• Room 01.059 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr Simpson welcomes PhD applications from candidates with appropriate science or clinical background. His research applies molecular biology and bioinformatics to study vision and cardiovascular diseases.

19962020

Research output per year

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Research Output

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Article
2020
2019

A comparison of RNA extraction and sequencing protocols for detection of small RNAs in plasma

Wong, R. K. Y., MacMahon, M., Woodside, J. V. & Simpson, D. A., 03 Jun 2019, In : BMC Genomics. 20, 12 p., 446.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
88 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
113 Downloads (Pure)

Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia

Kettyle, L., Lebert-Ghali, C. E., Grishagin, I., Dickson, G., O'Reilly, P., Simpson, D., Bijl, J., Mills, K., Sauvageau, G. & Thompson, A., 17 Dec 2019, In : Cancers. 11, 12, 13 p., 2036.

Research output: Contribution to journalArticle

Open Access
File
38 Downloads (Pure)
2018

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling

Vilà-González, M., Kelaini, S., Magee, C., Caines, R., Campbell, D., Eleftheriadou, M., Cochrane, A., Drehmer, D., Tsifaki, M., O'Neill, K., Pedrini, E., Yang, C., Medina, R., McDonald, D., Simpson, D., Zampetaki, A., Zeng, L., Grieve, D., Lois, N., Stitt, A. W. & 1 others, Margariti, A., 17 Nov 2018, In : Stem Cells.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
249 Downloads (Pure)
2017
Open Access
File
12 Citations (Scopus)
221 Downloads (Pure)

RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFAxxxb isoforms

Bridgett, S., Dellett, M. & Simpson, D. A., 03 Mar 2017, In : Scientific Reports. 7, 11 p., 58.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
223 Downloads (Pure)
2016
Open Access
File
16 Citations (Scopus)
555 Downloads (Pure)

TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles

McGahon, M. K., Fernández, J. A., Dash, D. P., McKee, J., Simpson, D. A., Zholos, A. V., McGeown, J. G. & Curtis, T. M., 01 Oct 2016, In : Investigative ophthalmology & visual science. 57, 13, p. 5637-5647 11 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
347 Downloads (Pure)
2015

Mutational Analysis of the Rhodopsin Gene in Sector Retinitis Pigmentosa

Napier, M. L., Durga, D., Wolsley, C. J., Chamney, S., Alexander, S., Brennan, R., Simpson, D. A., Silvestri, G. & Willoughby, C. E., 2015, In : Ophthalmic genetics. 36, 3, p. 239-243 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Rapid quantification of microRNAs in plasma using a fast real time PCR system

Andrews, W. J., Brown, E. D., Dellett, M., Hogg, R. E. & Simpson, D. A., May 2015, In : BioTechniques. 58, 5, p. 244-252 9 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
335 Downloads (Pure)

Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants

Sundaresan, P., Simpson, D. A., Sambare, C., Duffy, S., Lechner, J., Dastane, A., Dervan, E. W., Vallabh, N., Chelerkar, V., Deshpande, M., O'Brien, C., McKnight, A. J. & Willoughby, C. E., 2015, In : Genetics in medicine. 17, p. 279-284 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2014

Enrichment of pathogenic alleles in the brittle cornea gene, ZNF469, in keratoconus

Lechner, J., Porter, L. F., Rice, A., Vitart, V., Armstrong, D. J., Schorderet, D. F., Munier, F. L., Wright, A. F., Inglehearn, C. F., Black, G. C., Simpson, D. A., Manson, F. & Willoughby, C. E., 15 Oct 2014, In : Human Molecular Genetics. 23, 20, p. 5527–5535

Research output: Contribution to journalArticle

33 Citations (Scopus)

Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements

Wang, F., Wang, H., Tuan, H-F., Nguyen, D. H., Sun, V., Keser, V., Bowne, S. J., Sullivan, L. S., Luo, H., Zhao, L., Wang, X., Zaneveld, J. E., Salvo, J. S., Siddiqui, S., Mao, L., Wheaton, D. K., Birch, D. G., Branham, K. E., Heckenlively, J. R., Wen, C. & 21 others, Flagg, K., Ferreyra, H., Pei, J., Khan, A., Ren, H., Wang, K., Lopez, I., Qamar, R., Zenteno, J. C., Ayala-Ramirez, R., Buentello-Volante, B., Fu, Q., Simpson, D., Li, Y., Sui, R., Silvestri, G., Daiger, S. P., Koenekoop, R. K., Zhang, K., Chen, R. & Silvestri, G., Mar 2014, In : Human genetics. 133, 3, p. 331-345

