Projects per year
Personal profile
Particulars
Eneko Larrañeta is a Professor at Queen's University Belfast, specialising in drug delivery systems and biomaterials. He holds a BSc in Chemistry and a PhD in Physical Chemistry from the University of Navarra, where his research focused on self-assembled hydrogels. After completing his PhD in 2012, Prof. Larrañeta worked as a research fellow in nanotechnology for drug delivery before moving to Belfast in 2013 to develop microneedle technology for transdermal drug delivery at Queen's University.
Prof. Larrañeta's expertise includes hydrogels, nano/microparticles, and microneedle-based systems. Currently, he focuses on implantable systems for sustained drug release, using techniques such as melt processing and additive manufacturing. He has published over 100 papers in peer-reviewed journals, edited multiple books, and authored numerous book chapters. Prof. Larrañeta has secured funding from leading organisations and collaborated extensively with pharmaceutical and cosmetics companies.
In 2023, he was named a Clarivate Highly Cited Researcher, and since 2019, he has been recognised as a top 2% scientist in his field by Stanford University's analysis using Scopus data. He is a Fellow of the UK Higher Education Academy and a member of the Royal Society of Chemistry and the Society for Applied Microbiology.
Research Interests
Prof. Larrañeta research interests are centred on design and physicochemical characterisation of advanced implantabe drug delivery systems. These devices can be used for a wide variety of applications such as to replace a fraction of a biological structure or to provide a specific therapy.
It is estimated that between 5 and 6% of people in industrialized countries have experienced the implantation of a medical device for rebuilding some body functions. These devices can be manufactured containing drugs in their structures with diverse funcions such as prevent infection/inflamation or to provide a prolonged drug release. The latter application is particularly interesting, as long-acting and implantable drug delivery systems offer the possibility of providing localised and unattended therapy for a wide variety of conditions. These systems present multiple advantages over the conventional systems used for drug delivery and allow to reduce drug dosage while improving patient compliance. These features are particularly important for the treatment of chronic conditions. According to the World Health Organization, chronic conditions are the major cause of disabilities worldwide, and the burden of chronic diseases is increasing rapidly.
Prof. Larrañeta is currently working on the development of diverse types of drug eluting implantable devices. These devices are commonly made of polymeric materials. The properties of these materials can be tailored by altering the composition of these devices. In this way, drug release profiles can be tailored to the specific applications adapting to patient's needs. Finally, stateof-the-art techniques such as 3D printing can be applied for the development of implantable devices.
Teaching
PMY2203: Medicinal Substances
Prof. Larrañeta delivers the content related with Applied Pharmaceutical Analysis, Mass Spectrometry and Nuclear Magnetic resonance analysis during the first semester. Additionally, he covers Enzyme Kinetics, Pro-drugs and Beta-blockers during second semestre.
PMY2304: Pharmaceutical Analysis
Prof. Larrañeta delivers the content related with Applied Pharmaceutical Analysis, Mass Spectrometry and Nuclear Magnetic resonance analysis during the first semester.
