H., Yoder, M. C. & 6 others, McDonald, D. M., Watson, C. J., Stitt, A. W., Margariti, A., Medina, R. J. & Grieve, D. J., 01 Feb 2020, In : Cardiovascular Research. 116, 2, p. 393-405 13 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    29 Downloads (Pure)

    Role of a novel angiogenesis FKBPL-CD44 pathway in preeclampsia risk stratification and mesenchymal stem cell treatment

    Todd, N., McNally, R., Alqudah, A., Jerotic, D., Suvakov, S., Obradovic, D., Hoch, D., Hombrebueno, J. R., Campos, G. L., Watson, C. J., Gojnic-Dugalic, M., Simic, T. P., Kransodembskaya, A., Desoye, G., Eastwood, K-A., Hunter, A. J., Holmes, V. A., McCance, D. R., Young, I. S., Grieve, D. J. & 4 others, Kenny, L. C., Garovic, V. D., Robson, T. & McClements, L., 03 Jul 2020, In : The Journal of Clinical Endocrinology & Metabolism.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 4 Downloads (Pure)

    Targeting QKI-7 in vivo restores endothelial cell function in diabetes

    Yang, C., Eleftheriadou, M., Kelaini, S., Morrison, T., González, M. V., Caines, R., Edwards, N., Yacoub, A., Edgar, K., Moez, A., Ivetic, A., Zampetaki, A., Zeng, L., Wilkinson, F. L., Lois, N., Stitt, A. W., Grieve, D. J. & Margariti, A., 30 Jul 2020, In : Nature Communications. 11, 1, 17 p., 3812.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 3 Downloads (Pure)

    Prizes

    Best Poster Prize - 5th Annual REMERGE Meeting

    O'Neill, Karla (Recipient) & Grieve, David (Recipient), 26 Jun 2017

    Prize: Prize (including medals and awards)

    Best Poster Prize - Irish Association of Pharmacologists Annual Conference

    Rawan Abudalo (Recipient) & Grieve, David (Recipient), 30 Nov 2018

    Prize: Prize (including medals and awards)

    British Heart Foundation Heart Heroes Award

    Grieve, David (Recipient), 29 Jun 2017

    Prize: Prize (including medals and awards)

  • British Heart Foundation Heart Heroes Award

    Grieve, David (Recipient), 05 Oct 2018

    Prize: Prize (including medals and awards)

    British Heart Foundation Project Grants Committee

    Grieve, David (Recipient), 23 Jan 2017

    Prize: Appointment

  • Activities

    Invited Speaker at International Society for Heart Research European Section Meeting

    David Grieve (Invited speaker)

    30 Jun 202003 Jul 2020

    Activity: Talk or presentation typesInvited or keynote talk at national or international conference

    King's College London (External organisation)

    David Grieve (Reviewer)

    13 Jan 2020

    Activity: Membership typesMembership of peer review panel or committee

    Cardiovascular Drugs and Therapy (Journal)

    David Grieve (Associate editor)

    13 Jan 2020 → …

    Activity: Publication peer-review and editorial work typesEditorial activity

    Invited Speaker at Ulster University CVD NI Symposium

    David Grieve (Invited speaker)

    24 Sep 2019

    Activity: Talk or presentation typesInvited talk

    PhD External Examiner - University of Leeds

    David Grieve (Examiner)

    30 Oct 2019

    Activity: Examination typesPhD external examination

    Press / Media

    It’s not just heart research that’s important in Northern Ireland…

    David Grieve

    17/03/2018

    1 Media contribution

    Press/Media: Public Engagement Activities

    Investing in the future

    David Grieve

    01/10/2017

    1 Media contribution

    Press/Media: Other

    Half of heart attack patients delay seeking medical help

    David Grieve

    12/04/2016

    1 Media contribution

    Press/Media: Expert Comment

    Warning over number of people ignoring heart attack symptoms

    David Grieve

    12/04/2016

    1 Media contribution

    Press/Media: Expert Comment

    How mentoring is helping us develop the research stars of the future

    David Grieve

    01/10/2015

    1 Media contribution

    Press/Media: Public Engagement Activities

    Thesis

    Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling

    Author: Gill, E., Jul 2020

    Supervisor: Grieve, D. (Supervisor) & Curtis, T. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Targeting macrophages GLP-1 receptor pathways as emerging therapies to ameliorate cardiac remodelling associated with diabetes

    Author: Abudalo, R., Jul 2020

    Supervisor: Green, B. (Supervisor), Grieve, D. (Supervisor) & Ingram, R. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    The role of FKBPL in diabetes and associated cardiovascular health

    Author: Alqudah, A., Dec 2019

    Supervisor: Grieve, D. (Supervisor), Lyons, T. (Supervisor) & McClements, L. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy