Projects per year
Personal profile
Interests
Professor David Woolfson holds the Chair in Pharmaceutics (Drug Delivery). He is a graduate in Pharmacy from Queen's and is a registered pharmacist. Prof. Woolfson founded the McClay Research Centre for Pharmaceutical Sciences, from initial concept through to raising of the necessary funding. Starting as a lecturer in pharmaceutical analysis, he was appointed Reader in Pharmaceutical Sciences in 1991 and to the Chair in Pharmaceutics in 1995. He is Head of the School of Pharmacy at Queen's.
Prof. Woolfson became a member of the British Pharmacopoeia Commission (BPC) in 1997 and was appointed as Chair of the BPC in 2006. The Commission is responsible under the UK Medicines Act for the annual publication of the British Pharmacopoeia., which sets legally enforceable quality standards for medicinal chemicals, drugs and formulated products. He has extensive experience of work in the European Pharmacopoeia Commission (EPC) as leader of the UK delegation and formerly UK Expert on Formulated Medicinal Products. He is a member of the Editorial Advisory Board of CRC Books Inc. and formerly of the Scientific Advisory Board of the International Partnership for Microbicides. He has published 3 books, approximately 300 scientific publications, holds several patents on drug delivery systems and biomaterials and has given numerous invited conference presentations.
Research Statement
Prof. Woolfson's research interests are in polymeric drug delivery systems for transdermal and intravaginal applications, bioadhesion and biomaterials. The emphasis is on facilitated controlled drug delivery through challenging polymeric systems, where physicochemical aspects (drug molecular size, solubility or stability, polymer system tortuosity and relative hydrophobicity) present difficulties to efficient drug release. The current focus is on novel polymeric systems for transdermal delivery, vaginal delivery of HIV microbicides and the development of vaginally deliveryed HIV mucosal vaccines. Key achievements include the invention of the marketed percutaneous local anaesthetic product Ametop, and contributions to the development of several other pharmaceuticals, including the vaginal ring HRT product Femring. The research programmes are funded from a range of sources including UK Research Councils, major charities such as the Bill and Melinda Gates Foundation and the Wellcome Trust, the International Partnership for Microbicides and other charities for the prevention of HIV, and the Pharmaceutical Industry. Prof. Woolfson's career research grants to date total £17M.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 7 Finished
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R1530PMY: Delivery of novel peptide drugs for the purpose of modulating immune responses in disease and vaccines
Donnelly, R. (PI), Kissenpfennig, A. (CoI), Scott, C. (CoI) & Woolfson, D. (CoI)
15/05/2015 → 31/08/2016
Project: Research
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R1442PMY: MRC CiC 2013
Donnelly, R. (PI), Kissenpfennig, A. (CoI) & Woolfson, D. (CoI)
01/07/2014 → 31/08/2015
Project: Research
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R1199PMY: Manufacture and applicator technologies for commercialisation of polymeric microneedle arrays
Donnelly, R. (PI) & Woolfson, D. (CoI)
01/08/2012 → 07/08/2015
Project: Research
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R1046PMY: In vitro and vivo safety investigations to support the commercialisation of novel mirroneedle arrays for transdermal drug delivery
Donnelly, R. (PI) & Woolfson, D. (CoI)
01/08/2009 → 31/12/2010
Project: Research
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A facile system to evaluate in vitro drug release from dissolving microneedle arrays
Larrañeta, E., Stewart, S., Fallows, S. J., Birkhäuer, L. L., McCrudden, M. T. C., Woolfson, A. D. & Donnelly, R. F., 30 Jan 2016, In: International Journal of Pharmaceutics. 497, 1-2, p. 62-69 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile86 Citations (Scopus)769 Downloads (Pure) -
Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development
Larrañeta, E., Lutton, R. E. M., Woolfson, A. D. & Donnelly, R. F., Jun 2016, In: Materials Science and Engineering: R: Reports. 104, p. 1 - 32 32 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile702 Citations (Scopus)1942 Downloads (Pure) -
A novel scalable manufacturing process for the production of hydrogel-forming microneedle arrays
Lutton, R. E. M., Larrañeta, E., Kearney, M.-C., Boyd, P., Woolfson, A. D. & Donnelly, R. F., 15 Oct 2015, In: International Journal of Pharmaceutics. 494, 1, p. 417-429 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile82 Citations (Scopus)1389 Downloads (Pure) -
Considerations in the sterile manufacture of polymeric microneedle arrays
McCrudden, M. T. C., Zaid Alkilani, A., Courtenay, A., McCrudden, C. M., McCloskey, B., Walker, C., Alshraiedeh, N., Lutton, R. E. M., Gilmore, B. F., Woolfson, A. D. & Donnelly, R. F., Feb 2015, In: Drug Delivery and Translational Research. 5, 1, p. 3-14 12 p.Research output: Contribution to journal › Article › peer-review
118 Citations (Scopus) -
Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation
Lutton, R. E. M., Moore, J., Larrañeta, E., Ligett, S., Woolfson, A. D. & Donnelly, R. F., Aug 2015, In: Drug Delivery and Translational Research. 5, 4, p. 313-331 19 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile116 Citations (Scopus)4605 Downloads (Pure)
Prizes
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Elected Fellow of the Pharmaceutical Society NI
Woolfson, D. (Recipient), 2009
Prize: Fellowship awarded competitively
Activities
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Pharmaceutical Society of Northern Ireland (External organisation)
Woolfson, D. (Member)
2010 → 2012Activity: Membership types › Membership of peer review panel or committee
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China Medical University, Shenyang
Woolfson, D. (Visitor)
2010 → …Activity: Visiting an external institution types › Research and Teaching at External Organisation
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CRC Press (External organisation)
Woolfson, D. (Member)
2010 → 2012Activity: Membership types › Membership of peer review panel or committee
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Council of University Heads of Pharmacy Schools (External organisation)
Woolfson, D. (Member)
2009 → …Activity: Membership types › Membership of external research organisation
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Pharmaceutical Society of Northern Ireland (External organisation)
Woolfson, D. (Member)
2009 → 2012Activity: Membership types › Membership of external research organisation
Impacts
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Protecting Women from HIV AIDS: Dapivirine Vaginal Ring HIV Microbicide
Woolfson, D. (Participant), Malcolm, K. (Participant), McCullagh, S. (Participant) & Catney, M. (Participant)
Impact: Health Impact