Research output: Contribution to journalArticle

126 Citations (Scopus)
Open Access
File
37 Citations (Scopus)
260 Downloads (Pure)
2013

Distinctive Profile of IsomiR Expression and Novel MicroRNAs in Rat Heart Left Ventricle

McGahon, M. K., Yarham, J. M., Daly, A., Guduric-Fuchs, J., Ferguson, L. J., Simpson, D. A. & Collins, A., 14 Jun 2013, In : PLoS ONE. 8, 6, 17 p., e65809.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
269 Downloads (Pure)

Mutational Analysis of MIR184 in Sporadic Keratoconus and Myopia

Lechner, J., Bae, H. A., Guduric-Fuchs, J., Rice, A., Govindarajan, G., Siddiqui, S., Abi Farraj, L., Yip, S. P., Yap, M., Das, M., Souzeau, E., Coster, D., Mills, R. A., Lindsay, R., Phillips, T., Mitchell, P., Ali, M., Inglehearn, C. F., Sundaresan, P., Craig, J. E. & 3 others, Simpson, D. A., Burdon, K. P. & Willoughby, C. E., Aug 2013, In : Investigative Opthalmology and Visual Science. 54, 8, p. 5266-72 7 p.

Research output: Contribution to journalArticle

Open Access
File
39 Citations (Scopus)
235 Downloads (Pure)

Mutational spectrum of the ZEB1 gene in corneal dystrophies supports a genotype-phenotype correlation

Lechner, J., Dash, D. P., Muszynska, D., Hosseini, M., Segev, F., George, S., Frazer, D. G., Moore, J. E., Kaye, S. B., Young, T., Simpson, D. A., Churchill, A. J., Héon, E. & Willoughby, C. E., May 2013, In : Investigative Opthalmology and Visual Science. 54, 5, p. 3215-3223

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
126 Downloads (Pure)
2012
13 Citations (Scopus)

Pharmacological profiling of store-operated Ca(2+) entry in retinal arteriolar smooth muscle

McGahon, M. K., McKee, J., Dash, D. P., Brown, E., Simpson, D. A., Curtis, T. M., McGeown, J. G. & Scholfield, C. N., Oct 2012, In : Microcirculation (New York, N.Y. : 1994). 19, 7, p. 586-597 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2011

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1{alpha} Activity

Bruning, U., Cerone, L., Neufeld, Z., Cheong, A., Scholz, C. C., Simpson, D., Leonard, M. O., Tambuwala, M. M., Cummins, E. P. & Taylor, C. T., Oct 2011, In : Molecular and Cellular Biology. 31, 19, p. 4087-4096 10 p.

Research output: Contribution to journalArticle

168 Citations (Scopus)

Molecular diagnosis for heterogeneous genetic diseases with high-throughput DNA sequencing applied to retinitis pigmentosa

Simpson, D., Clark, G. R., Alexander, S., Silvestri, G. & Willoughby, C., Mar 2011, In : Journal of Medical Genetics. 48, 3, p. 145-151 7 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Mutation altering the miR-184 seed region causes keratoconus with cataract

Hughes, A., Bradley, D., Campbell, M., Lechner, J., Dash, D., Simpson, D. & Willoughby, C., 11 Nov 2011, In : The American Journal of Human Genetics. 89, 5, p. 628-633 6 p.

Research output: Contribution to journalArticle

Open Access
File
158 Citations (Scopus)
179 Downloads (Pure)
26 Citations (Scopus)
2010

Development of a Diagnostic Genetic Test for Simplex and Autosomal Recessive Retinitis Pigmentosa

Clark, G. R., Crowe, P., Muszynska, D., O'Prey, D., O'Neill, J., Alexander, S., Willoughby, C., McKay, G., Silvestri, G. & Simpson, D., Nov 2010, In : Ophthalmology. 117, 11, p. 2169-2177 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Prediction of microRNAs affecting mRNA expression during retinal development.

Arora, A., Guduric-Fuchs, J., Harwood, L., Dellett, M., Cogliati, T. & Simpson, D., 2010, In : BMC Developmental Biology. 10, p. 1-1 15 p., 1.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2009

Advanced glycation end product (AGE) accumulation on Bruch's membrane: links to age-related RPE dysfunction.

Glenn, J. V., Mahaffy, H., Wu, K., Smith, G., Nagai, R., Simpson, D., Boulton, M. E. & Stitt, A., Jan 2009, In : Investigative Ophthalmology and Visual Science. 50, 1, p. 441-451 11 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2008

Individual mRNA expression profiles reveal the effects of specific microRNAs

Arora, A. & Simpson, D., 16 May 2008, In : Genome Biology. 9, 5, p. R82-R82.16 67 p., R82.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2007

Diabetes downregulates large-conductance Ca2+-activated potassium beta 1 channel subunit in retinal arteriolar smooth muscle

McGahon, M. K., Dash, D. P., Arora, A., Wall, N., Dawicki, J., Simpson, D. A., Scholfield, C. N., McGeown, G. & Curtis, T., Mar 2007, In : Circulation Research. 100, 5, p. 703-11 9 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle.

