Projects per year
Personal profile
Interests
Receptor Pharmacology
Cancer Pharmacology
Mechanism of Drug Action
Cell Signalling
microRNA
RNA Biomarkers
Cancer Biology
Breast & Ovarian Cancer
Research Statement
Dr Furlong graduated from University College Dublin with a honours degree in Pharmacology and PhD in cell biology. Prior to joining QUB, Dr Furlong was a recipient of the Irish Cancer Society career development research fellowship and developed novel research on the role of the miR-433 microRNA as a biomarker of chemoresistance in ovarian cancer. Since then, Dr Furlong has established a program of research in cancer pharmacology and stratified biomarker development. The primary focus of this research is to elucidate the mechanism of action of anti-neoplastic agents. Current projects include dissecting the molecular pharmacology of the histone deacetylase 6 (HDAC6) protein and the RNA demethylase enzymes. New and emerging research is focused on developing methods to detect microRNA as biosensors of disease. Areas of expertise include researching the mechanism of drug actions and downstream protein signalling in cell models of cancer chemoresistance, cell and molecular biology, biomarker development and profiling microRNA in cells, tissue and plasma. This program of research has led to several high impacting publications and include studies of the miR-433 microRNA in chemoresistant ovarian cancer, IHC biomarker analyses and meta-analyse of the MAD2 protein in ovarian cancer prognosis. Dr Furlong has received funding from the Irish Cancer Society, the Health Research Board of Ireland, BBSRC and MRC.
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 2 Finished
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R1818PMY: MRIs (Modified RNA Indicators): next generation gene signature biomarkers
16/10/2017 → 30/06/2019
Project: Research
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R1565PMY: B vitamins and NAD metabolism, or when vitamin B3's bioavailability is not enough
25/09/2015 → 30/06/2019
Project: Research
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Hdac6 degradation inhibits the growth of high-grade serous ovarian cancer cells
Ali, A., Zhang, F., Maguire, A., Byrne, T., Weiner-Gorzel, K., Bridgett, S., O’toole, S., O’leary, J., Beggan, C., Fitzpatrick, P., McCann, A. & Furlong, F., 11 Dec 2020, In: Cancers. 12, 12, 20 p., 3734.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)10 Downloads (Pure) -
An update on Exosomes as Drug Delivery Vehicles: Obstacles to its Clinical Translation
Ali, A., Maguire, A. & Furlong, F., 02 Apr 2019, In: Novel Approaches in Drug Designing and Development. 5, 1, p. 0019Research output: Contribution to journal › Review article › peer-review
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FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4
McClements, L., Annett, S., Yakkundi, A., O'Rourke, M., Valentine, A., Moustafa, N., Alqudah, A., Simões, B. M., Furlong, F., Short, A., McIntosh, S. A., McCarthy, H. O., Clarke, R. B. & Robson, T., 11 Apr 2019, In: BMC Cancer. 19, 351.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)112 Downloads (Pure) -
FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer
Annett, S., Moore, G., Short, A., Marshall, A., McCrudden, C., Yakkundi, A., Das, S., McCluggage, W. G., Nelson, L., Harley, I., Moustafa, N., Kennedy, C. J., deFazio, A., Brand, A., Sharma, R., Brennan, D., O'Toole, S., O'Leary, J., Bates, M., O'Riain, C. & 6 others, , 27 Nov 2019, (Early online date) In: British Journal of Cancer. 2020, 126, p. 361Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)129 Downloads (Pure) -
Too MAD or not MAD enough: The duplicitous role of the spindle assembly checkpoint protein MAD2 in cancer
Bates, M., Furlong, F., Gallagher, M. F., Spillane, C. D., McCann, A., O'Toole, S. & O'Leary, J. J., 05 Oct 2019, (Early online date) In: Cancer Letters. 469, p. 11-21 11 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
Prizes
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Actin Cytoskeleton Rearrangement in Mesangial Cells. Novel implications of TGF-beta Signalling in Diabetic Nephropathy
Furlong, Fiona (Recipient), 2005
Prize: Prize (including medals and awards)
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Downregulation of MAD2 renders cancer cells resistant to Paclitaxel
Furlong, Fiona (Recipient), 2008
Prize: Prize (including medals and awards)
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microRNA Regulation of the Spindle Assembly Checkpoint (SAC): Implications for Cell Cycle Dysregulation in Ovarian Cancer and Taxol Responsiveness.
Furlong, Fiona (Recipient), 2008
Prize: Fellowship awarded competitively
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Predicting chemo-response in serous papillary epithelial ovarian cancer (EOC)
Furlong, Fiona (Recipient), 2011
Prize: Prize (including medals and awards)
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Unlocking the individualised response to chemotherapy in triple negative breast cancer
Furlong, Fiona (Recipient), 2010
Prize: Prize (including medals and awards)
Activities
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57th Irish Association for Cancer Research Annual Conference
Fiona Furlong (Member of the organising committee)
24 Mar 2021 → 26 Mar 2021Activity: Participating in or organising an event types › Participation in conference
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Irish Association for Cancer Research, 56th Annual Conference, Galway 2020
Fiona Furlong (Member of the organising committee)
26 Feb 2020 → 28 Feb 2020Activity: Participating in or organising an event types › Participation in conference
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The extracellular Matrix: A Target in Breast Cancer Treatment and Prognosis
Fiona Furlong (Examiner)
11 Nov 2020Activity: Examination types › PhD external examination
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11th TCD International Cancer Conference 2019
Fiona Furlong (Participant)
24 Sep 2019 → 25 Sep 2019Activity: Participating in or organising an event types › Participation in conference
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Annual meeting Irish Association of Cancer Research
Fiona Furlong (Session chair)
21 Feb 2019Activity: Participating in or organising an event types › Participation in conference