Projects per year
Personal profile
Interests
Research Statement
The Fitzgerald lab is a Regenerative NeuroImmunology research group at QUB with a particular focus on Multiple Sclerosis (MS), an immune-mediated, demyelinating disorder of the Central Nervous System (CNS). The central goal of our research is to identify new strategies to treat MS and other inflammatory and demyelinating disorders.
We are particularly interested in the process of myelin regeneration (remyelination) and aim to identify novel therapeutic targets to promote remyelination in MS. To do this, we are uncovering new knowledge of how the immune system influences tissue regeneration in the Central Nervous System (CNS). We also conduct a research programme on the pathogenesis of autoimmune inflammation. This programme mainly focuses on T cell biology with a view to identifying strategies to reduce disease activity in MS and other immune-mediated diseases. Previous work investigated the fundamental biology of IL-27 and its therapeutic potential in inflammatory/autoimmune disease, with particular focus on Th1- and Th17-mediated inflammatory responses.
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Projects
R4861CEM: Investigating lymphoid-like structures in Multiple Sclerosis
Fitzgerald, D., Lopez Campos, G. & Simpson, D.
02/06/2019 → …
Project: Research
R1034CII: Investigating the role of CD4+ T cells in CNS remyelination
01/08/2011 → 31/08/2015
Project: Research
Research Output
Inflammasome component expression in myelin damage and regeneration in vivo
McKay, E., Gritti, L., Fleville, S., Fitzgerald, D. & Dombrowski, Y., 2019.Research output: Contribution to conference › Poster
Inflammasome Product IL-1beta Enhances Myelination and Remyelination of Organotypic Brain Slices
Crooks, D., Fitzgerald, D., Bankhead, P. & Dombrowski, Y., 2019.Research output: Contribution to conference › Poster
Inflammasome Product IL-1beta Enhances Myelination and Remyelination of Organotypic Brain Slices
Crooks, D., Bankhead, P., Fitzgerald, D. & Dombrowski, Y., 2019.Research output: Contribution to conference › Poster
Inflammasomes: novel players in OPC proliferation and myelin regeneration
Gritti, L., McKay, E., Crooks, D., Boinet, A-L., Fleville, S., Fitzgerald, D. & Dombrowski, Y., 2019.Research output: Contribution to conference › Poster
Inflammasomes are expressed in murine CNS lesions and inflammasome products IL-1beta and IL-18 promote remyelination.
Crooks, D., Fleville, S., Boylan, N., Roets, L., Lavelle, E., Fitzgerald, D. & Dombrowski, Y., 2019.Research output: Contribution to conference › Poster
Prizes
Most Innovative Research Programme, School of Medicine, Dentistry and Biomedical Science
Denise Fitzgerald (Recipient), 2013
Prize: Prize (including medals and awards)
MS Society (GB & NI) ‘Research of the Year’ Award
Denise Fitzgerald (Recipient), 2018
Prize: National/international honour
Staff Excellence Award for ‘Outstanding Leadership’
Denise Fitzgerald (Recipient), 2018
Prize: Prize (including medals and awards)
Vice-Chancellor’s Prize for Research Innovation
Denise Fitzgerald (Recipient), 2017
Prize: Prize (including medals and awards)
Activities
Health and Social Care (Northern Ireland) Research and Development (External organisation)
Denise Fitzgerald (Advisor)2019 → …
Activity: Membership types › Membership of peer review panel or committee
MS Society (External organisation)
Denise Fitzgerald (Advisor)2019 → …
Activity: Membership types › Membership of network
Wellcome Trust (External organisation)
Denise Fitzgerald (Advisor)2018 → …
Activity: Membership types › Membership of peer review panel or committee
Biotechnology & Biological Sciences Research Council (External organisation)
Denise Fitzgerald (Advisor)2018 → …
Activity: Membership types › Membership of peer review panel or committee
National Multiple Sclerosis Society (External organisation)
Denise Fitzgerald (Advisor)2018 → …
Activity: Membership types › Membership of peer review panel or committee