Research Output per year
Research Output per year
Dr
Room 01.058 - CEM
United Kingdom
Accepting PhD Students
PhD projects
Dr McDonald is open to wide-ranging PhD applications from candidates with a basic science or clinical background. Her fields of interest include: - vascular biology - vision research - pharmacology Previous research experience is desirable although not essential.
Research output per year
Keywords: Vascular Biology; Cardiovascular Medicine; Ophthalmology; Angiogenesis; OIR; Endothelial cells (EC); Microglial cells; ROP; Hypoxia; Hyperoxia; NOS (eNOS and iNOS); BH4; NADPH oxidase; ROS; RNS; Notch/Dll
Vascular Biology and Cell-Cell Communication: Endothelial / Mural (Pericyte and Smooth Muscle)/ Microglial Cell cross talk
Disease Focus: Vascular Disease; Endothelial Dysfunction; Retinal Diseases; Retinopathy of Prematurity (ROP); Diabetic Retinopathy
Signalling Pathways: Nitric oxide Synthases (NOS); NADPH oxidase; Reactive Oxygen and Nitrogen Species (ROS/RNS); Notch/Delta (Dll), Hypoxia; Hyperoxia and Inflammation
Model Systems: Primary cell isolation and culture (endothelial cell, pericyte, microglial); gene delivery (adenoviral, lentiviral); retina as a model of vascular development in health and disease; oxygen-induced retinopathy (OIR); aortic explants; green fluorescent protein (GFP)-tagged fusion construct generation and imaging
Biography
I trained in Biochemistry and Molecular Cell Biology at Queen’s University Belfast, the University of Leeds and the University of Oxford (in the Cardiovascular Medicine Wellcome Trust Centre for Human Genetics, a British Heart Foundation Centre of Excellence).
I am currently Senior Lecturer in the Institute for Experimental Medicine where my research focuses on developing strategies to preserve normal vasculature and prevent vascular diseases caused by diabetes and aging, with a particular interest in oxidative stress and its impact on vascular growth/function/recovery and tissue repair.
My work has been funded externally by, among others, the Wellcome Trust, Fight for Sight, British Heart Foundation and Action Medical Research.
Cardiovascular Pathobiology & Treatment (BMS2017) – (Co-ordinator)
Masters in Medical Research Training Programme
Portfolio Mentor – Level 1 & 2 Medical students
Select Lecture titles
Vascular Development: Angiogenesis & Vasculogenesis
The Eye: Target and Model of Neovascular Disease
Retinopathy of Prematurity
Vasculogenesis & Angiogenesis I
Tumour Angiogenesis
Novel Therapeutic Targets for Tumour Angiogenesis: Role of Vessel Normalisation and Metabolism
Gene Therapy for the Eye & Cardiovascular Diseases
NOTCH in Retinal Angiogenesis
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Editorial
Denise McDonald (Speaker)
Activity: Participating in or organising an event types › Participation in conference
Denise McDonald (Guest editor)
Activity: Publication peer-review and editorial work types › Editorial activity