Frederick Campbell

Professor

20012021

Research activity per year

Personal profile

Research Interests

My work seeks a mechanistic basis for cancer morphology, one of the best established predictors of clinical outcome. To do this, I investigate mechanisms of epithelial assembly into mature glandular architecture in model systems. With others, I defined the role of the apical PTEN/CDC42/PRKCZ pathway in mitotic spindle orientation, epithelial alignment and lumen formation during colonic gland (crypt) assembly. I investigated oncogenic destabilization of these phenomena. I indentified mechanisms underlying cribriform morphology, a histological marker of malignant transformation in human, for the first time. I identified therapeutic targets, conduct translational studies and a cancer clinical trial. I have identified mechanistic links between 2 cancer hallmarks that were previously considered distinct viz genomic instability and cancer morphology.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Fingerprint

Dive into the research topics where Frederick Campbell is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or