• Room 06.019 - Medical Biology Centre

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the field of cancer research, cancer pharmacology, chemoresistance, cell and molecular biology, transcriptomics, biomarker development and drug discovery. Applications should meet the University's English language requirements, secured a source of funding, and who wish to pursue a research project in a relevant research topic. Exemplar PhD projects are detailed below: Mechanism of Drug activity in cancer https://www.dropbox.com/s/1r3f337i5m6mh32/PhD%20Studentship_HDAC6.pdf?dl=0 Molecular Pharmacology of GPCRs https://www.dropbox.com/s/04vjtc24i8svt3k/PhD%20Studentship_Neropeptide_galin.pdf?dl=0

20002019
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Research Output 2000 2019

2019
Exosomes
Pharmaceutical Preparations
Nanotechnology
Toxicology
Nucleic Acids
5 Citations (Scopus)
67 Downloads (Pure)

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

McClements, L., Annett, S., Yakkundi, A., O'Rourke, M., Valentine, A., Moustafa, N., Alqudah, A., Simões, B. M., Furlong, F., Short, A., McIntosh, S. A., McCarthy, H. O., Clarke, R. B. & Robson, T., 11 Apr 2019, In : BMC Cancer. 19, 351.

Research output: Contribution to journalArticle

Open Access
File
Neoplastic Stem Cells
Down-Regulation
Breast Neoplasms
Neoplasm Metastasis
Peptides

FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer

Annett, S., Moore, G., Short, A., Marshall, A., McCrudden, C., Yakkundi, A., Das, S., McCluggage, W. G., Nelson, L., Harley, I., Moustafa, N., Kennedy, C. J., deFazio, A., Brand, A., Sharma, R., Brennan, D., O'Toole, S., O'Leary, J., Bates, M., O'Riain, C. & 6 others, O'Connor, D., Furlong, F., McCarthy, H., Kissenpfennig, A., McClements, L. & Robson, T., 27 Nov 2019, In : British Journal of Cancer.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Ovarian Neoplasms
Peptides
Neoplasms
Heterografts

Too MAD or not MAD enough: The duplicitous role of the spindle assembly checkpoint protein MAD2 in cancer

Bates, M., Furlong, F., Gallagher, M. F., Spillane, C. D., McCann, A., O'Toole, S. & O'Leary, J. J., 05 Oct 2019, In : Cancer Letters. 469, p. 11-21 11 p.

Research output: Contribution to journalArticle

M Phase Cell Cycle Checkpoints
Kinetochores
Anaphase
Chromatids
Neoplasms
2018
2 Citations (Scopus)
179 Downloads (Pure)

BRCA1 and MAD2 are Co-expressed and are Prognostic Indicators in Tubo-ovarian High-grade Serous Carcinoma

Byrne, T., Nelson, L., Beirne, J., Sharpe, D., Quinn, J. E., Glenn McCluggage, W., Robson, T. & Furlong, F., 01 Mar 2018, In : International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 28, 3, p. 472-478

Research output: Contribution to journalArticle

Open Access
File
Protein Deficiency
Carcinoma
Survival Analysis
Survival
Paraffin

Selective HDAC6 inhibition with ACY-1215 promoted resistance to paclitaxel in epithelial ovarian cancer

Karolina Weiner-Gorzel, Tara Byrne, Alo McGoldrick, Caitlin Beggan, Nazia Faheem, Paula Cunnea, Eugene Dempsey, Sharon O'Toole, John O'Learry, Elaine Kay, Tracy Robson, Amanda McCann& Fiona Furlong, 22 Feb 2018, p. 32. 33 p.

Research output: Contribution to conferenceAbstract

2017
27 Citations (Scopus)
352 Downloads (Pure)
Open Access
File
cisplatin
ovarian neoplasms
drug resistance
Drug Resistance
Ovarian Neoplasms
3 Citations (Scopus)
172 Downloads (Pure)

The association between MAD2 and prognosis in cancer: A systematic review and meta-analyses

Byrne, T., Coleman, H., Cooper, J., McCluggage, W. G., McCann, A. & Furlong, F., 08 Jun 2017, In : Oncotarget.

Research output: Contribution to journalArticle

Open Access
File
Protein Deficiency
Meta-Analysis
Neoplasms
Ovarian Neoplasms
Confidence Intervals
2015

A miR-433 mediated mechanism of chemoresistance in high grade serous ovarian cancer (HGSOC).

Byrne, T., Karolina, W-G., Gallagher, M., Sharpe, D., Annett, S., O'Toole, S., O'Leary, J., Nelson, L., Glenn McCluggage, W., Beirne, J., Robson, T., McCann, A. & Furlong, F., 09 Oct 2015, (Accepted).

Research output: Contribution to conferencePoster

Ovarian Neoplasms
Histone Deacetylases
Paclitaxel
Survival
MicroRNAs
4 Citations (Scopus)
160 Downloads (Pure)

FKBPL: a marker of good prognosis in breast cancer

Nelson, L., McKeen, H. D., Marshall, A., Mulrane, L., Starczynski, J., Storr, S. J., Lanigan, F., Byrne, C., Arthur, K., Hegarty, S., Ali, A. A., Furlong, F., McCarthy, H. O., Ellis, I. O., Green, A. R., Rakha, E., Young, L., Kunkler, I., Thomas, J., Jack, W. & 10 others, Cameron, D., Jirström, K., Yakkundi, A., McClements, L., Martin, S. G., Gallagher, W. M., Dunn, J., Bartlett, J., O'Connor, D. & Robson, T., 03 Apr 2015, In : Oncotarget. 6, 14, p. 12209-12223 15 p.

Research output: Contribution to journalArticle

Open Access
File
Tacrolimus Binding Proteins
Breast Neoplasms
Confidence Intervals
Survival
Tamoxifen

MiR-433 induces cellular senescence rendering ovarian cancer cells less likely to undergo chemotherapy-induced apoptosis

Karolina, W-G., Sharpe, D., Milewska, M., McGoldrick, A., Beggan, C., Faheem, N., Toh, V., Fitzpatrick, P., Murphy, M., Madden, S. F., O'Leary, J., O'Toole, S., Kay, E., Kell, M., McCann, A. & Furlong, F., 15 Feb 2015, p. PMS14.

Research output: Contribution to conferenceAbstract

Cell Aging
Ovarian Neoplasms
Apoptosis
Drug Therapy
Paclitaxel
68 Citations (Scopus)
211 Downloads (Pure)

Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells

Weiner-Gorzel, K., Dempsey, E., Milewska, M., McGoldrick, A., Toh, V., Walsh, A., Lindsay, S., Gubbins, L., Cannon, A., Sharpe, D., O'Sullivan, J., Murphy, M., Madden, S. F., Kell, M., McCann, A. & Furlong, F., May 2015, In : Cancer Medicine. 4, 5, p. 745-758 14 p.

Research output: Contribution to journalArticle

Open Access
File
Cell Aging
Paclitaxel
MicroRNAs
Ovarian Neoplasms
Cyclin-Dependent Kinase 6

Resistance to chemotherapy in ovarian cancer is miRrored by the microRNA miR-433-dependent dysregulation of the cell cycle.

Karolina, W-G., Dempsey, E., Milewska, M., McGoldrick, A., Toh, V., Walsh, A., Lindsay, S., Gubbins, L., Cannon, A., Sharpe, D., O'Sullivan, J., Murphy, M., Madden, S. F., Kell, M., McCann, A. & Furlong, F., 26 Feb 2015.

Research output: Contribution to conferenceAbstract

MicroRNAs
Ovarian Neoplasms
Cell Cycle
Drug Therapy
Paclitaxel
141 Citations (Scopus)
443 Downloads (Pure)

The fate of chemoresistance in triple negative breast cancer (TNBC)

O'Reilly, E. A., Gubbins, L., Sharma, S., Tully, R., Ho Zhing Guang, M., Weiner-Gorzel, K., McCaffrey, J., Harrison, M., Furlong, F., Kell, M. & McCann, A., Jun 2015, In : BBA Clinical. 3, p. 257-275 19 p.

Research output: Contribution to journalArticle

Open Access
File
Triple Negative Breast Neoplasms
Cell Aging
Drug Therapy
Autophagy
Paclitaxel
2014
10 Citations (Scopus)

IHG-1 increases mitochondrial fusion and bioenergetic function

Hickey, F. B., Corcoran, J. B., Griffin, B., Breahtnach, U., Mortiboys, H., Reid, H. M., Andrews, D., Byrne, S., Furlong, F., Martin, F., Godson, C. & Murphy, M., Dec 2014, In : Diabetes. 63, 12, p. 4314-25 12 p., 25008184.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Energy Metabolism
Glucose
Diabetic Nephropathies
Transforming Growth Factors

MIR-433 Predicts poor response to chemotherapy in ovarian cancer patients by the induction of cellular senescence

K., W-G., Sharpe, D., Milewska, M., Beggan, C., Faheem, N., McGoldrick, A., Toh, V., Madden, S., Fitzpatrick, P., Murphy, M., McCaffrey, J., Harrison, M., Kay, E., Kell, M. R., McCann, A. & Furlong, F., 27 Feb 2014.

