• Room 06.019 - Medical Biology Centre

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the field of cancer research, cancer pharmacology, chemoresistance, cell and molecular biology, transcriptomics, biomarker development and drug discovery. Applications should meet the University's English language requirements, secured a source of funding, and who wish to pursue a research project in a relevant research topic. Exemplar PhD projects are detailed below: Mechanism of Drug activity in cancer https://www.dropbox.com/s/1r3f337i5m6mh32/PhD%20Studentship_HDAC6.pdf?dl=0 Molecular Pharmacology of GPCRs https://www.dropbox.com/s/04vjtc24i8svt3k/PhD%20Studentship_Neropeptide_galin.pdf?dl=0

20002019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

An update on Exosomes as Drug Delivery Vehicles: Obstacles to its Clinical Translation

Ali, A., Maguire, A. & Furlong, F., 02 Apr 2019, In : Novel Approaches in Drug Designing and Development. 5, 1, p. 0019

Research output: Contribution to journalReview article

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

McClements, L., Annett, S., Yakkundi, A., O'Rourke, M., Valentine, A., Moustafa, N., Alqudah, A., Simões, B. M., Furlong, F., Short, A., McIntosh, S. A., McCarthy, H. O., Clarke, R. B. & Robson, T., 11 Apr 2019, In : BMC Cancer. 19, 351.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
99 Downloads (Pure)

FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer

Annett, S., Moore, G., Short, A., Marshall, A., McCrudden, C., Yakkundi, A., Das, S., McCluggage, W. G., Nelson, L., Harley, I., Moustafa, N., Kennedy, C. J., deFazio, A., Brand, A., Sharma, R., Brennan, D., O'Toole, S., O'Leary, J., Bates, M., O'Riain, C. & 6 others, O'Connor, D., Furlong, F., McCarthy, H., Kissenpfennig, A., McClements, L. & Robson, T., 27 Nov 2019, In : British Journal of Cancer.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
22 Downloads (Pure)

Too MAD or not MAD enough: The duplicitous role of the spindle assembly checkpoint protein MAD2 in cancer

Bates, M., Furlong, F., Gallagher, M. F., Spillane, C. D., McCann, A., O'Toole, S. & O'Leary, J. J., 05 Oct 2019, In : Cancer Letters. 469, p. 11-21 11 p.

Research output: Contribution to journalArticle

2018

BRCA1 and MAD2 are Co-expressed and are Prognostic Indicators in Tubo-ovarian High-grade Serous Carcinoma

Byrne, T., Nelson, L., Beirne, J., Sharpe, D., Quinn, J. E., Glenn McCluggage, W., Robson, T. & Furlong, F., 01 Mar 2018, In : International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 28, 3, p. 472-478

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
218 Downloads (Pure)

Selective HDAC6 inhibition with ACY-1215 promoted resistance to paclitaxel in epithelial ovarian cancer

Karolina Weiner-Gorzel, Tara Byrne, Alo McGoldrick, Caitlin Beggan, Nazia Faheem, Paula Cunnea, Eugene Dempsey, Sharon O'Toole, John O'Learry, Elaine Kay, Tracy Robson, Amanda McCann& Fiona Furlong, 22 Feb 2018, p. 32. 33 p.

Research output: Contribution to conferenceAbstract

2017
Open Access
File
35 Citations (Scopus)
406 Downloads (Pure)

The association between MAD2 and prognosis in cancer: A systematic review and meta-analyses

Byrne, T., Coleman, H., Cooper, J., McCluggage, W. G., McCann, A. & Furlong, F., 08 Jun 2017, In : Oncotarget.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
202 Downloads (Pure)
2015

A miR-433 mediated mechanism of chemoresistance in high grade serous ovarian cancer (HGSOC).

Byrne, T., Karolina, W-G., Gallagher, M., Sharpe, D., Annett, S., O'Toole, S., O'Leary, J., Nelson, L., Glenn McCluggage, W., Beirne, J., Robson, T., McCann, A. & Furlong, F., 09 Oct 2015, (Accepted).

