• Room 01.062 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

My team offers an ideal environment for students interested in signal transduction and molecular cell biology, as well as mouse models of disease and drug discovery targeting Grem1 and other proteins involved in human disease.

19942019

Research output per year

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Research Output

2019

CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation

Ashraf, S., Bell, S., O'Leary, C., Canning, P., Micu, I., Fernandez, J. A., O'Hare, M., Barabas, P., McCauley, H., Brazil, D. P., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 21 Mar 2019, In : JCI insight. 4, 6, 18 p., e122442.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
185 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
98 Downloads (Pure)

No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells

Dutton, L. R., O'Neill, C. L., Medina, R. J. & Brazil, D. P., 29 Nov 2019, In : The Journal of biological chemistry. 294, 48, p. 18041-18045 5 p.

Research output: Contribution to journalArticle

Open Access
File
31 Downloads (Pure)
Open Access
1 Citation (Scopus)

Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy

Hombrebueno, J. R., Cairns, L., Dutton, L. R., Lyons, T. J., Brazil, D. P., Moynagh, P., Curtis, T. M. & Xu, H., 29 Oct 2019, In : JCI insight.

Research output: Contribution to journalArticle

Open Access
2018

The roles of TRIO and F-actin-binding protein in glioblastoma cells

Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H., Park, S., Hong, S., Brazil, D. P., Kim, S. H. & Park, J., 01 Mar 2018, In : Molecular Medicine Reports. 17, 3, p. 4540-4546 7 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
148 Downloads (Pure)
2017

Diabetic Nephropathy: a Tangled Web to Unweave

Magee, C., Grieve, D. J., Watson, C. J. & Brazil, D. P., 27 Sep 2017, In : Cardiovascular Drugs and Therapy. p. 1-14 14 p.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
227 Downloads (Pure)

Gremlin1 plays a key role in kidney development and renal fibrosis

Church, R. H., Ali, I., Tate, M., Lavin, D., Krishnakumar, A., Kok, H. M., Romero, J., Dunne, P., Bingham, V., Goldschmeding, R., Martin, F. & Brazil, D., 18 Jan 2017, In : American journal of physiology. Renal physiology.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
211 Downloads (Pure)

Recognition of Transmembrane Protein 39A as a Tumor-Specific Marker in Brain Tumor

Park, J., Lee, H., Tran, Q., Mun, K., Kim, D., Hong, Y., Kwon, S. H., Brazil, D., Park, J. & Kim, S-H., Jan 2017, In : Toxicological research. 33, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
238 Downloads (Pure)
2016

Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor

Hookham, M. B., Ali, I. H. A., O'Neill, C. L., Hackett, E., Lambe, M. H., Schmidt, T., Medina, R. J., Chamney, S., Rao, B., McLoone, E., Sweet, D., Stitt, A. W. & Brazil, D. P., 29 Nov 2016, In : Stem Cell Research & Therapy. 7, 173, 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
176 Downloads (Pure)

IRS proteins and diabetic complications

Lavin, D. P., White, M. F. & Brazil, D. P., Nov 2016, In : Diabetologia. 59, 11, p. 2280-2291 12 p.

Research output: Contribution to journalReview article

Open Access
File
26 Citations (Scopus)
230 Downloads (Pure)
2015

BMP signalling: agony and antagony in the family

Brazil, D. P., Church, R. H., Surae, S., Godson, C. & Martin, F., May 2015, In : Trends in Cell Biology. 25, 5, p. 249-264 16 p.

Research output: Contribution to journalLiterature review

Open Access
File
122 Citations (Scopus)
376 Downloads (Pure)

Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix

Robinson, E., Cassidy, R. S., Tate, M., Zhao, Y., Lockhart, S., Calderwood, D., Church, R., McGahon, M. K., Brazil, D. P., McDermott, B. J., Green, B. D. & Grieve, D. J., 01 Mar 2015, In : Basic Research in Cardiology. 110, 20, p. 20 15 p.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
238 Downloads (Pure)

Gremlin1 and chronic pancreatitis: a new clinical target and biomarker?

Brazil, D. P., Oct 2015, In : Journal of Molecular Medicine. 93, 10, p. 1057-60 4 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Gremlin1 preferentially binds to Bone Morphogenetic Protein-2 (BMP-2) and BMP-4 over BMP-7

Church, R. H., Krishnakumar, A., Urbanek, A., Geschwinder, S., Meneely, J., Bianchi, A., Basta, B., Monaghan, S., Elliott, C., Stromstedt, M., Ferguson, N., Martin, F. & Brazil, D. P., 15 Feb 2015, In : Biochemical Journal. 466, 1, p. 55-68 14 p.

Research output: Contribution to journalArticle

Open Access
File
46 Citations (Scopus)
1158 Downloads (Pure)

IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes

Santamaria, B., Marquez, E., Lay, A., Carew, R. M., Gonzalez-Rodriquez, A., Welsh, G. I., Ni, L., Hale, L. J., Ortiz, A., Saleem, M. A., Brazil, D. P., Coward, R. J. & Valverde, A. M., Dec 2015, In : Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1853, 12, p. 3224-34 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2014

Bone morphogenetic proteins and their antagonists: current and emerging clinical uses

Ali, I. H. A. & Brazil, D. P., Aug 2014, In : British Journal of Pharmacology. 171, 15, p. 3620-3632 13 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

β-Lapachone alleviates alcoholic fatty liver disease in rats

Shin, S., Park, J., Li, Y., Nam Min, K., Kong, G., Min Hur, G., Man Kim, J., Shong, M., Jung, M-S., Kook Park, J., Jeong, K-H., Gyu Park, M., Hwan Kwak, T. & Brazil, D., Feb 2014, In : Cellular Signalling. 26, 2, p. 295-305 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2013

Cardiomyopathy and Diastolic Dysfunction in the Embryo and Neonate of a Type 1 Diabetic Mouse Model

Corrigan, N., Treacy, A., Brazil, D. P. & McAuliffe, F. M., Jul 2013, In : Reproductive Sciences. 20, 7, p. 781-90 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Fetal and maternal leptin in pre-gestational diabetic pregnancy

Higgins, M. F., Russell, N. M., Brazil, D. P., Firth, R. G. & McAuliffe, F. M., Feb 2013, In : International journal of gynecology & obstetrics. 120, 2, p. 169-172 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy

Hookham, M. B., O'Donovan, H. C., Church, R. H., Mercier-Zuber, A., Luzi, L., Curran, S. P., Carew, R. M., Droguett, A., Mezzano, S., Schubert, M., White, M. F., Crean, J. K. & Brazil, D. P., Jul 2013, In : FEBS journal. 280, 14, p. 3232-3243 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage

Li, Y., Park, J., Piao, L., Kong, G., Kim, Y., Park, K. A., Zhang, T., Hong, J., Hur, G. M., Seok, J. H., Choi, S-W., Yoo, B. C., Hemmings, B. A., Brazil, D., Kim, S-H. & Park, J., Jan 2013, In : Cellular Signalling. 25, 1, p. 74–84 11 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
314 Downloads (Pure)

Under the right conditions: protecting podocytes from diabetes-induced damage

Ali, I. HA. & Brazil, D. P., 02 Oct 2013, In : Stem Cell Research & Therapy. 4, 5, 2 p., 119.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
165 Downloads (Pure)
2012

CCN2/CTGF increases expression of miR-302 micrornas, which target the TGFβ type II receptor with implications for nephropathic cell phenotypes

Faherty, N., Curran, S. P., O'Donovan, H., Martin, F., Godson, C., Brazil, D. P. & Crean, J. K., 01 Dec 2012, In : Journal of Cell Science. 125, 23, p. 5621-5629 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Connective tissue growth factor antagonizes transforming growth factor-β1/Smad signalling in renal mesangial cells

O'Donovan, H. C., Hickey, F., Brazil, D. P., Kavanagh, D. H., Oliver, N., Martin, F., Godson, C. & Crean, J., 01 Jan 2012, In : Biochemical Journal. 441, 1, p. 499-510 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Deletion of Gremlin1 increases cell proliferation and migration responses in mouse embryonic fibroblasts

Curran, S. P., Hickey, F. B., Watson, A., Godson, C. & Brazil, D. P., 01 Apr 2012, In : Cellular Signalling. 24, 4, p. 889-898 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Maternal and Fetal Placental Growth Hormone and IGF Axis in Type 1 Diabetic Pregnancy.