McGahon, M., Dawicki, J., Arora, A., Simpson, D., Gardiner, T., Stitt, A., Scholfield, N., McGeown, G. & Curtis, T., Oct 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 2, p. H1001-H1008 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2006

Machine learning approaches to supporting the identification of photoreceptor-enriched genes based on expression data.

Wang, H., Zheng, H., Simpson, D. & Azuaje, F., 08 Mar 2006, In : BMC Bioinformatics. 7(116), p. 1-13 13 p., 116.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Rod photoreceptor loss in Rho(-/-) mice reduces retinal hypoxia and hypoxia-regulated gene expression

de Gooyer, T. E., Stevenson, K. A., Humphries, P., Simpson, D. A. C., Curtis, T. M., Gardiner, T. A. & Stitt, A. W., Dec 2006, In : Investigative ophthalmology & visual science. 47, 12, p. 5553-5560 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2005

Characterisation of the advanced glycation endproduct receptor complex in the retinal pigment epithelium

McFarlane, S., Glenn, J., Lichanska, A. M., Simpson, D. & Stitt, A., Jan 2005, In : British Journal of Ophthalmology. 89, 1, p. 107-112 6 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Pigmented paravenous chorioretinal atrophy is associated with a mutation within the crumbs homolog 1 (CRB1) gene

McKay, G. J., Clarke, S., Davis, J. A., Simpson, D. A. C. & Silvestri, G., Jan 2005, In : Investigative ophthalmology & visual science. 46, 1, p. 322-8 7 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2004

Preparation of planar retinal specimens: verification by histology, mRNA profiling, and proteome analysis

McKay, G. J., Campbell, L., Oliver, M., Brockbank, S., Simpson, D. A. C. & Curry, W. J., 29 Mar 2004, In : Molecular Vision. 10, p. 240-7 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2003

Role of vascular endothelial growth factor and placental growth factors during retinal vascular development and hyaloid regression

Feeney, S. A., Simpson, D. A. C., Gardiner, T. A., Boyle, C., Jamison, P. & Stitt, A. W., 01 Feb 2003, In : Investigative Ophthalmology and Visual Science. 44, 2, p. 839-847 9 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Sources of PDGF expression in murine retina and the effect of short-term diabetes.

Cox, O. T., Simpson, D., Stitt, A. & Gardiner, T., 2003, In : Molecular Vision. 9, p. 665-672 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2002

Application of in silico positional cloning and bioinformatic mutation analysis to the study of eye disease

Lichanska, A. M. & Simpson, D., Mar 2002, In : Briefings in Bioinformatics. 3(1), 1, p. 59-72 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho-/- mice.

Kennan, A., Aherne, A., Palfi, A., Humphries, M., McKee, A., Stitt, A., Simpson, D., Demtroder, K., Orntoft, T., Ayuso, C., Kenna, P. F., Farrar, G. J. & Humphries, P., 01 Jan 2002, In : Human Molecular Genetics. 11(5), 5, p. 547-558 12 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)
2001
30 Citations (Scopus)
1999

Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia.

Simpson, D., Murphy, G. M., Bhaduri, T., Gardiner, T., Archer, D. & Stitt, A., 27 Aug 1999, In : Biochemical and Biophysical Research Communications. 262, 2, p. 333-340 8 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)
1998

Advanced glycation end products in vitreous: Structural and functional implications for diabetic vitreopathy

Stitt, A., Moore, J. E., Sharkey, J. A., Murphy, G., Simpson, D., Bucala, R., Vlassara, H. & Archer, D., Dec 1998, In : Investigative Ophthalmology and Visual Science. 39, 13, p. 2517-2523 7 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Expression of vascular endothelial growth factor (VEGF) and its receptors is regulated in eyes with intra-ocular tumours

Stitt, A. W., Simpson, D. A., Boocock, C., Gardiner, T. A., Murphy, G. M. & Archer, D. B., 01 Nov 1998, In : Journal of Pathology. 186, 3, p. 306-312 7 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

The 67-kd laminin receptor is preferentially expressed by proliferating retinal vessels in a murine model of ischemic retinopathy.

Stitt, A. W., McKenna, D., Simpson, D., Gardiner, T. A., Harriott, P., Archer, D. B. & Nelson, J., May 1998, In : American Journal of Pathology. 152(5), 5, p. 1359-1365 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
1996
53 Citations (Scopus)