Research output: Contribution to conferencePoster

FKBPL: a marker of good prognosis in breast cancer

Nelson, L., McKeen, H. D., Marshall, A., Mulrane, L., Starczynski, J., Storr, S. J., Lanigan, F., Byrne, C., Arthur, K., Hegarty, S., Ali, A. A., Furlong, F., McCarthy, H. O., Ellis, I. O., Green, A. R., Rakha, E., Young, L., Kunkler, I., Thomas, J., Jack, W. & 10 others, Cameron, D., Jirström, K., Yakkundi, A., McClements, L., Martin, S. G., Gallagher, W. M., Dunn, J., Bartlett, J., O'Connor, D. & Robson, T., 03 Apr 2015, In : Oncotarget. 6, 14, p. 12209-12223 15 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
194 Downloads (Pure)

MiR-433 induces cellular senescence rendering ovarian cancer cells less likely to undergo chemotherapy-induced apoptosis

Karolina, W-G., Sharpe, D., Milewska, M., McGoldrick, A., Beggan, C., Faheem, N., Toh, V., Fitzpatrick, P., Murphy, M., Madden, S. F., O'Leary, J., O'Toole, S., Kay, E., Kell, M., McCann, A. & Furlong, F., 15 Feb 2015, p. PMS14.

Research output: Contribution to conferenceAbstract

Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells

Weiner-Gorzel, K., Dempsey, E., Milewska, M., McGoldrick, A., Toh, V., Walsh, A., Lindsay, S., Gubbins, L., Cannon, A., Sharpe, D., O'Sullivan, J., Murphy, M., Madden, S. F., Kell, M., McCann, A. & Furlong, F., May 2015, In : Cancer Medicine. 4, 5, p. 745-758 14 p.

Research output: Contribution to journalArticle

Open Access
File
76 Citations (Scopus)
251 Downloads (Pure)

Resistance to chemotherapy in ovarian cancer is miRrored by the microRNA miR-433-dependent dysregulation of the cell cycle.

Karolina, W-G., Dempsey, E., Milewska, M., McGoldrick, A., Toh, V., Walsh, A., Lindsay, S., Gubbins, L., Cannon, A., Sharpe, D., O'Sullivan, J., Murphy, M., Madden, S. F., Kell, M., McCann, A. & Furlong, F., 26 Feb 2015.

Research output: Contribution to conferenceAbstract

The fate of chemoresistance in triple negative breast cancer (TNBC)

O'Reilly, E. A., Gubbins, L., Sharma, S., Tully, R., Ho Zhing Guang, M., Weiner-Gorzel, K., McCaffrey, J., Harrison, M., Furlong, F., Kell, M. & McCann, A., Jun 2015, In : BBA Clinical. 3, p. 257-275 19 p.

Research output: Contribution to journalArticle

Open Access
File
157 Citations (Scopus)
513 Downloads (Pure)
2014

IHG-1 increases mitochondrial fusion and bioenergetic function

Hickey, F. B., Corcoran, J. B., Griffin, B., Breahtnach, U., Mortiboys, H., Reid, H. M., Andrews, D., Byrne, S., Furlong, F., Martin, F., Godson, C. & Murphy, M., Dec 2014, In : Diabetes. 63, 12, p. 4314-25 12 p., 25008184.

Research output: Contribution to journalArticle

10 Citations (Scopus)

MIR-433 Predicts poor response to chemotherapy in ovarian cancer patients by the induction of cellular senescence

K., W-G., Sharpe, D., Milewska, M., Beggan, C., Faheem, N., McGoldrick, A., Toh, V., Madden, S., Fitzpatrick, P., Murphy, M., McCaffrey, J., Harrison, M., Kay, E., Kell, M. R., McCann, A. & Furlong, F., 27 Feb 2014.

Research output: Contribution to conferenceAbstract

Spindle assembly checkpoint protein expression correlates with cellular proliferation and shorter time to recurrence in ovarian cancer.

McGrogan, B., Phelan, S., Fitzpatrick, P., Maguire, A., Prencipe, M., Brennan, D., Doyle, E., O'Grady, A., Kay, E., Furlong, F. & McCann, A., Jul 2014, In : Human Pathology. 45, 7, p. 1509-19 11 p., 24792619.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2013

A miR-433regulatory network in cancer; diagnostic and therapeutic solutions for chemoresistant epithelial ovarian cancer (EOC)

Karolina, W-G., Sharpe, D., Fitzpatrick, P., McCann, A. & Furlong, F., 2013.

Research output: Contribution to conferenceAbstract

IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses

Corcoran, J. B., McCarthy, S., Griffin, B., Gaffney, A., Bhreathnach, U., Börgeson, E., Hickey, F. B., Docherty, N. G., Higgins, D. F., Furlong, F., Martin, F., Godson, C. & Murphy, M., 2013, In : Biochimica et biophysica acta. 1833, 8, p. 1969-1978

Research output: Contribution to journalArticle

16 Citations (Scopus)

Novel Hypoxia-Associated Markers of Chemoresistance in Ovarian Cancer

L McEvoy, S O'Toole, C Spillane, B Stordal, M Gallagher, C Martin, L Norris, N Gleeson, A McGoldrick, F Furlong, A McCann, O Sheils, J O'Leary, 01 Feb 2013, p. 288A.

Research output: Contribution to conferenceAbstract

2012

Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer

Furlong, F., Fitzpatrick, P., O'Toole, S., Phelan, S., McGrogan, B., Maguire, A., O'Grady, A., Gallagher, M., Prencipe, M., McGoldrick, A., McGettigan, P., Brennan, D., Sheils, O., Martin, C., W Kay, E., O'Leary, J. & McCann, A., Apr 2012, In : Journal of Pathology. 226, 5, p. 746-755 10 p.

Research output: Contribution to journalArticle

Open Access
File
52 Citations (Scopus)
301 Downloads (Pure)

Mitotic Arrest Deficiency Protein 2 (MAD2) and Histone Deacetylase 6 (HDAC6) Present a Complex Relationship in Their Regulation and Expression and Subsequent Impact on Chemoresponsiveness

K. Weiner-Gorzel, E. O'Reilly, A. McGoldrick, P. Fitzpatrick, S. O'Toole, A. Maguire, E. Kay, J. O'Leary, A. McCann, & Furlong, F., 01 Jul 2012, p. S214.

Research output: Contribution to conferenceAbstract

Resistance to paclitaxel in MAD2-depleted epithelial ovarian cancer (EOC) cells is not mediated by the histone deacetylase HDAC6

Karolina, W-G., O'Reilly, E. A., McGoldrick, A., Fitzpatrick, P., O'Toole, S., O'Grady, A., Kay, E., O'Leary, J., Kell, M., McCann, A. & Furlong, F., 2012.

Research output: Contribution to conferencePoster

2011

EACR/IACR Conference on Tumour Microenvironment

English, S., Li, B., Furlong, F. & McCann, A., 01 Sep 2011.

Research output: Contribution to conferenceAbstract

Open Access

Hypoxia in Epithelial Ovarian Cancer – Remodelling the Epigenome and Paclitaxel Response

English, S., Li, B., Furlong, F. & McCann, A., 01 Sep 2011.

Research output: Contribution to conferenceAbstract

Open Access

IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α

Hickey, F. B., Corcoran, J. B., Docherty, N. G., Griffin, B., Bhreathnach, U., Furlong, F., Martin, F., Godson, C. & Murphy, M., 2011, In : Journal of the American Society of Nephrology. 22, 8, p. 1475-85 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Stabilisation of MAD2 expression through inhibition of miR-433; A novel mechanism for restoring chemo-responsiveness in ovarian tumours

Furlong, F. & Fiona M Furlong, Sine Phelan, Alo McGoldrick, Aoife Maguire, Patricia Fitzpatrick, Sharon O'Toole, Orla Shiels, John J O'Leary, Amanda McCann, 15 Apr 2011, p. LB-338.

