Photo of Graham McGeown

Graham McGeown

Professor

  • Room 02.013 - Whitla Medical Building

    United Kingdom

1984 …2020

Research output per year

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Research Output

2020

Ion channels and myogenic activity in retinal arterioles

Barabas, P., Augustine, J., Fernandez Gonzalez, J., McGeown, G., McGahon, M. & Curtis, T., 26 Feb 2020, In : Current Topics in Membranes. 85, 44 p.

Research output: Contribution to journalArticle

2018

Involvement of TRPV1 and TRPV4 Channels in Pathological Retinal Angiogenesis: Oral presentation

Curtis, T., O'leary, C., McGahon, M., Ashraf, S., McNaughten, J., Fernandez, J., Stitt, A. & McGeown, G., 2018, p. 150. 1 p.

Research output: Contribution to conferenceOther

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies

Curtis, T. M., McLaughlin, D., O'Hare, M., Kur, J., Barabas, P., Revolta, G., Scholfield, C. N., McGeown, G. & McGahon, M. K., 14 Jul 2018, In : Journal of visualized experiments : JoVE. 137, 19 p., e57944.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
63 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
243 Downloads (Pure)
2017

TRPA1 activation in a human sensory neuronal model: Relevance to cough hypersensitivity?

Clarke, R., Monaghan, K., About, I., Griffin, C. S., Sergeant, G., El Karim, I., McGeown, J. G., Cosby, S. L., Curtis, T. M., McGarvey, L. P. & Lundy, F. T., 20 Sep 2017, In : European Respiratory Journal. 50, 3, 10 p., 1700995.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
104 Downloads (Pure)
2016

Diabetes Impairs the Aldehyde Detoxifying Capacity of the Retina

McDowell, R. E., McGahon, M. K., Augustine, J., Chen, M., McGeown, G. & Curtis, T. M., 01 Sep 2016, In : Investigative ophthalmology & visual science. 57, 11, p. 4762-4771 10 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
283 Downloads (Pure)

TRPV2 channels are critical in retinal arteriolar myogenic signalling.

McGahon, M., Fernandez, J., McKee, J., Dash, D., Simpson, D., Zholos, A., McGeown, G. & Curtis, T., 2016, p. 409P. 1 p.

Research output: Contribution to conferencePoster

TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles

McGahon, M. K., Fernández, J. A., Dash, D. P., McKee, J., Simpson, D. A., Zholos, A. V., McGeown, J. G. & Curtis, T. M., 01 Oct 2016, In : Investigative ophthalmology & visual science. 57, 13, p. 5637-5647 11 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
347 Downloads (Pure)

TRPV4: Molecular Conductor of a Diverse Orchestra

White, J. P. M., Cibelli, M., Urban, L., Nilius, B., McGeown, J. G. & Nagy, I., 01 Jun 2016, In : Physiological reviews. 96, 3, p. 911-973 63 p.

Research output: Contribution to journalArticle

Open Access
File
100 Citations (Scopus)
426 Downloads (Pure)
2015

CaV3.1 T-Type Ca2+ Channels Contribute to Myogenic Signalling in Rat Retinal Arterioles

Fernandez, J. A., McGahon, M. K., McGeown, J. G. & Curtis, T. M., Aug 2015, In : Investigative Ophthalmology and Visual Science. 56, 9, p. 5125-5132 8 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
224 Downloads (Pure)

Evidence of a role for TRPV2 channels in retinal arteriolar myogenic signalling. Oral presentation

McGahon, M., Fernandez, J., McKee, J., Dash, D., Zholos, A., McGeown, G. & Curtis, T., 17 Apr 2015, p. 753-781. 1 p.

Research output: Contribution to conferenceAbstract

Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium

Monaghan, K., McNaughten, J., McGahon, M. K., Kelly, C., Kyle, D., Yong, P. H., McGeown, G. & Curtis, T. M., 05 Jun 2015, In : PloS one. 10, 6, 16 p., e0128359.

Research output: Contribution to journalArticle

Open Access
File
30 Citations (Scopus)
308 Downloads (Pure)

The viral mimic polyinosinic: polycytidylic acid (Poly I:C) induces TRPA1 channel hyper-responsiveness in an adult human stem cell-derived sensory neuronal model

Clarke, R., Monaghan, K., About, I., El Karim, I., McGeown, G., Cosby, S. L., Curtis, T. M., Lundy, F. T. & McGarvey, L., 02 Dec 2015, In : Thorax. 70, 3, p. A50-A51

Research output: Contribution to journalMeeting abstract

Open Access
2014

Acridine orange leukocyte fluorography in mice

Cahoon, J. M., Olson, P. R., Nielson, S., Miya, T. R., Bankhead, P., McGeown, J. G., Curtis, T. M. & Ambati, B. K., Mar 2014, In : Experimental Eye Research. 120, p. 15-19 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Automated detection and measurement of isolated retinal arterioles by a combination of edge enhancement and cost analysis

Fernández, J. A., Bankhead, P., Zhou, H., McGeown, J. G. & Curtis, T. M., Mar 2014, In : PloS one. 9, 3, 11 p., e91791.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
261 Downloads (Pure)

Role of ion channels and subcellular Ca2+ signalling in arachidonic acid induced dilation of pressurised retinal arterioles

Kur, J., McGahon, M., Fernández, J. A., Scholfield, N., McGeown, G. & Curtis, T., 02 May 2014, In : Investigative ophthalmology & visual science. 55, 5, p. 2893-2902

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
165 Downloads (Pure)

Targeting of calcium/calmodulin-dependent protein kinase II delta and gamma isoforms inhibits growth factor-induced retinal angiogenesis in vitro

Ashraf, S., McCauley, H., Stitt, A. W., McGeown, G. J. & Curtis, T. M., Apr 2014, Investigative Opthalmology and Visual Science (Journal - Meeting abstract). Vol. 55 (13). p. 3019 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

The Role of K+ and Cl- Channels in the Regulation of Retinal Arteriolar Tone and Blood Flow

Needham, M., McGahon, M. K., Bankhead, P., Gardiner, T. A., Scholfield, C. N., Curtis, T. M. & McGeown, J. G., 07 Apr 2014, In : Investigative ophthalmology & visual science. 55, 4, p. 2157-2165 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

TRPV1 channels are functionally expressed in the retinal microvascular endothelium and contribute to retinal angiogenic signalling in vitro

O'Leary, C., McNaughten, J. E., Stitt, A. W., McGeown, G. J. & Curtis, T. M., Apr 2014, Investigative Opthalmology and Visual Science. Vol. 55 (13). p. 5373-5374 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2013

Ca(2+) sparks promote myogenic tone in retinal arterioles

Kur, J., Bankhead, P., Scholfield, C. N., Curtis, T. M. & McGeown, JG., Apr 2013, In : British Journal of Pharmacology. 168, 7, p. 1675–1686 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
Open Access
File
20 Citations (Scopus)
186 Downloads (Pure)

GABAergic control of arteriolar diameter in the rat retina

Hinds, K., Monaghan, K. P., Frølund, B., McGeown, G. & Curtis, T. M., Oct 2013, In : Investigative ophthalmology & visual science. 54, 10, p. 6798-805 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Therapeutic potential of targeting lipid aldehydes and lipoxidation end-products in the treatment of ocular disease

McDowell, R. E., McGeown, G., Stitt, A. W. & Curtis, T., Feb 2013, In : FUTURE MEDICINAL CHEMISTRY. 5, 2, p. 189-211

Research output: Contribution to journalLiterature review

6 Citations (Scopus)
2012

Fast Retinal Vessel Detection and Measurement Using Wavelets and Edge Location Refinement

Bankhead, P., Scholfield, C. N., McGeown, J. G. & Curtis, T. M., 12 Mar 2012, In : PLoS ONE. 7, 3, 12 p., e32435.

Research output: Contribution to journalArticle

Open Access
File
185 Citations (Scopus)
358 Downloads (Pure)

Feedback via Ca²⁺-activated ion channels modulates endothelin 1 signaling in retinal arteriolar smooth muscle

Stewart, M., Needham, M., Bankhead, P., Gardiner, T., Scholfield, N., Curtis, T. & McGeown, G., Mar 2012, In : Investigative Ophthalmology and Visual Science. 53, 6, p. 3059-3066 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Pharmacological profiling of store-operated Ca(2+) entry in retinal arteriolar smooth muscle

McGahon, M. K., McKee, J., Dash, D. P., Brown, E., Simpson, D. A., Curtis, T. M., McGeown, J. G. & Scholfield, C. N., Oct 2012, In : Microcirculation (New York, N.Y. : 1994). 19, 7, p. 586-597 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Short Isoforms of the Cold Receptor TRPM8 Inhibit Channel Gating by Mimicking Heat Action Rather than Chemical Inhibitors

Fernandez, J. A., Skryma, R., Bidaux, G., Magleby, K. L., Scholfield, C. N., McGeown, J. G., Prevarskaya, N. & Zholos, A. V., 27 Jan 2012, In : Journal of Biological Chemistry. 287, 5, p. 2963-2970 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2011

Detecting Ca2+ sparks on stationary and varying baselines.

Bankhead, P., Scholfield, N., Curtis, T. & McGeown, G., Mar 2011, In : American Journal of Physiology - Cell Physiology. 301, 3, p. C717-C728 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
26 Citations (Scopus)

Voltage and cold dependent gating of single TRPM8 ion channels

Fernandez, J., Skryma, R., Bidaux, G., Magleby, K. L., Scholfield, N., McGeown, G., Prevarskaya, N. & Zholos, A., Feb 2011, In : Journal of General Physiology. 137, 2, p. 173-195 23 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2010

cAMP/PKA-dependent increases in Ca Sparks, oscillations and SR Ca stores in retinal arteriolar myocytes after exposure to vasopressin.

