Projects per year
Personal profile
Research Statement
After being awarded a BSc honours degree by the University of Dundee in 1995, I completed a PhD on ‘The role of dietary lipoproteins in the initiation of atherosclerosis’ at The Royal Veterinary College, University of London, in 1998. I then worked as a post-doctoral researcher in the laboratory of Professor Ajay Shah in the Cardiovascular Division at King’s College London for almost 7 years. In 2005, I took up an academic position within the School of Medicine, Dentistry and Biomedical Sciences at Queen's University Belfast where I am now a Professor with an established independent research programme. Notable achievements include receipt of the International Society for Heart Research Young Investigator Award (2003) and a prestigious Medical Research Council UK New Investigator Research Grant (2007), and election to the committee of the British Society for Cardiovascular Research (2008) on which I served as Honorary Secretary from 2014-2019. I am also currently Vice-Chair of the British Heart Foundation Projects Grants Committee and Associate Editor of Cardiovascular Drugs and Therapy. To date, I have published 61 peer-reviewed papers in the cardiovascular field in high impact journals such as Circulation, Circulation Research, Journal of the American College of Cardiology and Proceedings of the National Academy of Sciences USA, with >4000 citations and an H-index of 28 (according to Scopus) and have been awarded >£4.1M in competitive research grant funding.
Research Interests
My research programme is mainly focussed on investigating mechanisms underlying cardiovascular remodelling and dysfunction, with a particular interest in the role of oxidative stress, novel peptide hormones, endothelial progenitor cells, and the influence of diabetes. My group employs a wide range of laboratory techniques, from in vivo physiology to molecular biology and tissue culture, to investigate mechanisms underlying the adaptive but ultimately detrimental changes that occur in various cardiovascular disease states and how these may be modulated for potential therapeutic benefit.
Teaching
I make a significant contribution to both undergraduate and postgraduate teaching across a range of modules:
Undergraduate
40 BSc, Masters and Summer Students
Postgraduate
SCM8110 - Diabetes and Cardiovascular Disease (Module Co-ordinator)
SMDBS Postgraduate Training Programme (Co-ordinator)
PhD Supervision
22 students, 11 of whom are current
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Network
Projects
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R2200CEM: Influence of Nox4 on OEC function and their ability to promote Angiogenesis in tissue Ischaemia
Grieve, D., Margariti, A. & Medina, R.
13/02/2015 → …
Project: Research
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R2723CVS: GLP-1 in diabetic cardiomyopathy
Grieve, D., Green, B. & McDermott, B.
01/08/2010 → …
Project: Research
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R2289MSC: NADPH oxidase-derived ROS and cardiac dysfunction in doxorubicin chemotherapy.
01/08/2006 → …
Project: Research
Research Output
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Author Correction: Targeting QKI-7 in vivo restores endothelial cell function in diabetes (Nature Communications, (2020), 11, 1, (3812), 10.1038/s41467-020-17468-y)
Yang, C., Eleftheriadou, M., Kelaini, S., Morrison, T., González, M. V., Caines, R., Edwards, N., Yacoub, A., Edgar, K., Moez, A., Ivetic, A., Zampetaki, A., Zeng, L., Wilkinson, F. L., Lois, N., Stitt, A. W., Grieve, D. J. & Margariti, A., 01 Dec 2020, In : Nature Communications. 11, 1, 1 p., 4770.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart
Ghita, M., Gill, E., Walls, G., Edgar, K., McMahon, S., Vasquez Osorio, E., Bergom, C., Grieve, D., Watson, C., McWilliam, A., Aznar, M., van herk, M., Williams, K. J. & Butterworth, K., 11 Jul 2020, In : Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology. DOI: 10.1016/j.radonc.2020.07.016 .Research output: Contribution to journal › Article › peer-review
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Endothelial cells derived from patients with diabetic macular edema recapitulate clinical evaluations of anti-VEGF responsiveness through the Neuronal Pentraxin 2 pathway
Vila-Gonzalez, M., Kelaini, S., Naderi-Meshkin, H., Margariti, A., Stewart, S., Virgili, G., Grieve, D. J., Stitt, A. W., Lois, N. & Margariti, A., 13 Aug 2020, In : Diabetes.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)97 Downloads (Pure) -
Epigenetic Regulation of Endothelial Cell Function by Nucleic Acid Methylation in Cardiac Homeostasis and Disease
Russell-Hallinan, A., Watson, C. J., O'Dwyer, D., Grieve, D. J. & O'Neill, K. M., 04 Aug 2020, In : Cardiovascular Drugs and Therapy.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation
O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., O'Neill, C. L., Dellett, M., Hargey, C. J., Abudalo, R. A., O'Hare, M., Doyle, P., Toh, T., Khoo, J., Wong, J., McCrudden, C. M., Meloni, M., Brunssen, C., Morawietz, H., Yoder, M. C. & 6 others, , 01 Feb 2020, In : Cardiovascular Research. 116, 2, p. 393-405 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)39 Downloads (Pure)
Prizes
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Best Poster Prize - 5th Annual REMERGE Meeting
O'Neill, Karla (Recipient) & Grieve, David (Recipient), 26 Jun 2017
Prize: Prize (including medals and awards)
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Best Poster Prize - Irish Association of Pharmacologists Annual Conference
Rawan Abudalo (Recipient) & Grieve, David (Recipient), 30 Nov 2018
Prize: Prize (including medals and awards)
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British Heart Foundation Heart Heroes Award
Grieve, David (Recipient), 05 Oct 2018
Prize: Prize (including medals and awards)
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British Heart Foundation Heart Heroes Award
Grieve, David (Recipient), 29 Jun 2017
Prize: Prize (including medals and awards)
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British Heart Foundation Project Grants Committee
Grieve, David (Recipient), 23 Jan 2017
Prize: Appointment
Activities
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Invited Speaker at International Society for Heart Research European Section Meeting
David Grieve (Invited speaker)
30 Jun 2020 → 03 Jul 2020Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Cardiovascular Drugs and Therapy (Journal)
David Grieve (Associate editor)
13 Jan 2020 → …Activity: Publication peer-review and editorial work types › Editorial activity
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King's College London (External organisation)
David Grieve (Reviewer)
13 Jan 2020Activity: Membership types › Membership of peer review panel or committee
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Invited Seminar at Shenyang Pharmaceutical University
David Grieve (Invited speaker)
18 Nov 2019Activity: Talk or presentation types › Invited talk
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Invited Speaker at QUB Jordan Research Symposium
David Grieve (Invited speaker)
08 Jan 2019Activity: Talk or presentation types › Invited talk
Press / Media
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It’s not just heart research that’s important in Northern Ireland…
17/03/2018
1 Media contribution
Press/Media: Public Engagement Activities
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Half of heart attack patients delay seeking medical help
12/04/2016
1 Media contribution
Press/Media: Expert Comment
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Warning over number of people ignoring heart attack symptoms
12/04/2016
1 Media contribution
Press/Media: Expert Comment
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How mentoring is helping us develop the research stars of the future
01/10/2015
1 Media contribution
Press/Media: Public Engagement Activities