Research output per year
Research output per year
- 1 - 50 out of 77 results
Search results
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2024
NOX4 NADPH oxidase signalling is a key determinant of angiogenic function of cord-blood endothelial colony-forming cells in hypoxia
Pun, S. H., O'Neill, K. M., Naderi-Meshkin, H., Malla, S., Botezatu, B., King, W., Dunne, P. D., Brazil, D. P., Watson, C. J. & Grieve, D. J., 26 Aug 2024, In: Medical Sciences Forum. 27, 1 (2), 1 p., 1.2.Research output: Contribution to journal › Meeting abstract › peer-review
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2023
GREM1 signaling in cancer: tumor promotor and suppressor?
Gao, Z., Houthuijzen, J. M., ten Dijke, P. & Brazil, D. P., 24 Aug 2023, (Early online date) In: Journal of Cell Communication and Signaling. 10 p.Research output: Contribution to journal › Comment/debate › peer-review
Open AccessFile3 Citations (Scopus)28 Downloads (Pure) -
Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis
Su, Y., Silva, J. D., Doherty, D., Simpson, D. A., Weiss, D. J., Rolandsson-Enes, S., McAuley, D. F., O'Kane, C. M., Brazil, D. P. & Krasnodembskaya, A. D., 24 Oct 2023, In: Thorax. 78, 6, p. 617-630 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)48 Downloads (Pure) -
PLAC8-mediated activation of NOX4 signalling restores angiogenic function of endothelial colony-forming cells in experimental hypoxia
Pun, S. H., O’Neill, K. M., Edgar, K. S., Gill, E. K., Moez, A., Naderi-Meshkin, H., Malla, S. B., Hookham, M. B., Alsaggaf, M., Madishetti, V. V., Botezatu, B., King, W., Brunssen, C., Morawietz, H., Dunne, P. D., Brazil, D. P., Medina, R. J., Watson, C. J. & Grieve, D. J., 06 Sept 2023, In: Cells. 12, 18, 19 p., 2220.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)66 Downloads (Pure) -
2022
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats
O'Hare, M., Esquiva, G., McGahon, M. K., Hombrebueno, J. M. R., Augustine, J., Canning, P., Edgar, K. S., Barabas, P., Friedel, T., Cincolà, P., Henry, J., Mayne, K., Ferrin, H., Stitt, A. W., Lyons, T. J., Brazil, D. P., Grieve, D. J., McGeown, J. G. & Curtis, T. M., 22 Sept 2022, In: JCI insight. 7, 18, 18 p., e155128.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)60 Downloads (Pure) -
Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids
Davis, J. L., Kennedy, C., Clerkin, S., Treacy, N. J., Dodd, T., Moss, C., Murphy, A., Brazil, D. P., Cagney, G., Brougham, D. F., Murad, R., Finlay, D., Vuori, K. & Crean, J., 27 Nov 2022, In: Communications Biology. 5, 16 p., 1301.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)27 Downloads (Pure) -
2021
Comparisons of α2-Adrenergic Agents, Medetomidine and Xylazine, with Pentobarbital for Anesthesia: Important Pitfalls in Diabetic and Nondiabetic Rats
Connell, A. R., Hookham, M. B., Fu, D., Brazil, D. P., Lyons, T. J. & Yu, J. Y., 29 Dec 2021, (Early online date) In: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)213 Downloads (Pure) -
Effects of modified lipoproteins on human trophoblast cells: a role in pre-eclampsia in pregnancies complicated by diabetes
McLeese, R. H., Zhao, J., Fu, D., Yu, J. Y., Brazil, D. P. & Lyons, T. J., 27 Jan 2021, In: BMJ open diabetes research & care. 9, 10 p., e001696.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)111 Downloads (Pure) -
The potential of albuminuria as a biomarker of diabetic complications
Raja, P., Maxwell, A. P. & Brazil, D. P., 01 Jun 2021, In: Cardiovascular Drugs and Therapy. 35, p. 455-466Research output: Contribution to journal › Review article › peer-review
Open AccessFile25 Citations (Scopus)90 Downloads (Pure) -
2020
Secreted BMP antagonists and their role in cancer and bone metastases
Todd, G. M., Gao, Z., Hyvönen, M., Brazil, D. P. & Ten Dijke, P., Aug 2020, In: Bone. 137, 115455.Research output: Contribution to journal › Review article › peer-review
20 Citations (Scopus) -
2019
CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
Ashraf, S., Bell, S., O'Leary, C., Canning, P., Micu, I., Fernandez, J. A., O'Hare, M., Barabas, P., McCauley, H., Brazil, D. P., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 21 Mar 2019, In: JCI insight. 4, 6, 18 p., e122442.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)390 Downloads (Pure) -
Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt
Dutton, L. R., Hoare, O. P., McCorry, A. M. B., Redmond, K. L., Adam, N. E., Canamara, S., Bingham, V., Mullan, P. B., Lawler, M., Dunne, P. D. & Brazil, D. P., 23 Jul 2019, In: Oncotarget. 10, 45, p. 4630-4639 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)238 Downloads (Pure) -
No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells
Dutton, L. R., O'Neill, C. L., Medina, R. J. & Brazil, D. P., 29 Nov 2019, In: The Journal of Biological Chemistry. 294, 48, p. 18041-18045 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)181 Downloads (Pure) -
The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic
O'Leary, O. E., Canning, P., Reid, E., Bertelli, P. M., McKeown, S., Brines, M., Cerami, A., Du, X., Xu, H., Chen, M., Dutton, L., Brazil, D. P., Medina, R. J. & Stitt, A. W., 01 May 2019, In: Experimental Eye Research. 182, p. 144-155 12 p.Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus) -
Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy
Hombrebueno, J. R., Cairns, L., Dutton, L. R., Lyons, T. J., Brazil, D. P., Moynagh, P., Curtis, T. M. & Xu, H., 29 Oct 2019, (Early online date) In: JCI insight. 4, 23, e129760.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)106 Downloads (Pure) -
2018
The roles of TRIO and F-actin-binding protein in glioblastoma cells
Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H., Park, S., Hong, S., Brazil, D. P., Kim, S. H. & Park, J., 01 Mar 2018, In: Molecular Medicine Reports. 17, 3, p. 4540-4546 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)254 Downloads (Pure) -
2017
Diabetic Nephropathy: a Tangled Web to Unweave
Magee, C., Grieve, D. J., Watson, C. J. & Brazil, D. P., 27 Sept 2017, (Early online date) In: Cardiovascular Drugs and Therapy. p. 1-14 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile159 Citations (Scopus)350 Downloads (Pure) -
Gremlin1 plays a key role in kidney development and renal fibrosis
Church, R. H., Ali, I., Tate, M., Lavin, D., Krishnakumar, A., Kok, H. M., Romero, J., Dunne, P., Bingham, V., Goldschmeding, R., Martin, F. & Brazil, D., 18 Jan 2017, In: American journal of physiology. Renal physiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile57 Citations (Scopus)310 Downloads (Pure) -
Recognition of Transmembrane Protein 39A as a Tumor-Specific Marker in Brain Tumor
Park, J., Lee, H., Tran, Q., Mun, K., Kim, D., Hong, Y., Kwon, S. H., Brazil, D., Park, J. & Kim, S.-H., Jan 2017, In: Toxicological research. 33, 1, p. 63-69 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)354 Downloads (Pure) -
2016
Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor
Hookham, M. B., Ali, I. H. A., O'Neill, C. L., Hackett, E., Lambe, M. H., Schmidt, T., Medina, R. J., Chamney, S., Rao, B., McLoone, E., Sweet, D., Stitt, A. W. & Brazil, D. P., 29 Nov 2016, (Early online date) In: Stem Cell Research & Therapy. 7, 173, 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)273 Downloads (Pure) -
IRS proteins and diabetic complications
Lavin, D. P., White, M. F. & Brazil, D. P., Nov 2016, In: Diabetologia. 59, 11, p. 2280-2291 12 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile79 Citations (Scopus)346 Downloads (Pure) -
2015
BMP signalling: agony and antagony in the family
Brazil, D. P., Church, R. H., Surae, S., Godson, C. & Martin, F., May 2015, In: Trends in Cell Biology. 25, 5, p. 249-264 16 p.Research output: Contribution to journal › Literature review › peer-review
Open AccessFile255 Citations (Scopus)1471 Downloads (Pure) -
Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix
Robinson, E., Cassidy, R. S., Tate, M., Zhao, Y., Lockhart, S., Calderwood, D., Church, R., McGahon, M. K., Brazil, D. P., McDermott, B. J., Green, B. D. & Grieve, D. J., 01 Mar 2015, In: Basic Research in Cardiology. 110, 20, 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile59 Citations (Scopus)332 Downloads (Pure) -
Gremlin1 and chronic pancreatitis: a new clinical target and biomarker?
Brazil, D. P., Oct 2015, In: Journal of Molecular Medicine. 93, 10, p. 1057-60 4 p.Research output: Contribution to journal › Comment/debate
5 Citations (Scopus) -
Gremlin1 preferentially binds to Bone Morphogenetic Protein-2 (BMP-2) and BMP-4 over BMP-7
Church, R. H., Krishnakumar, A., Urbanek, A., Geschwinder, S., Meneely, J., Bianchi, A., Basta, B., Monaghan, S., Elliott, C., Stromstedt, M., Ferguson, N., Martin, F. & Brazil, D. P., 15 Feb 2015, In: Biochemical Journal. 466, 1, p. 55-68 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile76 Citations (Scopus)2102 Downloads (Pure) -
IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes
Santamaria, B., Marquez, E., Lay, A., Carew, R. M., Gonzalez-Rodriquez, A., Welsh, G. I., Ni, L., Hale, L. J., Ortiz, A., Saleem, M. A., Brazil, D. P., Coward, R. J. & Valverde, A. M., Dec 2015, In: Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1853, 12, p. 3224-34 11 p.Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus) -
2014
Bone morphogenetic proteins and their antagonists: current and emerging clinical uses
Ali, I. H. A. & Brazil, D. P., Aug 2014, In: British Journal of Pharmacology. 171, 15, p. 3620-3632 13 p.Research output: Contribution to journal › Article › peer-review
94 Citations (Scopus) -
β-Lapachone alleviates alcoholic fatty liver disease in rats
Shin, S., Park, J., Li, Y., Nam Min, K., Kong, G., Min Hur, G., Man Kim, J., Shong, M., Jung, M.-S., Kook Park, J., Jeong, K.-H., Gyu Park, M., Hwan Kwak, T. & Brazil, D., Feb 2014, In: Cellular Signalling. 26, 2, p. 295-305 11 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
2013
Cardiomyopathy and diastolic dysfunction in the embryo and neonate of a Type 1 diabetic mouse model
Corrigan, N., Treacy, A., Brazil, D. P. & McAuliffe, F. M., Jul 2013, In: Reproductive Sciences. 20, 7, p. 781-790 10 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Fetal and maternal leptin in pre-gestational diabetic pregnancy
Higgins, M. F., Russell, N. M., Brazil, D. P., Firth, R. G. & McAuliffe, F. M., Feb 2013, In: International Journal of Gynecology & Obstetrics. 120, 2, p. 169-172 4 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy
Hookham, M. B., O'Donovan, H. C., Church, R. H., Mercier-Zuber, A., Luzi, L., Curran, S. P., Carew, R. M., Droguett, A., Mezzano, S., Schubert, M., White, M. F., Crean, J. K. & Brazil, D. P., Jul 2013, In: FEBS journal. 280, 14, p. 3232-3243 12 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage
Li, Y., Park, J., Piao, L., Kong, G., Kim, Y., Park, K. A., Zhang, T., Hong, J., Hur, G. M., Seok, J. H., Choi, S.-W., Yoo, B. C., Hemmings, B. A., Brazil, D., Kim, S.-H. & Park, J., Jan 2013, In: Cellular Signalling. 25, 1, p. 74–84 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)569 Downloads (Pure) -
Under the right conditions: protecting podocytes from diabetes-induced damage
Ali, I. H. & Brazil, D. P., 02 Oct 2013, In: Stem Cell Research & Therapy. 4, 5, 2 p., 119.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus)212 Downloads (Pure) -
2012
CCN2/CTGF increases expression of miR-302 micrornas, which target the TGFβ type II receptor with implications for nephropathic cell phenotypes
Faherty, N., Curran, S. P., O'Donovan, H., Martin, F., Godson, C., Brazil, D. P. & Crean, J. K., 01 Dec 2012, In: Journal of Cell Science. 125, 23, p. 5621-5629 9 p.Research output: Contribution to journal › Article › peer-review
Open Access48 Citations (Scopus) -
Connective tissue growth factor antagonizes transforming growth factor-β1/Smad signalling in renal mesangial cells
O'Donovan, H. C., Hickey, F., Brazil, D. P., Kavanagh, D. H., Oliver, N., Martin, F., Godson, C. & Crean, J., 01 Jan 2012, In: Biochemical Journal. 441, 1, p. 499-510 12 p.Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
Deletion of Gremlin1 increases cell proliferation and migration responses in mouse embryonic fibroblasts
Curran, S. P., Hickey, F. B., Watson, A., Godson, C. & Brazil, D. P., 01 Apr 2012, In: Cellular Signalling. 24, 4, p. 889-898 10 p.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy
Higgins, M. F., Russell, N. E., Crossey, P. A., Nyhan, K. C., Brazil, D. P. & McAuliffe, F. M., 17 Feb 2012, In: PLoS ONE. 7, 2, 8 p., e29164.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)212 Downloads (Pure) -
Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy
Brennan, E. P., Morine, M. J., Walsh, D. W., Roxburgh, S. A., Lindenmeyer, M. T., Brazil, D. P., Gaora, P. Ó., Roche, H. M., Sadlier, D. M., Cohen, C. D., Godson, C. & Martin, F., 01 Apr 2012, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1822, 4, p. 589-599 11 p.Research output: Contribution to journal › Article › peer-review
Open Access69 Citations (Scopus) -
2011
CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: implications for the pathogenesis of diabetic nephropathy
Rooney, B., O'Donovan, H., Gaffney, A., Browne, M., Faherty, N., Curran, S. P., Sadlier, D., Godson, C., Brazil, D. P. & Crean, J., 04 Feb 2011, In: FEBS Letters. 585, 3, p. 531-538 8 p.Research output: Contribution to journal › Article › peer-review
69 Citations (Scopus) -
Insulin receptor substrate 2 and FoxO3a signalling are involved in E-cadherin expression and transforming growth factor-β1-induced repression in kidney epithelial cells
Carew, R. M., Browne, M. B., Hickey, F. B. & Brazil, D. P., Sept 2011, In: The FEBS Journal. 278, 18, p. 3370-3380 11 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Citations (Scopus) -
Protein kinase B/Akt regulation in diabetic kidney disease
Heljic, M. & Brazil, D. P., Jan 2011, In: Frontiers in Biosciences. 3, 1, p. 98-104 7 p.Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
2010
Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3 beta?
Carew, R. M., Sadagurski, M., Goldschmeding, R., Martin, F., White, M. F. & Brazil, D., 2010, In: BMC Developmental Biology. 10, 8 p., 73.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)13 Downloads (Pure) -
DNA methylation profiling in cell models of diabetic nephropathy
Brennan, E. P., Ehrich, M., O'Donovan, H., Brazil, D., Crean, J. K., Murphy, M., Sadlier, D. M., Martin, F., Godson, C., Boom, D. V. D., Maxwell, A. P. & Savage, D. A., 01 Jul 2010, In: Epigenetics. 5, 5, p. 396-401 6 p.Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus)109 Downloads (Pure) -
Extracellular BMP-antagonist regulation in development and disease: tied up in knots
Walsh, D. W., Godson, C., Brazil, D. P. & Martin, F., May 2010, In: Trends in Cell Biology. 20, 5, p. 244-256 13 p.Research output: Contribution to journal › Article › peer-review
202 Citations (Scopus) -
High-Frequency Ultrasound Assessment of the Murine Heart From Embryo Through to Juvenile
Corrigan, N., Brazil, D. & Auliffe, F. M., Feb 2010, In: Reproductive sciences (Thousand Oaks, Calif.). 17, 2, p. 147-157 11 p.Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus) -
Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells
Nyhan, K. C., Faherty, N., Murray, G., Cooey, L. B., Godson, C., Crean, J. K. & Brazil, D. P., 01 Dec 2010, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1803, 12, p. 1386-1395 10 p.Research output: Contribution to journal › Article › peer-review
61 Citations (Scopus) -
2009
Allelic depletion of grem1 attenuates diabetic kidney disease
Roxburgh, S. A., Kattla, J. J., Curran, S. P., O'Meara, Y. M., Pollock, C. A., Goldschemding, R., Godson, C., Martin, F. & Brazil, D. P., 01 Jul 2009, In: Diabetes. 58, 7, p. 1641-1650 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile64 Citations (Scopus)16 Downloads (Pure) -
Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death
Piao, L., Li, Y., Kim, S. J., Byun, H. S., Huang, S. M., Hwang, S. K., Yang, K. J., Park, K. A., Won, M., Hong, J., Hur, G. M., Seok, J. H., Shong, M., Cho, M. H., Brazil, D. P., Hemmings, B. A. & Park, J., 15 Apr 2009, In: Cancer Research. 69, 8, p. 3397-3404 8 p.Research output: Contribution to journal › Article › peer-review
67 Citations (Scopus) -
Comparative analysis of dna methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines
Brennan, E., Ehrich, M., Brazil, D., Crean, J. K., Murphy, M., Sadlier, D. M., Martin, F., Godson, C., McKnight, A. J., Van Den Boom, D., Maxwell, A. & Savage, D. A., 01 Apr 2009, In: Epigenetics. 4, 3, p. 159-164 6 p.Research output: Contribution to journal › Article › peer-review
32 Citations (Scopus) -
DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif
Park, J., Feng, J., Li, Y., Hammarsten, O., Brazil, D. P. & Hemmings, B. A., 06 Mar 2009, In: Journal of Biological Chemistry. 284, 10, p. 6169-6174 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)14 Downloads (Pure)