• Room 01.112 - Biological Sciences

    United Kingdom

Accepting PhD Students

PhD projects

I am open to PhD applications from individuals holding or expecting to hold at least a 2.1 degree (or equivalent) in the fields of immunology, biochemistry or parasitology. A strategy for obtaining funding for a PhD is required. Applicants should be interested in helminthology or parasitology with a view to research pathogens of clinical and/or veterinary significance.

19962020

Research output per year

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Personal profile

Research Interests

Dr Gobert is an internationally recognised researcher in the field of helminth biology, and more specifically transcriptional profiling of the blood fluke Schistosoma. Schistosomiasis is a major human disease of tropical and sub-tropical countries. He has published extensively in peer reviewed journals, and contributed to two book chapters, in the fields of parasitology and cellular/molecular biology. His research interests cover a range of fields including Leishmania metabolomics, schistosome calcium homeostasis and drug design, microbiomes and helminths, schistosome induced hepatic granuloma formation and resolution, and helminth tegumental structure/function. Overall his research agenda and expertise falls under the broad banner of host-parasite interactions, and the use of transcriptomics, functional genomics and cellular biology. He has active research collaboration with groups in Australia, USA, Malaysia, Thailand, Laos, China, the Philippines and Mexico. His local research collaborations include the University of Edinburgh, University of Newcastle, Kingston University, Lancaster University and the Sanger Institute.

Achievements

Editorial Board

Experimental Parasitology (since 2009)

PLoS One (Associate Editor 2011-2015)

Awards

2008: NHMRC (National Health and Medical Research Council of Australia) Parasitology Network Travel Bursary.

2006: Australian Academy of Sciences, Scientific Visits Program.

2005: Travel Award, NHMRC Australia.

2002: Howard Florey Centenary Research Fellowship, NHMRC Australia.

1998: 5th Biennial Goodchild Award, Australian Society for Electron Microscopy.

1998: Dean’s Award for Excellence, Faculty of Science, Queensland University of Technology.

Research Statement

My research is primarily focused on host-pathogen interactions, specifically schistosome parasites and hepatic inflammation/granuloma formation. I am particularly interested in the identification of specific parasite factors that suppress host fibrosis and inflammation, which could represent valuable cellular regenerative options for a broad range of hepatic diseases, beyond those caused by helminths.

I am interested in exosome biology, and investigating miRNA and protein populations packaged within these structures derived from parasites. The impact of exosomes on the host microenvironment and immunopathology is a particular research priority.

I lead research projects investigating how the Calcium Signalling Pathway is pivotal to the mode of action of the anthelmintic praziquantel in schistosomes. Specific components within this pathway represent pivotal factors essential for parasite survival after drug administration. The targeting of these components represent an important strategy for the future development of new anthelmintic compounds.

I strive to answer biological questions investigating the molecular and cellular aspects of parasite disease. I utilise leading research methods such as transcriptomics (microarray and RNAseq), advanced microscopy (including electron microscopy and laser microdissection capture) and gene atlasing, and have published in the areas of immunological signaling and regulation, as associated with parasite induced hepatic fibrosis. I am interested in further expanding my research into antigen processing and presentation in the liver, using in vitro, ex vivo and in vitro techniques I have recently established.

 

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Projects

Research Output

Helminths, polyparasitism, and the gut microbiome in the Philippines

Gordon, C. A., Krause, L., McManus, D. P., Morrison, M., Weerakoon, K. G., Connor, M. C., Olveda, R. M., Ross, A. G. & Gobert, G. N., Mar 2020, In : International Journal for Parasitology. 50, 3, p. 217-225 9 p.

Research output: Contribution to journalArticle

  • Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

    Pearen, M. A., Lim, H. K., Gratte, F. D., Fernandez-Rojo, M. A., Nawaratna, S. K., Gobert, G. N., Olynyk, J. K., Tirnitz-Parker, J. E. E. & Ramm, G. A., 14 Mar 2020, In : Journal of visualized experiments : JoVE. 157, e60992.

    Research output: Contribution to journalArticle

  • A Call for Systems Epidemiology to Tackle the Complexity of Schistosomiasis, Its Control, and Its Elimination

    Krauth, S. J., Balen, J., Gobert, G. N. & Lamberton, P. H. L., 29 Jan 2019, In : Tropical medicine and infectious disease. 4, 1, 11 p., 21.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 3 Citations (Scopus)
    102 Downloads (Pure)

    Schistosomiasis in Malaysia: A review

    Chuah, C., Gobert, G. N., Latif, B., Heo, C. C. & Leow, C. Y., Feb 2019, In : Acta Tropica. 190, p. 137-143 7 p.

    Research output: Contribution to journalReview article

  • 6 Citations (Scopus)

    Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium

    Oey, H., Zakrzewski, M., Gravermann, K., Young, N. D., Korhonen, P. K., Gobert, G. N., Nawaratna, S., Hasan, S., Martínez, D. M., You, H., Lavin, M., Jones, M. K., Ragan, M. A., Stoye, J., Oleaga, A., Emery, A. M., Webster, B., Rollinson, D., Gasser, R. B., McManus, D. P. & 1 others, Krause, L., 23 Jan 2019, In : PLoS Pathogens. 15, 1, e1007513.

    Research output: Contribution to journalArticle

    Open Access
  • 6 Citations (Scopus)

    Activities

    Addressing key research priorities for parasitic helminth diseases in China

    Geoffrey Gobert (Organiser)

    2019

    Activity: Participating in or organising an event typesParticipation in conference

    Helminth Diagnostics

    Geoffrey Gobert (Invited speaker)

    2019

    Activity: Talk or presentation typesInvited or keynote talk at national or international conference

    Practical workshop for research priorities for helminth diseases in China.

    Geoffrey Gobert (Organiser)

    2019

    Activity: Participating in or organising an event typesParticipation in conference

    Helminth diagnostics

    Geoffrey Gobert (Invited speaker)

    2019

    Activity: Talk or presentation typesInvited talk

    Helminth diagnostics

    Geoffrey Gobert (Invited speaker)

    2019

    Activity: Talk or presentation typesInvited talk