Projects per year
Personal profile
Research Interests
METABOLIC REPROGRAMMING: OPPORTUNITIES FOR THERAPEUTIC INTERVENTION
Cancer cells frequently hijack the metabolic processes hardwired in normal cells to support their enhanced growth, proliferation and spread. Importantly, changes in tumour cell metabolism can present novel vulnerabilities, that when targeted pharmacologically can limit tumour growth; and also alter the sensitivity of these tumour cells to standard-of-care chemotherapies and targeted therapies. Thus, defining the impact of metabolic reprogramming on dictating therapeutic susceptibilities and driving resistance mechanisms is imperative to improving treatment response for cancer patients.
Our aim is to integrate state-of-the-art cancer models, metabolic analyses and multi-omics platforms to comprehensively map metabolic reprogramming, uncover induced vulnerabilities, mechanisms of drug resistance and novel therapeutic opportunities in defined cancer subtypes (KRASmutant, TP53mutant/null, APCmutant/null), allowing us to better aid in patient stratification, and suggesting novel therapeutic combinations to improve patient outcome.
Achievements
Dr Kerr is a CRUK Career Development Fellowship holder
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R1589CNR: Dissecting the role of macrophage-derived cysteine cathepsin S in lung adenocarcinoma
Small, D. (PI), Kerr, E. (CoI), Scott, C. (CoI) & Williams, R. (CoI)
06/12/2021 → …
Project: Research
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R1049CNR: The cell death regulator FLIP: evaluation of novel inhibitors in colorectal cancer
Longley, D. (PI), Dunne, P. (CoI), Harrison, T. (CoI), Kerr, E. (CoI) & McDade, S. (CoI)
29/03/2019 → …
Project: Research
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R2652CNR: High Parameter Flow Cytometry in Health and Disease - Full application
Small, D. (PI), Buckley, N. (CoI), Fitzgerald, D. (CoI), Guzman de la Fuente, A. (CoI), Ingram, B. (CoI), Kerr, E. (CoI) & Longley, D. (CoI)
28/10/2019 → 29/09/2025
Project: Research
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Mitochondrial metabolism determines chemotherapy sensitivity in colorectal cancer
Moss, D. Y., Brown, C. N., Shaw, A. M., McCann, C., Lewis, N., Downs, M., Wurelly, R., Cunningham, C., Philips, A., Doherty, N., Gallagher, S., McDaid, W. J., Roe, A., Coughlan, A. Y., Cavanagh, B., Ormsby, C., Falcone, F., McCole, R., Monteith, S. & Rogan, E. & 29 others, , 23 Jul 2026, (Early online date) In: Nature Metabolism. 36 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)10 Downloads (Pure) -
Identification of a novel GREMLIN1 uptake pathway in epithelial cells that requires BMP binding
Gao, Z., Gao, Y., Dutton, L. R., Suner, M. B., Todd, G., Gipson, G. R., Brown, C., Kerr, E. M., Daly, C., Plouffe, B., Dunne, P. D., Malinova, D. & Brazil, D. P., Nov 2025, In: Journal of Biological Chemistry. 301, 11, 17 p., 110780.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)43 Downloads (Pure) -
Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure
Roe, A., Dowling, C. M., D’Arcy, C., Alencar Rodrigues, D., Wang, Y., Hiller, M., Keogh, C., Hollinshead, K. E. R., Garre, M., Cavanagh, B., Wynne, K., Liu, T., Chen, Z., Kerr, E., McIlroy, M., H. M. Prehn, J., Schoen, I. & Chonghaile, T. N., 28 Jul 2025, In: Nature Communications. 16, 17 p., 6923.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Link opens in a new tab Citations (Scopus)5 Downloads (Pure) -
Mannose and PMI depletion overcomes radiation resistance in HPV-negative head and neck cancer
Wang, T., Brown, C., Doherty, N., Byrne, N. M., Islam, R., Doherty, M., Feng, J., Yin, C., Chambers, S., McQuoid, L., Mohamed-Smith, L., Butterworth, K. T., Kerr, E. M. & Coulter, J. A., 21 Apr 2025, In: Cell communication and signaling : CCS. 23, 20 p., 189.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)51 Downloads (Pure) -
Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer
Malla, S. B., Byrne, R. M., Lafarge, M. W., Corry, S. M., Fisher, N. C., Tsantoulis, P. K., Mills, M. L., Ridgway, R. A., Lannagan, T. R. M., Najumudeen, A. K., Gilroy, K. L., Amirkhah, R., Maguire, S. L., Mulholland, E. J., Belnoue-Davis, H. L., Grassi, E., Viviani, M., Rogan, E., Redmond, K. L. & Sakhnevych, S. & 23 others, , 01 Jun 2024, In: Nature Genetics. 56, 6, 1 p., 1321.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Link opens in a new tab Citations (Scopus)54 Downloads (Pure)
Prizes
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2021 NYAS *Rising Star* in Cancer Metabolism
Kerr, E. (Recipient), 27 Jan 2021
Prize: Prize (including medals and awards)
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CRUK Career Development Fellowship
Kerr, E. (Recipient), 01 Jun 2018
Prize: Fellowship awarded competitively
Activities
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Experimental Cancer Medicine Centres (ECMC), Junior Investigator Network (JING) - Training the Next Generation of Cancer Research Leaders - Leicester, UK
Kerr, E. (Member of scientific committee)
05 Feb 2023 → 07 Feb 2023Activity: Participating in or organising an event types › Participation in conference
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Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer
Kerr, E. (Invited speaker)
24 Oct 2022Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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Business Beats Cancer Belfast - invited speaker
Kerr, E. (Invited speaker)
05 Oct 2022Activity: Talk or presentation types › Invited talk
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Experimental Cancer Medicine Centres (ECMC), Junior Investigator Network (JING) - Training the Next Generation of Cancer Research Leaders - Sheffield, UK
Kerr, E. (Member of scientific committee)
08 May 2022 → 10 May 2022Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Guest Speaker at CRUK Legenderry Event
Kerr, E. (Invited speaker)
08 May 2022Activity: Talk or presentation types › Invited talk
Press/Media
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The Undertones Mickey Bradley joins cancer-fighting scientist Dr Emma Kerr to support Race for Life
15/09/2020
1 item of Media coverage
Press/Media: Public Engagement Activities
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CRUK CDF funding announcement linked to Stand Up to Cancer
22/10/2018 → 26/10/2018
4 items of Media coverage
Press/Media: Public Engagement Activities
Thesis
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Characterisation of an acetylation-dependent FLIP/Ku70 complex that regulates FLIP expression
Kerr, E. M. (Author), Longley, D. (Supervisor), Jul 2012Student thesis: Doctoral Thesis › Doctor of Philosophy
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