If you made any changes in Pure these will be visible here soon.

Personal profile

Research Interests

My work seeks a mechanistic basis for cancer morphology, one of the best established predictors of clinical outcome. To do this, I investigate mechanisms of epithelial assembly into mature glandular architecture in model systems. With others, I defined the role of the apical PTEN/CDC42/PRKCZ pathway in mitotic spindle orientation, epithelial alignment and lumen formation during colonic gland (crypt) assembly. I investigated oncogenic destabilization of these phenomena. I indentified mechanisms underlying cribriform morphology, a histological marker of malignant transformation in human, for the first time. I identified therapeutic targets, conduct translational studies and a cancer clinical trial. I have identified mechanistic links between 2 cancer hallmarks that were previously considered distinct viz genomic instability and cancer morphology.

Fingerprint Dive into the research topics where Frederick Campbell is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Osteopontin Medicine & Life Sciences
Colorectal Neoplasms Medicine & Life Sciences
Phenotype Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Spindle Apparatus Medicine & Life Sciences
Vitamin D Medicine & Life Sciences
Calcitriol Receptors Medicine & Life Sciences
Acute Lung Injury Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2018

Research Output 2001 2018

2 Citations (Scopus)
162 Downloads (Pure)

Mechanistic Insights into Colorectal Cancer Phenomics from Fundamental and Organotypic Model Studies

Campbell, F. C., Loughrey, M. B., McClements, J., Deevi, R. K., Javadi, A. & Rainey, L., 01 Sep 2018, In : The American journal of pathology. 188, 9, p. 1936-1948

Research output: Contribution to journalReview article

Open Access
File
Colorectal Neoplasms
Neoplasms
Phenotype
Homeostasis
Genome
1 Citation (Scopus)
149 Downloads (Pure)

Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring

Deevi, R. K., Javadi, A., McClements, J., Vohhodina, J., Savage, K., Loughrey, M. B., Evergren, E. & Campbell, F. C., 09 Mar 2018, In : Journal of Pathology. p. 1-15

Research output: Contribution to journalArticle

Open Access
File
Centrosome
Interphase
Colorectal Neoplasms
Phenotype
Spindle Apparatus
9 Citations (Scopus)
138 Downloads (Pure)

PTEN 1 controls glandular morphogenesis through a juxtamembrane 2 β-Arrestin1/ARHGAP21 scaffolding complex

Javadi, A., Deevi, R. K., Evergren, E., Blondel-Tepaz, E., Baillie, G. S., Scott, M. G. H. & Campbell, F. C., 27 Jul 2017, In : eLife. 6, e24578

Research output: Contribution to journalArticle

Open Access
File
Morphogenesis
Spindle Apparatus
Membranes
cdc42 GTP-Binding Protein
GTPase-Activating Proteins
5 Citations (Scopus)
291 Downloads (Pure)

Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype

Deevi, R., McClements, J., McCloskey, K. D., Fatehullah, A., Tkocz, D., Javadi, A., Higginson, R., Durban, V. M., Jansen, M., Clarke, A., Loughrey, M. & Campbell, F., 02 Aug 2016, In : Oncotarget. 7, 31, p. 49042-49064

Research output: Contribution to journalArticle

Open Access
File
Spindle Apparatus
Cholecalciferol
Vitamin D
Intestinal Neoplasms
Phenotype
21 Citations (Scopus)
153 Downloads (Pure)

Functional and genetic analysis of the colon cancer network

Emmert-Streib, F., de Matos Simoes, R., Glazko, G., McDade, S., Haibe-Kains, B., Holzinger, A., Dehmer, M. & Campbell, F. C., 16 May 2014, In : BMC Bioinformatics. 15 , Suppl 6, 15 p.

Research output: Contribution to journalArticle

Open Access
File
Colonic Neoplasms
Cancer
Genes
Gene
Interaction