1992 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research Statement

My research theme focuses on pain and inflammation in the oral cavity and respiratory tract. I have developed non-animal models, including neuronal models differentiated from adult human dental pulp stem cells and induced pluripotent stem cells (iPSCs) to gain a better insight into neuronal responses that reflect human physiology. My work on pain and neurogenic inflammation, and the neuro-inflammatory response to infection, has naturally extended into the related field of transient receptor potential (TRP) channel research and the modulation of these important channels during the inflammatory and regenerative processes. I am particularly interested in the interplay between the innate immune response to infection, and the reparative and regenerative potential of adult stem cells. I also have an interest in studying the stability of host defence peptides and proteins in the inflammatory milieu, and in the design of peptide mimetics with resistance to proteinases and enhanced efficacy against bacterial and fungal pathogens in biofilm form. I have published >70 peer reviewed articles in learned journals and have been successful in obtaining competitive research grant income from a range of funding agencies such as EU INTERREG, NC3Rs, MRC, Pain Relief Foundation, Animal Free Research, HSC R&D Office and the British Society for Antimicrobial Chemotherapy. I currently chair the successful regenerative medicine (REMERGE) group, a multidisciplinary team of academic and clinical researchers, with a focus on using regenerative medicine techniques to study and treat a range of clinical conditions.

Fingerprint Dive into the research topics where Fionnuala Lundy is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

Research Output

A connectivity mapping approach predicted acetylsalicylic acid (aspirin) to induce osteo/odontogenic differentiation of dental pulp cells

Rankin, R., Lundy, F., Schock, B. C., Zhang, S. D., Al-Natour, B., About, I., Irwin, C., Linden, G. J. & El Karim, I. A., Jun 2020, In : International Endodontic Journal. 53, 6, p. 834-845 12 p.

Research output: Contribution to journalArticle

  • A Comparative Analysis of the Osteogenic Potential of Dental Mesenchymal Stem Cells

    Winning, L., El Karim, I. A. & Lundy, F. T., 01 Aug 2019, In : Stem Cells and Development. 28, 15, p. 1050-1058 9 p.

    Research output: Contribution to journalArticle

  • 2 Citations (Scopus)

    Current and Future Views on Pulpal Pain and Neurogenesis

    Lundy, F., El Karim, I. & Scheven, B., 2019, Clinical Approaches in Endodontic Regeneration, Current and Emerging Therapeutic Perspectives. Springer Nature Switzerland, p. 19-36

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    Evaluation of Novel Serine Protease Inhibitors to Ameliorate Cockroach-Induced Airway Inflammation and Cell Damage

    Reihill, J., Yang, Z., Carroll, E., McGarvey, L., Lundy, F., Lockhart, J., Sergeant, G. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.10.

    Research output: Contribution to journalMeeting abstract

    Healthy Primary Epithelial Cells Show an Elevated Inflammatory Response to Bacterial Stimulus Compared to COPD Cells

    Carson, S., Reihill, J., Lundy, F., McGarvey, L., Crilly, A., Fulton, C., Thornbury, K. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.7.

    Research output: Contribution to journalMeeting abstract

    Prizes

    Asthma/COPD Project of the Year, 19th Northern Ireland Healthcare Awards

    Martin, Lorraine (Recipient), McGarvey, Lorcan (Recipient), Lundy, Fionnuala (Recipient), Keith Thornbury (Recipient), Mark Hollywood (Recipient), Gerard Sergeant (Recipient), John Lockhart (Recipient), Gary Litherland (Recipient) & Anne Crilly (Recipient), 22 Feb 2018

    Prize: Prize (including medals and awards)

    File
  • Activities

    Efficacy and Mechanism Evaluation (EME) Programme (External organisation)

    Fionnuala Lundy (Reviewer)

    20192022

    Activity: Membership typesMembership of peer review panel or committee

    Hosting Lurgan College, Work Experience Student

    Fionnuala Lundy (Host)

    16 Jan 201918 Jan 2019

    Activity: Other activity typesHosting a school group or open day

    International Association for Dental Research Annual Conference, London 2018

    Fionnuala Lundy (Session chair)

    25 Jul 201828 Jul 2018

    Activity: Participating in or organising an event typesParticipation in conference

    Maria del Carmen Jiménez Sànchez

    Fionnuala Lundy (Host)

    Sep 2018Dec 2018

    Activity: Hosting a visitor typesHosting an academic visitor

    Hosting Our Lady & St Patrick's College Knock, Work Experience Student

    Fionnuala Lundy (Host)

    22 Jan 201824 Jan 2018

    Activity: Other activity typesHosting a school group or open day

    Press / Media

    MATRIX NI Successful Women in Science

    Fionnuala Lundy

    23/05/2018

    1 Media contribution

    Press/Media: Public Engagement Activities

    Thesis

    An in vitro model for the study of transient receptor potential channels on human sensory neurons

    Author: Clarke, R., 2015

    Supervisor: Lundy, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    A study of the oncolytic and cytolytic effects of human α - defensin 1 (HNP-1) and its truncated analogs

    Author: Lockhart, T., 2009

    Supervisor: Lundy, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Defence Mechanisms of Dental Pulp Stem Cells

    Author: Ravenscroft, H., 2018

    Supervisor: Lundy, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Functional studies of novel alpha helical peptides

    Author: McLean, D., 2013

    Supervisor: Lundy, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    MRGX1-TRPAI in lnflammatory Pain Signalling

    Author: McMillan, H., Jul 2020

    Supervisor: El Karim, I. (Supervisor), Lundy, F. (Supervisor) & Curtis, T. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy