David Grieve

Professor

Phone+44 (0)28 9097 6468
Emaild.grieve@qub.ac.uk

Room 01.063 - CEM
United Kingdom

Accepting PhD Students

PhD projects

Professor Grieve is open to wide-ranging PhD applications from candidates with a basic science or clinical background. His fields of interest include: - cardiovascular biology - pathophysiology - pharmacology Previous research experience is desirable although not essential.

Research output per year

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Personal profile

Research Statement

After being awarded a BSc honours degree by the University of Dundee in 1995, I completed a PhD on ‘The role of dietary lipoproteins in the initiation of atherosclerosis’ at The Royal Veterinary College, University of London, in 1998. I then worked as a post-doctoral researcher in the laboratory of Professor Ajay Shah in the Cardiovascular Division at King’s College London for almost 7 years. In 2005, I took up an academic position within the School of Medicine, Dentistry and Biomedical Sciences at Queen's University Belfast where I am now a Professor with an established independent research programme. Notable achievements include receipt of the International Society for Heart Research Young Investigator Award (2003) and a prestigious Medical Research Council UK New Investigator Research Grant (2007), and election to the committee of the British Society for Cardiovascular Research (2008) on which I served as Honorary Secretary from 2014-2019. I am also currently Vice-Chair of the British Heart Foundation Projects Grants Committee and Associate Editor of Cardiovascular Drugs and Therapy. To date, I have published 61 peer-reviewed papers in the cardiovascular field in high impact journals such as Circulation, Circulation Research, Journal of the American College of Cardiology and Proceedings of the National Academy of Sciences USA, with >4000 citations and an H-index of 28 (according to Scopus) and have been awarded >£4.1M in competitive research grant funding.

Research Interests

My research programme is mainly focussed on investigating mechanisms underlying cardiovascular remodelling and dysfunction, with a particular interest in the role of oxidative stress, novel peptide hormones, endothelial progenitor cells, and the influence of diabetes. My group employs a wide range of laboratory techniques, from in vivo physiology to molecular biology and tissue culture, to investigate mechanisms underlying the adaptive but ultimately detrimental changes that occur in various cardiovascular disease states and how these may be modulated for potential therapeutic benefit.

Dr Grieve's laboratory page

Teaching

I make a significant contribution to both undergraduate and postgraduate teaching across a range of modules:

Undergraduate

Medicine

MED1017 - Physiological Basis of Clinical Practice

MED2013 - Physiological Basis of Clinical Practice

MED3013 - Student-Selected Component

Biomedical Sciences
BMS2027 - Physiological Sciences
BMS3013 - Sports and Exercise Physiology

Laboratory Projects Supervised:
40 BSc, Masters and Summer Students

Postgraduate

MSc Experimental Medicine
SCM8110 - Diabetes and Cardiovascular Disease (Module Co-ordinator)

SMDBS Postgraduate Training Programme (Co-ordinator)

PhD Supervision
22 students, 11 of whom are current

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Projects

6 Finished
7 Active

R2636CEM: Defining key mechanisms underlying NOX4 signalling in endothelial colony-forming cells towards improved vasoreparative capacity in ischaemic disease

Grieve, D., Medina, R., Plouffe, B. & Simpson, D.

02/09/2019 → …

Project: Research

R2515CEM: Investigation of aberrant QKI splicing in diabetes and the specific role of QKI7 as a novel target to reverse EC dysfunction

Margariti, A., Curtis, T., Grieve, D., Simpson, D. & Stitt, A.

30/07/2018 → …

Project: Research

R2200CEM: Influence of Nox4 on OEC function and their ability to promote Angiogenesis in tissue Ischaemia

Grieve, D., Margariti, A. & Medina, R.

13/02/2015 → …

Project: Research

R2723CVS: GLP-1 in diabetic cardiomyopathy

Grieve, D., Green, B. & McDermott, B.

01/08/2010 → …

Project: Research

R1827MSC: Role of PPAR-alpha and NadPH oxidases in hypetensive cardiac remodeling

Grieve, D.

01/08/2006 → …

Project: Research

Research Output

60 Abstract
27 Article
3 Meeting abstract
2 Chapter (peer-reviewed)
3 More
- 2 Editorial
- 1 Other

Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart

Ghita, M., Gill, E., Walls, G., Edgar, K., McMahon, S., Vasquez Osorio, E., Bergom, C., Grieve, D., Watson, C., McWilliam, A., Aznar, M., van herk, M., Williams, K. J. & Butterworth, K., 11 Jul 2020, In : Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology. DOI: 10.1016/j.radonc.2020.07.016 .

Research output: Contribution to journal › Article

Endothelial cells derived from patients with diabetic macular edema recapitulate clinical evaluations of anti-VEGF responsiveness through the Neuronal Pentraxin 2 pathway

Vila-Gonzalez, M., Kelaini, S., Naderi-Meshkin, H., Margariti, A., Stewart, S., Virgili, G., Grieve, D. J., Stitt, A. W., Lois, N. & Margariti, A., 30 Jul 2020, (Accepted) In : Diabetes.

Research output: Contribution to journal › Article

NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation

O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., O'Neill, C. L., Dellett, M., Hargey, C. J., Abudalo, R. A., O'Hare, M., Doyle, P., Toh, T., Khoo, J., Wong, J., McCrudden, C. M., Meloni, M., Brunssen, C., Morawietz, H., Yoder, M. C. & 6 others, McDonald, D. M., Watson, C. J., Stitt, A. W., Margariti, A., Medina, R. J. & Grieve, D. J., 01 Feb 2020, In : Cardiovascular Research. 116, 2, p. 393-405 13 p.

Research output: Contribution to journal › Article

Open Access

File

2 Citations (Scopus)

29 Downloads (Pure)

Role of a novel angiogenesis FKBPL-CD44 pathway in preeclampsia risk stratification and mesenchymal stem cell treatment

Todd, N., McNally, R., Alqudah, A., Jerotic, D., Suvakov, S., Obradovic, D., Hoch, D., Hombrebueno, J. R., Campos, G. L., Watson, C. J., Gojnic-Dugalic, M., Simic, T. P., Kransodembskaya, A., Desoye, G., Eastwood, K-A., Hunter, A. J., Holmes, V. A., McCance, D. R., Young, I. S., Grieve, D. J. & 4 others, Kenny, L. C., Garovic, V. D., Robson, T. & McClements, L., 03 Jul 2020, In : The Journal of Clinical Endocrinology & Metabolism.

Research output: Contribution to journal › Article

Open Access

File

4 Downloads (Pure)

Targeting QKI-7 in vivo restores endothelial cell function in diabetes

Yang, C., Eleftheriadou, M., Kelaini, S., Morrison, T., González, M. V., Caines, R., Edwards, N., Yacoub, A., Edgar, K., Moez, A., Ivetic, A., Zampetaki, A., Zeng, L., Wilkinson, F. L., Lois, N., Stitt, A. W., Grieve, D. J. & Margariti, A., 30 Jul 2020, In : Nature Communications. 11, 1, 17 p., 3812.

Research output: Contribution to journal › Article

Open Access

File