Jeffries, O., McGahon, M., Bankhead, P., Lozano, M. M., Scholfield, N., Curtis, T. & McGeown, G., Mar 2010, In : Investigative Ophthalmology and Visual Science. 51, 3, p. 1591-1598 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Endothelin 1 Stimulates Ca2+-Sparks and Oscillations in Retinal Arteriolar Myocytes via IP3R and RyR-Dependent Ca2+ Release

Tumelty, J., Hinds, K., Bankhead, P., McGeown, N. J., Scholfield, N., Curtis, T. & McGeown, G., 2010, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 3874-3879 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

GL Brown Lecture 2010 : Seeing is believing: imaging Ca2+-signalling events in living cells.

McGeown, G., Nov 2010, In : Experimental Physiology. -, 11, p. 1049-1060 12 p.

Research output: Contribution to journalLiterature review

5 Citations (Scopus)

'Heat-sensing' TRP channel expression in human odontoblasts

Lundy, F., Linden, G., Curtis, T., About, I., Monaghan, K., McGeown, G., Irwin, C. & El Karim, I., 2010, In : Journal of Dental Research.

Research output: Contribution to journalMeeting abstract

2009

Ca2+-activated Cl- current in retinal arteriolar smooth muscle.

McGahon, M., Needham, M. A., Scholfield, C. N., McGeown, G. & Curtis, T., Jan 2009, In : Investigative Ophthalmology and Visual Science. 50(1), 1, p. 364-371 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2008

Modification of smooth muscle Ca2+-sparks by tetracaine: evidence for sequential RyR activation.

Curtis, T., Tumelty, J., Stewart, M., Arora, A., Lai, F. A., McGahon, M., Scholfield, N. & McGeown, G., Feb 2008, In : Cell Calcium. 43(2), 2, p. 142-154 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Physiological and morphological effects of genistein against the liver fluke, Fasciola hepatica.

Toner, E., Brennan, G., Wells, K., McGeown, G. & Fairweather, I., Sep 2008, In : Parasitology. 135, 10, p. 1189-1203 15 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2007

Ca(2+)-sparks constitute elementary building blocks for global Ca(2+)-signals in myocytes of retinal arterioles.

Tumelty, J., Scholfield, N., Stewart, M., Curtis, T. & McGeown, G., May 2007, In : Cell Calcium. 41, 5, p. 451-466 16 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Calcium signaling in ocular arterioles

Curtis, T., Scholfield, N. & McGeown, G., 2007, In : Critical Reviews in Eukaryotic Gene Expression. 17, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cellular physiology of retinal and choroidal arteriolar smooth muscle cells.

Scholfield, N., McGeown, G. & Curtis, T., Jan 2007, In : Microcirculation (New York, N.Y. : 1994). 14, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Diabetes downregulates large-conductance Ca2+-activated potassium beta 1 channel subunit in retinal arteriolar smooth muscle

McGahon, M. K., Dash, D. P., Arora, A., Wall, N., Dawicki, J., Simpson, D. A., Scholfield, C. N., McGeown, G. & Curtis, T., Mar 2007, In : Circulation Research. 100, 5, p. 703-11 9 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle.

McGahon, M., Dawicki, J., Arora, A., Simpson, D., Gardiner, T., Stitt, A., Scholfield, N., McGeown, G. & Curtis, T., Oct 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 2, p. H1001-H1008 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

New Developments in Diabetic Retinopathy

Curtis, T., Stitt, A., McGahon, M., Scholfield, N. & McGeown, G., 2007, In : Expert Review of Ophthalmology. 2, p. 947-956 10 p.

Research output: Contribution to journalArticle

Selective downregulation of the BKbeta1 subunit in diabetic arteriolar myocytes

McGahon, M., Zhang, X., Scholfield, N., Curtis, T. & McGeown, G., May 2007, In : Channels (Austin, Tex.). 1 (3), 3, p. e1-e3 3 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2006
5 Citations (Scopus)
2005

A-type K+ current in retinal arteriolar smooth muscle.

McGahon, M., Dawicki, J., Scholfield, N., Gardiner, T., McGeown, G. & Curtis, T., 2005, In : Investigative Ophthalmology and Visual Science. 46, p. 3281-3287 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2004

Advanced glycation endproduct modified basement membrane attenuates endothelin-1 induced [Ca2+]i signalling and contraction in retinal microvascular pericytes

Hughes, S. J., Wall, N., Scholfield, C. N., McGeown, G., Gardiner, T. A., Stitt, A. W. & Curtis, T. M., 27 Dec 2004, In : Molecular Vision. 10, p. 996-1004 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Electrophysiological and pharmacological characterization of K+-currents in muscle fibres isolated from the ventral sucker of Fasciola hepatica.

Fairweather, I., McGeown, G., Kumar, D. & White, C., Dec 2004, In : Parasitology. 129(6), 6, p. 779-793 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
21 Citations (Scopus)