Projects per year
Personal profile
Research Statement
After being awarded a BSc honours degree by the University of Dundee (1995), I completed a PhD focussed on dietary lipoproteins and atherosclerosis at The Royal Veterinary College, University of London (1998). I then worked as a PDRA in the Cardiovascular Division at King’s College London until 2005, when I took up an academic position within the School of Medicine, Dentistry and Biomedical Sciences at Queen's University Belfast, where I am currently a full Professor leading an established research programme and also Faculty Dean. Notable achievements include receipt of the International Society for Heart Research Young Investigator Award (2003) and a prestigious Medical Research Council UK New Investigator Research Grant (2007), and election to the committee of the British Society for Cardiovascular Research (2008) on which I served as Honorary Secretary (2014-20). I am currently Associate Editor of Cardiovascular Drugs and Therapy (2020- ), serve on the Medical Research Council Populations and Systems Medicine Board (2023- ), and recently completed a term as Vice-Chair of the British Heart Foundation Projects Grants Committee (2017-21). I have published 83 peer-reviewed papers in the cardiovascular field in high impact journals such as Circulation, Circulation Research, Journal of the American College of Cardiology and Proceedings of the National Academy of Sciences USA, with >5,700 citations and an H-index of 35 (Scopus) and have been awarded >£7M in competitive research funding.
Research Interests
My research programme is mainly focussed on investigating mechanisms underlying cardiovascular remodelling and dysfunction, with a particular interest in the role of oxidative stress, novel peptide hormones, endothelial progenitor cells, and the influence of diabetes. My group employs a wide range of laboratory techniques, from in vivo physiology to molecular biology and tissue culture, to investigate mechanisms underlying the adaptive but ultimately detrimental changes that occur in various cardiovascular disease states and how these may be modulated for potential therapeutic benefit.
Teaching
Current undergraduate and postgraduate teaching contribution:
BSc Biomedical Sciences
BMS3013 - Sports and Exercise Physiology
BMS3112 - Research Project
MSc Experimental Medicine
SCM8180 - Advanced Research Skills in Experimental Medicine
SCM8146 and SCM8147 - Research Project
PhD Supervision
33 students, 9 of whom are current
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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R2636CEM: Defining key mechanisms underlying NOX4 signalling in endothelial colony-forming cells towards improved vasoreparative capacity in ischaemic disease
Grieve, D. (PI), Medina, R. (CoI), Plouffe, B. (CoI) & Simpson, D. (CoI)
02/09/2019 → …
Project: Research
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R2723CVS: GLP-1 in diabetic cardiomyopathy
Grieve, D. (PI), Green, B. (CoI) & McDermott, B. (CoI)
01/08/2010 → …
Project: Research
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R1827MSC: Role of PPAR-alpha and NadPH oxidases in hypetensive cardiac remodeling
Grieve, D. (PI)
01/08/2006 → …
Project: Research
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R2330MSC: Role of glucagon-like peptide-1 in heart remodeling after myocardial infarction
Grieve, D. (PI) & Green, B. (CoI)
01/08/2006 → …
Project: Research
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R2289MSC: NADPH oxidase-derived ROS and cardiac dysfunction in doxorubicin chemotherapy.
