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Research Interests

My work seeks a mechanistic basis for cancer morphology, one of the best established predictors of clinical outcome. To do this, I investigate mechanisms of epithelial assembly into mature glandular architecture in model systems. With others, I defined the role of the apical PTEN/CDC42/PRKCZ pathway in mitotic spindle orientation, epithelial alignment and lumen formation during colonic gland (crypt) assembly. I investigated oncogenic destabilization of these phenomena. I indentified mechanisms underlying cribriform morphology, a histological marker of malignant transformation in human, for the first time. I identified therapeutic targets, conduct translational studies and a cancer clinical trial. I have identified mechanistic links between 2 cancer hallmarks that were previously considered distinct viz genomic instability and cancer morphology.

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  • 6 Similar Profiles
Osteopontin Medicine & Life Sciences
Colorectal Neoplasms Medicine & Life Sciences
Phenotype Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Spindle Apparatus Medicine & Life Sciences
Vitamin D Medicine & Life Sciences
Calcitriol Receptors Medicine & Life Sciences
Acute Lung Injury Medicine & Life Sciences

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Projects 2014 2018

Research Output 2001 2018

2 Citations (Scopus)
162 Downloads (Pure)

Mechanistic Insights into Colorectal Cancer Phenomics from Fundamental and Organotypic Model Studies

Campbell, F. C., Loughrey, M. B., McClements, J., Deevi, R. K., Javadi, A. & Rainey, L., 01 Sep 2018, In : The American journal of pathology. 188, 9, p. 1936-1948

Research output: Contribution to journalReview article

Open Access
Colorectal Neoplasms
1 Citation (Scopus)
149 Downloads (Pure)

Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring

Deevi, R. K., Javadi, A., McClements, J., Vohhodina, J., Savage, K., Loughrey, M. B., Evergren, E. & Campbell, F. C., 09 Mar 2018, In : Journal of Pathology. p. 1-15

Research output: Contribution to journalArticle

Open Access
Colorectal Neoplasms
Spindle Apparatus
9 Citations (Scopus)
138 Downloads (Pure)

PTEN 1 controls glandular morphogenesis through a juxtamembrane 2 β-Arrestin1/ARHGAP21 scaffolding complex

Javadi, A., Deevi, R. K., Evergren, E., Blondel-Tepaz, E., Baillie, G. S., Scott, M. G. H. & Campbell, F. C., 27 Jul 2017, In : eLife. 6, e24578

Research output: Contribution to journalArticle

Open Access
Spindle Apparatus
cdc42 GTP-Binding Protein
GTPase-Activating Proteins
5 Citations (Scopus)
291 Downloads (Pure)

Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype

Deevi, R., McClements, J., McCloskey, K. D., Fatehullah, A., Tkocz, D., Javadi, A., Higginson, R., Durban, V. M., Jansen, M., Clarke, A., Loughrey, M. & Campbell, F., 02 Aug 2016, In : Oncotarget. 7, 31, p. 49042-49064

Research output: Contribution to journalArticle

Open Access
Spindle Apparatus
Vitamin D
Intestinal Neoplasms
21 Citations (Scopus)
153 Downloads (Pure)

Functional and genetic analysis of the colon cancer network

Emmert-Streib, F., de Matos Simoes, R., Glazko, G., McDade, S., Haibe-Kains, B., Holzinger, A., Dehmer, M. & Campbell, F. C., 16 May 2014, In : BMC Bioinformatics. 15 , Suppl 6, 15 p.

Research output: Contribution to journalArticle

Open Access
Colonic Neoplasms