Photo of Graham McGeown

Graham McGeown

Professor

  • Room 02.013 - Whitla Medical Building

    United Kingdom

1984 …2020

Research activity per year

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Personal profile

Research Statement

My interests focus on the role played by intracellular Ca2+ in the control of contractility in smooth muscle, particularly in retinal microvessels. This research makes use of microfluorimetry and fast, Ca2+-imaging techniques to investigate how [Ca2+] changes within the cytoplasm and what the functional significance of such changes are. This includes consideration of the effects of localised Ca2+-sparks, cell-wide Ca2+-waves and oscillations, and cell-to-cell spread of Ca2+-signals within microvessels. Much of this work is part of longstanding investigations into how diabetes, a major cause of blindness, affects these small blood vessels, and is carried out with an internationally recognised group of scientists studying the mechanisms responsible for diabetic retinopathy. Other techniques used include electrophysiology, immuno- and histochemistry with confocal microscopy, real time quantitative PCR, and in vitro and in vivo imaging of blood vessels and blood flow in retinal vessels. This multi-faceted approach is revealing new details of physiological and pathophysiological cell signalling within the microvasculature, especially in the context of the early functional changes seen in diabetes.

Teaching

MED1015 Systems, people and populations

MED2013 Physiological basis of clinical practice (Module co-ordinator (Semester 2) 2009-11)

BMS3005 Advanced Cardiovascular Physiology (Module co-ordinator 1997-2010)

BMS3006 Advanced Cell Physiology (Module co-ordinator 1997-2009)

Expertise related to UN SDGs

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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