Denise Fitzgerald

Personal profile

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Research Statement

The Fitzgerald lab is a Regenerative NeuroImmunology research group at QUB with a particular focus on Multiple Sclerosis (MS), an immune-mediated, demyelinating disorder of the Central Nervous System (CNS). The central goal of our research is to identify new strategies to treat MS and other inflammatory and demyelinating disorders.

We are particularly interested in the process of myelin regeneration (remyelination) and aim to identify novel therapeutic targets to promote remyelination in MS. To do this, we are uncovering new knowledge of how the immune system influences tissue regeneration in the Central Nervous System (CNS). We also conduct a research programme on the pathogenesis of autoimmune inflammation. This programme mainly focuses on T cell biology with a view to identifying strategies to reduce disease activity in MS and other immune-mediated diseases. Previous work investigated the fundamental biology of IL-27 and its therapeutic potential in inflammatory/autoimmune disease, with particular focus on Th1- and Th17-mediated inflammatory responses.

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Projects

1 Finished
3 Active

R4861CEM: Investigating lymphoid-like structures in Multiple Sclerosis

Fitzgerald, D., Lopez Campos, G. & Simpson, D.

02/06/2019 → …

Project: Research

R1586CII: Defining molecular pathways of regulatory T cell-mediated oligodendrocyte differentiation and remyelination

Fitzgerald, D.

03/11/2015 → …

Project: Research

R1263CII: The role of macrophages in CNS remyelination

Fitzgerald, D.

01/08/2010 → …

Project: Research

R1034CII: Investigating the role of CD4+ T cells in CNS remyelination

Fitzgerald, D.

01/08/2011 → 31/08/2015

Project: Research

Research Output

37 Article
31 Poster
8 Review article
3 Chapter (peer-reviewed)
3 More
- 2 Chapter
- 1 Paper

Changes in the oligodendrocyte progenitor cell proteome with ageing

de la Fuente, A. G., Queiroz, R. M. L., Ghosh, T., McMurran, C. E., Cubillos, J. F., Bergles, D. E., Fitzgerald, D. C., Jones, C. A., Lilley, K. S., Glover, C. P. & Franklin, R. J. M., 20 May 2020, In : Molecular & cellular proteomics : MCP.

Research output: Contribution to journal › Article

Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination

de la Vega Gallardo, N., Penalva, R., Dittmer, M., Naughton, M., Falconer, J., Moffat, J., de la Fuente, A. G., Hombrebueno, J. R., Lin, Z., Perbal, B., Ingram, R. J., Evergren, E. & Fitzgerald, D. C., 10 Jul 2020, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journal › Article

Open Access

File

5 Downloads (Pure)

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Pasciuto, E., Burton, O. T., Roca, C. P., Lagou, V., Rajan, W. D., Theys, T., Mancuso, R., Tito, R. Y., Kouser, L., Callaerts-Vegh, Z., de la Fuente, A. G., Prezzemolo, T., Mascali, L. G., Brajic, A., Whyte, C. E., Yshii, L., Martinez-Muriana, A., Naughton, M., Young, A., Moudra, A. & 7 others, Lemaitre, P., Poovathingal, S., Raes, J., De Strooper, B., Fitzgerald, D. C., Dooley, J. & Liston, A., 20 Jul 2020, In : Cell.

Research output: Contribution to journal › Article

Open Access

File