Research output per year
Research output per year
Personal profile
Interests
Keywords: Vascular Biology; Cardiovascular Medicine; Ophthalmology; Angiogenesis; OIR; Endothelial cells (EC); Microglial cells; ROP; Hypoxia; Hyperoxia; NOS (eNOS and iNOS); BH4; NADPH oxidase; ROS; RNS; Notch/Dll
Research Interests
Vascular Biology and Cell-Cell Communication: Endothelial / Mural (Pericyte and Smooth Muscle)/ Microglial Cell cross talk
Disease Focus: Vascular Disease; Endothelial Dysfunction; Retinal Diseases; Retinopathy of Prematurity (ROP); Diabetic Retinopathy
Signalling Pathways: Nitric oxide Synthases (NOS); NADPH oxidase; Reactive Oxygen and Nitrogen Species (ROS/RNS); Notch/Delta (Dll), Hypoxia; Hyperoxia and Inflammation
Model Systems: Primary cell isolation and culture (endothelial cell, pericyte, microglial); gene delivery (adenoviral, lentiviral); retina as a model of vascular development in health and disease; oxygen-induced retinopathy (OIR); aortic explants; green fluorescent protein (GFP)-tagged fusion construct generation and imaging
Biography
I trained in Biochemistry and Molecular Cell Biology at Queen’s University Belfast, the University of Leeds and the University of Oxford (in the Cardiovascular Medicine Wellcome Trust Centre for Human Genetics, a British Heart Foundation Centre of Excellence).
I am currently Senior Lecturer in the Institute for Experimental Medicine where my research focuses on developing strategies to preserve normal vasculature and prevent vascular diseases caused by diabetes and aging, with a particular interest in oxidative stress and its impact on vascular growth/function/recovery and tissue repair.
My work has been funded externally by, among others, the Wellcome Trust, Fight for Sight, British Heart Foundation and Action Medical Research.
Teaching
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Cardiovascular Pathobiology & Treatment (BMS2017) – (Co-ordinator)
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Masters in Medical Research Training Programme
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Portfolio Mentor – Level 1 & 2 Medical students
Select Lecture titles
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Vascular Development: Angiogenesis & Vasculogenesis
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The Eye: Target and Model of Neovascular Disease
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Retinopathy of Prematurity
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Vasculogenesis & Angiogenesis I
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Tumour Angiogenesis
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Novel Therapeutic Targets for Tumour Angiogenesis: Role of Vessel Normalisation and Metabolism
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Gene Therapy for the Eye & Cardiovascular Diseases
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NOTCH in Retinal Angiogenesis
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Markers of Hypoxia and Metabolism Correlate With Cell Differentiation in Retina and Lens Development
Gardiner, T. A., Branagh, T., Tipping, N. & McDonald, D. M., 22 Apr 2022, In: Frontiers in Ophthalmology. 2, 20 p., 867326.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation
O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., O'Neill, C. L., Dellett, M., Hargey, C. J., Abudalo, R. A., O'Hare, M., Doyle, P., Toh, T., Khoo, J., Wong, J., McCrudden, C. M., Meloni, M., Brunssen, C., Morawietz, H., Yoder, M. C. & 6 others, , 01 Feb 2020, In: Cardiovascular Research. 116, 2, p. 393-405 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)59 Downloads (Pure) -
Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling
Vilà-González, M., Kelaini, S., Magee, C., Caines, R., Campbell, D., Eleftheriadou, M., Cochrane, A., Drehmer, D., Tsifaki, M., O'Neill, K., Pedrini, E., Yang, C., Medina, R., McDonald, D., Simpson, D., Zampetaki, A., Zeng, L., Grieve, D., Lois, N., Stitt, A. W. & 1 others, , 17 Nov 2018, In: Stem Cells. 37, 2, p. 226Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)337 Downloads (Pure) -
BH4-mediated enhancement of endothelial nitric oxide synthase activity reduces hyperoxia-induced endothelial damage and preserves vascular integrity in the neonate
Edgar, K. S., Galvin, O. M., Collins, A., Katusic, Z. S. & McDonald, D. M., 01 Jan 2017, In: Investigative Opthalmology and Visual Science. 58, 1, p. 230-241 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)248 Downloads (Pure) -
Development of polymeric–cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery
Jain, A. K., Massey, A., Yusuf, H., McDonald, D. M., McCarthy, H. O. & Kett, V. L., 24 Nov 2015, In: International Journal of Nanomedicine. 2015, 10, p. 7183—7196 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)383 Downloads (Pure)
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ISOPT
Denise McDonald (Speaker)
Jul 2015Activity: Participating in or organising an event types › Participation in conference
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BioMed Research International (Journal)
Denise McDonald (Guest editor)
2015Activity: Publication peer-review and editorial work types › Editorial activity