Projects per year
Personal profile
Interests
Research Statement
The Fitzgerald lab is a Regenerative NeuroImmunology research group at QUB with a particular focus on Multiple Sclerosis (MS), an immune-mediated, demyelinating disorder of the Central Nervous System (CNS). The central goal of our research is to identify new strategies to treat MS and other inflammatory and demyelinating disorders.
We are particularly interested in the process of myelin regeneration (remyelination) and aim to identify novel therapeutic targets to promote remyelination in MS. To do this, we are uncovering new knowledge of how the immune system influences tissue regeneration in the Central Nervous System (CNS). We also conduct a research programme on the pathogenesis of autoimmune inflammation. This programme mainly focuses on T cell biology with a view to identifying strategies to reduce disease activity in MS and other immune-mediated diseases. Previous work investigated the fundamental biology of IL-27 and its therapeutic potential in inflammatory/autoimmune disease, with particular focus on Th1- and Th17-mediated inflammatory responses.
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R4861CEM: Investigating lymphoid-like structures in Multiple Sclerosis
Fitzgerald, D., Lopez Campos, G. & Simpson, D.
02/06/2019 → …
Project: Research
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R1034CII: Investigating the role of CD4+ T cells in CNS remyelination
01/08/2011 → 31/08/2015
Project: Research
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CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis.
Naughton, M., Moffat, J., Eleftheriadis, G., De La Vega Gallardo, N., Young, A., Falconer, J., Hawkins, K., Pearson, B., Perbal, B., Hogan, A. E., Moynagh, P., Loveless, S., Robertson, N., Gran, B., Kee, R., Hughes, S., McDonnell, G., Howell, O. W. & Fitzgerald, D., 22 Nov 2020, In: Journal of neuroinflammation.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)11 Downloads (Pure) -
Changes in the oligodendrocyte progenitor cell proteome with ageing
de la Fuente, A. G., Queiroz, R. M. L., Ghosh, T., McMurran, C. E., Cubillos, J. F., Bergles, D. E., Fitzgerald, D. C., Jones, C. A., Lilley, K. S., Glover, C. P. & Franklin, R. J. M., 20 May 2020, (Early online date) In: Molecular & cellular proteomics : MCP.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination
de la Vega Gallardo, N., Penalva, R., Dittmer, M., Naughton, M., Falconer, J., Moffat, J., de la Fuente, A. G., Hombrebueno, J. R., Lin, Z., Perbal, B., Ingram, R. J., Evergren, E. & Fitzgerald, D. C., 10 Jul 2020, (Early online date) In: Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 18018Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)19 Downloads (Pure) -
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
Pasciuto, E., Burton, O. T., Roca, C. P., Lagou, V., Rajan, W. D., Theys, T., Mancuso, R., Tito, R. Y., Kouser, L., Callaerts-Vegh, Z., de la Fuente, A. G., Prezzemolo, T., Mascali, L. G., Brajic, A., Whyte, C. E., Yshii, L., Martinez-Muriana, A., Naughton, M., Young, A., Moudra, A. & 7 others, , 20 Jul 2020, (Early online date) In: Cell. 182, 3, p. 625Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)90 Downloads (Pure) -
Inflammasome component expression in myelin damage and regeneration in vivo
McKay, E., Gritti, L., Fleville, S., Fitzgerald, D. & Dombrowski, Y., 2019.Research output: Contribution to conference › Poster › peer-review
Prizes
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Most Innovative Research Programme, School of Medicine, Dentistry and Biomedical Science
Fitzgerald, Denise (Recipient), 2013
Prize: Prize (including medals and awards)
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MS Society (GB & NI) ‘Research of the Year’ Award
Fitzgerald, Denise (Recipient), 2018
Prize: National/international honour
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Staff Excellence Award for ‘Outstanding Leadership’
Fitzgerald, Denise (Recipient), 2018
Prize: Prize (including medals and awards)
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Vice-Chancellor’s Prize for Research Innovation
Fitzgerald, Denise (Recipient), 2017
Prize: Prize (including medals and awards)
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MS Society (External organisation)
Denise Fitzgerald (Advisor)
2019 → …Activity: Membership types › Membership of network
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Health and Social Care (Northern Ireland) Research and Development (External organisation)
Denise Fitzgerald (Advisor)
2019 → …Activity: Membership types › Membership of peer review panel or committee
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National Multiple Sclerosis Society (External organisation)
Denise Fitzgerald (Advisor)
2018 → …Activity: Membership types › Membership of peer review panel or committee
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Wellcome Trust (External organisation)
Denise Fitzgerald (Advisor)
2018 → …Activity: Membership types › Membership of peer review panel or committee
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Biotechnology & Biological Sciences Research Council (External organisation)
Denise Fitzgerald (Advisor)
2018 → …Activity: Membership types › Membership of peer review panel or committee