PMY1024: Properties and analysis of drug molecules
Prof. Larrañeta delivers the content related with UV-visible, fluorescence, IR and Raman spectroscopies
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R6617PMY: Ocular Research By Integrated Training And Learning
Singh, T. R. R. (PI), Donnelly, R. (CoI) & Larrañeta, E. (CoI)
03/05/2019 → …
Project: Research
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R1040PMY: Nanoengineered microneedle arrays for enhanced delivery of long-acting HIV medicines
Donnelly, R. (PI) & Larrañeta, E. (CoI)
27/03/2019 → 30/09/2023
Project: Research
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R2493PMY: 3D printable antimicrobial materials for the development of safer medical devices
Larrañeta, E. (PI) & Irwin, N. (CoI)
11/06/2018 → 10/08/2018
Project: Research
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R2481PMY: Development of antimicrobial materials made of natural compounds prepared using 3D printing
Larrañeta, E. (PI) & Irwin, N. (CoI)
23/04/2018 → 27/07/2018
Project: Research
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R2473PMY: Sustainable materials for prevention of catheter complications
Irwin, N. (PI) & Larrañeta, E. (CoI)
13/04/2018 → 17/08/2018
Project: Research
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Formulation and evaluation of PVA-based composite hydrogels: physicochemical, leachables, and in vitro immunogenicity studies
Himawan, A., Korelidou, A., Pérez-Moreno, A. M., Paris, J. L., Domínguez-Robles, J., Vora, L. K., Permana, A. D., Larrañeta, E., Graham, R., Scott, C. J. & Donnelly, R., 06 Jan 2025, (Early online date) In: Journal of Materials Chemistry B. p. -Research output: Contribution to journal › Article › peer-review
Open Access -
Reservoir-type subcutaneous implantable devices containing porous rate controlling membranes for sustained delivery of risperidone
Li, L., Permana, A. D., Domínguez-Robles, J., Amir, M. N., Habibie, H., Anjani, Q. K., Zhao, L., Moreno-Castellanos, N., Donnelly, R. F. & Larrañeta, E., 16 Jan 2025, (Early online date) In: Advanced Healthcare Materials. 2403689.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
3D-printed implants loaded with acriflavine for glioblastoma treatment
Korelidou, A., Domínguez-Robles, J., Islam, R., Donnelly, R. F., Coulter, J. A. & Larrañeta, E., 15 Nov 2024, In: International Journal of Pharmaceutics. 665, 13 p., 124710.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure) -
3D-printing of dipyridamole/thermoplastic polyurethane materials for bone regeneration
Adhami, M., Dastidar, A. G., Anjani, Q. K., Detamornrat, U., Tarrés, Q., Delgado-Aguilar, M., Acheson, J. G., Manda, K., Clarke, S. A., Moreno-Castellanos, N., Larrañeta, E. & Domínguez-Robles, J., 22 Nov 2024, (Early online date) In: Drug Delivery and Translational Research. 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
An isocratic RP-HPLC-UV method for simultaneous quantification of tizanidine and lidocaine: application to in vitro release studies of a subcutaneous implant
Picco, C. J., Anjani, Q. K., Donnelly, R. F. & Larrañeta, E., 21 Feb 2024, In: Analytical Methods. 16, 7, p. 979-989 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile61 Downloads (Pure)
Prizes
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Academy of Medical Sciences Springboard Award
Larrañeta, E. (Recipient), 31 Jan 2020
Prize: Fellowship awarded competitively
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Best Paper Award of Pharmaceutics Special Issue on 3D Printing of Pharmaceuticals and Drug Delivery Devices
Dominguez Robles, J. (Recipient), Martin, N. K. (Recipient), Fong, M. L. (Recipient), Stewart, S. (Recipient), Irwin, N. (Recipient), Rial, I. (Recipient), Donnelly, R. (Recipient) & Larrañeta, E. (Recipient), 2020
Prize: Other distinction
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Fellow of the Higher Education Academy
Larrañeta, E. (Recipient), 2018
Prize: Election to learned society
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Front Cover for Macromolecular Materials and Engineering 6/2015
Larrañeta, E. (Recipient), 2015
Prize: Other distinction
Activities
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Biomaterials Advances (Journal)
Larrañeta, E. (Peer reviewer)
15 Jan 2025 → …Activity: Publication peer-review and editorial work types › Editorial activity
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Preparation of Biodegradable Lipid-based Indocyanine Green J-aggregate Nanoparticles for Photothermal Therapy
Larrañeta, E. (Examiner)
17 Dec 2024Activity: Examination types › Other examination
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Long-acting drug delivery across the skin
Larrañeta, E. (Speaker)
04 Sept 2024Activity: Talk or presentation types › Invited talk
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Subdermal implants for controlled release of small molecule drugs
Larrañeta, E. (Examiner)
30 Jul 2024Activity: Examination types › Other examination
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Floating gastroretentive systems prepared using 3D-printing for drug administration
Larrañeta, E. (Examiner)
23 Jul 2024Activity: Examination types › PhD external examination
Press/Media
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Queen’s University Belfast provides NHS with protective facemasks
Lamprou, D., Larrañeta, E., Dominguez Robles, J. & Falzon, B.
26/03/2020 → 23/04/2020
20 items of Media coverage
Press/Media: Research