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Denise McDonald

Dr

  • Room 01.058 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr McDonald is open to wide-ranging PhD applications from candidates with a basic science or clinical background. Her fields of interest include: - vascular biology - vision research - pharmacology Previous research experience is desirable although not essential.

19952019

Research output per year

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Personal profile

Interests

 

Keywords: Vascular Biology; Cardiovascular Medicine; Ophthalmology; Angiogenesis; OIR; Endothelial cells (EC); Microglial cells; ROP; Hypoxia; Hyperoxia; NOS (eNOS and iNOS); BH4; NADPH oxidase; ROS; RNS; Notch/Dll

 

 

Research Interests

 

Vascular Biology and Cell-Cell Communication: Endothelial / Mural (Pericyte and Smooth Muscle)/ Microglial Cell cross talk 

Disease Focus:  Vascular Disease; Endothelial Dysfunction; Retinal Diseases; Retinopathy of Prematurity (ROP); Diabetic Retinopathy

Signalling Pathways:  Nitric oxide Synthases (NOS); NADPH oxidase; Reactive Oxygen and Nitrogen Species (ROS/RNS); Notch/Delta (Dll), Hypoxia; Hyperoxia and Inflammation

Model Systems:   Primary cell isolation and culture (endothelial cell, pericyte, microglial); gene delivery (adenoviral, lentiviral); retina as a model of vascular development in health and disease; oxygen-induced retinopathy (OIR); aortic explants; green fluorescent protein (GFP)-tagged fusion construct generation and imaging

 

Biography

 

I trained in Biochemistry and Molecular Cell Biology at Queen’s University Belfast, the University of Leeds and the University of Oxford (in the Cardiovascular Medicine Wellcome Trust Centre for Human Genetics, a British Heart Foundation Centre of Excellence). 

I am currently Senior Lecturer in the Institute for Experimental Medicine where my research focuses on developing strategies to preserve normal vasculature and prevent vascular diseases caused by diabetes and aging, with a particular interest in oxidative stress and its impact on vascular growth/function/recovery and tissue repair.

My work has been funded externally by, among others, the Wellcome Trust, Fight for Sight, British Heart Foundation and Action Medical Research.

 

Teaching

  • Cardiovascular Pathobiology & Treatment (BMS2017) – (Co-ordinator)

  • Masters in Medical Research Training Programme

  • Portfolio Mentor – Level 1 & 2 Medical students

 

Select Lecture titles

  • Vascular Development: Angiogenesis & Vasculogenesis

  • The Eye: Target and Model of Neovascular Disease

  • Retinopathy of Prematurity

  • Vasculogenesis & Angiogenesis I

  • Tumour Angiogenesis

  • Novel Therapeutic Targets for Tumour Angiogenesis: Role of Vessel Normalisation and Metabolism

  • Gene Therapy for the Eye & Cardiovascular Diseases

  • NOTCH in Retinal Angiogenesis  

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Research Output

NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation

O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., O'Neill, C. L., Dellett, M., Hargey, C. J., Abudalo, R. A., O'Hare, M., Doyle, P., Toh, T., Khoo, J., Wong, J., McCrudden, C. M., Meloni, M., Brunssen, C., Morawietz, H., Yoder, M. C. & 6 others, McDonald, D. M., Watson, C. J., Stitt, A. W., Margariti, A., Medina, R. J. & Grieve, D. J., 01 Apr 2019, In : Cardiovascular Research.

Research output: Contribution to journal › Article

Open Access
File
    • 29 Downloads (Pure)

    Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling

    Vilà-González, M., Kelaini, S., Magee, C., Caines, R., Campbell, D., Eleftheriadou, M., Cochrane, A., Drehmer, D., Tsifaki, M., O'Neill, K., Pedrini, E., Yang, C., Medina, R., McDonald, D., Simpson, D., Zampetaki, A., Zeng, L., Grieve, D., Lois, N., Stitt, A. W. & 1 others, Margariti, A., 17 Nov 2018, In : Stem Cells.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 1 Citation (Scopus)
    231 Downloads (Pure)

    BH4-mediated enhancement of endothelial nitric oxide synthase activity reduces hyperoxia-induced endothelial damage and preserves vascular integrity in the neonate

    Edgar, K. S., Galvin, O. M., Collins, A., Katusic, Z. S. & McDonald, D. M., 01 Jan 2017, In : Investigative Opthalmology and Visual Science. 58, 1, p. 230-241 12 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 5 Citations (Scopus)
    198 Downloads (Pure)

    Development of polymeric–cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery

    Jain, A. K., Massey, A., Yusuf, H., McDonald, D. M., McCarthy, H. O. & Kett, V. L., 24 Nov 2015, In : International Journal of Nanomedicine. 2015, 10, p. 7183—7196 14 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 9 Citations (Scopus)
    293 Downloads (Pure)

    Diabetic Retinopathy: Mechanism, Diagnosis, Prevention, and Treatment

    Al-Shabrawey, M., Zhang, W. & McDonald, D., 2015, In : BioMed Research International. 2015, 2 p., 854593.

    Research output: Contribution to journal › Editorial

    Open Access
    File
    10 Citations (Scopus)
    178 Downloads (Pure)

    Activities

    • 1 Participation in conference
    • 1 Editorial activity

    BioMed Research International (Journal)

    Denise McDonald (Guest editor)
    2015

    Activity: Publication peer-review and editorial work types › Editorial activity

    ISOPT

    Denise McDonald (Speaker)
    Jul 2015

    Activity: Participating in or organising an event types › Participation in conference