• Room 02.061 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

If you are interested in learning more about current research projects in the field epigenetics and working on my group, please do not hesitate to contact me: E.Kostareli@qub.ac.uk.

20082019

Research output per year

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Personal profile

Research Statement

I am a molecular biologist & geneticist specialized in epigenetics in cancer & leukaemia. I have been actively researching Chronic Lymphocytic Leukaemia as a fellow of Propondis Foundation with a focus on intraclonal diversity and immunogenetics. My research path includes work at the field of tumor immunology (T regulatory cells in melanoma and antitumor responses) as a Onassis fellow at German Cancer Research Center (DKFZ). Over the past years I have developed strong expertise and interest in the field of Epigenetics including DNA methylation & histone modifications research projects. As a research fellow at Heidelberg University and DKFZ I have investigated epigenetics mechanisms of HPV-related head neck squamous cell carcinomas and I have identified a novel epigenetic signature which can serve as a robust biomarker for patient stratification and treatment de-escallation.

Since 2018 I joined Queen’s University Belfast (School of Medicine, Dentistry and Biomedical Sciences - The Wellcome-Wolfson Institute for Experimental Medicine) where I lead a research group on Epigenetics with a focus on Leukaemia and Lymphocytes biology.

Research Interests

Understanding the molecular mechanisms underlying treatment failure in chronic diseases such as leukaemia is an essential biological question with important clinical impact. In the last years, we have performed high throughput characterization of the enhancer landscape in Chronic Lymphocytic Leukaemia upon BTK inhibitory treatment aiming at shedding lights into treatment resistance mechanisms beyond the well-described mutations. Next, our lab research mission is to:

  1. investigate the role of key enhancers and transcription factors as major modulators of the transcriptional landscape in malignant B-cells and other immune cells  
  2. defining the molecular and epigenomic feature of normal vs. malignant B -cell of diverse maturation status in the presence of 1st and 2nd generation targeted therapeutic agents 
  3. investigate the role of epigenomics and  BTK signalling in autoimmune disease

Teaching

MED1012: Personal and Professional Development Portfolio

MED 2018: Personal and Professional Development Portfolio

SCM8097-SCM8134: Immunity in Health and Disease (MSc Experimental Medicine) 

SCM8108: Applied Genomics (MSc Bioinformatics and Computational Genomics)

BMS3104: Molecular Markers of Disease

BMS3112: The Research Project Module (Biomedical Sciences) (supervision)

SCM8146-Research Project and Dissertation (Msc Experimental Medicine) (supervision)

Other

EDUCATIONAL RESEARCH INTERESTS

  • The Sandwich Principle and Active Learning 
  • Transferable skills for biomedical/medical students and scientists
  • Flip-the-classroom with e-learning platforms
  • Personal Response systems in the virtual classroom
  • Social media and research-informed teaching

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Research Output

Advances in Epigenetics and Epigenomics in Chronic Lymphocytic Leukemia

Xanthopoulos, C. & Kostareli, E., 27 Nov 2019, In : Epigenetics and Epigenomics .

Research output: Contribution to journalArticle

Open Access
File
  • 36 Downloads (Pure)

    Ibrutinib treatment alters enhancer activity patterns in Chronic Lymphocytic Leukemia

    Lambe, A., Papakonstantinou, N., Gounari, M., Stamatopoulos, K. & Kostareli, E., Jun 2019, In : HemaSphere. 3, Suppl 1, p. 508

    Research output: Contribution to journalMeeting abstract

    Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients

    Kostareli, E., Hielscher, T., Zucknick, M., Baboci, L., Wichmann, G., Holzinger, D., Mücke, O., Pawlita, M., Del Mistro, A., Boscolo-Rizzo, P., Da Mosto, M. C., Tirelli, G., Plinkert, P., Dietz, A., Plass, C., Weichenhan, D. & Hess, J., 19 Jan 2016, In : Epigenetics. 11, 1, p. 61-73

    Research output: Contribution to journalArticle

  • 11 Citations (Scopus)

    An entity evolving into a community: defining the common ancestor and evolutionary trajectory of chronic lymphocytic leukemia stereotyped subset #4

    Sutton, L-A., Papadopoulos, G., Hadzidimitriou, A., Papadopoulos, S., Kostareli, E., Rosenquist, R., Tzovaras, D. & Stamatopoulos, K., 02 Apr 2015, In : Molecular medicine. 20, p. 720-8 9 p.

    Research output: Contribution to journalArticle

  • 3 Citations (Scopus)

    HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas

    Kostareli, E., Holzinger, D., Bogatyrova, O., Hielscher, T., Wichmann, G., Keck, M., Lahrmann, B., Grabe, N., Flechtenmacher, C., Schmidt, C. R., Seiwert, T., Dyckhoff, G., Dietz, A., Höfler, D., Pawlita, M., Benner, A., Bosch, F. X., Plinkert, P., Plass, C., Weichenhan, D. & 1 others, Hess, J., Jun 2013, In : The Journal of clinical investigation. 123, 6, p. 2488-501 14 p.

    Research output: Contribution to journalArticle

  • 72 Citations (Scopus)

    Prizes

    Top Abstract Award (Plenary Session) at the Annual Scientific BSH Meeting

    Kostareli, Effie (Recipient), 01 Apr 2019

    Prize: Prize (including medals and awards)

  • Activities

    • 2 Membership of network
    • 1 Participation in conference
    • 1 Invited talk

    COST action CA18127- International Nucleome Consortium (External organisation)

    Effie Kostareli (Contributor)

    01 Mar 2020 → …

    Activity: Membership typesMembership of network

    59th Annual Scientific Meeting - British Society for Haematology

    Effie Kostareli (Meta-reviewer)

    01 Feb 201903 Apr 2019

    Activity: Participating in or organising an event typesParticipation in conference

    Epigenetics and targeted therapies in Chronic Lymphocytic Leukaemia

    Effie Kostareli (Invited speaker)

    02 May 2019

    Activity: Talk or presentation typesInvited talk

    British Society for Haematology (External organisation)

    Effie Kostareli (Member)

    Feb 2019 → …

    Activity: Membership typesMembership of network