Projects per year
Personal profile
Research Focus
Living with diabetes has been made easier with insulin pumps and medications. However, the risk of developing complications remains high, and a diagnosis of diabetic retinopathy, the most common diabetic complication can be scary and confusing.
Over the years, Dr Beli have made contributions into our understanding of the pathobiology of retinopathy by examining the role of inflammatory and progenitors cells. But most importantly, she has investigated the impact of diabetes on many daily oscillatory parameters, from microbiome rhythms, immune cell trafficking and retina's gene expression and found that intermittent fasting may be a good intervention to prevent diabetic retinopathy. In 2017 she was awarded the Advanced Postdoctoral Fellowship from JDRF and the JDRF transition award to start her independent work on how having diabetes impacts the circadian system.
The current goal of the Beli laboratory is mainly the understanding of how circadian disruption impacts diabetic retinopathy. We are focused in two main areas: 1) to undertsand how diabetes affects the retina pathways governing our circadian system and the individual cellular clock components of the retina and 2) to understand the impact of such disruption in the progression of diabetic retinopathy, using genetic, physiological and molecular approaches.
Our short-term goal is to increase awareness of a dysfunctional circadian system in diabetes and provide evidence for its impact on the progression of the disease.
Ultimately our long-term goal is to design interventions that will harsen modifiable environmental signals and behavioral patterns to protect from progression of diabetic retinopthy. Understanding the impact of diabetes on the rhythmic functions in the retina would also allow to design therapies targeting the circadian clock, chronotherapies and noninvasive lifestyle interventions for diabetic retinopathy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- RE Ophthalmology
- Diabetic retinopathy
- circadian disruption
- retina
- pathogenesis
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Collaborations and top research areas from the last five years
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R2121CEM: Understanding the role of the vascular clock in diabetic retinopathy
Beli, E. (PI)
19/04/2024 → …
Project: Research
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R2098CEM: Linking circadian disruption and diabetic eye disease
Beli, E. (PI)
14/02/2024 → …
Project: Research
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R2896CEM: Microglia circadian disruption in pathogenesis of diabetic retinopathy
Beli, E. (PI) & Chen, M. (CoI)
09/06/2022 → …
Project: Research
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R2847CEM: The impact of misaligned daily light cycles on the progression of diabetic retinopathy
Beli, E. (PI)
22/02/2022 → 30/09/2023
Project: Research
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R8466CEM: Novel Insights on the Link between Diabetic Retinopathy and the Splenic Clock
Beli, E. (PI)
28/10/2019 → 31/07/2021
Project: Research
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Loss of Diurnal Oscillatory Rhythms in Gut Microbiota Correlates with Changes in Circulating Metabolites in Type 2 Diabetic db/db Mice
Beli, E., Prabakaran , S., Krishnan, P., Evans-Molina, C. & Grant, M. B., 29 Sept 2019, In: Nutrients. 11, 10, 19 p., 2310.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Citations (Scopus)149 Downloads (Pure) -
Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction
Duan, Y., Beli, E., Li Calzi, S., Quigley, J. L., Miller, R. C., Moldovan, L., Feng, D., Salazar, T. E., Hazra, S., Al-Sabah, J., Chalam, K. V., Phuong Trinh, T. L., Meroueh, M., Markel, T. A., Murray, M. C., Vyas, R. J., Boulton, M. E., Parsons-Wingerter, P., Oudit, G. Y. & Obukhov, A. G. & 1 others, , 15 Jul 2018, (Early online date) In: Stem Cells. 36, 9, p. 1430-1440 11 p.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice
Beli, E., Yan, Y., Moldovan, L., Vieira, C. P., Gao, R., Duan, Y., Prasad, R., Bhatwadekar, A., White, F. A., Townsend, S. D., Chan, L., Ryan, C. N., Morton, D., Moldovan, E. G., Chu, F.-I., Oudit, G. Y., Derendorf, H., Adorini, L., Wang, X. X. & Evans-Molina, C. & 7 others, , 22 Aug 2018, In: Diabetes. 67, 9, p. 1867-1879 13 p.Research output: Contribution to journal › Article › peer-review
262 Citations (Scopus) -
Bone Marrow-Derived Cell Recruitment to the Neurosensory Retina and Retinal Pigment Epithelial Cell Layer Following Subthreshold Retinal Phototherapy
Caballero, S., Kent, D. L., Sengupta, N., Li Calzi, S., Shaw, L., Beli, E., Moldovan, L., Dominguez, J. M., Moorthy, R. S. & Grant, M. B., 01 Oct 2017, In: Investigative ophthalmology & visual science. 58, 12, p. 5164-5176 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)37 Downloads (Pure) -
The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor
Hammer, S. S., Beli, E., Kady, N., Wang, Q., Wood, K., Lydic, T. A., Malek, G., Saban, D. R., Wang, X. X., Hazra, S., Levi, M., Busik, J. V. & Grant, M. B., 11 Jul 2017, (Early online date) In: EBioMedicine. 22, p. 181-190 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Citations (Scopus)52 Downloads (Pure)
Datasets
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Dataset for "Reshaping lipid metabolism with long-term alternate day feeding in type 2 diabetes mice "
Beli, E. (Creator), Queen's University Belfast, 10 Oct 2024
DOI: 10.17034/47fc2b9e-becd-4dee-861d-f4425f8660b4
Dataset
File
Prizes
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JDRF Advanced Postdoctoral Fellowship
Beli, E. (Recipient), 01 Mar 2017
Prize: Fellowship awarded competitively
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American Diabetes Association Young Investigator Award
Beli, E. (Recipient), 2017
Prize: Prize (including medals and awards)
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Chronobiology Training School SRBR Travel Award
Beli, E. (Recipient), 2019
Prize: Prize (including medals and awards)
Activities
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WVUK Annual Meeting 2023
Beli, E. (Participant)
12 Dec 2024Activity: Participating in or organising an event types › Participation in conference
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The impact of misalignment with the external light cycle on diabetic retinopathy
Beli, E. (Speaker)
31 May 2024Activity: Talk or presentation types › Oral presentation
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Balmoral Show 2024
Beli, E. (Participant), Lengyel, I. (Participant) & Peto, T. (Participant)
18 May 2024Activity: Participating in or organising an event types › Participation in Festival/Exhibition
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Northern Ireland Science Festival 2024- BiomedXperience@WWIEM
Beli, E. (Organiser) & Simpson, D. (Organiser)
29 Feb 2024Activity: Participating in or organising an event types › Participation in Festival/Exhibition
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The impact of misalignment with the external light cycle on diabetic retinopathy
Beli, E. (Presenter)
12 Dec 2023Activity: Talk or presentation types › Oral presentation