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Desmond Archer

Prof

1980 …2015
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Research Output 1980 2015

2015
2 Citations (Scopus)

Abnormal Glycogen Storage by Retinal Neurons in Diabetes

Gardiner, T. A., Canning, P., Tipping, N., Archer, D. B. & Stitt, A. W., 01 Dec 2015, In : Investigative Opthalmology and Visual Science. 56, 13, p. 8008-18 11 p.

Research output: Contribution to journalArticle

Open Access
Retinal Neurons
Glycogen
Retina
Glycogen Synthase
Glycogen Phosphorylase
2011
8 Citations (Scopus)
Retinal Diseases
Cell- and Tissue-Based Therapy
Stem cells
Stem Cells
Safety
47 Citations (Scopus)

Vascular stem cells and ischaemic retinopathies

Stitt, A. W., O'Neill, C. L., O'Doherty, M. T., Archer, D. B., Gardiner, T. A. & Medina, R. J., May 2011, In : Progress in Retinal and Eye Research. 30, 3, p. 149-166 18 p.

Research output: Contribution to journalArticle

Blood Vessels
Stem Cells
Retina
Ischemia
Vitreoretinal Surgery
2009
39 Citations (Scopus)

Immunohistochemical study of pig retinal development

Guduric-Fuchs, J., Ringland, L. J., Gu, P., Dellett, M., Archer, D. B. & Cogliati, T., 2009, In : Molecular Vision. 15, p. 1915-28 14 p.

Research output: Contribution to journalArticle

Retina
Swine
Antibodies
Retinal Diseases
Rhodopsin
2007
98 Citations (Scopus)
Diabetic Retinopathy
Retina
Clinical Pathology
Diabetes Complications
Blindness
7 Citations (Scopus)

Functional anatomy, fine structure and basic pathology of the retinal vasculature.

Archer, D., Stitt, A. & Gardiner, T., 01 Jun 2007, Retinal Vascular Disease. Joussen, A., Gardner, T., Kirchhof, B. & Ryan, S. (eds.). Springer, p. 3-22 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2004
62 Citations (Scopus)

Chloroquine causes lysosomal dysfunction in neural retina and RPE: Implications for retinopathy

Mahon, G., Anderson, H., Gardiner, T., McFarlane, S., Archer, D. & Stitt, A., Apr 2004, In : Current eye research. 28, 4, p. 277-284 8 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Chloroquine
Retina
Retinal Neurons
Pharmaceutical Preparations
2003
20 Citations (Scopus)

Prevention of retinal capillary basement membrane thickening in diabetic dogs by a non-steroidal anti-inflammatory drug

Gardiner, T. A., Anderson, H. R., Degenhardt, T., Thorpe, S. R., Baynes, J. W., Archer, D. B. & Stitt, A. W., 01 Sep 2003, In : Diabetologia. 46, 9, p. 1269-1275 7 p.

Research output: Contribution to journalArticle

Basement Membrane
Anti-Inflammatory Agents
Sulindac
Dogs
Pharmaceutical Preparations
153 Citations (Scopus)

The role of advanced glycation end products in retinal microvascular leukostasis

Moore, T. C., Moore, J. E., Kaji, Y., Frizzell, N., Usui, T., Poulaki, V., Campbell, I. L., Stitt, A. W., Gardiner, T. A., Archer, D. B. & Adamis, A. P., 01 Oct 2003, In : Investigative Ophthalmology and Visual Science. 44, 10, p. 4457-4464 8 p.

Research output: Contribution to journalArticle

Leukostasis
Advanced Glycosylation End Products
Albumins
Blood-Retinal Barrier
Leukocytes
2002

Methodological Analyses and Selective Characterisation of the Neuroretinal Proteome

Brockbank, S., Archer, D. & Curry, J., Apr 2002, p. U1010-U1010. 1 p.

Research output: Contribution to conferencePaper

25 Citations (Scopus)

Retinal Pigment Epithelial Cell DNA is Damaged by Exposure to Benzo[a]pyrene, a Constituent of Cigarette Smoke.

