Projects per year
Personal profile
Research Statement
I am Dean of Internationalisation within the Faculty of Health and Life Sciences at Queen’s University Belfast, UK. I received my PhD from the Royal Veterinary College (University of London) in 1998 before working as a Postdoctoral Research Associate in the Cardiovascular Division at King’s College London until 2005, when I took up an academic position at the School of Medicine, Dentistry and Biomedical Sciences at Queen’s University Belfast where I am now a full Professor. In addition to my Faculty Dean role, I lead an independent international research programme focused on investigating mechanisms underlying cardiovascular remodelling and dysfunction. I have published 92 peer-reviewed papers in the cardiovascular field in top journals such as Circulation, Circulation Research, Journal of the American College of Cardiology and Proceedings of the National Academy of Sciences USA, with >6,300 citations and an H-index of 38 (Scopus) and have been awarded >£8M in competitive research funding. I am currently a member of the UK Medical Research Council College of Experts and Editor-in-Chief of Cardiovascular Drugs and Therapy and have completed terms as Vice-Chair of the British Heart Foundation Projects Grants Committee and Honorary Secretary of the British Society for Cardiovascular Research.
Research Interests
My translational research programme is mainly focussed on investigating mechanisms underlying cardiovascular remodelling and dysfunction, with a particular interest in the role of oxidative stress, microvascular signalling, endothelial progenitor cells, and the influence of diabetes. My group employs a wide range of innovative research techniques, incorporating cell culture, molecular biology, omics analysis, experimental physiology, and clinical samples/data, to investigate mechanisms underlying the adaptive but ultimately detrimental changes that occur in various cardiovascular disease states and how these may be modulated for patient benefit.
Teaching
Current undergraduate and postgraduate teaching contribution:
BSc Biomedical Sciences
BMS3013 - Sports and Exercise Physiology
BMS3112 - Research Project
MSc Biomedical and Clinical Research
SCM8180 - Advanced Research Skills
SCM8146 and SCM8147 - Research Project
PhD Supervision
34 students, 5 of whom are current
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R2975CEM: Understanding the mechanistic basis of phenotypic heterogeneity in HTRA1-related vascular disease
Lockhart, S. (PI), Collins, B. (CoI), Grieve, D. (CoI), Margariti, A. (CoI) & Watson, C. (CoI)
25/08/2025 → …
Project: Research
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R2636CEM: Defining key mechanisms underlying NOX4 signalling in endothelial colony-forming cells towards improved vasoreparative capacity in ischaemic disease
Grieve, D. (PI), Medina, R. (CoI), Plouffe, B. (CoI) & Simpson, D. (CoI)
02/09/2019 → …
Project: Research
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R2723CVS: GLP-1 in diabetic cardiomyopathy
Grieve, D. (PI), Green, B. (CoI) & McDermott, B. (CoI)
01/08/2010 → …
Project: Research
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R2515CEM: Investigation of aberrant QKI splicing in diabetes and the specific role of QKI7 as a novel target to reverse EC dysfunction
Margariti, A. (PI), Curtis, T. (CoI), Grieve, D. (CoI), Simpson, D. (CoI) & Stitt, A. (CoI)
30/07/2018 → 20/05/2022
Project: Research
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R2293CEM: Invesigate the gynamic role of Quaking mRNA splicing in endothelial cell differentiation and it's efficacy for vascular regeneration
Margariti, A. (PI), Grieve, D. (CoI) & Stitt, A. (CoI)
22/04/2016 → 09/02/2019
Project: Research
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Author Correction: Targeting QKI-7 in vivo restores endothelial cell function in diabetes
Yang, C., Eleftheriadou, M., Kelaini, S., Morrison, T., González, M. V., Caines, R., Edwards, N., Yacoub, A., Edgar, K., Moez, A., Ivetic, A., Zampetaki, A., Zeng, L., Wilkinson, F. L., Lois, N., Stitt, A. W., Grieve, D. J. & Margariti, A., 25 Feb 2026, In: Nature Communications. 17Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Downloads (Pure) -
DNA/RNA methylation-driven coronary microvascular dysfunction: emerging pathogenic mechanisms and therapeutic opportunities for heart failure in diabetes
Bacelar-Jimenez, A., Alamareen, A. S., Madishetti, V. V., Samarah, M. S., Watson, C. J., Grieve, D. J. & O'Neill, K. M., 11 Jul 2026, (Early online date) In: Cardiovascular Drugs and Therapy. 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)5 Downloads (Pure) -
Epigenetic regulation by HDAC11-driven STAT3 activation promotes pro-inflammatory cytokine production and endothelial dysfunction upon bacterial infection in diabetes
Setyaningsih, W. A. W., Naderi-Meshkin, H., Yacoub, A., Cornelius, V. A., Silva, J. D., Fitriawan, A. S., Guduric-Fuchs, J., Tashkandi, A. J. A., Kuburas, R., Zampetaki, A., Lois, N., Stitt, A. W., Valvano, M. A., Grieve, D. J., Atlasi, Y., Krasnodembskaya, A. & Margariti, A., Dec 2026, In: Cell Communication and Signaling. 24, 1, 19 p., 173.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Downloads (Pure) -
Investigation of biomarker response to SGLT2 inhibition in heart failure (SiN-HF)
Savage, P., Linden, K., Dixon, L., Grieve, D. & Watson, C., Aug 2026, In: Cardiovascular Drugs and Therapy. 40, p. 1423–1433 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)10 Downloads (Pure) -
Patient-specific iPSC-derived ECs identify QKI-7 as a key regulator of endothelial dysfunction and potential therapeutic target in diabetes
Cornelius, V. A., Fulton, J., Donaghy, C., McKeown, S., Naderi-Meshkin, H., Zhang, S.-D., Setyaningsih, W. A. W., Yacoub, A., Zampetaki, A., Stitt, A. W., Lois, N., Grieve, D. J. & Margariti, A., 06 Aug 2026, In: Stem Cells Translational Medicine. 15, 8, 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure)
Prizes
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Best Oral Presentation Prize - Scottish Cardiovascular Forum
O'Neill, K. (Recipient) & Grieve, D. (Recipient), 05 Feb 2021
Prize: Prize (including medals and awards)
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Best Oral Presentation Prize - Scottish Cardiovascular Forum
O'Neill, K. (Recipient) & Grieve, D. (Recipient), 03 Feb 2018
Prize: Prize (including medals and awards)
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Best Poster Prize - 5th Annual REMERGE Meeting
O'Neill, K. (Recipient) & Grieve, D. (Recipient), 26 Jun 2017
Prize: Prize (including medals and awards)
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Best Poster Prize - Irish Association of Pharmacologists Annual Conference
Abudalo, R. (Recipient) & Grieve, D. (Recipient), 30 Nov 2018
Prize: Prize (including medals and awards)
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Best Poster Prize - Scottish Cardiovascular Forum
Gill, E. (Recipient) & Grieve, D. (Recipient), 03 Feb 2018
Prize: Prize (including medals and awards)
Activities
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Foreign, Commonwealth & Development Office (External organisation)
Grieve, D. (Board Member)
20 Feb 2024 → …Activity: Membership types › Membership of peer review panel or committee
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Keynote Speaker at Young Global Talent in Science Symposium
Grieve, D. (Keynote speaker)
29 Jan 2024Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Keynote Speaker at China Medical University, Shenyang
Grieve, D. (Keynote speaker)
14 Sept 2023Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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British Heart Foundation Northern Ireland Staff Research Showcase
Grieve, D. (Host)
22 Jun 2023Activity: Other activity types › Hosting a delegation or group
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Cardiovascular Drugs and Therapy (Journal)
Grieve, D. (Deputy editor)
01 Jan 2023Activity: Publication peer-review and editorial work types › Editorial activity
Press/Media
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BBC NI Online Heart Failure Awareness Video
28/12/2022
1 Media contribution
Press/Media: Public Engagement Activities
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U105 interview - Heart failure research
28/07/2021
1 Media contribution
Press/Media: Public Engagement Activities
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Belfast Telegraph - Scientists getting to the heart of the matter
04/03/2021
1 Media contribution
Press/Media: Public Engagement Activities
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The Irish News - QUB heart failure scientist backs campaign to protect medical research
18/11/2020
1 Media contribution
Press/Media: Public Engagement Activities
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BBC News website - Covid-19 has 'devastating' effect on medical research charities
17/11/2020
1 Media contribution
Press/Media: Public Engagement Activities