Photo of Graham McGeown
  • Room 02.013 - Whitla Medical Building

    United Kingdom

1984 …2018
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Personal profile

Research Statement

My interests focus on the role played by intracellular Ca2+ in the control of contractility in smooth muscle, particularly in retinal microvessels. This research makes use of microfluorimetry and fast, Ca2+-imaging techniques to investigate how [Ca2+] changes within the cytoplasm and what the functional significance of such changes are. This includes consideration of the effects of localised Ca2+-sparks, cell-wide Ca2+-waves and oscillations, and cell-to-cell spread of Ca2+-signals within microvessels. Much of this work is part of longstanding investigations into how diabetes, a major cause of blindness, affects these small blood vessels, and is carried out with an internationally recognised group of scientists studying the mechanisms responsible for diabetic retinopathy. Other techniques used include electrophysiology, immuno- and histochemistry with confocal microscopy, real time quantitative PCR, and in vitro and in vivo imaging of blood vessels and blood flow in retinal vessels. This multi-faceted approach is revealing new details of physiological and pathophysiological cell signalling within the microvasculature, especially in the context of the early functional changes seen in diabetes.

Teaching

MED1015 Systems, people and populations

MED2013 Physiological basis of clinical practice (Module co-ordinator (Semester 2) 2009-11)

BMS3005 Advanced Cardiovascular Physiology (Module co-ordinator 1997-2010)

BMS3006 Advanced Cell Physiology (Module co-ordinator 1997-2009)

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  • 8 Similar Profiles
Arterioles Medicine & Life Sciences
Smooth Muscle Medicine & Life Sciences
Muscle Cells Medicine & Life Sciences
Ion Channels Medicine & Life Sciences
Retina Medicine & Life Sciences
Smooth Muscle Myocytes Medicine & Life Sciences
Endothelin-1 Medicine & Life Sciences
Tetracaine Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2017

Research Output 1984 2018

Involvement of TRPV1 and TRPV4 Channels in Pathological Retinal Angiogenesis: Oral presentation

Curtis, T., O'leary, C., McGahon, M., Ashraf, S., McNaughten, J., Fernandez, J., Stitt, A. & McGeown, G., 2018, p. 150. 1 p.

Research output: Contribution to conferenceOther

Pathologic Neovascularization
Retinal Neovascularization
Retina
Ischemia
Retinal Diseases
28 Downloads (Pure)

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies

Curtis, T. M., McLaughlin, D., O'Hare, M., Kur, J., Barabas, P., Revolta, G., Scholfield, C. N., McGeown, G. & McGahon, M. K., 14 Jul 2018, In : Journal of visualized experiments : JoVE. 137, 19 p., e57944.

Research output: Contribution to journalArticle

Open Access
File
Cell Physiological Phenomena
Physiology
Arterioles
Retina
Blood
2 Citations (Scopus)
202 Downloads (Pure)
Open Access
File
Acrolein
Diabetic Retinopathy
Neuroglia
Lysine
Pharmaceutical Preparations
2 Citations (Scopus)
65 Downloads (Pure)

TRPA1 activation in a human sensory neuronal model: Relevance to cough hypersensitivity?

Clarke, R., Monaghan, K., About, I., Griffin, C. S., Sergeant, G., El Karim, I., McGeown, J. G., Cosby, S. L., Curtis, T. M., McGarvey, L. P. & Lundy, F. T., 20 Sep 2017, In : European Respiratory Journal. 50, 3, 10 p., 1700995.

Research output: Contribution to journalArticle

Open Access
File
Ankyrins
Cough
Hypersensitivity
Poly I-C
Nerve Growth Factor
7 Citations (Scopus)
235 Downloads (Pure)

Diabetes Impairs the Aldehyde Detoxifying Capacity of the Retina

McDowell, R. E., McGahon, M. K., Augustine, J., Chen, M., McGeown, G. & Curtis, T. M., 01 Sep 2016, In : Investigative ophthalmology & visual science. 57, 11, p. 4762-4771 10 p.

Research output: Contribution to journalArticle

Open Access
File
Aldehydes
Aldehyde Dehydrogenase
Retina
Neuroglia
Lysine

Prizes

GL Brown Research Prize 2010

Graham McGeown (Recipient), 2010

Prize: Prize (including medals and awards)

honors and awards

Activities 2003 2015

GLIA Bilbao 2015

Graham McGeown (Participant)
15 Jul 201518 Jul 2015

Activity: Participating in or organising an event typesParticipation in conference

Northern Ireland Executive (External organisation)

Graham McGeown (Member)
05 Feb 2015

Activity: Membership typesMembership of public/government advisory/policy group or panel

Science Media Centre Public Engagement

Graham McGeown (Contributor)
2015 → …

Activity: Consultancy typesWork on advisory panels for social community and cultural engagement

Physiology 2015

Graham McGeown (Participant)
07 Jul 2015

Activity: Participating in or organising an event typesParticipation in conference

65th British Microcirculation Society Meeting 2015

Graham McGeown (Participant)
16 Apr 201517 Apr 2015

Activity: Participating in or organising an event typesParticipation in conference