Research output per year
Research output per year
Dr
Room 01.058 - CEM
United Kingdom
Accepting PhD Students
PhD projects
Dr McDonald is open to wide-ranging PhD applications from candidates with a basic science or clinical background.
Her fields of interest include:
- vascular biology
- vision research
- pharmacology
Previous research experience is desirable although not essential.
Research activity per year
Keywords: Vascular Biology; Cardiovascular Medicine; Ophthalmology; Angiogenesis; OIR; Endothelial cells (EC); Microglial cells; ROP; Hypoxia; Hyperoxia; NOS (eNOS and iNOS); BH4; NADPH oxidase; ROS; RNS; Notch/Dll
Vascular Biology and Cell-Cell Communication: Endothelial / Mural (Pericyte and Smooth Muscle)/ Microglial Cell cross talk
Disease Focus: Vascular Disease; Endothelial Dysfunction; Retinal Diseases; Retinopathy of Prematurity (ROP); Diabetic Retinopathy
Signalling Pathways: Nitric oxide Synthases (NOS); NADPH oxidase; Reactive Oxygen and Nitrogen Species (ROS/RNS); Notch/Delta (Dll), Hypoxia; Hyperoxia and Inflammation
Model Systems: Primary cell isolation and culture (endothelial cell, pericyte, microglial); gene delivery (adenoviral, lentiviral); retina as a model of vascular development in health and disease; oxygen-induced retinopathy (OIR); aortic explants; green fluorescent protein (GFP)-tagged fusion construct generation and imaging
Biography
I trained in Biochemistry and Molecular Cell Biology at Queen’s University Belfast, the University of Leeds and the University of Oxford (in the Cardiovascular Medicine Wellcome Trust Centre for Human Genetics, a British Heart Foundation Centre of Excellence).
I am currently Senior Lecturer in the Institute for Experimental Medicine where my research focuses on developing strategies to preserve normal vasculature and prevent vascular diseases caused by diabetes and aging, with a particular interest in oxidative stress and its impact on vascular growth/function/recovery and tissue repair.
My work has been funded externally by, among others, the Wellcome Trust, Fight for Sight, British Heart Foundation and Action Medical Research.
Cardiovascular Pathobiology & Treatment (BMS2017) – (Co-ordinator)
Masters in Medical Research Training Programme
Portfolio Mentor – Level 1 & 2 Medical students
Select Lecture titles
Vascular Development: Angiogenesis & Vasculogenesis
The Eye: Target and Model of Neovascular Disease
Retinopathy of Prematurity
Vasculogenesis & Angiogenesis I
Tumour Angiogenesis
Novel Therapeutic Targets for Tumour Angiogenesis: Role of Vessel Normalisation and Metabolism
Gene Therapy for the Eye & Cardiovascular Diseases
NOTCH in Retinal Angiogenesis
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Denise McDonald (Speaker)
Activity: Participating in or organising an event types › Participation in conference
Denise McDonald (Guest editor)
Activity: Publication peer-review and editorial work types › Editorial activity