• Room 0G.005 - CEM

    United Kingdom

Accepting PhD Students

20062019
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Personal profile

Interests

 

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https://www.facebook.com/TheFitzgeraldGroup1/

Research Statement

The Fitzgerald lab is a Regenerative NeuroImmunology research group at QUB with a particular focus on Multiple Sclerosis (MS), an immune-mediated, demyelinating disorder of the Central Nervous System (CNS).  The central goal of our research is to identify new strategies to treat MS and other inflammatory and demyelinating disorders.

We are particularly interested in the process of myelin regeneration (remyelination) and aim to identify novel therapeutic targets to promote remyelination in MS. To do this, we are uncovering new knowledge of how the immune system influences tissue regeneration in the Central Nervous System (CNS). We also conduct a research programme on the pathogenesis of autoimmune inflammation. This programme mainly focuses on T cell biology with a view to identifying strategies to reduce disease activity in MS and other immune-mediated diseases. Previous work investigated the fundamental biology of IL-27 and its therapeutic potential in inflammatory/autoimmune disease, with particular focus on Th1- and Th17-mediated inflammatory responses.

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  • 33 Similar Profiles
Autoimmune Experimental Encephalomyelitis Medicine & Life Sciences
Demyelinating Diseases Medicine & Life Sciences
Regulatory T-Lymphocytes Medicine & Life Sciences
Myelin Sheath Medicine & Life Sciences
Multiple Sclerosis Medicine & Life Sciences
Oligodendroglia Medicine & Life Sciences
Interleukin-27 Medicine & Life Sciences
Central Nervous System Medicine & Life Sciences

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Projects 2010 2019

Research Output 2006 2019

Inflammasome component expression in myelin damage and regeneration in vivo

McKay, E., Gritti, L., Fleville, S., Fitzgerald, D. & Dombrowski, Y., 2019.

Research output: Contribution to conferencePoster

Inflammasomes: novel players in OPC proliferation and myelin regeneration

Gritti, L., McKay, E., Crooks, D., Boinet, A-L., Fleville, S., Fitzgerald, D. & Dombrowski, Y., 2019.

Research output: Contribution to conferencePoster

Prizes

MS Society (GB & NI) ‘Research of the Year’ Award

Denise Fitzgerald (Recipient), 2018

Prize: National/international honour

Staff Excellence Award for ‘Outstanding Leadership’

Denise Fitzgerald (Recipient), 2018

Prize: Prize (including medals and awards)

Vice-Chancellor’s Prize for Research Innovation

Denise Fitzgerald (Recipient), 2017

Prize: Prize (including medals and awards)

Activities 2012 2019

  • 4 Membership of peer review panel or committee

Health and Social Care (Northern Ireland) Research and Development (External organisation)

Denise Fitzgerald (Advisor)
2019 → …

Activity: Membership typesMembership of peer review panel or committee

National Multiple Sclerosis Society (External organisation)

Denise Fitzgerald (Advisor)
2018 → …

Activity: Membership typesMembership of peer review panel or committee

Wellcome Trust (External organisation)

Denise Fitzgerald (Advisor)
2018 → …

Activity: Membership typesMembership of peer review panel or committee

MS Society (External organisation)

Denise Fitzgerald (Advisor)
2012 → …

Activity: Membership typesMembership of peer review panel or committee