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Personal profile

Research Interests

My work seeks a mechanistic basis for cancer morphology, one of the best established predictors of clinical outcome. To do this, I investigate mechanisms of epithelial assembly into mature glandular architecture in model systems. With others, I defined the role of the apical PTEN/CDC42/PRKCZ pathway in mitotic spindle orientation, epithelial alignment and lumen formation during colonic gland (crypt) assembly. I investigated oncogenic destabilization of these phenomena. I indentified mechanisms underlying cribriform morphology, a histological marker of malignant transformation in human, for the first time. I identified therapeutic targets, conduct translational studies and a cancer clinical trial. I have identified mechanistic links between 2 cancer hallmarks that were previously considered distinct viz genomic instability and cancer morphology.

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Projects

Research Output

Open Access
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  • 5 Downloads (Pure)

    Mechanistic Insights into Colorectal Cancer Phenomics from Fundamental and Organotypic Model Studies

    Campbell, F. C., Loughrey, M. B., McClements, J., Deevi, R. K., Javadi, A. & Rainey, L., 01 Sep 2018, In : The American journal of pathology. 188, 9, p. 1936-1948

    Research output: Contribution to journalReview article

    Open Access
    File
  • 3 Citations (Scopus)
    229 Downloads (Pure)

    Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring

    Deevi, R. K., Javadi, A., McClements, J., Vohhodina, J., Savage, K., Loughrey, M. B., Evergren, E. & Campbell, F. C., 09 Mar 2018, In : Journal of Pathology. p. 1-15

    Research output: Contribution to journalArticle

    Open Access
    File
  • 3 Citations (Scopus)
    195 Downloads (Pure)

    PTEN 1 controls glandular morphogenesis through a juxtamembrane 2 β-Arrestin1/ARHGAP21 scaffolding complex

    Javadi, A., Deevi, R. K., Evergren, E., Blondel-Tepaz, E., Baillie, G. S., Scott, M. G. H. & Campbell, F. C., 27 Jul 2017, In : eLife. 6, e24578

    Research output: Contribution to journalArticle

    Open Access
    File
  • 10 Citations (Scopus)
    189 Downloads (Pure)

    Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype

    Deevi, R., McClements, J., McCloskey, K. D., Fatehullah, A., Tkocz, D., Javadi, A., Higginson, R., Durban, V. M., Jansen, M., Clarke, A., Loughrey, M. & Campbell, F., 02 Aug 2016, In : Oncotarget. 7, 31, p. 49042-49064

    Research output: Contribution to journalArticle

    Open Access
    File
  • 6 Citations (Scopus)
    348 Downloads (Pure)