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Research Interests

Dr. Small is a Medical Research Foundation (MRF) research fellow and a principle investigator with a focus on the role of anti-proteases in immunoregulation, particularly in the development and progression of respiratory-associated cancers, such as malignant pleural mesothelioma (MPM). More specifically, this research intends to elucidate how anti-proteases may be involved in CD4+ T helper Th17 cell and regulatory T-cell (Treg) responses in MPM.

Fingerprint Dive into the research topics where Donna Small is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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cathepsin S Medicine & Life Sciences
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Secretory Leukocyte Peptidase Inhibitor Medicine & Life Sciences
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Neoplasms Medicine & Life Sciences
Adult Respiratory Distress Syndrome Medicine & Life Sciences

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Research Output 2009 2019

4 Citations (Scopus)

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo

Harris, A. J., Mirchandani, A. S., Lynch, R. W., Delaney, L., Small, D., Coelho, P., Watts, E. R., Sadiku, P., Griffith, D., Dickinson, R. S., Clark, E., Willson, J. A., Morrison, T., Mazzone, M., Carmeliet, P., Ghesquiere, B., O'Kane, C., McAuley, D., Jenkins, S. J., Whyte, M. K. B. & 1 others, Walmsley, S. R., 08 Mar 2019, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticle

Acute Lung Injury
Adult Respiratory Distress Syndrome
1 Citation (Scopus)

Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease

Small, D. M., Brown, R. R., Doherty, D. F., Abladey, A., Zhou- Suckow, Z., Delaney, R. J., Kerrigan, L., Dougan, C. M., Borensztajn, K. S., Holsinger, L., Booth, R., Scott, C. J., Lopez Campos, G., Elborn, J. S., Mall, M. A., Weldon, S. & Taggart, C. C., 28 Mar 2019, In : European Respiratory Journal. 53, 3, 1801523.

Research output: Contribution to journalArticle

cathepsin S
Cystic Fibrosis
Lung Diseases
Epithelial Sodium Channels
4 Citations (Scopus)
130 Downloads (Pure)
Open Access
Klebsiella Infections
Klebsiella pneumoniae
Microbial Viability
4 Citations (Scopus)
14 Downloads (Pure)
Open Access
1 Citation (Scopus)
89 Downloads (Pure)

Characterisation of eppin function: expression and activity in the lung

Scott, A., Glasgow, A., Small, D., Carlile, S., McCrudden, M., McLean, D., Brown, R., Doherty, D., Lundy, F., Hamid, U., O'Kane, C., McAuley, D., Brodlie, M., Tunney, M., Elborn, J., Irwin, C., Timson, D., Taggart, C. & Weldon, S., 13 Jul 2017, In : European Respiratory Journal. 50, 1, 1601937.

Research output: Contribution to journalArticle

Open Access
Myeloid Cells
Chemokine CXCL2
Serine Proteinase Inhibitors
Neutrophil Infiltration


Medical Research Foundation Fellowship

Donna Small (Recipient), 2016

Prize: Fellowship awarded competitively