Higgins, M. F., Russell, N. E., Crossey, P. A., Nyhan, K. C., Brazil, D. P. & McAuliffe, F. M., 17 Feb 2012, In : PLoS ONE. 7, 2, 8 p., e29164.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
142 Downloads (Pure)

Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy

Brennan, E. P., Morine, M. J., Walsh, D. W., Roxburgh, S. A., Lindenmeyer, M. T., Brazil, D. P., Gaora, P. Ó., Roche, H. M., Sadlier, D. M., Cohen, C. D., Godson, C. & Martin, F., 01 Apr 2012, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1822, 4, p. 589-599 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2011

CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy

Rooney, B., O'Donovan, H., Gaffney, A., Browne, M., Faherty, N., Curran, S. P., Sadlier, D., Godson, C., Brazil, D. P. & Crean, J., 04 Feb 2011, In : FEBS Letters. 585, 3, p. 531-538 8 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Insulin receptor substrate 2 and FoxO3a signalling are involved in E-cadherin expression and transforming growth factor-β1-induced repression in kidney epithelial cells

Carew, R. M., Browne, M. B., Hickey, F. B. & Brazil, D. P., Sep 2011, In : The FEBS Journal. 278, 18, p. 3370-80 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Protein kinase B/Akt regulation in diabetic kidney disease

Heljic, M. & Brazil, D., Jan 2011, In : Frontiers in Biosciences. 3, p. 98-104 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2010

Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3 beta?

Carew, R. M., Sadagurski, M., Goldschmeding, R., Martin, F., White, M. F. & Brazil, D., 2010, In : BMC Developmental Biology. 10, p. 73 1 p., 73.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Extracellular BMP-antagonist regulation in development and disease: tied up in knots

Walsh, D. W., Godson, C., Brazil, D. & Martin, F., May 2010, In : Trends in Cell Biology. 20, 5, p. 244-256 13 p.

Research output: Contribution to journalArticle

160 Citations (Scopus)

High-Frequency Ultrasound Assessment of the Murine Heart From Embryo Through to Juvenile

Corrigan, N., Brazil, D. & Auliffe, F. M., Feb 2010, In : Reproductive sciences (Thousand Oaks, Calif.). 17, 2, p. 147-157 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells.

Nyhan, K. C., Faherty, N., Murray, G., Cooey, L. B., Godson, C., Crean, J. K. & Brazil, D. P., Dec 2010, In : Biochimica et biophysica acta. 1803, 12, p. 1386-1395 10 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2009

Allelic depletion of grem1 attenuates diabetic kidney disease.

Roxburgh, S. A., Kattla, J. J., Curran, S. P., O'Meara, Y. M., Pollock, C. A., Goldschemding, R., Godson, C., Martin, F. & Brazil, D. P., Jul 2009, In : Diabetes. 58, 7, p. 1641-1650 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Association of LETM1 and mrpl36 contributes to the regulation of mitochondrial ATP production and necrotic cell death

Piao, L., Li, Y., Kim, S. J., Byun, H. S., Huang, S. M., Hwang, S. K., Yang, K. J., Park, K. A., Won, M., Hong, J., Hur, G. M., Seok, J. H., Shong, M., Cho, M. H., Brazil, D. P., Hemmings, B. A. & Park, J., 15 Apr 2009, In : Cancer Research. 69, 8, p. 3397-3404 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Comparative analysis of dna methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines

Brennan, E., Ehrich, M., Brazil, D., Crean, J. K., Murphy, M., Sadlier, D. M., Martin, F., Godson, C., McKnight, A. J., Van Den Boom, D., Maxwell, A. & Savage, D. A., 01 Apr 2009, In : Epigenetics. 4, 3, p. 159-164 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif

Park, J., Feng, J., Li, Y., Hammarsten, O., Brazil, D. P. & Hemmings, B. A., 06 Mar 2009, In : Journal of Biological Chemistry. 284, 10, p. 6169-6174 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Fetal cardiac effects of maternal hyperglycemia during pregnancy

Corrigan, N., Brazil, D. P. & McAuliffe, F., 01 Jun 2009, In : Birth Defects Research Part A - Clinical and Molecular Teratology. 85, 6, p. 523-530 8 p.

Research output: Contribution to journalReview article

73 Citations (Scopus)

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein

Piao, L. Z., Li, Y., Yang, K. J., Park, K. A., Byun, H. S., Won, M., Hong, J., Kim, J. L., Kweon, G. R., Hur, G. M., Seok, J. H., Cho, J. Y., Chun, T., Hess, D., Sack, R., Maira, S. M., Brazil, D., Hemmings, B. A. & Park, J., 15 Jul 2009, In : BMC Cell Biology. 10, p. 53 1 p., 53.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis

Piao, L. Z., Li, Y. W., Kim, S. J., Sohn, K. C., Yang, K. J., Park, Y. A., Byun, H. S., Won, M. H., Hong, J. H., Hur, G. M., Seok, J. H., Shong, M. H., Sack, R., Brazil, D., Hemmings, B. A. & Park, J., May 2009, In : Cellular Signalling. 21, 5, p. 767-777 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase

Alvarez, Y., Astudillo, O., Jensen, L., Reynolds, A. L., Waghorne, N., Brazil, D., Cao, Y. H., O'Connor, J. J. & Kennedy, B. N., 17 Nov 2009, In : PLoS ONE. 4, 11, p. e7867 1 p., e7867.

Research output: Contribution to journalArticle

54 Citations (Scopus)

The Carboxy-Terminal Modulator Protein (CTMP) Regulates Mitochondrial Dynamics

Parcellier, A., Tintignac, L. A., Zhuravleva, E., Dummler, B., Brazil, D., Hynx, D., Cron, P., Schenk, S., Olivieri, V. & Hemmings, B. A., 07 May 2009, In : PLoS ONE. 4, 5, p. e5471 1 p., e5471.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2008

Co-regulation of Gremlin and Notch signalling in diabetic nephropathy

Walsh, D. W., Roxburgh, S. A., McGettigan, P., Berthier, C. C., Higgins, D. G., Kretzler, M., Cohen, C. D., Mezzano, S., Brazil, D. P. & Martin, F., Jan 2008, In : BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 1782, 1, p. 10-21 12 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Protein kinase B/Akt activity is involved in renal TGF-beta 1-driven epithelial-mesenchymal transition in vitro and in vivo

Kattla, J. J., Carew, R. M., Heljic, M., Godson, C. & Brazil, D. P., Jul 2008, In : AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 295, 1, p. F215-F225 11 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Regulation and consequences of differential gene expression in diabetic kidney disease

Murphy, M., Crean, J., Brazil, D., Saidlier, D., Martin, F. & Godson, C., Oct 2008, In : Biochemical society transactions. 36, 5, p. 941-945 5 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding

Yang, K. J., Shin, S., Piao, L., Shin, E., Li, Y. W., Park, K. A., Byun, H. S., Won, M. H., Hong, J. H., Kweon, G. R., Hur, G. M., Seok, J. H., Chun, T., Brazil, D., Hemmings, B. A. & Park, J., 18 Jan 2008, In : Journal of Biological Chemistry. 283, 3, p. 1480-1491 12 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2007

Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1 alpha and promotes cell viability

Barry, R. E., Allan, B. B., Cummins, E. P., Kattla, J. J., Giblin, A., Scally, N., Taylor, C. T. & Brazil, D., 27 Jul 2007, In : European Journal of Cell Biology. 86, 7, p. 393-403 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2006

Recapitulation of embryological programmes in renal fibrosis - The importance of epithelial cell plasticity and developmental genes

Roxburgh, S. A., Murphy, M., Pollock, C. A. & Brazil, D. P., 01 Jun 2006, In : Nephron - Physiology. 103, 3

Research output: Contribution to journalShort survey

34 Citations (Scopus)