Elizabeth Trimble

Professor

  • Room 03.027 - Clinical Science B

    United Kingdom

19932015
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Research Output 1993 2015

1993

BASAL AND NITRIC OXIDE-MEDIATED CGMP LEVELS IN RETINAL PERICYTES CULTURED IN CONDITIONS OF ELEVATED GLUCOSE

McGinty, A., Anderson, P. & Trimble, E., 1993, In : Diabetologia. 36, p. A12-A12 1 p.

Research output: Contribution to journalArticle

1994
26 Citations (Scopus)

Altered endothelin-1 induced contraction and second messenger generation in bovine retinal microvascular pericytes cultured in high glucose medium.

Chakravarthy, U., McGinty, A., McKillop, J., Anderson, P., Archer, D. B. & Trimble, E., 1994, In : Diabetologia. 37, p. 36-42 7 p.

Research output: Contribution to journalArticle

Pericytes
Second Messenger Systems
Endothelin-1
Glucose
Inositol

ENDOTHELIN-1-INDUCED CALCIUM TRANSIENTS IN PERICYTES - THE EFFECT OF CULTURE IN HIGH AMBIENT GLUCOSE

McGinty, A., Anderson, P. & Trimble, E., 1994, In : Diabetologia. 37, p. A208-A208 1 p.

Research output: Contribution to journalArticle

1995

ENDOTHELIN-1 ACTIVATED L-TYPE CALCIUM-CHANNEL ACTIVITY IS COMPROMISED FOLLOWING CULTURE OF RETINAL PERICYTES IN ELEVATED GLUCOSE-CONCENTRATIONS

Trimble, E., McGinty, A. & Anderson, P., 1995, In : Diabetologia. 38, p. A265-A265 1 p.

Research output: Contribution to journalArticle

1997
37 Citations (Scopus)

Susceptibility of VLDL to oxidation in patients on regular haemodialysis

McEneny, J., Loughrey, C. M., McNamee, P. T., Trimble, E. & Young, I., 1997, In : Atherosclerosis. 129, p. 215-220 6 p.

Research output: Contribution to journalArticle

Renal Dialysis
Foam Cells
Lipid Peroxides
Dyslipidemias
Chronic Kidney Failure

VLDL composition and susceptibility to oxidation in haemodialysis patients

McEneny, J., Loughrey, C. M., McNamee, P., Trimble, E. & Young, I., 1997, In : Atherosclerosis. 128, p. 9-9 1 p.

Research output: Contribution to journalArticle

1998
14 Citations (Scopus)
VLDL Lipoproteins
Ultracentrifugation
Copper
Oxidation
Atherosclerosis
84 Citations (Scopus)

Glucose-induced oxidative stress in vascular contractile cells - Comparison of aortic smooth muscle cells and retinal pericytes

Sharpe, D., Liu, W., Yue, A., McMaster, B., Catherwood, J., McGinty, A. & Trimble, E., 1998, In : Diabetes. 47, 5, p. 801-809 9 p.

Research output: Contribution to journalArticle

Pericytes
Smooth Muscle Myocytes
Blood Vessels
Oxidative Stress
Vascular Smooth Muscle
1999

Composition and oxidation potential of very low density lipoprotein subfractions in type 2 diabetes

McEneny, J., O'Kane, M. J., Moles, K. W., McMaster, B., McMaster, D., Mercer, C., Trimble, E. & Young, I., 1999, In : Diabetologia. 42, p. A285-A285 1 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Effect of glucose on endothelin-1-induced calcium transients in cultured bovine retinal pericytes

McGinty, A., Scholfield, N., Liu, W., Anderson, P., Hoey, E. & Trimble, E., 03 Sep 1999, In : Journal of Biological Chemistry. 274, 36, p. 25250-25253 4 p.

Research output: Contribution to journalArticle

Pericytes
Endothelin-1
Calcium
Glucose
Endothelins

VLDL subfractions (A-D) in type 2 diabetes: Their susceptibility to oxidation and lipid composition

McEneny, J., O'Kane, M. M. J., McMaster, B., McMaster, D., Mercer, C., Trimble, E. & Young, I., 1999, In : Atherosclerosis. 144, p. 125-125 1 p.

Research output: Contribution to journalArticle

2000
110 Citations (Scopus)

Chemotaxis and oxidative stress in vascular smooth muscle: Effects of long chain fatty acids and glucose.

