• Room 02.013 - CCRCB

    United Kingdom

Accepting PhD Students

20092019

Research output per year

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Research Output

2019

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo

Harris, A. J., Mirchandani, A. S., Lynch, R. W., Delaney, L., Small, D., Coelho, P., Watts, E. R., Sadiku, P., Griffith, D., Dickinson, R. S., Clark, E., Willson, J. A., Morrison, T., Mazzone, M., Carmeliet, P., Ghesquiere, B., O'Kane, C., McAuley, D., Jenkins, S. J., Whyte, M. K. B. & 1 others, Walmsley, S. R., 08 Mar 2019, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
14 Downloads (Pure)

Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease

Small, D. M., Brown, R. R., Doherty, D. F., Abladey, A., Zhou- Suckow, Z., Delaney, R. J., Kerrigan, L., Dougan, C. M., Borensztajn, K. S., Holsinger, L., Booth, R., Scott, C. J., Lopez Campos, G., Elborn, J. S., Mall, M. A., Weldon, S. & Taggart, C. C., 28 Mar 2019, In : European Respiratory Journal. 53, 3, 1801523.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2018
Open Access
File
6 Citations (Scopus)
216 Downloads (Pure)
4 Citations (Scopus)
59 Downloads (Pure)
2017

Characterisation of eppin function: expression and activity in the lung

Scott, A., Glasgow, A., Small, D., Carlile, S., McCrudden, M., McLean, D., Brown, R., Doherty, D., Lundy, F., Hamid, U., O'Kane, C., McAuley, D., Brodlie, M., Tunney, M., Elborn, J., Irwin, C., Timson, D., Taggart, C. & Weldon, S., 13 Jul 2017, In : European Respiratory Journal. 50, 1, 1601937.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
128 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
235 Downloads (Pure)

The Role of Whey Acidic Protein Four-Disulfide-Core Proteins in Respiratory Health and Disease

Small, D. M., Doherty, D. F., Dougan, C. M., Weldon, S. & Taggart, C. C., 01 Apr 2017, In : Biological Chemistry. 398, 3, p. 425-440

Research output: Contribution to journalReview article

Open Access
File
2 Citations (Scopus)
338 Downloads (Pure)
2016

A Secretory Leukocyte Protease Inhibitor Variant with Improved Activity against Lung Infection

Camper, N., Glasgow, A. M. A., Osbourn, M., Quinn, D. J., Small, D. M., McLean, D. T., Lundy, F. T., Elborn, J. S., McNally, P., Ingram, R. J., Weldon, S. & Taggart, C. C., May 2016, In : Mucosal immunology. 9, 3, p. 669-676

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
263 Downloads (Pure)
Open Access
File
21 Citations (Scopus)
283 Downloads (Pure)
2015

A Functional Variant of Elafin With Improved Anti-inflammatory Activity for Pulmonary Inflammation

Small, D. M., Zani, M. L., Quinn, D. J., Dallet-Choisy, S., Glasgow, A. MA., O'Kane, C., Mcauley, D. F., Mcnally, P., Weldon, S., Moreau, T. & Taggart, C. C., 2015, In : Molecular therapy : the journal of the American Society of Gene Therapy. 23, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
121 Downloads (Pure)

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung

Glasgow, A. M. A., Small, D. M., Scott, A., McLean, D. T., Camper, N., Hamid, U., Hegarty, S., Parekh, D., O'Kane, C., Lundy, F. T., McNally, P., Elborn, J. S., McAuley, D. F., Weldon, S. & Taggart, C. C., May 2015, In : Thorax. 70, 5, p. 426-32

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
172 Downloads (Pure)

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

Wilkinson, R., Magorrian, S., Williams, R., Young, A., Small, D., Scott, C. & Burden, R., 22 Aug 2015, In : Oncotarget. p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
204 Downloads (Pure)

Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation

Spence, S., Greene, M. K., Fay, F., Hams, E., Saunders, S. P., Hamid, U., Fitzgerald, M., Beck, J., Bains, B. K., Smyth, P., Themistou, E., Small, D. M., Schmid, D., O'Kane, C. M., Fitzgerald, D. C., Abdelghany, S. M., Johnston, J. A., Fallon, P. G., Burrows, J. F., McAuley, D. F. & 2 others, Kissenpfennig, A. & Scott, C. J., 02 Sep 2015, In : Science Translational Medicine. 7, 303, 12 p., 140.

Research output: Contribution to journalArticle

Open Access
File
50 Citations (Scopus)
740 Downloads (Pure)
2014

Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine

Schmid, D., Fay, F., Small, D. M., Jaworski, J., Riley, J. S., Tegazzini, D., Fenning, C., Jones, D. S., Johnston, P. G., Longley, D. B. & Scott, C. J., Dec 2014, In : Molecular therapy : the journal of the American Society of Gene Therapy. 22, 12, p. 2083-2092 10 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
304 Downloads (Pure)
Open Access
File
24 Citations (Scopus)
219 Downloads (Pure)
2013

Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

Research output: Contribution to journalArticle

Open Access
File
51 Citations (Scopus)
304 Downloads (Pure)
2011

Conatumumab (AMG 655) coated nanoparticles for targeted pro-apoptotic drug delivery

Fay, F., McLaughlin, K. M., Small, D. M., Fennell, D. A., Johnston, P. G., Longley, D. B. & Scott, C. J., Nov 2011, In : Biomaterials. 32, 33, p. 8645-8653 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
21 Citations (Scopus)
2010

Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF

Ward, C., Kuehn, D., Burden, R. E., Gormley, J. A., Jaquin, T. J., Gazdoiu, M., Small, D., Bicknell, R., Johnston, J. A., Scott, C. J. & Olwill, S. A., 2010, In : PLoS ONE. 5, 9, 8 p., e12543.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2009

Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis

Burden, R. E., Gormley, J. A., Jaquin, T. J., Small, D., Quinn, D. J., Hegarty, S., Ward, C., Walker, B., Johnston, J. A., Olwill, S. A. & Scott, C. J., 01 Oct 2009, In : Clinical Cancer Research. 15, 19, p. 6042-6051 10 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)