Projects per year
Personal profile
Research Interests
METABOLIC REPROGRAMMING: OPPORTUNITIES FOR THERAPEUTIC INTERVENTION
Cancer cells frequently hijack the metabolic processes hardwired in normal cells to support their enhanced growth, proliferation and spread. Importantly, changes in tumour cell metabolism can present novel vulnerabilities, that when targeted pharmacologically can limit tumour growth; and also alter the sensitivity of these tumour cells to standard-of-care chemotherapies and targeted therapies. Thus, defining the impact of metabolic reprogramming on dictating therapeutic susceptibilities and driving resistance mechanisms is imperative to improving treatment response for cancer patients.
Our aim is to integrate state-of-the-art cancer models, metabolic analyses and multi-omics platforms to comprehensively map metabolic reprogramming, uncover induced vulnerabilities, mechanisms of drug resistance and novel therapeutic opportunities in defined cancer subtypes (KRASmutant, TP53mutant/null, APCmutant/null), allowing us to better aid in patient stratification, and suggesting novel therapeutic combinations to improve patient outcome.
Achievements
Dr Kerr is a CRUK Career Development Fellowship holder
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Projects
- 3 Active
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R1589CNR: Dissecting the role of macrophage-derived cysteine cathepsin S in lung adenocarcinoma
Small, D. (PI), Kerr, E. (CoI), Scott, C. (CoI) & Williams, R. (CoI)
06/12/2021 → …
Project: Research
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R2652CNR: High Parameter Flow Cytometry in Health and Disease - Full application
Small, D. (PI), Buckley, N. (CoI), Fitzgerald, D. (CoI), Guzman de la Fuente, A. (CoI), Ingram, B. (CoI), Kerr, E. (CoI) & Longley, D. (CoI)
28/10/2019 → …
Project: Research
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R1049CNR: The cell death regulator FLIP: evaluation of novel inhibitors in colorectal cancer
Longley, D. (PI), Dunne, P. (CoI), Harrison, T. (CoI), Kerr, E. (CoI) & McDade, S. (CoI)
29/03/2019 → …
Project: Research
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Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer
Malla, S. B., Byrne, R. M., Lafarge, M. W., Corry, S. M., Fisher, N. C., Tsantoulis, P. K., Mills, M. L., Ridgway, R. A., Lannagan, T. R. M., Najumudeen, A. K., Gilroy, K. L., Amirkhah, R., Maguire, S. L., Mulholland, E. J., Belnoue-Davis, H. L., Grassi, E., Viviani, M., Rogan, E., Redmond, K. L. & Sakhnevych, S. & 23 others, , 01 Jun 2024, In: Nature Genetics. 56, 6, 1 p., 1321.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)19 Downloads (Pure) -
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer
Malla, S. B., Byrne, R. M., Lafarge, M. W., Corry, S. M., Fisher, N. C., Tsantoulis, P. K., Mills, M. L., Ridgway, R. A., Lannagan, T. R. M., Najumudeen, A. K., Gilroy, K. L., Amirkhah, R., Maguire, S. L., Mulholland, E. J., Belnoue-Davis, H. L., Grassi, E., Viviani, M., Rogan, E., Redmond, K. L. & Sakhnevych, S. & 23 others, , Mar 2024, In: Nature Genetics. 56, 3, p. 458-472 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)35 Downloads (Pure) -
Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
Flanagan, D. J., Amirkhah, R., Vincent, D. F., Gunduz, N., Gentaz, P., Cammareri, P., McCooey, A. J., McCorry, A. M. B., Fisher, N. C., Davis, H. L., Ridgway, R. A., Lohuis, J., Leach, J. D. G., Jackstadt, R., Gilroy, K., Mariella, E., Nixon, C., Clark, W., Hedley, A. & Markert, E. K. & 19 others, , 31 Jan 2023, In: Nature Communications. 14, p. 522Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment
Egan, H., Treacy, O., Lynch, K., Leonard, N. A., O'Malley, G., Reidy, E., O'Neill, A., Corry, S. M., De Veirman, K., Vanderkerken, K., Egan, L. J., Ritter, T., Hogan, A. M., Redmond, K., Peng, L., Che, J., Gatlin, W., Jayaraman, P., Sheehan, M. & Canney, A. & 5 others, , 10 May 2023, (Early online date) In: Cell Reports. 26 p., 112475.Research output: Contribution to journal › Article › peer-review
Open Access27 Citations (Scopus) -
Activation of innate-adaptive immune machinery by Poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer
Corry, S. M., McCorry, A. M., Lannagan, T. R. M., Leonard, N. A., Fisher, N. C., Byrne, R. M., Tsantoulis, P., Cortes-Lavaud, X., Amirkhah, R., Redmond, K. L., McCooey, A. J., Malla, S. B., Rogan, E., Sakhnevych, S., Gillespie, M., White, M., Richman, S., Jackstadt, R., Campbell, C. A. & Maguire, S. & 13 others, , 07 Nov 2022, In: Gut. 71, 12, p. 2502–2517 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)122 Downloads (Pure)
Prizes
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2021 NYAS *Rising Star* in Cancer Metabolism
Kerr, E. (Recipient), 27 Jan 2021
Prize: Prize (including medals and awards)
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CRUK Career Development Fellowship
Kerr, E. (Recipient), 01 Jun 2018
Prize: Fellowship awarded competitively
Activities
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Experimental Cancer Medicine Centres (ECMC), Junior Investigator Network (JING) - Training the Next Generation of Cancer Research Leaders - Leicester, UK
Kerr, E. (Member of scientific committee)
05 Feb 2023 → 07 Feb 2023Activity: Participating in or organising an event types › Participation in conference
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Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer
Kerr, E. (Invited speaker)
24 Oct 2022Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Business Beats Cancer Belfast - invited speaker
Kerr, E. (Invited speaker)
05 Oct 2022Activity: Talk or presentation types › Invited talk
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Experimental Cancer Medicine Centres (ECMC), Junior Investigator Network (JING) - Training the Next Generation of Cancer Research Leaders - Sheffield, UK
Kerr, E. (Member of scientific committee)
08 May 2022 → 10 May 2022Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Guest Speaker at CRUK Legenderry Event
Kerr, E. (Invited speaker)
08 May 2022Activity: Talk or presentation types › Invited talk
Press/Media
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The Undertones Mickey Bradley joins cancer-fighting scientist Dr Emma Kerr to support Race for Life
15/09/2020
1 item of Media coverage
Press/Media: Public Engagement Activities
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CRUK CDF funding announcement linked to Stand Up to Cancer
22/10/2018 → 26/10/2018
4 items of Media coverage
Press/Media: Public Engagement Activities
Thesis
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Characterisation of an acetylation-dependent FLIP/Ku70 complex that regulates FLIP expression
Kerr, E. M. (Author), Longley, D. (Supervisor), Jul 2012Student thesis: Doctoral Thesis › Doctor of Philosophy
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