Research output: Contribution to conferenceAbstract

Cell Aging
Ovarian Neoplasms
Drug Therapy
Paclitaxel
MicroRNAs
10 Citations (Scopus)

Spindle assembly checkpoint protein expression correlates with cellular proliferation and shorter time to recurrence in ovarian cancer.

McGrogan, B., Phelan, S., Fitzpatrick, P., Maguire, A., Prencipe, M., Brennan, D., Doyle, E., O'Grady, A., Kay, E., Furlong, F. & McCann, A., Jul 2014, In : Human Pathology. 45, 7, p. 1509-19 11 p., 24792619.

Research output: Contribution to journalArticle

M Phase Cell Cycle Checkpoints
Ovarian Neoplasms
Cell Proliferation
Carcinoma
Recurrence
2013
15 Citations (Scopus)

IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses

Corcoran, J. B., McCarthy, S., Griffin, B., Gaffney, A., Bhreathnach, U., Börgeson, E., Hickey, F. B., Docherty, N. G., Higgins, D. F., Furlong, F., Martin, F., Godson, C. & Murphy, M., 2013, In : Biochimica et biophysica acta. 1833, 8, p. 1969-1978

Research output: Contribution to journalArticle

Mitochondria
Glucose
Smad7 Protein
Kidney
Connective Tissue Growth Factor

Novel Hypoxia-Associated Markers of Chemoresistance in Ovarian Cancer

L McEvoy, S O'Toole, C Spillane, B Stordal, M Gallagher, C Martin, L Norris, N Gleeson, A McGoldrick, F Furlong, A McCann, O Sheils, J O'Leary, 01 Feb 2013, p. 288A.

Research output: Contribution to conferenceAbstract

Ovarian Neoplasms
Cisplatin
Survival
Biomarkers
Genes
2012
48 Citations (Scopus)
232 Downloads (Pure)

Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer

Furlong, F., Fitzpatrick, P., O'Toole, S., Phelan, S., McGrogan, B., Maguire, A., O'Grady, A., Gallagher, M., Prencipe, M., McGoldrick, A., McGettigan, P., Brennan, D., Sheils, O., Martin, C., W Kay, E., O'Leary, J. & McCann, A., Apr 2012, In : Journal of Pathology. 226, 5, p. 746-755 10 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Deficiency
Disease-Free Survival
Paclitaxel
3' Untranslated Regions
Ovarian epithelial cancer

Mitotic Arrest Deficiency Protein 2 (MAD2) and Histone Deacetylase 6 (HDAC6) Present a Complex Relationship in Their Regulation and Expression and Subsequent Impact on Chemoresponsiveness

K. Weiner-Gorzel, E. O'Reilly, A. McGoldrick, P. Fitzpatrick, S. O'Toole, A. Maguire, E. Kay, J. O'Leary, A. McCann, & Furlong, F., 01 Jul 2012, p. S214.

Research output: Contribution to conferenceAbstract

Histone Deacetylase 2
Protein Deficiency
Histone Deacetylases
Paclitaxel
Tubulin
2011
29 Citations (Scopus)

IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α

Hickey, F. B., Corcoran, J. B., Docherty, N. G., Griffin, B., Bhreathnach, U., Furlong, F., Martin, F., Godson, C. & Murphy, M., 2011, In : Journal of the American Society of Nephrology. 22, 8, p. 1475-85 11 p.

Research output: Contribution to journalArticle

Organelle Biogenesis
Glucose
Fibrosis
Mitochondrial Proteins
Diabetic Nephropathies

Stabilisation of MAD2 expression through inhibition of miR-433; A novel mechanism for restoring chemo-responsiveness in ovarian tumours

Furlong, F. & Fiona M Furlong, Sine Phelan, Alo McGoldrick, Aoife Maguire, Patricia Fitzpatrick, Sharon O'Toole, Orla Shiels, John J O'Leary, Amanda McCann, 15 Apr 2011, p. LB-338.

Research output: Contribution to conferenceAbstract

Paclitaxel
Ovarian Neoplasms
Neoplasms
Cell Line
Proteins
2010
11 Citations (Scopus)

MAD2 downregulation in hypoxia is independent of promoter hypermethylation

Prencipe, M., McGoldrick, A., Perry, A. S., O'Grady, A., Phelan, S., McGrogan, B., Fitzpatrick, P., Watson, J. A., Furlong, F., Brennan, D. J., Lawler, M., Kay, E. & McCann, A., 15 Jul 2010, In : Cell Cycle . 9, 14, p. 2856-65 10 p.

Research output: Contribution to journalArticle

Down-Regulation
Methylation
Ovarian Neoplasms
Breast Neoplasms
Cell Line

miR-433 overexpression attenuates the spindle assembly checkpoint response to paclitaxel

Furlong, F., Prencipe, M., McGoldrick, A., McGettigan, P., Carney, D., Doyle, E., W Kay, E. & McCann, A., 2010, p. 35.

Research output: Contribution to conferenceAbstract

M Phase Cell Cycle Checkpoints
Paclitaxel
MicroRNAs
HeLa Cells
Ovarian Neoplasms
2009
32 Citations (Scopus)

Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro

Prencipe, M., Fitzpatrick, P., Gorman, S., Mosetto, M., Klinger, R., Furlong, F., Harrison, M., O'Connor, D., Roninson, I. B., O'Sullivan, J. & McCann, A., Nov 2009, In : British Journal of Cancer. 101, 11, p. 1900-8 9 p.

Research output: Contribution to journalArticle

Protein Deficiency
Cell Aging
Paclitaxel
M Phase Cell Cycle Checkpoints
Anaphase
2008
41 Citations (Scopus)

IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis

Murphy, M., Docherty, N. G., Griffin, B., Howlin, J., McArdle, E., McMahon, R., Schmid, H., Kretzler, M., Droguett, A., Mezzano, S., Brady, H. R., Furlong, F., Godson, C. & Martin, F., Sep 2008, In : Journal of the American Society of Nephrology. 19, 9, p. 1672-80 9 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta1
Fibrosis
Kidney
Glucose
Diabetic Nephropathies
11 Citations (Scopus)

Recurrence of Urothelial Carcinoma of the Bladder: A Role for Insulin-Like Growth Factor-II Loss of Imprinting and Cytoplasmic E-Cadherin Immunolocalization

Gallagher, E. M., O'Shea, D. M., Fitzpatrick, P., Harrison, M., Gilmartin, B., Watson, J. A., Clarke, T., Leonard, M. O., McGoldrick, A., Meehan, M., Watson, C., Furlong, F., O'Kelly, P., Fitzpatrick, J. M., Dervan, P. A., O'Grady, A., Kay, E. W. & McCann, A., 01 Nov 2008, In : Clinical Cancer Research. 14, 21, p. 6829-38 10 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor II
Cadherins
Urinary Bladder
Carcinoma
Recurrence
2007
18 Citations (Scopus)

Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose

Furlong, F., Crean, J., Thornton, L., O'Leary, R., Murphy, M. & Martin, F., Jun 2007, In : American Journal of Physiology - Renal Physiology. 292, 6, p. F1691-700

Research output: Contribution to journalArticle

Connective Tissue Growth Factor
Mesangial Cells
Protein Kinase C beta
Glucose
Phosphorylation
2006
33 Citations (Scopus)

Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1)

Crean, J. K., Furlong, F., Mitchell, D., McArdle, E., Godson, C. & Martin, F., Aug 2006, In : The FASEB Journal. 20, 10, p. 1712-4 3 p.

Research output: Contribution to journalArticle

Connective Tissue Growth Factor
Proto-Oncogene Proteins c-akt
Phosphorylation
Actins
Mesangial Cells
2005
9 Citations (Scopus)

PTPase inhibition restores ERK1/2 phosphorylation and protects mammary epithelial cells from apoptosis

Furlong, F., Finlay, D. & Martin, F., 04 Nov 2005, In : Biochemical and Biophysical Research Communications. 336, 4, p. 1292-9 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein Tyrosine Phosphatases
Cell Survival
Signal transduction
Breast
2004
60 Citations (Scopus)

Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization

Crean, J. K., Furlong, F., Finlay, D., Mitchell, D., Murphy, M., Conway, B., Brady, H. R., Godson, C. & Martin, F., Oct 2004, In : The FASEB Journal. 18, 13, p. 1541-3 3 p.

Research output: Contribution to journalArticle

Connective Tissue Growth Factor
Focal Adhesions
Mesangial Cells
cell movement
connective tissues
47 Citations (Scopus)

Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling

Murtagh, J., McArdle, E., Gilligan, E., Thornton, L., Furlong, F. & Martin, F., 05 Jul 2004, In : The Journal of cell biology. 166, 1, p. 133-43 11 p.

Research output: Contribution to journalArticle

Integrin beta4
Glucocorticoids
Transcription Factor AP-1
Breast
Epithelial Cells
2000
33 Citations (Scopus)

MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival

Finlay, D., Healy, V., Furlong, F., O'Connell, F. C., Keon, N. K. & Martin, F., Mar 2000, In : Cell Death and Differentiation. 7, 3, p. 302-13 12 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Extracellular Matrix
Cell Survival
Breast
Cell Death