• Room 01.059 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr Simpson welcomes PhD applications from candidates with appropriate science or clinical background. His research applies molecular biology and bioinformatics to study vision and cardiovascular diseases.

19962020

Research output per year

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Research Output

2020
2019

A comparison of RNA extraction and sequencing protocols for detection of small RNAs in plasma

Wong, R. K. Y., MacMahon, M., Woodside, J. V. & Simpson, D. A., 03 Jun 2019, In : BMC Genomics. 20, 12 p., 446.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
88 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
113 Downloads (Pure)

Evidence of somatic mitochondrial DNA mutations in primary open angle glaucoma: ARVO Annual Meeting Abstract

Vallabh, N. A., Lane, B., Simpson, D. A., Fuchs, M., Choudhary, A., Criddle, D., Cheeseman, R. & Willoughby, C., 01 Jul 2019, In : Investigative ophthalmology & visual science. 60, 9

Research output: Contribution to journalMeeting abstract

Genome-wide Transcriptome Profiling of Human Trabecular Meshwork Cells treated with Dexamethasone

Senthilkumari, S., Lester, K., Lane, B., Whysall, K., Sheridon, C., Simpson, D. A., R, K. S., VR, M. & Willoughby, C., 01 Jul 2019, In : Investigative ophthalmology & visual science. 60, 9, 5669.

Research output: Contribution to journalMeeting abstract

Open Access
File
2 Downloads (Pure)

Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia

Kettyle, L., Lebert-Ghali, C. E., Grishagin, I., Dickson, G., O'Reilly, P., Simpson, D., Bijl, J., Mills, K., Sauvageau, G. & Thompson, A., 17 Dec 2019, In : Cancers. 11, 12, 13 p., 2036.

Research output: Contribution to journalArticle

Open Access
File
38 Downloads (Pure)
2018

Differential Expression of Urinary Exosomal MicroRNAs in Type 2 Diabetic Kidney Disease

Zang, J., Maxwell, P., Simpson, D. & McKay, G., 02 Oct 2018.

Research output: Contribution to conferencePaper

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling

Vilà-González, M., Kelaini, S., Magee, C., Caines, R., Campbell, D., Eleftheriadou, M., Cochrane, A., Drehmer, D., Tsifaki, M., O'Neill, K., Pedrini, E., Yang, C., Medina, R., McDonald, D., Simpson, D., Zampetaki, A., Zeng, L., Grieve, D., Lois, N., Stitt, A. W. & 1 others, Margariti, A., 17 Nov 2018, In : Stem Cells.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
249 Downloads (Pure)
2017

Complete, streamlined, reduced-bias workflow for RNA extraction and small RNA library preparation from serum and plasma samples

Wong, R., Eun, S., Lukasiewicz, A., Allen, K., Simpson, D., Morris, A. & Toloue, M., 27 Jul 2017.

Research output: Contribution to conferencePaper

Open Access
File
12 Citations (Scopus)
221 Downloads (Pure)

RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFAxxxb isoforms

Bridgett, S., Dellett, M. & Simpson, D. A., 03 Mar 2017, In : Scientific Reports. 7, 11 p., 58.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
223 Downloads (Pure)
2016
Open Access
File
16 Citations (Scopus)
555 Downloads (Pure)
Open Access

TRPV2 channels are critical in retinal arteriolar myogenic signalling.

McGahon, M., Fernandez, J., McKee, J., Dash, D., Simpson, D., Zholos, A., McGeown, G. & Curtis, T., 2016, p. 409P. 1 p.

Research output: Contribution to conferencePoster

TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles

McGahon, M. K., Fernández, J. A., Dash, D. P., McKee, J., Simpson, D. A., Zholos, A. V., McGeown, J. G. & Curtis, T. M., 01 Oct 2016, In : Investigative ophthalmology & visual science. 57, 13, p. 5637-5647 11 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
347 Downloads (Pure)

Use of endothelial colony forming cell vesicles to modulate retinal angiogenesis

Dellett, M., Brown, E., Guduric-Fuchs, J., Medina, R. & Simpson, D. A., Sep 2016, In : Investigative Opthalmology and Visual Science. 57, 12, 1 p., 3658.

