• Room 06.019 - Medical Biology Centre

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the field of cancer research, cancer pharmacology, chemoresistance, cell and molecular biology, transcriptomics, biomarker development and drug discovery. Applications should meet the University's English language requirements, secured a source of funding, and who wish to pursue a research project in a relevant research topic. Exemplar PhD projects are detailed below: Mechanism of Drug activity in cancer https://www.dropbox.com/s/1r3f337i5m6mh32/PhD%20Studentship_HDAC6.pdf?dl=0 Molecular Pharmacology of GPCRs https://www.dropbox.com/s/04vjtc24i8svt3k/PhD%20Studentship_Neropeptide_galin.pdf?dl=0

20002019

Research output per year

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Personal profile

Interests

Receptor Pharmacology

Cancer Pharmacology

Mechanmis of Drug action

Cell Signalling

microRNA

Methylated RNA Biomarkers

Cancer Biology

Ovarian Cancer

Research Statement

I am a University College Dublin Graduate and joined the School of Pharmacy, QUB, as a Lecturer in Pharmacology and cancer researcher in 2012.  Prior to joining QUB, I was a recipient of the Irish Cancer Society career development research fellowship in which I developed novel research on the role of the miR-433 microRNA as a biomarker of chemoresistance in ovarian cancer.  My research focus is on cancer pharmacology and stratified biomarker development and I primarily research the mechanism of action of anti-neoplastic agents.  Current projects include dissecting the molecular pharmacology of the histone deacetylase 6 (HDAC6) protein and the RNA demethylase enzymes.  New and emerging research from my group is focused on developing methods to detect methylated microRNA as next generation biomarkers of disease.  Areas of expertise include elucidating the mechanism of drug actions and downstream protein signalling in cell models of disease, cancer research and chemoresistance, cell and molecular biology, biomarker development and profiling microRNA in cells, tissue and plasma. My most significant research publications include studies of the miR-433 microRNA in chemoresistant ovarian cancer, IHC biomarker analyses and meta-analyse of the MAD2 protein in ovarian cancer prognosis.  Research from my group has been funded by the Irish Cancer Society, the Health Research Board of Ireland, BBSRC and MRC.

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Projects

Research Output

An update on Exosomes as Drug Delivery Vehicles: Obstacles to its Clinical Translation

Ali, A., Maguire, A. & Furlong, F., 02 Apr 2019, In : Novel Approaches in Drug Designing and Development. 5, 1, p. 0019

Research output: Contribution to journalReview article

  • FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

    McClements, L., Annett, S., Yakkundi, A., O'Rourke, M., Valentine, A., Moustafa, N., Alqudah, A., Simões, B. M., Furlong, F., Short, A., McIntosh, S. A., McCarthy, H. O., Clarke, R. B. & Robson, T., 11 Apr 2019, In : BMC Cancer. 19, 351.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 10 Citations (Scopus)
    99 Downloads (Pure)

    FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer

    Annett, S., Moore, G., Short, A., Marshall, A., McCrudden, C., Yakkundi, A., Das, S., McCluggage, W. G., Nelson, L., Harley, I., Moustafa, N., Kennedy, C. J., deFazio, A., Brand, A., Sharma, R., Brennan, D., O'Toole, S., O'Leary, J., Bates, M., O'Riain, C. & 6 others, O'Connor, D., Furlong, F., McCarthy, H., Kissenpfennig, A., McClements, L. & Robson, T., 27 Nov 2019, In : British Journal of Cancer.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)
    13 Downloads (Pure)

    Too MAD or not MAD enough: The duplicitous role of the spindle assembly checkpoint protein MAD2 in cancer

    Bates, M., Furlong, F., Gallagher, M. F., Spillane, C. D., McCann, A., O'Toole, S. & O'Leary, J. J., 05 Oct 2019, In : Cancer Letters. 469, p. 11-21 11 p.

    Research output: Contribution to journalArticle

  • BRCA1 and MAD2 are Co-expressed and are Prognostic Indicators in Tubo-ovarian High-grade Serous Carcinoma

    Byrne, T., Nelson, L., Beirne, J., Sharpe, D., Quinn, J. E., Glenn McCluggage, W., Robson, T. & Furlong, F., 01 Mar 2018, In : International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 28, 3, p. 472-478

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    214 Downloads (Pure)

    Prizes

  • Downregulation of MAD2 renders cancer cells resistant to Paclitaxel

    Furlong, Fiona (Recipient), 2008

    Prize: Prize (including medals and awards)

  • Activities

    ERNEST FIRST MEETINGCOST CA18133GPCR PHARMACOLOGY: ACTIVATION, SIGNALLING AND DRUG DESIGN

    Fiona Furlong (Participant)

    28 Oct 201930 Oct 2019

    Activity: Participating in or organising an event typesParticipation in conference

    11th TCD International Cancer Conference 2019

    Fiona Furlong (Participant)

    24 Sep 201925 Sep 2019

    Activity: Participating in or organising an event typesParticipation in conference

    The role of MAD2, miR-433 and HDAC6 in chemoresistance of high grade serous ovarian cancer (HGSC)

    Fiona Furlong (Invited speaker)

    04 Mar 2019

    Activity: Talk or presentation typesInvited talk

    Annual meeting Irish Association of Cancer Research

    Fiona Furlong (Session chair)

    21 Feb 2019

    Activity: Participating in or organising an event typesParticipation in conference

    Sentinus Young Innovators 2019

    Fiona Furlong (Advisor)

    24 Jun 2019

    Activity: Participating in or organising an event typesParticipation in Festival/Exhibition

    Thesis

    Computational and Pharmacological Characterization of HDAC6 Inhibition and Function

    Author: Maguire, A., Dec 2020

    Supervisor: Tikhonova, I. (Supervisor) & Furlong, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    The Role of DNA Damage Associated microRNAs in Enhancing the Chemotherapeutic Responses in Triple Negative Breast Cancer (TNBC)

    Author: Abderahman, S., Jul 2020

    Supervisor: Furlong, F. (Supervisor), Coulter, J. (Supervisor) & Buckley, N. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy