1992 …2019

Research output per year

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Personal profile

Research Statement

My research theme focuses on the interplay between the innate immune response to infection, and the reparative and regenerative potential of adult stem cells. I am particularly interested in the potential for the adult stem cell secretome to modulate the local microenvironment. I am also interested in the role of neuro-inflammatory / innate immune peptides in adult stem cell differentiation. My work on pain and neurogenic inflammation, and the neuro-inflammatory response to infection, has naturally extended into the related field of transient receptor potential (TRP) channel research and the modulation of these important channels during the inflammatory and regenerative processes. I also have an interest in studying the stability of host defence peptides and proteins in the inflammatory milieu, and in the design of peptide mimetics with resistance to proteinases and enhanced efficacy against bacterial and fungal pathogens in biofilm form. I have published >60 peer reviewed articles in learned journals and have been successful in obtaining competitive research grant income from a range of funding agencies such as EU INTERREG, NC3Rs, MRC, Pain Relief Foundation, Animal Free Research, HSC R&D Office and the British Society for Antimicrobial Chemotherapy. I currently chair the successful regenerative medicine (REMERGE) group,  a multidisciplinary team of academic and clinical researchers, with a focus on using regenerative medicine techniques to study and treat a range of clinical conditions.

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Projects

Research Output

A Comparative Analysis of the Osteogenic Potential of Dental Mesenchymal Stem Cells

Winning, L., El Karim, I. A. & Lundy, F. T., 01 Aug 2019, In : Stem Cells and Development. 28, 15, p. 1050-1058 9 p.

Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Current and Future Views on Pulpal Pain and Neurogenesis

    Lundy, F., El Karim, I. & Scheven, B., 2019, Clinical Approaches in Endodontic Regeneration, Current and Emerging Therapeutic Perspectives. Springer Nature Switzerland, p. 19-36

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    Evaluation of Novel Serine Protease Inhibitors to Ameliorate Cockroach-Induced Airway Inflammation and Cell Damage

    Reihill, J., Yang, Z., Carroll, E., McGarvey, L., Lundy, F., Lockhart, J., Sergeant, G. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.10.

    Research output: Contribution to journalMeeting abstract

    Healthy Primary Epithelial Cells Show an Elevated Inflammatory Response to Bacterial Stimulus Compared to COPD Cells

    Carson, S., Reihill, J., Lundy, F., McGarvey, L., Crilly, A., Fulton, C., Thornbury, K. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.7.

    Research output: Contribution to journalMeeting abstract

    Inhibition of ENaC Activity by Novel Peptide Trypsin-Like Inhibitors Derived from Amphibian Skin Secretions

    Carroll, E., Douglas, L., Reihill, J., Zhou, M., Chen, T., McGarvey, L., Lundy, F., Hollywood, M., Lockhart, J. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.9.

    Research output: Contribution to journalMeeting abstract

    Prizes

    Asthma/COPD Project of the Year, 19th Northern Ireland Healthcare Awards

    Lorraine Martin (Recipient), Lorcan McGarvey (Recipient), Fionnuala Lundy (Recipient), Keith Thornbury (Recipient), Mark Hollywood (Recipient), Gerard Sergeant (Recipient), John Lockhart (Recipient), Gary Litherland (Recipient) & Anne Crilly (Recipient), 22 Feb 2018

    Prize: Prize (including medals and awards)

    File
  • Activities

    Efficacy and Mechanism Evaluation (EME) Programme (External organisation)

    Fionnuala Lundy (Reviewer)
    20192022

    Activity: Membership typesMembership of peer review panel or committee

    Hosting Lurgan College, Work Experience Student

    Fionnuala Lundy (Host)
    16 Jan 201918 Jan 2019

    Activity: Other activity typesHosting a school group or open day

    STEM Ambassador

    Fionnuala Lundy (Contributor)
    20182021

    Activity: Other activity typesOther

    International Association for Dental Research Annual Conference, London 2018

    Fionnuala Lundy (Session chair)
    25 Jul 201828 Jul 2018

    Activity: Participating in or organising an event typesParticipation in conference

    Northern Ireland Science Festival 'Know Your Enemy' - Outreach activity for disease focused research at Queen's 2018

    Fionnuala Lundy (Organiser)
    17 Feb 2018

    Activity: Participating in or organising an event typesParticipation in Festival/Exhibition

    Press / Media

    MATRIX NI Successful Women in Science

    Fionnuala Lundy

    23/05/2018

    1 Media contribution

    Press/Media: Public Engagement Activities

    Thesis

    An in vitro model for the study of transient receptor potential channels on human sensory neurons

    Author: Clarke, R., 2015

    Supervisor: Lundy, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    A study of the oncolytic and cytolytic effects of human α - defensin 1 (HNP-1) and its truncated analogs

    Author: Lockhart, T., 2009

    Supervisor: Lundy, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Defence Mechanisms of Dental Pulp Stem Cells

    Author: Ravenscroft, H., 2018

    Supervisor: Lundy, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Functional studies of novel alpha helical peptides

    Author: McLean, D., 2013

    Supervisor: Lundy, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Neuropeptide Y and vasoactive intestinal polypeptide in human dental pulps from carious and non-carious teeth

    Author: El Karim, I., 2003

    Supervisor: Lundy, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy