Gareth McKay

Dr

  • Room 03.020 - Clinical Science B

    United Kingdom

Accepting PhD Students

PhD projects

Dr McKay is open to wide-ranging PhD applications from candidates with a basic science or clinical background. Fields of research interests include: Diabetic complications Biomarker discovery Stratified Medicine Previous research experience is desirable although not essential.

19972020

Research output per year

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Personal profile

Interests

In 2002, I started a research fellowship in the Centre for Vision and Vascular Science at Queen's, undertaking genetic analyses of inherited retinal dystrophies and complex ophthalmic conditions.  I was offered a faculty position as a Lecturer in Bioinformatics within the Centre for Public Health in 2010 and Senior Lecturer in 2020. To date, I have successfully trained 9 PhD, 4 Masters and 6 undergraduate intercalating medical students.  I have authored 2 book chapters,  >80 peer-reviewed articles (Scopus h-index 26, >4200 citations, July 20) and been PI on successful research grant awards from the MRC, NI Health and Social Care and Diabetes UK, with over £3.3M of grant income as co-I.

Research interests include biomarker discovery associated with microvascular dysfunction in diabetes and its complications in the kidney, heart and eye.  Data from non-invasive retinal imaging may provide informative biomarkers to identify early microvascular decline in ‘at risk’ individuals. In addition, given the neural retina is an extension of the brain, these biomarkers may also help identify cognitive decline.

Additional interests include identification of (epi)genetic risk factors associated with diabetes and its complications, dementia and other chronic diseases, including nutrigenomic disease risk, socioeconomic factors and serum carotenoid and antioxidant levels, particularly vitamin E.

Novel biomarker discovery to prioritise ‘at risk’ individuals for appropriate preventative strategies will improve patient outcomes, particularly when clinical options are limited.

Research Statement

I lead a small international team of postdocs, PhD and Masters students investigating the molecular pathogenesis of dementia and diabetes-associated complications through research on genomic, physiological and nutritional factors that influence healthy ageing and human disease. Studies have focused on candidate genes, prioritised genetic regions, genome-wide and epigenome-wide screens, and whole exome/genome sequencing.  Data has been evaluated from individuals recruited as part of multi-centre collections, including UK Biobank and the Northern Ireland Cohort of Longitudinal Ageing, which focuses on older individuals living in Northern Ireland.

Teaching

I contribute to undergraduate medicine and biomedical science teaching in the School of Medicine, Dentistry and Biomedical Sciences, including the development of 2 new modules. I also contribute to postgraduate teaching in our centre and medical school. Current teaching commitments also include participation in standard setting, exam boards, progress reviews, postgraduate research boards.  The following are a list of my teaching activities:

Undergraduate Teaching

Medicine Year 1

MED1023: Principles of Disease and Treatment 1

MED1012: Personal and Professional Development Portfolio

MED1021: Student Selected Component (Module coordinator - Genomic Impact in Medicine) 

Medicine Year 2 

MED2016: Student Selected Component

MED2018: Personal and Professional Development Portfolio

Biomedical Science Year 2

BMS2103: Cell Biology and Clinical Genetics (Module co-coordinator) 

Biomedical Science Year 3 

BMS3112: Research Project 

Biological Sciences Year 3

BIO3308: Research Project

Postgraduate Teaching 

Masters in Public Health 

SCM8030: Dissertation - Public Health

Masters in Bioinformatics and Computational Genomics 

SCM8095: Genomics and Human Disease (Module co-coordinator)

Achievements

I am a Fellow of the Higher Education Academy and an Editorial Board Member for the journals, Scientific Reports (Nature Publishing Group), the International Journal of Molecular Epidemiology and Genetics (e-Century Publishing Corporation) and the Journal of Diabetes Research (Hindawi Publishing Group).

 

Administrative and Managerial roles

Since 2015, I have been an expert reviewer and Vice Chair for multiple EU Horizon 2020 LIF programmes including Innovative Medicines Initiative 2, Use of Real World Data to Advance Research on the Management of Complex Chroinic Conditions, Marie Sktodowska-Curie Innovative Training Networks and Marie Sktodowska-Curie Individual Fellowships.  I am the DI licence holder for the Queen’s University Royal Victoria Hospital site with statutory regulatory responsibilities for licensed activities under the Human Tissue Act (2004) and sit on the University HTA Committee.  I chair the Centre for Public Health ‘Health and Safety Committee’ and sit on the School of Medicine, Dentistry and Biomedical Science Health and Safety Committee.  I am a member of the Senior Management Team in the Centre for Public Health. I have undertaken external examiner roles at the University of Edinburgh (2016), University College Dublin (2017) and University of Dundee (2020).

Other

Outreach Activities

I meet with patient groups from Alzheimer's Research UK and Diabetes UK to discuss our research. I have undertaken STEM activities at W5 including heading the judging panel for 'Debating Science Issues' in addition to public engagement events as part of the Northern Ireland Science Festival on genetics. We host regular work-placement students and I am a champion for the Nuffield Research Placement Programme for Northern Ireland. I have given talks at secondary schools, science fairs and other events aimed at encouraging students to pursue careers in science and medicine.

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