1992 …2019
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Personal profile

Research Statement

My research theme focuses on the interplay between the innate immune response to infection, and the reparative and regenerative potential of adult stem cells. I am particularly interested in the potential for the adult stem cell secretome to modulate the local microenvironment. I am also interested in the role of neuro-inflammatory / innate immune peptides in adult stem cell differentiation. My work on pain and neurogenic inflammation, and the neuro-inflammatory response to infection, has naturally extended into the related field of transient receptor potential (TRP) channel research and the modulation of these important channels during the inflammatory and regenerative processes. I also have an interest in studying the stability of host defence peptides and proteins in the inflammatory milieu, and in the design of peptide mimetics with resistance to proteinases and enhanced efficacy against bacterial and fungal pathogens in biofilm form. I have published >60 peer reviewed articles in learned journals and have been successful in obtaining competitive research grant income from a range of funding agencies such as EU INTERREG, NC3Rs, MRC, Pain Relief Foundation, Animal Free Research, HSC R&D Office and the British Society for Antimicrobial Chemotherapy. I currently chair the successful regenerative medicine (REMERGE) group,  a multidisciplinary team of academic and clinical researchers, with a focus on using regenerative medicine techniques to study and treat a range of clinical conditions.

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  • 3 Similar Profiles
Dental Pulp Medicine & Life Sciences
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Tooth Medicine & Life Sciences
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Neuropeptide Y Medicine & Life Sciences
Inflammation Medicine & Life Sciences

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Research Output 1992 2019

A Comparative Analysis of the Osteogenic Potential of Dental Mesenchymal Stem Cells

Winning, L., El Karim, I. A. & Lundy, F. T., 01 Aug 2019, In : Stem Cells and Development. 28, 15, p. 1050-1058 9 p.

Research output: Contribution to journalArticle

Dental Pulp
Mesenchymal Stromal Cells
Deciduous Tooth
Tooth
Periodontal Ligament

Current and Future Views on Pulpal Pain and Neurogenesis

Lundy, F., El Karim, I. & Scheven, B., 2019, Clinical Approaches in Endodontic Regeneration, Current and Emerging Therapeutic Perspectives. Springer Nature Switzerland, p. 19-36

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Evaluation of Novel Serine Protease Inhibitors to Ameliorate Cockroach-Induced Airway Inflammation and Cell Damage

Reihill, J., Yang, Z., Carroll, E., McGarvey, L., Lundy, F., Lockhart, J., Sergeant, G. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.10.

Research output: Contribution to journalMeeting abstract

Healthy Primary Epithelial Cells Show an Elevated Inflammatory Response to Bacterial Stimulus Compared to COPD Cells

Carson, S., Reihill, J., Lundy, F., McGarvey, L., Crilly, A., Fulton, C., Thornbury, K. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.7.

Research output: Contribution to journalMeeting abstract

Inhibition of ENaC Activity by Novel Peptide Trypsin-Like Inhibitors Derived from Amphibian Skin Secretions

Carroll, E., Douglas, L., Reihill, J., Zhou, M., Chen, T., McGarvey, L., Lundy, F., Hollywood, M., Lockhart, J. & Martin, L., 01 Apr 2019, In : The FASEB Journal. 33, Suppl. 1, 127.9.

Research output: Contribution to journalMeeting abstract

Prizes

Asthma/COPD Project of the Year, 19th Northern Ireland Healthcare Awards

Lorraine Martin (Recipient), Lorcan McGarvey (Recipient), Fionnuala Lundy (Recipient), Keith Thornbury (Recipient), Mark Hollywood (Recipient), Gerard Sergeant (Recipient), John Lockhart (Recipient), Gary Litherland (Recipient) & Anne Crilly (Recipient), 22 Feb 2018

Prize: Prize (including medals and awards)

File
Northern Ireland
Chronic Obstructive Pulmonary Disease
Asthma
Delivery of Health Care
Research Personnel

Activities 1995 2019

Efficacy and Mechanism Evaluation (EME) Programme (External organisation)

Fionnuala Lundy (Reviewer)
20192022

Activity: Membership typesMembership of peer review panel or committee

Hosting Lurgan College, Work Experience Student

Fionnuala Lundy (Host)
16 Jan 201918 Jan 2019

Activity: Other activity typesHosting a school group or open day

Invited Plenary Lecture International Association for Dental Research London 2018: The neurogenic inflammatory response and its role in pulpal healing and repair

Fionnuala Lundy (Invited speaker)
25 Jul 2018

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

Maria del Carmen Jiménez Sànchez

Fionnuala Lundy (Host)
Sep 2018Dec 2018

Activity: Hosting a visitor typesHosting an academic visitor

Hosting Our Lady & St Patrick's College Knock, Work Experience Student

Fionnuala Lundy (Host)
22 Jan 201824 Jan 2018

Activity: Other activity typesHosting a school group or open day

Press / Media

MATRIX NI Successful Women in Science

Fionnuala Lundy

23/05/2018

1 media contribution

Press/Media: Public Engagement Activities

Thesis

An in vitro model for the study of transient receptor potential channels on human sensory neurons

Author: Clarke, R., 2015

Supervisor: Lundy, F. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

A study of the oncolytic and cytolytic effects of human α - defensin 1 (HNP-1) and its truncated analogs

Author: Lockhart, T., 2009

Supervisor: Lundy, F. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Defence Mechanisms of Dental Pulp Stem Cells

Author: Ravenscroft, H., 2018

Supervisor: Lundy, F. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Functional studies of novel alpha helical peptides

Author: McLean, D., 2013

Supervisor: Lundy, F. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Neuropeptide Y and vasoactive intestinal polypeptide in human dental pulps from carious and non-carious teeth

Author: El Karim, I., 2003

Supervisor: Lundy, F. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy