Fionnuala Lundy

Personal profile

Research Statement

My research theme focuses on the interplay between the innate immune response to infection, and the reparative and regenerative potential of adult stem cells. I am particularly interested in the potential for the adult stem cell secretome to modulate the local microenvironment. I am also interested in the role of neuro-inflammatory / innate immune peptides in adult stem cell differentiation. My work on pain and neurogenic inflammation, and the neuro-inflammatory response to infection, has naturally extended into the related field of transient receptor potential (TRP) channel research and the modulation of these important channels during the inflammatory and regenerative processes. I also have an interest in studying the stability of host defence peptides and proteins in the inflammatory milieu, and in the design of peptide mimetics with resistance to proteinases and enhanced efficacy against bacterial and fungal pathogens in biofilm form. I have published >60 peer reviewed articles in learned journals and have been successful in obtaining competitive research grant income from a range of funding agencies such as EU INTERREG, NC3Rs, MRC, Pain Relief Foundation, Animal Free Research, HSC R&D Office and the British Society for Antimicrobial Chemotherapy. I currently chair the successful regenerative medicine (REMERGE) group, a multidisciplinary team of academic and clinical researchers, with a focus on using regenerative medicine techniques to study and treat a range of clinical conditions.

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3 Similar Profiles

Dental Pulp Medicine & Life Sciences

Gingival Crevicular Fluid Medicine & Life Sciences

Neuropeptides Medicine & Life Sciences

Peptides Medicine & Life Sciences

Tooth Medicine & Life Sciences

Fibroblasts Medicine & Life Sciences

Neuropeptide Y Medicine & Life Sciences

Inflammation Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1992 2019

75 Meeting abstract
70 Article
4 Poster
2 Chapter (peer-reviewed)
2 More
- 1 Abstract
- 1 Review article

A Comparative Analysis of the Osteogenic Potential of Dental Mesenchymal Stem Cells

Winning, L., El Karim, I. A. & Lundy, F. T., 01 Aug 2019, In : Stem Cells and Development. 28, 15, p. 1050-1058 9 p.

Research output: Contribution to journal › Article

Dental Pulp

Mesenchymal Stromal Cells

Deciduous Tooth

Tooth

Periodontal Ligament

Current and Future Views on Pulpal Pain and Neurogenesis

Lundy, F., El Karim, I. & Scheven, B., 2019, Clinical Approaches in Endodontic Regeneration, Current and Emerging Therapeutic Perspectives. Springer Nature Switzerland, p. 19-36

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

Evaluation of Novel Serine Protease Inhibitors to Ameliorate Cockroach-Induced Airway Inflammation and Cell Damage

Reihill, J., Yang, Z., Carroll, E., McGarvey, L., Lundy, F., Lockhart, J., Sergeant, G. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.10.

Research output: Contribution to journal › Meeting abstract

Healthy Primary Epithelial Cells Show an Elevated Inflammatory Response to Bacterial Stimulus Compared to COPD Cells

Carson, S., Reihill, J., Lundy, F., McGarvey, L., Crilly, A., Fulton, C., Thornbury, K. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.7.

Research output: Contribution to journal › Meeting abstract

Inhibition of ENaC Activity by Novel Peptide Trypsin-Like Inhibitors Derived from Amphibian Skin Secretions

Carroll, E., Douglas, L., Reihill, J., Zhou, M., Chen, T., McGarvey, L., Lundy, F., Hollywood, M., Lockhart, J. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.9.

Research output: Contribution to journal › Meeting abstract

Prizes

Asthma/COPD Project of the Year, 19th Northern Ireland Healthcare Awards

Lorraine Martin (Recipient), Lorcan McGarvey (Recipient), Fionnuala Lundy (Recipient), Keith Thornbury (Recipient), Mark Hollywood (Recipient), Gerard Sergeant (Recipient), John Lockhart (Recipient), Gary Litherland (Recipient) & Anne Crilly (Recipient), 22 Feb 2018

Prize: Prize (including medals and awards)

File

Northern Ireland

Chronic Obstructive Pulmonary Disease

Asthma

Delivery of Health Care

Research Personnel