Projects per year
Personal profile
Interests
Research Statement
The Fitzgerald lab is a Regenerative NeuroImmunology research group at QUB with a particular focus on Multiple Sclerosis (MS), an immune-mediated, demyelinating disorder of the Central Nervous System (CNS). The central goal of our research is to identify new strategies to treat MS and other inflammatory and demyelinating disorders.
We are particularly interested in the process of myelin regeneration (remyelination) and aim to identify novel therapeutic targets to promote remyelination in MS. To do this, we are uncovering new knowledge of how the immune system influences tissue regeneration in the Central Nervous System (CNS). We also conduct a research programme on the pathogenesis of autoimmune inflammation. This programme mainly focuses on T cell biology with a view to identifying strategies to reduce disease activity in MS and other immune-mediated diseases. Previous work investigated the fundamental biology of IL-27 and its therapeutic potential in inflammatory/autoimmune disease, with particular focus on Th1- and Th17-mediated inflammatory responses.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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R2652CNR: High Parameter Flow Cytometry in Health and Disease - Full application
Small, D., Buckley, N., Fitzgerald, D., Guzman de la Fuente, A., Ingram, B., Kerr, E. & Longley, D.
28/10/2019 → …
Project: Research
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R4861CEM: Investigating lymphoid-like structures in Multiple Sclerosis
Fitzgerald, D., Lopez Campos, G. & Simpson, D.
02/06/2019 → …
Project: Research
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R1034CII: Investigating the role of CD4+ T cells in CNS remyelination
01/08/2011 → 31/08/2015
Project: Research
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Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis
Evans, R., Watkins, L. M., Hawkins, K., Santiago, G., Demetriou, C., Naughton, M., Dittmer, M., Rees, M. I., Fitzgerald, D., Morgan, B. P., Neal, J. W. & Howell, O. W., 22 Mar 2023, In: Frontiers in Cellular Neuroscience. 17, 17 p., 1094106.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Reduced cone density is associated with multiple sclerosis
McIlwaine, G., Csincsik, L., Coey, R., Wang, L., Fitzgerald, D., Moffat, J., Dubis, A. M., McDonnell, G., Hughes, S., Peto, T. & Lengyel, I., Sep 2023, In: Ophthalmology Science. 3, 3, 100308.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A review of compartmentalised inflammation and tertiary lymphoid structures in the pathophysiology of multiple sclerosis
Kee, R., Naughton, M., McDonnell, G. V., Howell, O. W. & Fitzgerald, D. C., 17 Oct 2022, In: Biomedicines. 10, 10, 24 p., 2604.Research output: Contribution to journal › Review article › peer-review
Open AccessFile23 Downloads (Pure) -
Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non‐cell‐autonomous neuronal damage
Matute‐Blanch, C., Brito, V., Midaglia, L., Villar, L. M., Garcia‐Diaz Barriga, G., Guzman de la Fuente, A., Borrás, E., Fernández‐García, S., Calvo‐Barreiro, L., Miguez, A., Costa‐Frossard, L., Pinteac, R., Sabidó, E., Alberch, J., Fitzgerald, D. C., Montalban, X. & Comabella, M., 11 May 2022, In: Clinical and Translational Medicine. 12, 5, e837.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Downloads (Pure) -
Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030
MacKenzie, G., Subramaniam, S., Caldwell, L. J., Fitzgerald, D., Harrison, N. A., Hong, S., Irani, S. R., Khandaker, G. M., Liston, A., Miron, V. E., Mondelli, V., Morgan, B. P., Pariante, C., Shah, D. K., Taams, L. S., Teeling, J. L. & Upthegrove, R., 29 Jul 2021, (Early online date) In: Wellcome open research. 6, 194.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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British Society for Immunology Outstanding Team Award
Lengyel, Imre (Recipient), Fitzgerald, Denise (Recipient), Hughes, Stella (Recipient), Naughton, Michael (Recipient), Kee, Rachael (Recipient), Dombrowski, Yvonne (Recipient), McIlwaine, Gemma (Recipient), Moffat, Jill (Recipient), McDonnell, Gavin (Recipient), McDonnell, Gavin (Recipient) & Kennedy, Fiona (Recipient), 25 Apr 2023
Prize: Prize (including medals and awards)
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Most Innovative Research Programme, School of Medicine, Dentistry and Biomedical Science
Fitzgerald, Denise (Recipient), 2013
Prize: Prize (including medals and awards)
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MS Society (GB & NI) ‘Research of the Year’ Award
Fitzgerald, Denise (Recipient), 2018
Prize: National/international honour
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Staff Excellence Award for ‘Outstanding Leadership’
Fitzgerald, Denise (Recipient), 2018
Prize: Prize (including medals and awards)
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Vice-Chancellor’s Prize for Research Innovation
Fitzgerald, Denise (Recipient), 2017
Prize: Prize (including medals and awards)
Activities
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External Academic progression/promotion/fellowship assessment
Denise Fitzgerald (Advisor)
2023 → …Activity: Other activity types › Other
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External Academic progression/promotion/fellowship assessment
Denise Fitzgerald (Advisor)
2022Activity: Other activity types › Other
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Medical Research Council (External organisation)
Denise Fitzgerald (Advisor)
2021Activity: Membership types › Membership of peer review panel or committee
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Wellcome Trust (External organisation)
Denise Fitzgerald (Board Member)
2021 → …Activity: Membership types › Membership of peer review panel or committee
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MS Society (External organisation)
Denise Fitzgerald (Chair)
2020 → …Activity: Membership types › Membership of national or international committees and working groups