Hamilton, J. S., McMaster, D., Mercer, C., Allen, W. & Trimble, E., 2000, In : Diabetologia. 43, p. A3-A3 1 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Effect of genotype on changes in intelligence quotient after dietary relaxation in phenylketonuria and hyperphenylalaninaemia

Greeves, L. G., Patterson, C., Carson, D., Thom, R., Wolfenden, M. C., Zschocke, J., Graham, C., Nevin, N. & Trimble, E., 2000, In : Archives of Disease in Childhood. 82, 3, p. 216-221 6 p.

Research output: Contribution to journalArticle

Phenylketonurias
Intelligence
Genotype
Diet
Population

Effects of glucose and fatty acids on antioxidant defences and function in porcine vascular smooth muscle cells (VSMC) in vitro

Hamilton, J. S., McMaster, D., Mercer, C., Silversides, J., Conlon, N., Allen, W. & Trimble, E., 2000, In : Diabetes. 49, p. A138-A138 1 p.

Research output: Contribution to journalArticle

Effects of glucose on redox sensitive transcription factors in vascular smooth muscle cells.

Powell, L., Anderson, P., Catherwood, M. A. & Trimble, E., 2000, In : Diabetologia. 43, p. A74-A74 1 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

The lactulose-mannitol intestinal permeability test: a useful test for adult coeliac disease

Johnston, S., Smye, M., Watson, R., McMillan, S. & Trimble, E., 2000, In : Annals of Clinical Biochemistry. 37, 4, p. 512 - 519 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Vascular smooth muscle cell and macrophage chemotaxis: Modulation by glucose

Allen, W., Campbell, M., McCorry, A. & Trimble, E., 2000, In : Diabetologia. 43, p. A69-A69 1 p.

Research output: Contribution to journalArticle

2001
17 Citations (Scopus)

Effects of glucose and alpha-lipoic acid on glutathione levels, DNA damage and apoptotic proteins in smooth muscle cells.

Nally, S. M., Powell, L., Allen, W. & Trimble, E., 2001, In : Diabetologia. 44, p. A21-A21 1 p.

Research output: Contribution to journalArticle

Effects of glucose and fatty acids on free radical-induced damage in vascular smooth muscle cells.

Powell, L., Hamilton, J. S., McMaster, D. & Trimble, E., 2001, In : Diabetologia. 44, p. A21-A21 1 p.

Research output: Contribution to journalArticle

Glucose-potentiated vascular smooth muscle cell chemotaxis is mediated by phospholnositide-3-kinase-p110 beta

Allen, W., Sawyer, C., Campbell, M., Vanhaesebroeck, B. & Trimble, E., 2001, In : Diabetologia. 44, p. A22-A22 1 p.

Research output: Contribution to journalArticle

Glucose-potentiated vascular smooth muscle cell chemotaxis to fetal calf serum is mediated by PI3Kinase and MAPKinase

Trimble, E., Campbell, M. & Allen, W., 2001, In : Diabetes. 50, p. A168-A168 1 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Platelet derived growth Factor-B induced chemotaxis in vascular smooth muscle cells: Glucose potentiation

Campbell, M., Trimble, E. & Allen, W., 2001, In : Diabetologia. 44, p. A22-A22 1 p.

Research output: Contribution to journalArticle

High glucose mediates vascular smooth muscle cell survival through the activation of protein kinase B and extracellular regulated kinase 1/2.

Nally, S. M. J., Powell, L., Allen, W. & Trimble, E., Sep 2002, In : Diabetologia. 45, p. A375-A375 1 p.

Research output: Contribution to journalArticle

Pathway interactions and transcription factors involved in PDGF-beta receptor upregulation in raised glucose conditions.

Campbell, M., Powell, L., Allen, W. & Trimble, E., Sep 2002, In : Diabetologia. 45, p. A374-A375 2 p.

Research output: Contribution to journalArticle

The involvement of PI3K and MAPK in regulation of PDGF-beta receptor number by glucose

Campbell, M., Powell, L., Trimble, E. & Allen, W., 2002, In : Diabetes. 51, p. A503-A503 1 p.

Research output: Contribution to journalArticle

2003
30 Citations (Scopus)

Diabetes-induced activation of protein kinase C inhibits store-operated Ca2+ uptake in rat retinal microvascular smooth muscle.

Curtis, T., Major, E. H., Trimble, E. & Scholfield, N., 01 Sep 2003, In : Diabetologia. 46(9), 9, p. 1252-1259 8 p.

Research output: Contribution to journalArticle

Protein Kinase C
Smooth Muscle
Microvessels
Staurosporine
Arterioles

The effect of high glucose and cyclic stress on pathways dependent on extracellular-regulated kinase (ERK) activation in vascular smooth muscle cells.

Malcolmson, J., Campbell, M., Trimble, E. & Allen, W., Aug 2003, In : Diabetologia. 46, p. A387-A387 1 p.

Research output: Contribution to journalArticle

The effects of a 'Mediterranean' diet versus a 'Northern European' diet on glucose-treated vascular endothelial cells

Powell, L., McGuire, G. M., Jewhurst, V. & Trimble, E., Sep 2004, In : Diabetologia. 47, p. A24-A25 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Oleic acid reduces monocyte adhesion to activated glucose-treated human endothelial cells

Powell, L., Flood, A., Jewhurst, V., Owens, D., Tomkin, G. H. & Trimble, E., 2005, In : Diabetologia. 48, p. A403-A403 1 p.

Research output: Contribution to journalArticle

2006

Integration of local and central laboratory functions in a worldwide multicentre study: Experience from Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

Nesbitt, G. S., Smye, M., Sheridan, B., Lappin, T. & Trimble, E., 2006, In : Clin Trials. 3(4), p. 397-407 11 p.

Research output: Contribution to journalArticle

2007
25 Citations (Scopus)

Glucose-potentiated vascular smooth muscle cell (VSMC) migration to angiotensin II is modulated through PKC beta II-dependent protein phosphatase (PP) 2A activation

Campbell, M., Mussen, J., Powell, L. & Trimble, E., Sep 2007, In : Diabetologia. 50, p. S481-S481 1 p.

Research output: Contribution to journalArticle

Linoleic acid increases TNF-alpha-induced monocyte adhesion to human aortic endothelial cells via Cox-2 and PKC

Matesanz, N., Jewhurst, V., Powell, L. & Trimble, E., Sep 2007, In : Diabetologia. 50, p. S479-S480 2 p.

Research output: Contribution to journalArticle

2008
9 Citations (Scopus)

Glucose lowers the threshold for human aortic vascular smooth muscle cell migration: inhibition by protein phosphatase-2A

Campbell, M., Anderson, P. & Trimble, E. R., Jun 2008, In : Diabetologia. 51, 6, p. 1068-1080 13 p.

Research output: Contribution to journalArticle

Cell Migration Inhibition
Protein Phosphatase 2
Vascular Smooth Muscle
Smooth Muscle Myocytes
Chemotaxis
2010
64 Citations (Scopus)

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: preeclampsia

Yogev, Y., Chen, R., Hod, M., Coustan, D. R., Oats, J. J. N., Metzger, B. E., Lowe, L. P., Dyer, A. R., Trimble, E. & McCance, D., 01 Mar 2010, In : American Journal of Obstetrics and Gynecology. 202, 3

Research output: Contribution to journalArticle

Pregnancy Outcome
Pre-Eclampsia
C-Peptide
Hyperglycemia
Fasting
2012
10 Citations (Scopus)
9 Downloads (Pure)

Linoleic acid increases monocyte chemotaxis and adhesion to human aortic endothelial cells through protein kinase C- and cyclooxygenase-2-dependent mechanisms

Matesanz, N., Jewhurst, V., Trimble, E., McGinty, A., Owens, D., Tomkin, G. H. & Powell, L., Jun 2012, In : The Journal of nutritional biochemistry. 23, 6, p. 685-690 6 p.

Research output: Contribution to journalArticle

Endothelial cells
Linoleic Acid
Chemotaxis
Cyclooxygenase 2
Protein Kinase C
10 Citations (Scopus)
358 Downloads (Pure)

Restoration of adipose function in obese, glucose-tolerant men following pioglitazone treatment is associated with CCAAT enhancer-binding protein β upregulation

McGinty, A., Powell, L., Crowe, P., Kankara, C., McPeake, J., McCance, D., Young, I. & Trimble, E., Aug 2012, In : Clinical Science. 123, 3, p. 135–146 12 p.

Research output: Contribution to journalArticle

Open Access
File
pioglitazone
CCAAT-Enhancer-Binding Proteins
Up-Regulation
Macrophages
Monocytes
2015
5 Citations (Scopus)

Retinopathy in type 1 diabetes mellitus: Major differences between rural and urban dwellers in northwest Ethiopia

Alemu, S., Dessie, A., Tsegaw, A., Patterson, C. C., Parry, E. H. O., Phillips, D. I. W. & Trimble, E. R., Jul 2015, In : Diabetes Research and Clinical Practice. 109, 1, p. 191–198 8 p.

Research output: Contribution to journalArticle

Ethiopia
Type 1 Diabetes Mellitus
Hypertension
Cataract
Life Style