Research output: Contribution to journalMeeting abstract

Open Access
2015

Development of a combined RT-PCR: NGS assay for microRNA biomarkers

Andrews, W. J., Brown, E., Dellett, M. & Simpson, D. A., 16 Mar 2015. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
136 Downloads (Pure)

Mutational Analysis of the Rhodopsin Gene in Sector Retinitis Pigmentosa

Napier, M. L., Durga, D., Wolsley, C. J., Chamney, S., Alexander, S., Brennan, R., Simpson, D. A., Silvestri, G. & Willoughby, C. E., 2015, In : Ophthalmic genetics. 36, 3, p. 239-243 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Rapid quantification of microRNAs in plasma using a fast real time PCR system

Andrews, W. J., Brown, E. D., Dellett, M., Hogg, R. E. & Simpson, D. A., May 2015, In : BioTechniques. 58, 5, p. 244-252 9 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
335 Downloads (Pure)

Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants

Sundaresan, P., Simpson, D. A., Sambare, C., Duffy, S., Lechner, J., Dastane, A., Dervan, E. W., Vallabh, N., Chelerkar, V., Deshpande, M., O'Brien, C., McKnight, A. J. & Willoughby, C. E., 2015, In : Genetics in medicine. 17, p. 279-284 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2014

Enrichment of pathogenic alleles in the brittle cornea gene, ZNF469, in keratoconus

Lechner, J., Porter, L. F., Rice, A., Vitart, V., Armstrong, D. J., Schorderet, D. F., Munier, F. L., Wright, A. F., Inglehearn, C. F., Black, G. C., Simpson, D. A., Manson, F. & Willoughby, C. E., 15 Oct 2014, In : Human Molecular Genetics. 23, 20, p. 5527–5535

Research output: Contribution to journalArticle

33 Citations (Scopus)

Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements

Wang, F., Wang, H., Tuan, H-F., Nguyen, D. H., Sun, V., Keser, V., Bowne, S. J., Sullivan, L. S., Luo, H., Zhao, L., Wang, X., Zaneveld, J. E., Salvo, J. S., Siddiqui, S., Mao, L., Wheaton, D. K., Birch, D. G., Branham, K. E., Heckenlively, J. R., Wen, C. & 21 others, Flagg, K., Ferreyra, H., Pei, J., Khan, A., Ren, H., Wang, K., Lopez, I., Qamar, R., Zenteno, J. C., Ayala-Ramirez, R., Buentello-Volante, B., Fu, Q., Simpson, D., Li, Y., Sui, R., Silvestri, G., Daiger, S. P., Koenekoop, R. K., Zhang, K., Chen, R. & Silvestri, G., Mar 2014, In : Human genetics. 133, 3, p. 331-345

Research output: Contribution to journalArticle

126 Citations (Scopus)
Open Access
File
37 Citations (Scopus)
260 Downloads (Pure)
2013

Distinctive Profile of IsomiR Expression and Novel MicroRNAs in Rat Heart Left Ventricle

McGahon, M. K., Yarham, J. M., Daly, A., Guduric-Fuchs, J., Ferguson, L. J., Simpson, D. A. & Collins, A., 14 Jun 2013, In : PLoS ONE. 8, 6, 17 p., e65809.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
269 Downloads (Pure)

Manipulation of the MicroRNA Content of Endothelial Progenitor Cell-derived Extracellular Vesicles

Simpson, D., Brown, E., O'Neill, C., Medina, R. & Guduric-Fuchs, J., 2013, Investigative Ophthalmology & Visual Science. 15 ed. Vol. 54. 1586. (Investigative ophthalmology & visual science).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mutational Analysis of MIR184 in Sporadic Keratoconus and Myopia

Lechner, J., Bae, H. A., Guduric-Fuchs, J., Rice, A., Govindarajan, G., Siddiqui, S., Abi Farraj, L., Yip, S. P., Yap, M., Das, M., Souzeau, E., Coster, D., Mills, R. A., Lindsay, R., Phillips, T., Mitchell, P., Ali, M., Inglehearn, C. F., Sundaresan, P., Craig, J. E. & 3 others, Simpson, D. A., Burdon, K. P. & Willoughby, C. E., Aug 2013, In : Investigative Opthalmology and Visual Science. 54, 8, p. 5266-72 7 p.

Research output: Contribution to journalArticle

Open Access
File
39 Citations (Scopus)
235 Downloads (Pure)

Mutational spectrum of the ZEB1 gene in corneal dystrophies supports a genotype-phenotype correlation

Lechner, J., Dash, D. P., Muszynska, D., Hosseini, M., Segev, F., George, S., Frazer, D. G., Moore, J. E., Kaye, S. B., Young, T., Simpson, D. A., Churchill, A. J., Héon, E. & Willoughby, C. E., May 2013, In : Investigative Opthalmology and Visual Science. 54, 5, p. 3215-3223

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
126 Downloads (Pure)

Senescent endothelial progenitor cells show impaired vasoregenerative capacity in the ischemic retina

Reid, E., Medina, R., O'Doherty, M., O'Neill, C., Chambers, S., Guduric-Fuchs, J., Stitt, A. & Simpson, D., 2013, p. 4539-40.

