• Room 0G.005 - CEM

    United Kingdom

Accepting PhD Students

20062020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Interests

 

Latest news from the Fitzgerald lab available here:

https://www.facebook.com/TheFitzgeraldGroup1/

Research Statement

The Fitzgerald lab is a Regenerative NeuroImmunology research group at QUB with a particular focus on Multiple Sclerosis (MS), an immune-mediated, demyelinating disorder of the Central Nervous System (CNS).  The central goal of our research is to identify new strategies to treat MS and other inflammatory and demyelinating disorders.

We are particularly interested in the process of myelin regeneration (remyelination) and aim to identify novel therapeutic targets to promote remyelination in MS. To do this, we are uncovering new knowledge of how the immune system influences tissue regeneration in the Central Nervous System (CNS). We also conduct a research programme on the pathogenesis of autoimmune inflammation. This programme mainly focuses on T cell biology with a view to identifying strategies to reduce disease activity in MS and other immune-mediated diseases. Previous work investigated the fundamental biology of IL-27 and its therapeutic potential in inflammatory/autoimmune disease, with particular focus on Th1- and Th17-mediated inflammatory responses.

Fingerprint Dive into the research topics where Denise Fitzgerald is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 29 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

Research Output

Changes in the oligodendrocyte progenitor cell proteome with ageing

de la Fuente, A. G., Queiroz, R. M. L., Ghosh, T., McMurran, C. E., Cubillos, J. F., Bergles, D. E., Fitzgerald, D. C., Jones, C. A., Lilley, K. S., Glover, C. P. & Franklin, R. J. M., 20 May 2020, In : Molecular & cellular proteomics : MCP.

Research output: Contribution to journalArticle

  • Open Access
    File
  • 5 Downloads (Pure)

    Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

    Pasciuto, E., Burton, O. T., Roca, C. P., Lagou, V., Rajan, W. D., Theys, T., Mancuso, R., Tito, R. Y., Kouser, L., Callaerts-Vegh, Z., de la Fuente, A. G., Prezzemolo, T., Mascali, L. G., Brajic, A., Whyte, C. E., Yshii, L., Martinez-Muriana, A., Naughton, M., Young, A., Moudra, A. & 7 others, Lemaitre, P., Poovathingal, S., Raes, J., De Strooper, B., Fitzgerald, D. C., Dooley, J. & Liston, A., 20 Jul 2020, In : Cell.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 7 Downloads (Pure)

    Inflammasome component expression in myelin damage and regeneration in vivo

    McKay, E., Gritti, L., Fleville, S., Fitzgerald, D. & Dombrowski, Y., 2019.

    Research output: Contribution to conferencePoster

    Prizes

    MS Society (GB & NI) ‘Research of the Year’ Award

    Fitzgerald, Denise (Recipient), 2018

    Prize: National/international honour

    Staff Excellence Award for ‘Outstanding Leadership’

    Fitzgerald, Denise (Recipient), 2018

    Prize: Prize (including medals and awards)

    Vice-Chancellor’s Prize for Research Innovation

    Fitzgerald, Denise (Recipient), 2017

    Prize: Prize (including medals and awards)

    Activities

    • 5 Membership of peer review panel or committee
    • 1 Membership of network

    MS Society (External organisation)

    Denise Fitzgerald (Advisor)

    2019 → …

    Activity: Membership typesMembership of network

    Health and Social Care (Northern Ireland) Research and Development (External organisation)

    Denise Fitzgerald (Advisor)

    2019 → …

    Activity: Membership typesMembership of peer review panel or committee

    National Multiple Sclerosis Society (External organisation)

    Denise Fitzgerald (Advisor)

    2018 → …

    Activity: Membership typesMembership of peer review panel or committee

    Biotechnology & Biological Sciences Research Council (External organisation)

    Denise Fitzgerald (Advisor)

    2018 → …

    Activity: Membership typesMembership of peer review panel or committee

    Wellcome Trust (External organisation)

    Denise Fitzgerald (Advisor)

    2018 → …

    Activity: Membership typesMembership of peer review panel or committee

    Thesis

    Investigating interplay between human regulatory T cells and oligodendrocyte lineage cells

    Author: Eleftheriadis, G., Jul 2020

    Supervisor: Chandran, S. (Supervisor), Fitzgerald, D. (Supervisor) & Margariti, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy