Fionnuala Lundy

Personal profile

Research Statement

My research theme focuses on pain and inflammation in the oral cavity and respiratory tract. I have developed non-animal models, including neuronal models differentiated from adult human dental pulp stem cells and induced pluripotent stem cells (iPSCs) to gain a better insight into neuronal responses that reflect human physiology. My work on pain and neurogenic inflammation, and the neuro-inflammatory response to infection, has naturally extended into the related field of transient receptor potential (TRP) channel research and the modulation of these important channels during the inflammatory and regenerative processes. I am particularly interested in the interplay between the innate immune response to infection, and the reparative and regenerative potential of adult stem cells. I also have an interest in studying the stability of host defence peptides and proteins in the inflammatory milieu, and in the design of peptide mimetics with resistance to proteinases and enhanced efficacy against bacterial and fungal pathogens in biofilm form. I have published >70 peer reviewed articles in learned journals and have been successful in obtaining competitive research grant income from a range of funding agencies such as EU INTERREG, NC3Rs, MRC, Pain Relief Foundation, Animal Free Research, HSC R&D Office and the British Society for Antimicrobial Chemotherapy. I currently chair the successful regenerative medicine (REMERGE) group, a multidisciplinary team of academic and clinical researchers, with a focus on using regenerative medicine techniques to study and treat a range of clinical conditions.

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Projects

1 Finished

R1558CII: MRC P2D 2015 - Adult mesenchymal stem cell culture and differentiation in commercial hydrogels

Lundy, F.

04/09/2015 → 30/11/2016

Project: Research

Research Output

75 Meeting abstract
72 Article
6 Poster
2 Chapter (peer-reviewed)
2 More
- 1 Abstract
- 1 Review article

A connectivity mapping approach predicted acetylsalicylic acid (aspirin) to induce osteo/odontogenic differentiation of dental pulp cells

Rankin, R., Lundy, F., Schock, B. C., Zhang, S. D., Al-Natour, B., About, I., Irwin, C., Linden, G. J. & El Karim, I. A., Jun 2020, In : International Endodontic Journal. 53, 6, p. 834-845 12 p.

Research output: Contribution to journal › Article

A Comparative Analysis of the Osteogenic Potential of Dental Mesenchymal Stem Cells

Winning, L., El Karim, I. A. & Lundy, F. T., 01 Aug 2019, In : Stem Cells and Development. 28, 15, p. 1050-1058 9 p.

Research output: Contribution to journal › Article

2 Citations (Scopus)

Current and Future Views on Pulpal Pain and Neurogenesis

Lundy, F., El Karim, I. & Scheven, B., 2019, Clinical Approaches in Endodontic Regeneration, Current and Emerging Therapeutic Perspectives. Springer Nature Switzerland, p. 19-36

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

Evaluation of Novel Serine Protease Inhibitors to Ameliorate Cockroach-Induced Airway Inflammation and Cell Damage

Reihill, J., Yang, Z., Carroll, E., McGarvey, L., Lundy, F., Lockhart, J., Sergeant, G. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.10.

Research output: Contribution to journal › Meeting abstract

Healthy Primary Epithelial Cells Show an Elevated Inflammatory Response to Bacterial Stimulus Compared to COPD Cells

Carson, S., Reihill, J., Lundy, F., McGarvey, L., Crilly, A., Fulton, C., Thornbury, K. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.7.

Research output: Contribution to journal › Meeting abstract

Prizes

Asthma/COPD Project of the Year, 19th Northern Ireland Healthcare Awards

Martin, Lorraine (Recipient), McGarvey, Lorcan (Recipient), Lundy, Fionnuala (Recipient), Keith Thornbury (Recipient), Mark Hollywood (Recipient), Gerard Sergeant (Recipient), John Lockhart (Recipient), Gary Litherland (Recipient) & Anne Crilly (Recipient), 22 Feb 2018

Prize: Prize (including medals and awards)

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