Research output: Contribution to conferenceAbstract

2012

Age Alters MicroRNA Expression Profile in Mouse Retinal Pigment Epithelium (RPE)/choroid

Soundara Pandi, S., Chen, M., Guduric-Fuchs, J., Simpson, D. & Xu, H., 2012, p. 5132. 1 p.

Research output: Contribution to conferenceAbstract

13 Citations (Scopus)

Characterisation of the Effect of miR-26a Upon Global mRNA Expression in Bovine Retinal Microvascular Endothelial Cells

Simpson, D. A., Connor, A. O., Guduric-Fuchs, J. & Curtis, T. M., 2012, Investigative Ophthalmology & Visual Science. 14 ed. Vol. 53. 5133. (Investigative ophthalmology & visual science).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pharmacological profiling of store-operated Ca(2+) entry in retinal arteriolar smooth muscle

McGahon, M. K., McKee, J., Dash, D. P., Brown, E., Simpson, D. A., Curtis, T. M., McGeown, J. G. & Scholfield, C. N., Oct 2012, In : Microcirculation (New York, N.Y. : 1994). 19, 7, p. 586-597 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Response to Iliff et al

Hughes, A. E., Bradley, D. T., Campbell, M., Simpson, D. A. & Willoughby, C. E., 04 May 2012, In : The American Journal of Human Genetics. 90, 5, p. 934-935 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)
2011

Deep Sequencing Reveals Predominant Expression of a Small Number of MicroRNAs in Bovine Retinal Endothelial Cells

O'Connor, A., Guduric-Fuchs, J., Banumathi, E., Cullen, A., Curtis, T. M. & Simpson, D. A., 2011, Investigative Ophthalmology & Visual Science. 14 ed. Vol. 52. 1422. (Investigative ophthalmology & visual science).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1{alpha} Activity

Bruning, U., Cerone, L., Neufeld, Z., Cheong, A., Scholz, C. C., Simpson, D., Leonard, M. O., Tambuwala, M. M., Cummins, E. P. & Taylor, C. T., Oct 2011, In : Molecular and Cellular Biology. 31, 19, p. 4087-4096 10 p.

Research output: Contribution to journalArticle

168 Citations (Scopus)

Molecular diagnosis for heterogeneous genetic diseases with high-throughput DNA sequencing applied to retinitis pigmentosa

Simpson, D., Clark, G. R., Alexander, S., Silvestri, G. & Willoughby, C., Mar 2011, In : Journal of Medical Genetics. 48, 3, p. 145-151 7 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Mutation altering the miR-184 seed region causes keratoconus with cataract

Hughes, A., Bradley, D., Campbell, M., Lechner, J., Dash, D., Simpson, D. & Willoughby, C., 11 Nov 2011, In : The American Journal of Human Genetics. 89, 5, p. 628-633 6 p.

Research output: Contribution to journalArticle

Open Access
File
158 Citations (Scopus)
179 Downloads (Pure)
26 Citations (Scopus)

Development of a Diagnostic Genetic Test for Simplex and Autosomal Recessive Retinitis Pigmentosa

Clark, G. R., Crowe, P., Muszynska, D., O'Prey, D., O'Neill, J., Alexander, S., Willoughby, C., McKay, G., Silvestri, G. & Simpson, D., Nov 2010, In : Ophthalmology. 117, 11, p. 2169-2177 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Prediction of microRNAs affecting mRNA expression during retinal development.

Arora, A., Guduric-Fuchs, J., Harwood, L., Dellett, M., Cogliati, T. & Simpson, D., 2010, In : BMC Developmental Biology. 10, p. 1-1 15 p., 1.

Research output: Contribution to journalArticle

45 Citations (Scopus)

The practicalities of testing for causative genes

Simpson, D., Jun 2010.

Research output: Contribution to conferencePaper

2009

Advanced glycation end product (AGE) accumulation on Bruch's membrane: links to age-related RPE dysfunction.

Glenn, J. V., Mahaffy, H., Wu, K., Smith, G., Nagai, R., Simpson, D., Boulton, M. E. & Stitt, A., Jan 2009, In : Investigative Ophthalmology and Visual Science. 50, 1, p. 441-451 11 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

New approaches to genetic screening for inherited eye diseases

Simpson, D., Dec 2009.

Research output: Contribution to conferencePaper

Recent advances in genetic testing for Retinitis Pigmentosa

Simpson, D., Oct 2009.

Research output: Contribution to conferencePaper