Photo of Emma Kerr
  • Room 03.007 - CCRCB

    United Kingdom

Accepting PhD Students

20122019

Research output per year

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Personal profile

Research Interests

METABOLIC REPROGRAMMING: OPPORTUNITIES FOR THERAPEUTIC INTERVENTION

Cancer cells frequently hijack the metabolic processes hardwired in normal cells to support their enhanced growth, proliferation and spread. Importantly, changes in tumour cell metabolism can present novel vulnerabilities, that when targeted pharmacologically can limit tumour growth; and also alter the sensitivity of these tumour cells to standard-of-care chemotherapies and targeted therapies. Thus, defining the impact of metabolic reprogramming on dictating therapeutic susceptibilities and driving resistance mechanisms is imperative to improving treatment response for cancer patients.

Our aim is to integrate state-of-the-art cancer models, metabolic analyses and multi-omics platforms to comprehensively map metabolic reprogramming, uncover induced vulnerabilities, mechanisms of drug resistance and novel therapeutic opportunities in defined cancer subtypes (KRASmutantTP53mutant/nullAPCmutant/null), allowing us to better aid in patient stratification, and suggesting novel therapeutic combinations to improve patient outcome.

Achievements

Dr Kerr is a CRUK Career Development Fellowship holder

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Projects

Research Output

Exploring the role of stromal osmoregulation in cancer and disease using executable modelling

Shorthouse, D., Reidel, A., Kerr, E., Pedro, L., Bihary, D., Samarajiwa, S., Martins, C., Shields, J. & Hall, B., 01 Aug 2018, In : Nature Communications. 9, 15 p., 3011.

Research output: Contribution to journalArticle

Open Access
File
  • 5 Citations (Scopus)
    22 Downloads (Pure)

    Metabolic rewiring in mutant Kras lung cancer

    Kerr, E. M. & Martins, C. P., 01 Jun 2018, In : The FEBS Journal. 285, 1, p. 28-41 14 p.

    Research output: Contribution to journalReview article

  • 15 Citations (Scopus)

    The ERBB network facilitates KRAS-driven lung tumorigenesis

    Kruspig, B., Monteverde, T., Neidler, S., Hock, A., Kerr, E., Nixon, C., Clark, W., Hedley, A., Laing, S., Coffelt, S. B., Le Quesne, J., Dick, C., Vousden, K., Martins, C. P. & Murphy, D. J., 20 Jun 2018, In : Science Translational Medicine. 10, 446

    Research output: Contribution to journalArticle

  • 20 Citations (Scopus)

    KRAS Allelic Imbalance Strengths and Weaknesses in Numbers

    Doherty, G. J., Kerr, E. M. & Martins, C. P., 31 Mar 2017, In : Trends in molecular medicine. 23, 5, p. 377-378

    Research output: Contribution to journalArticle

    Open Access
    File
  • 4 Citations (Scopus)
    174 Downloads (Pure)

    Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity

    Turrell, F. K., Kerr, E. M., Gao, M., Thorpe, H., Doherty, G. J., Cridge, J., Shorthouse, D., Speed, A., Samarajiwa, S., Hall, B. A., Griffiths, M. & Martins, C. P., 08 Aug 2017, In : Genes & development. 31, 13, p. 1339-1353 15 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 30 Citations (Scopus)
    134 Downloads (Pure)

    Prizes

    CRUK Career Development Fellowship

    Kerr, Emma (Recipient), 01 Jun 2018

    Prize: Fellowship awarded competitively

  • Activities

    • 3 Publication peer-review
    • 1 Participation in workshop, seminar, course

    Early Career Researchers Forum Inaugural

    Aidan Cole (Organiser), , Cristina Branco (Chair), , Seyed Mehdi Jafarnejad (Organiser), , Emma Allott (Organiser), , Stephen McMahon (Participant), , Karl Butterworth (Participant), , Emma Kerr (Participant), , Philip Dunne (Participant), , Adone Tielenius Kruythoff-Mohd Sarip (Participant), & Melissa LaBonte Wilson (Participant)

    25 Nov 2019

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

    Journal of Cellular and Molecular Medicine (Journal)

    Emma Kerr (Peer reviewer)

    04 Sep 2018

    Activity: Publication peer-review and editorial work typesPublication peer-review

    Cell, Death & Disease (Journal)

    Emma Kerr (Peer reviewer)

    23 Jul 2018

    Activity: Publication peer-review and editorial work typesPublication peer-review

    Journal of Cellular and Molecular Medicine (Journal)

    Emma Kerr (Peer reviewer)

    18 Oct 2018

    Activity: Publication peer-review and editorial work typesPublication peer-review

    Press / Media

    CRUK CDF funding announcement linked to Stand Up to Cancer

    Emma Kerr

    22/10/201826/10/2018

    4 items of Media coverage

    Press/Media: Public Engagement Activities

    Thesis

    Characterisation of an acetylation-dependent FLIP/Ku70 complex that regulates FLIP expression

    Author: Kerr, E. M., Jul 2012

    Supervisor: Longley, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File