Photo of Graham McGeown
  • Room 02.013 - Whitla Medical Building

    United Kingdom

1984 …2020

Research output per year

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Personal profile

Research Statement

My interests focus on the role played by intracellular Ca2+ in the control of contractility in smooth muscle, particularly in retinal microvessels. This research makes use of microfluorimetry and fast, Ca2+-imaging techniques to investigate how [Ca2+] changes within the cytoplasm and what the functional significance of such changes are. This includes consideration of the effects of localised Ca2+-sparks, cell-wide Ca2+-waves and oscillations, and cell-to-cell spread of Ca2+-signals within microvessels. Much of this work is part of longstanding investigations into how diabetes, a major cause of blindness, affects these small blood vessels, and is carried out with an internationally recognised group of scientists studying the mechanisms responsible for diabetic retinopathy. Other techniques used include electrophysiology, immuno- and histochemistry with confocal microscopy, real time quantitative PCR, and in vitro and in vivo imaging of blood vessels and blood flow in retinal vessels. This multi-faceted approach is revealing new details of physiological and pathophysiological cell signalling within the microvasculature, especially in the context of the early functional changes seen in diabetes.

Teaching

MED1015 Systems, people and populations

MED2013 Physiological basis of clinical practice (Module co-ordinator (Semester 2) 2009-11)

BMS3005 Advanced Cardiovascular Physiology (Module co-ordinator 1997-2010)

BMS3006 Advanced Cell Physiology (Module co-ordinator 1997-2009)

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Projects

Research Output

Ion channels and myogenic activity in retinal arterioles

Barabas, P., Augustine, J., Fernandez Gonzalez, J., McGeown, G., McGahon, M. & Curtis, T., 26 Feb 2020, In : Current Topics in Membranes. 85, 44 p.

Research output: Contribution to journalArticle

  • Involvement of TRPV1 and TRPV4 Channels in Pathological Retinal Angiogenesis: Oral presentation

    Curtis, T., O'leary, C., McGahon, M., Ashraf, S., McNaughten, J., Fernandez, J., Stitt, A. & McGeown, G., 2018, p. 150. 1 p.

    Research output: Contribution to conferenceOther

  • Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies

    Curtis, T. M., McLaughlin, D., O'Hare, M., Kur, J., Barabas, P., Revolta, G., Scholfield, C. N., McGeown, G. & McGahon, M. K., 14 Jul 2018, In : Journal of visualized experiments : JoVE. 137, 19 p., e57944.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 55 Downloads (Pure)
    Open Access
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  • 2 Citations (Scopus)
    231 Downloads (Pure)

    TRPA1 activation in a human sensory neuronal model: Relevance to cough hypersensitivity?

    Clarke, R., Monaghan, K., About, I., Griffin, C. S., Sergeant, G., El Karim, I., McGeown, J. G., Cosby, S. L., Curtis, T. M., McGarvey, L. P. & Lundy, F. T., 20 Sep 2017, In : European Respiratory Journal. 50, 3, 10 p., 1700995.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    95 Downloads (Pure)

    Prizes

    GL Brown Research Prize 2010

    Graham McGeown (Recipient), 2010

    Prize: Prize (including medals and awards)

  • Activities

    65th British Microcirculation Society Meeting 2015

    Graham McGeown (Participant)
    16 Apr 201517 Apr 2015

    Activity: Participating in or organising an event typesParticipation in conference

    Northern Ireland Executive (External organisation)

    Graham McGeown (Member)
    05 Feb 2015

    Activity: Membership typesMembership of public/government advisory/policy group or panel

    Science Media Centre Public Engagement

    Graham McGeown (Contributor)
    2015 → …

    Activity: Consultancy typesWork on advisory panels for social community and cultural engagement

    GLIA Bilbao 2015

    Graham McGeown (Participant)
    15 Jul 201518 Jul 2015

    Activity: Participating in or organising an event typesParticipation in conference

    ARVO Annual Meeting 2015- Powerful Connections: Vision Research and Online Networking.

    Graham McGeown (Participant)
    05 May 201507 May 2015

    Activity: Participating in or organising an event typesParticipation in conference