Research output: Contribution to conferenceAbstract

2010

MAD2 downregulation in hypoxia is independent of promoter hypermethylation

Prencipe, M., McGoldrick, A., Perry, A. S., O'Grady, A., Phelan, S., McGrogan, B., Fitzpatrick, P., Watson, J. A., Furlong, F., Brennan, D. J., Lawler, M., Kay, E. & McCann, A., 15 Jul 2010, In : Cell Cycle . 9, 14, p. 2856-65 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

miR-433 overexpression attenuates the spindle assembly checkpoint response to paclitaxel

Furlong, F., Prencipe, M., McGoldrick, A., McGettigan, P., Carney, D., Doyle, E., W Kay, E. & McCann, A., 2010, p. 35.

Research output: Contribution to conferenceAbstract

2009

Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro

Prencipe, M., Fitzpatrick, P., Gorman, S., Mosetto, M., Klinger, R., Furlong, F., Harrison, M., O'Connor, D., Roninson, I. B., O'Sullivan, J. & McCann, A., Nov 2009, In : British Journal of Cancer. 101, 11, p. 1900-8 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2008

IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis

Murphy, M., Docherty, N. G., Griffin, B., Howlin, J., McArdle, E., McMahon, R., Schmid, H., Kretzler, M., Droguett, A., Mezzano, S., Brady, H. R., Furlong, F., Godson, C. & Martin, F., Sep 2008, In : Journal of the American Society of Nephrology. 19, 9, p. 1672-80 9 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Recurrence of Urothelial Carcinoma of the Bladder: A Role for Insulin-Like Growth Factor-II Loss of Imprinting and Cytoplasmic E-Cadherin Immunolocalization

Gallagher, E. M., O'Shea, D. M., Fitzpatrick, P., Harrison, M., Gilmartin, B., Watson, J. A., Clarke, T., Leonard, M. O., McGoldrick, A., Meehan, M., Watson, C., Furlong, F., O'Kelly, P., Fitzpatrick, J. M., Dervan, P. A., O'Grady, A., Kay, E. W. & McCann, A., 01 Nov 2008, In : Clinical Cancer Research. 14, 21, p. 6829-38 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2007

Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose

Furlong, F., Crean, J., Thornton, L., O'Leary, R., Murphy, M. & Martin, F., Jun 2007, In : American Journal of Physiology - Renal Physiology. 292, 6, p. F1691-700

Research output: Contribution to journalArticle

18 Citations (Scopus)
2006

Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1)

Crean, J. K., Furlong, F., Mitchell, D., McArdle, E., Godson, C. & Martin, F., Aug 2006, In : The FASEB Journal. 20, 10, p. 1712-4 3 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2005

PTPase inhibition restores ERK1/2 phosphorylation and protects mammary epithelial cells from apoptosis

Furlong, F., Finlay, D. & Martin, F., 04 Nov 2005, In : Biochemical and Biophysical Research Communications. 336, 4, p. 1292-9 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2004

Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization

Crean, J. K., Furlong, F., Finlay, D., Mitchell, D., Murphy, M., Conway, B., Brady, H. R., Godson, C. & Martin, F., Oct 2004, In : The FASEB Journal. 18, 13, p. 1541-3 3 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling

Murtagh, J., McArdle, E., Gilligan, E., Thornton, L., Furlong, F. & Martin, F., 05 Jul 2004, In : The Journal of cell biology. 166, 1, p. 133-43 11 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2000

MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival

Finlay, D., Healy, V., Furlong, F., O'Connell, F. C., Keon, N. K. & Martin, F., Mar 2000, In : Cell Death and Differentiation. 7, 3, p. 302-13 12 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)