Davies, J., Patton, W., Routledge, M. N., Chakravarthy, U., Jones, G. D., Lewis, S. & Archer, D., Apr 2002, In : Experimental Eye Research. 74, 4, p. 513-522 10 p.

Research output: Contribution to journalArticle

Retinal Pigments
Benzo(a)pyrene
Smoke
Tobacco Products
Epithelial Cells
2001
9 Citations (Scopus)

Nerve pathology in the type 1 diabetic dog: effects of treatment with sulindac

Walker, D., Siddique, I., Anderson, H., Gardiner, T. A., Archer, D. B., Boulton, A. J. M. & Malik, R. A., 01 Dec 2001, In : Journal of the peripheral nervous system : JPNS. 6, 4, p. 219-226 8 p.

Research output: Contribution to journalArticle

2000
114 Citations (Scopus)

Advanced glycation end products induce blood-retinal barrier dysfunction in normoglycemic rats

Stitt, A. W., Bhaduri, T., McMullen, C. B., Gardiner, T. A. & Archer, D. B., 01 Jun 2000, In : Molecular cell biology research communications : MCBRC. 3, 6, p. 380-388 9 p.

Research output: Contribution to journalArticle

Blood-Retinal Barrier
Advanced Glycosylation End Products
Vascular Endothelial Growth Factor A
Diabetic Retinopathy
Albumins
1999
63 Citations (Scopus)

Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia.

Simpson, D., Murphy, G. M., Bhaduri, T., Gardiner, T., Archer, D. & Stitt, A., 27 Aug 1999, In : Biochemical and Biophysical Research Communications. 262, 2, p. 333-340 8 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Genes
Proto-Oncogene Proteins c-sis
Vascular Endothelial Growth Factor C
1998
105 Citations (Scopus)

Advanced glycation end products in vitreous: Structural and functional implications for diabetic vitreopathy

Stitt, A., Moore, J. E., Sharkey, J. A., Murphy, G., Simpson, D., Bucala, R., Vlassara, H. & Archer, D., Dec 1998, In : Investigative Ophthalmology and Visual Science. 39, 13, p. 2517-2523 7 p.

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
Collagen
Glucose
Enzyme-Linked Immunosorbent Assay
Temazepam
85 Citations (Scopus)

Expression of vascular endothelial growth factor (VEGF) and its receptors is regulated in eyes with intra-ocular tumours

Stitt, A. W., Simpson, D. A., Boocock, C., Gardiner, T. A., Murphy, G. M. & Archer, D. B., 01 Nov 1998, In : Journal of Pathology. 186, 3, p. 306-312 7 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor
Vascular Endothelial Growth Factor A
Choroid
Retina
Neoplasms
111 Citations (Scopus)

Increased levels of advanced glycation endproducts in the lenses and blood vessels of cigarette smokers.

Nicholl, I. D., Stitt, A. W., Moore, J. E., Ritchie, A. J., Archer, D. B. & Bucala, R., Sep 1998, In : Molecular medicine. 4(9), 9, p. 594-601 8 p.

Research output: Contribution to journalArticle

Tobacco Products
Lenses
Blood Vessels
Coronary Vessels
Fluorescence
32 Citations (Scopus)

The 67-kd laminin receptor is preferentially expressed by proliferating retinal vessels in a murine model of ischemic retinopathy.

Stitt, A. W., McKenna, D., Simpson, D., Gardiner, T. A., Harriott, P., Archer, D. B. & Nelson, J., May 1998, In : American Journal of Pathology. 152(5), 5, p. 1359-1365 7 p.

Research output: Contribution to journalArticle

Laminin Receptors
Retinal Vessels
Hyperoxia
Retina
Retinal Ganglion Cells
1997
49 Citations (Scopus)

Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats

Stitt, A. W., Li, Y. M., Gardiner, T. A., Bucala, R., Archer, D. B. & Vlassara, H., 01 Feb 1997, In : The American journal of pathology. 150, 2, p. 523-531 9 p.

Research output: Contribution to journalArticle

Pericytes
Advanced Glycosylation End Products
Basement Membrane
Smooth Muscle Myocytes
Retinal Vessels
1996
47 Citations (Scopus)

Endothelin-like immunoreactivity and receptor binding in the choroid and retina

Stitt, A. W., Chakravarthy, U., Gardiner, T. A. & Archer, D. B., 01 Jan 1996, In : Current eye research. 15, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

Retinal Vessels
Choroid
Endothelins
Retina
Immunohistochemistry
1995
30 Citations (Scopus)
Diabetic Retinopathy
Basement Membrane
Retina
Arteries
Nerve Fibers
67 Citations (Scopus)
8 Citations (Scopus)

Histological and ultrastructural investigation of retinal microaneurysm development in diabetic patients

Stitt, A. W., Gardiner, T. A. & Archer, D. B., 01 Apr 1995, In : British Journal of Ophthalmology. 79, 4, p. 362-367 6 p.

Research output: Contribution to journalArticle

Pericytes
Erythrocytes
Diabetic Retinopathy
Trypsin
Microaneurysm
23 Citations (Scopus)
Retinal Vessels
Endocytosis
Glycosylation
Endothelial Cells
Glucose
7 Citations (Scopus)
18 Citations (Scopus)
Light Coagulation
Retinal Pigments
Retina
Choroid
Bruch Membrane
17 Citations (Scopus)

Retinal vascular endothelial cell endocytosis increases in early diabetes.

Gardiner, T. A., Stitt, A. W. & Archer, D. B., 01 Apr 1995, In : Laboratory investigation. 72, 4, p. 439-444 6 p.

Research output: Contribution to journalArticle

Retinal Vessels
Endocytosis
Endothelial Cells
Horseradish Peroxidase
Streptozocin
56 Citations (Scopus)

Ionizing radiation and the retina

Archer, D. B. & Gardiner, T. A., 01 Jun 1994, In : Current Opinion in Ophthalmology. 5, 3, p. 59-65 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Receptor-mediated endocytosis and intracellular trafficking of insulin and low-density lipoprotein by retinal vascular endothelial cells

Stitt, A., Anderson, H., Gardiner, T. A., Bailie, J. R. & Archer, D. B., 01 Aug 1994, In : Investigative ophthalmology & visual science. 35, 9, p. 3384-3392 9 p.

Research output: Contribution to journalArticle

Retinal Vessels
Endocytosis
LDL Lipoproteins
Endothelial Cells
Gold
50 Citations (Scopus)

Selective loss of vascular smooth muscle cells in the retinal microcirculation of diabetic dogs

Gardiner, T. A., Stitt, A., Anderson, H. & Archer, D. B., 01 Jan 1994, In : British Journal of Ophthalmology. 78, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

Microcirculation
Vascular Smooth Muscle
Smooth Muscle Myocytes
Pericytes
Arterioles
5 Citations (Scopus)

Stereological estimation of Weibel-Palade bodies in the retinal vasculature of normal and diabetic dogs

Anderson, H. R., Stitt, A. W., Gardiner, T. A. & Archer, D. B., Sep 1994, In : Current eye research. 13, 9, p. 705-10 6 p.

Research output: Contribution to journalArticle

Weibel-Palade Bodies
Endothelium
Dogs
Retinal Artery
Retinal Vein
13 Citations (Scopus)

The combined effects of diabetes and ionising radiation on the rat retina: an ultrastructural study

Stitt, A., Anderson, H., Gardiner, T. A., McIntyre, I. & Archer, D. B., 01 Jan 1994, In : Current eye research. 13, 1, p. 79-86 8 p.

Research output: Contribution to journalArticle

1993
25 Citations (Scopus)

Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique

Anderson, H., Stitt, A. W., Gardiner, T. A., Lloyd, S. J. & Archer, D. B., 01 Jul 1993, In : Laboratory animals. 27, 3, p. 281-285 5 p.

Research output: Contribution to journalArticle

alloxan
Alloxan
Experimental Diabetes Mellitus
streptozotocin
islets of Langerhans
15 Citations (Scopus)

The combined effect of diabetes and ionising radiation on the retinal vasculature of the rat

Gardiner, T. A., Amoaku, W. M. & Archer, D. B., 01 Nov 1993, In : Current eye research. 12, 11, p. 1009-1014 6 p.

Research output: Contribution to journalArticle

235 Citations (Scopus)

Treatment of age-related subfoveal neovascular membranes by teletherapy: a pilot study

Chakravarthy, U., Houston, R. F. & Archer, D. B., May 1993, In : British Journal of Ophthalmology. 77, 5, p. 265-273 9 p.

Research output: Contribution to journalArticle

Membranes
Macular Degeneration
Radiation
Therapeutics
Visual Acuity
63 Citations (Scopus)

Ultrastructural findings in solar retinopathy

Hope-Ross, M. W., Mahon, G. J., Gardiner, T. A. & Archer, D. B., 1993, In : Eye. 7 ( Pt 1), Pt 1, p. 29-33 5 p.

Research output: Contribution to journalArticle

1992
22 Citations (Scopus)
96 Citations (Scopus)

The effect of endothelin 1 on the retinal microvascular pericyte

Chakravarthy, U., Gardiner, T. A., Anderson, P., Archer, D. B. & Trimble, E. R., 01 May 1992, In : Microvascular Research. 43, 3, p. 241-254 14 p.

Research output: Contribution to journalArticle

1991
1 Citation (Scopus)

In vitro viability of choroidal melanomata following pre-enucleation irradiation

Chakravarthy, U., Frew, L., Gardiner, T. A. & Archer, D. B., 01 Sep 1991, In : International ophthalmology. 15, 5, p. 303-310 8 p.

Research output: Contribution to journalArticle

166 Citations (Scopus)

Radiation retinopathy--clinical, histopathological, ultrastructural and experimental correlations

Archer, D. B., Amoaku, W. M. & Gardiner, T. A., 1991, In : Eye. 5 ( Pt 2), Pt 2, p. 239-251 13 p.

Research output: Contribution to journalArticle

1989
59 Citations (Scopus)

A light microscopic and autoradiographic study of non-irradiated and irradiated ocular wounds

Chakravarthy, U., Gardiner, T. A., Archer, D. B. & Maguire, C. J., 01 Apr 1989, In : Current eye research. 8, 4, p. 337-348 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Early ultrastructural changes after low-dose X-irradiation in the retina of the rat

Amoaku, W. M., Frew, L., Mahon, G. J., Gardiner, T. A. & Archer, D. B., 1989, In : Eye. 3 ( Pt 5), Pt 5, p. 638-646 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Focal irradiation of perforating eye injuries

Chakravarthy, U., Biggart, J. H., Gardiner, T. A., Archer, D. B. & Maguire, C. J., 01 Dec 1989, In : Current eye research. 8, 12, p. 1241-1250 10 p.

Research output: Contribution to journalArticle

Eye Injuries
Cell Proliferation
Wounds and Injuries
Radiation
Rabbits
1988
2 Citations (Scopus)

Retinal ultrastructural findings in cone degeneration

Buchanan, T. A., Gardiner, T. A., Jesus, V. D., Eustace, P. & Archer, D. B., 15 Oct 1988, In : American Journal of Ophthalmology. 106, 4, p. 405-413 9 p.

Research output: Contribution to journalArticle

1987
12 Citations (Scopus)

An experimental study of quinine blindness

Buchanan, T. A., Lyness, R. W., Collins, A. D., Gardiner, T. A. & Archer, D. B., 1987, In : Eye. 1 ( Pt 4), Pt 4, p. 522-524 3 p.

Research output: Contribution to journalArticle

Post-photocoagulation retinitis

Archer, D. B. & Gardiner, T. A., 1987, In : Bulletin de la Societe belge d'ophtalmologie. 224, p. 43-49 7 p.

Research output: Contribution to journalArticle

1986
8 Citations (Scopus)

Does unidirectional vesicular transport occur in retinal vessels?

Gardiner, T. A. & Archer, D. B., 01 Apr 1986, In : British Journal of Ophthalmology. 70, 4, p. 249-254 6 p.

Research output: Contribution to journalArticle