Projects per year
Personal profile
Research Statement
My research theme focuses on pain and inflammation in the oral cavity and respiratory tract. I have developed non-animal models, including neuronal models differentiated from adult human dental pulp stem cells and induced pluripotent stem cells (iPSCs) to gain a better insight into neuronal responses that reflect human physiology. My work on pain and neurogenic inflammation, and the neuro-inflammatory response to infection, has naturally extended into the related field of transient receptor potential (TRP) channel research and the modulation of these important channels during the inflammatory and regenerative processes. I am particularly interested in the interplay between the innate immune response to infection, and the reparative and regenerative potential of adult stem cells. I also have an interest in studying the stability of host defence peptides and proteins in the inflammatory milieu, and in the design of peptide mimetics with resistance to proteinases and enhanced efficacy against bacterial and fungal pathogens in biofilm form. I have published >70 peer reviewed articles in learned journals and have been successful in obtaining competitive research grant income from a range of funding agencies such as EU INTERREG, NC3Rs, MRC, Pain Relief Foundation, Animal Free Research, HSC R&D Office and the British Society for Antimicrobial Chemotherapy. I currently chair the successful regenerative medicine (REMERGE) group, a multidisciplinary team of academic and clinical researchers, with a focus on using regenerative medicine techniques to study and treat a range of clinical conditions.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R2714CEM: A single centre pilot prospective study to determine the association between oral health and development of ventilator associated pneumonia
Lundy, F. (PI) & El Karim, I. (CoI)
11/03/2020 → …
Project: Research
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R4826CEM: Endodontic infections and CardiOvascular disease risk (ECO): A prospective study of a possible link?
El Karim, I. (PI), Linden, G. (CoI) & Lundy, F. (CoI)
08/06/2018 → …
Project: Research
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R6964PMY: Interreg VA: BREATH - Border and REgions Airways Training Hub (Full Proposal)
Martin, L. (PI), Lundy, F. (CoI), McGarvey, L. (CoI) & Tikhonova, I. (CoI)
02/05/2017 → …
Project: Research
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R2570RED: Molecular mechanisms in detine sensitivity and pain <MEDICI/BIOMED>
El Karim, I. (PI), Curtis, T. (CoI) & Lundy, F. (CoI)
01/08/2007 → …
Project: Research
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aMMP-8 POCT vs. other potential biomarkers in chair-side diagnostics and treatment monitoring of severe periodontitis
Aji, N. R. A. S., Räisänen, I. T., Rathnayake, N., Lundy, F. T., Mc Crudden, M. T. C., Goyal, L., Sorsa, T. & Gupta, S., 01 Sept 2024, In: International Journal of Molecular Sciences. 25, 17, 9421.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Immunological isolation and characterization of neuronal progenitors from human dental pulp: a laboratory‐based investigation
McMillan, H. P., Lundy, F. T., Dunne, O. M., McLoughlin, K. J., About, I., Curtis, T. M. & El Karim, I., 07 May 2024, (Early online date) In: International Endodontic Journal. 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)43 Downloads (Pure) -
In vivo regulation of active matrix metalloproteinase-8 (aMMP-8) in periodontitis: from transcriptomics to real-time online diagnostics and treatment monitoring
Aji, N. R. A. S., Yucel-Lindberg, T., Räisänen, I. T., Kuula, H., Nieminen, M. T., Mc Crudden, M. T. C., Listyarifah, D., Lundmark, A., Lundy, F. T., Gupta, S. & Sorsa, T., 15 May 2024, In: Diagnostics. 14, 10, 14 p., 1011.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)13 Downloads (Pure) -
Modulation of fast sodium current in airway smooth muscle cells by Exchange Protein Directly Activated by cAMP (Epac)
Matthews, R. M., Bradley, E., Hollywood, M. A., Lundy, F. T., McGarvey, L. P., Sergeant, G. P. & Thornbury, K. D., 01 Jan 2024, In: American Journal of Physiology - Cell Physiology. 326, p. C1-C9 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Downloads (Pure) -
TRPV2 modulates mechanically induced ATP release from human bronchial epithelial cells
Dunne, O. M., Martin, S. L., Sergeant, G. P., McAuley, D. F., O’Kane, C. M., Button, B., McGarvey, L. P. & Lundy, F. T., 27 Apr 2024, In: Respiratory Research. 25, 10 p., 188.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Downloads (Pure)
Prizes
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Asthma/COPD Project of the Year, 19th Northern Ireland Healthcare Awards
Martin, Lorraine (Recipient), McGarvey, Lorcan (Recipient), Lundy, Fionnuala (Recipient), Thornbury, Keith (Recipient), Hollywood, Mark (Recipient), Sergeant, Gerard (Recipient), Lockhart, John (Recipient), Litherland, Gary (Recipient) & Crilly, Anne (Recipient), 22 Feb 2018
Prize: Prize (including medals and awards)
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Distinguished Scientist Award from the International Association for Dental Research in the field of Pulp Biology & Regeneration
Lundy, F. (Recipient), 21 Jul 2021
Prize: Prize (including medals and awards)
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International Association for Dental Research (IADR)/ GlakoSmithKline (GSK) Innovation in Oral Care Award. The IADR's most prestigious monetary prize (CI, Dr F Lundy)
Lundy, Fionnuala (Recipient), 2011
Prize: Prize (including medals and awards)
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International Association for Dental Research (IADR)/ GlakoSmithKline (GSK) Innovation in Oral Care Award. The IADR's most prestigious monetary prize (PI, Dr F Lundy)
Lundy, Fionnuala (Recipient), 2007
Prize: Prize (including medals and awards)
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PhD student Denise McLean (Principal Supervisor Dr F Lundy) won the Best Poster Prize at the 18th International Symposium on Regulatory Peptides
Lundy, Fionnuala (Recipient), 2010
Prize: Prize (including medals and awards)
Activities
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External Examiner PhD Thesis, University of Bergen
Fionnuala Lundy (Examiner)
24 Feb 2023Activity: Examination types › PhD external examination
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Gordon Research Conference Tuscany, Italy, 2023: Novel Antimicrobial Properties of the Stem Cell Secretome
Fionnuala Lundy (Invited speaker)
15 Jan 2023 → 20 Jan 2023Activity: Talk or presentation types › Invited or keynote talk at national or international conference
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IADR Pan European Region Oral Health Congress 2022
Lundy, F. (President)
15 Sept 2022 → 17 Sept 2022Activity: Participating in or organising an event types › Participation in conference
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International Association for Dental Research Annual Conference, China 2022: (Held online)
Fionnuala Lundy (Session chair)
14 Sept 2022 → 17 Sept 2022Activity: Participating in or organising an event types › Participation in conference
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Expert Reviewer, Promotions Exercise, University of Texas Health Centre at Houston
Fionnuala Lundy (Reviewer)
01 Sept 2022 → 30 Sept 2022Activity: Other activity types › Other
Press/Media
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Dr Fionnuala Lundy (PER-IADR President) opens the PER-IADR meeting in Marseille
16/09/2022
1 item of Media coverage
Press/Media: Research
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International Foundation for Ethical Research: Graduate Fellowship Recipient - Orla Dunne 2020-2021
30/07/2021
1 Media contribution
Press/Media: Research
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Fionnuala Lundy Named 2021 Recipient of the IADR Distinguished Scientist Award in Pulp Biology and Regeneration
21/07/2021 → 30/07/2021
1 item of Media coverage, 1 Media contribution
Press/Media: Research
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MATRIX NI (WISE) Successful Women in Science Role Model
23/05/2018
1 Media contribution
Press/Media: Public Engagement Activities
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QUEEN’S COLLABORATIVE PROJECT WINS ASTHMA / COPD PROJECT OF THE YEAR
Lorraine Martin, Lorcan McGarvey & Fionnuala Lundy
28/02/2018
1 item of Media coverage
Press/Media: Research