Projects per year
Personal profile
Interests
Research Statement
The Fitzgerald lab is a Regenerative NeuroImmunology research group at QUB with a particular focus on Multiple Sclerosis (MS), an immune-mediated, demyelinating disorder of the Central Nervous System (CNS). The central goal of our research is to identify new strategies to treat MS and other inflammatory and demyelinating disorders.
We are particularly interested in the process of myelin regeneration (remyelination) and aim to identify novel therapeutic targets to promote remyelination in MS. To do this, we are uncovering new knowledge of how the immune system influences tissue regeneration in the Central Nervous System (CNS). We also conduct a research programme on the pathogenesis of autoimmune inflammation. This programme mainly focuses on T cell biology with a view to identifying strategies to reduce disease activity in MS and other immune-mediated diseases. Previous work investigated the fundamental biology of IL-27 and its therapeutic potential in inflammatory/autoimmune disease, with particular focus on Th1- and Th17-mediated inflammatory responses.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R2652CNR: High Parameter Flow Cytometry in Health and Disease - Full application
Small, D. (PI), Buckley, N. (CoI), Fitzgerald, D. (CoI), Guzman de la Fuente, A. (CoI), Ingram, B. (CoI), Kerr, E. (CoI) & Longley, D. (CoI)
28/10/2019 → …
Project: Research
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R4861CEM: Investigating lymphoid-like structures in Multiple Sclerosis
Fitzgerald, D. (PI), Lopez Campos, G. (CoI) & Simpson, D. (CoI)
02/06/2019 → …
Project: Research
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R1263CII: The role of macrophages in CNS remyelination
Fitzgerald, D. (PI)
01/08/2010 → …
Project: Research
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R1586CII: Defining molecular pathways of regulatory T cell-mediated oligodendrocyte differentiation and remyelination
Fitzgerald, D. (PI)
03/11/2015 → 04/10/2019
Project: Research
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R1034CII: Investigating the role of CD4+ T cells in CNS remyelination
Fitzgerald, D. (PI)
01/08/2011 → 31/08/2015
Project: Research
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Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination
de la Fuente, A. G., Dittmer, M., Heesbeen, E. J., de la Vega Gallardo, N., White, J. A., Young, A., McColgan, T., Dashwood, A., Mayne, K., Cabeza-Fernández, S., Falconer, J., Rodriguez-Baena, F. J., McMurran, C. E., Inayatullah, M., Rawji, K. S., Franklin, R. J. M., Dooley, J., Liston, A., Ingram, R. J. & Tiwari, V. K. & 3 others, , 11 Mar 2024, In: Nature Communications. 15, 19 p., 1870.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)25 Downloads (Pure) -
Nurturing a positive research culture within your laboratory
Liston, A. & Fitzgerald, D. C., 15 Oct 2024, In: Wellcome Open Research. 9, 341.Research output: Contribution to journal › Article
Open AccessFile1 Citation (Scopus)22 Downloads (Pure) -
Nurturing a positive research culture within your organization
Liston, A. & Fitzgerald, D. C., Aug 2024, In: Immunology and Cell Biology. 102, 7, p. 538-547 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
Llorián-Salvador, M., de Fuente, A. G., McMurran, C. E., Dashwood, A., Dooley, J., Liston, A., Penalva, R., Dombrowski, Y., Stitt, A. W. & Fitzgerald, D. C., 05 Apr 2024, In: Molecular Neurodegeneration. 19, 17 p., 32.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)19 Downloads (Pure) -
Brain regulatory T cells
Liston, A., Pasciuto, E., Fitzgerald, D. C. & Yshii, L., 01 Dec 2023, (Early online date) In: Nature Reviews Immunology.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus)
Prizes
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British Society for Immunology Outstanding Team Award
Lengyel, I. (Recipient), Fitzgerald, D. (Recipient), Hughes, S. (Recipient), Naughton, M. (Recipient), Kee, R. (Recipient), Dombrowski, Y. (Recipient), McIlwaine, G. (Recipient), Moffat, J. (Recipient), McDonnell, G. (Recipient), McDonnell, G. (Recipient) & Kennedy, F. (Recipient), 25 Apr 2023
Prize: Prize (including medals and awards)
File -
Most Innovative Research Programme, School of Medicine, Dentistry and Biomedical Science
Fitzgerald, D. (Recipient), 2013
Prize: Prize (including medals and awards)
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MS Society (GB & NI) ‘Research of the Year’ Award
Fitzgerald, D. (Recipient), 2018
Prize: National/international honour
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Staff Excellence Award for ‘Outstanding Leadership’
Fitzgerald, D. (Recipient), 2018
Prize: Prize (including medals and awards)
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Vice-Chancellor’s Prize for Research Innovation
Fitzgerald, D. (Recipient), 2017
Prize: Prize (including medals and awards)
Activities
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External Academic progression/promotion/fellowship assessment
Fitzgerald, D. (Advisor)
2023 → …Activity: Other activity types › Other
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External Academic progression/promotion/fellowship assessment
Fitzgerald, D. (Advisor)
2022Activity: Other activity types › Other
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Wellcome Trust (External organisation)
Fitzgerald, D. (Board Member)
2021 → …Activity: Membership types › Membership of peer review panel or committee
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Medical Research Council (External organisation)
Fitzgerald, D. (Advisor)
2021Activity: Membership types › Membership of peer review panel or committee
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Multiple Sclerosis Society (External organisation)
Fitzgerald, D. (Board Member)
2020 → …Activity: Membership types › Membership of national or international committees and working groups