Photo of Emma Kerr
  • Room 03.007 - CCRCB

    United Kingdom

Accepting PhD Students

20122019
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Personal profile

Research Interests

METABOLIC REPROGRAMMING: OPPORTUNITIES FOR THERAPEUTIC INTERVENTION

Cancer cells frequently hijack the metabolic processes hardwired in normal cells to support their enhanced growth, proliferation and spread. Importantly, changes in tumour cell metabolism can present novel vulnerabilities, that when targeted pharmacologically can limit tumour growth; and also alter the sensitivity of these tumour cells to standard-of-care chemotherapies and targeted therapies. Thus, defining the impact of metabolic reprogramming on dictating therapeutic susceptibilities and driving resistance mechanisms is imperative to improving treatment response for cancer patients.

Our aim is to integrate state-of-the-art cancer models, metabolic analyses and multi-omics platforms to comprehensively map metabolic reprogramming, uncover induced vulnerabilities, mechanisms of drug resistance and novel therapeutic opportunities in defined cancer subtypes (KRASmutantTP53mutant/nullAPCmutant/null), allowing us to better aid in patient stratification, and suggesting novel therapeutic combinations to improve patient outcome.

Achievements

Dr Kerr is a CRUK Career Development Fellowship holder

Fingerprint Dive into the research topics where Emma Kerr is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Projects 2019 2019

Research Output 2012 2018

1 Citation (Scopus)
15 Downloads (Pure)

Exploring the role of stromal osmoregulation in cancer and disease using executable modelling

Shorthouse, D., Reidel, A., Kerr, E., Pedro, L., Bihary, D., Samarajiwa, S., Martins, C., Shields, J. & Hall, B., 01 Aug 2018, In : Nature Communications. 9, 15 p., 3011.

Research output: Contribution to journalArticle

Open Access
File
Osmoregulation
cancer
Cells
Ions
Membranes
11 Citations (Scopus)

Metabolic rewiring in mutant Kras lung cancer

Kerr, E. M. & Martins, C. P., 01 Jun 2018, In : The FEBS Journal. 285, 1, p. 28-41 14 p.

Research output: Contribution to journalReview article

Rats
Tumors
Lung Neoplasms
Cells
Oncogenes
17 Citations (Scopus)

The ERBB network facilitates KRAS-driven lung tumorigenesis

Kruspig, B., Monteverde, T., Neidler, S., Hock, A., Kerr, E., Nixon, C., Clark, W., Hedley, A., Laing, S., Coffelt, S. B., Le Quesne, J., Dick, C., Vousden, K., Martins, C. P. & Murphy, D. J., 20 Jun 2018, In : Science Translational Medicine. 10, 446

Research output: Contribution to journalArticle

Carcinogenesis
Lung
Mitogen-Activated Protein Kinase Kinases
Receptor Protein-Tyrosine Kinases
Neoplasms
3 Citations (Scopus)
131 Downloads (Pure)

KRAS Allelic Imbalance Strengths and Weaknesses in Numbers

Doherty, G. J., Kerr, E. M. & Martins, C. P., 31 Mar 2017, In : Trends in molecular medicine. 23, 5, p. 377-378

Research output: Contribution to journalArticle

Open Access
File
Allelic Imbalance
Mitogen-Activated Protein Kinase Kinases
Leukemia
Neoplasms
Therapeutics
21 Citations (Scopus)
88 Downloads (Pure)

Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity

Turrell, F. K., Kerr, E. M., Gao, M., Thorpe, H., Doherty, G. J., Cridge, J., Shorthouse, D., Speed, A., Samarajiwa, S., Hall, B. A., Griffiths, M. & Martins, C. P., 08 Aug 2017, In : Genes & development. 31, 13, p. 1339-1353 15 p.

Research output: Contribution to journalArticle

Open Access
File
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Genotype
Lung
Mutation
Neoplasms

Prizes

CRUK Career Development Fellowship

Emma Kerr (Recipient), 01 Jun 2018

Prize: Fellowship awarded competitively

Drug Resistance
Colorectal Neoplasms

Activities 2018 2018

  • 3 Publication peer-review

Cell, Death & Disease (Journal)

Emma Kerr (Peer reviewer)
23 Jul 2018

Activity: Publication peer-review and editorial work typesPublication peer-review

Journal of Cellular and Molecular Medicine (Journal)

Emma Kerr (Peer reviewer)
18 Oct 2018

Activity: Publication peer-review and editorial work typesPublication peer-review

Journal of Cellular and Molecular Medicine (Journal)

Emma Kerr (Peer reviewer)
04 Sep 2018

Activity: Publication peer-review and editorial work typesPublication peer-review

Press / Media

CRUK CDF funding announcement linked to Stand Up to Cancer

Emma Kerr

22/10/201826/10/2018

4 items of Media coverage

Press/Media: Public Engagement Activities

Thesis

Characterisation of an acetylation-dependent FLIP/Ku70 complex that regulates FLIP expression

Author: Kerr, E. M., Jul 2012

Supervisor: Longley, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File