Grieve, D. (PI) & McDermott, B. (CoI)
01/08/2006 → …
Project: Research
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A multimodality assessment of the protective capacity of statin therapy in a mouse model of radiation cardiotoxicity
Walls, G. M., Ghita, M., Herron, B., Edgar, K. S., Kuburas, R., Watson, C. J., Grieve, D. J., Cole, A. J., Jain, S. & Butterworth, K. T., Jan 2024, In: Radiotherapy and Oncology. 190, 8 p., 110004.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)42 Downloads (Pure) -
Dose-dependent changes in cardiac function, strain and remodelling in a preclinical model of heart base irradiation
Ghita-Pettigrew, M., Edgar, K. S., Kuburas, R., Brown, K. H., Walls, G. M., Facchi, C., Grieve, D. J., Watson, C. J., McWilliam, A., van Herk, M., Williams, K. J. & Butterworth, K. T., Apr 2024, In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 193, 9 p., 110113.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)26 Downloads (Pure) -
Endothelial colony-forming cell NOX4 signalling promotes vasoreparative capacity of coronary microvascular endothelial cells and reduces adverse cardiac remodelling
Pun, S. H., O'Neill, K. M., Edgar, K., Alsaggaf, M., Madishetti, V. V., Karuna, N., Brunssen, C., Morawietz, H., Watson, C. & Grieve, D. J., Jun 2024, In: Heart (British Cardiovascular Society). 110, Suppl 3, p. A276-A277 BS47.Research output: Contribution to journal › Meeting abstract › peer-review
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Impact of SGLT2 inhibition on markers of reverse cardiac remodelling in heart failure: systematic review and meta-analysis
Savage, P., Watson, C., Coburn, J., Cox, B., Shahmohammadi, M., Grieve, D. & Dixon, L., 26 Jul 2024, (Early online date) In: ESC Heart Failure. 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Downloads (Pure) -
Integrin beta-like 1 is regulated by DNA methylation and increased in heart failure patients
Kerrigan, L., Edgar, K., Russell-Hallinan, A., Cappa, O., Glezeva, N., Galan-Arriola, C., Oliver, E., Ibanez, B., Baugh, J., Collier, P., Ledwidge, M., McDonald, K., Simpson, D., Das, S., Grieve, D. J. & Watson, C. J., 05 Sept 2024, (Early online date) In: ESC Heart Failure. 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Downloads (Pure)
Prizes
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Best Oral Presentation Prize - Scottish Cardiovascular Forum
O'Neill, K. (Recipient) & Grieve, D. (Recipient), 03 Feb 2018
Prize: Prize (including medals and awards)
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Best Oral Presentation Prize - Scottish Cardiovascular Forum
O'Neill, K. (Recipient) & Grieve, D. (Recipient), 05 Feb 2021
Prize: Prize (including medals and awards)
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Best Poster Prize - 5th Annual REMERGE Meeting
O'Neill, K. (Recipient) & Grieve, D. (Recipient), 26 Jun 2017
Prize: Prize (including medals and awards)
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Best Poster Prize - Irish Association of Pharmacologists Annual Conference
Abudalo, R. (Recipient) & Grieve, D. (Recipient), 30 Nov 2018
Prize: Prize (including medals and awards)
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Best Poster Prize - Scottish Cardiovascular Forum
Gill, E. (Recipient) & Grieve, D. (Recipient), 03 Feb 2018
Prize: Prize (including medals and awards)
Activities
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Foreign, Commonwealth & Development Office (External organisation)
Grieve, D. (Board Member)
20 Feb 2024 → …Activity: Membership types › Membership of peer review panel or committee
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Keynote Speaker at Young Global Talent in Science Symposium
Grieve, D. (Keynote speaker)
29 Jan 2024Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Keynote Speaker at China Medical University, Shenyang
Grieve, D. (Keynote speaker)
14 Sept 2023Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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British Heart Foundation Northern Ireland Staff Research Showcase
Grieve, D. (Host)
22 Jun 2023Activity: Other activity types › Hosting a delegation or group
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Cardiovascular Drugs and Therapy (Journal)
Grieve, D. (Deputy editor)
01 Jan 2023Activity: Publication peer-review and editorial work types › Editorial activity
Press/Media
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BBC NI Online Heart Failure Awareness Video
28/12/2022
1 Media contribution
Press/Media: Public Engagement Activities
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U105 interview - Heart failure research
28/07/2021
1 Media contribution
Press/Media: Public Engagement Activities
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Belfast Telegraph - Scientists getting to the heart of the matter
04/03/2021
1 Media contribution
Press/Media: Public Engagement Activities
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The Irish News - QUB heart failure scientist backs campaign to protect medical research
18/11/2020
1 Media contribution
Press/Media: Public Engagement Activities
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BBC NI interview - Covid-19 and cardiovascular research
17/11/2020
1 Media contribution
Press/Media: Public Engagement Activities