Projects per year
Personal profile
Research Focus
My research focuses on the spatial regulation of gene expression in the context of endothelial biology. I investigate how RNAs are transported in endothelial cells, how protein synthesis is regulated within subcellular domains and how these mechanisms regulate blood vessel development and function.
Lab website: https://gcosta064.wixsite.com/costa-lab
Research Interests
RNA localisation and localised protein synthesis are fundamental steps between gene transcription and protein activity. This mode of post-transcriptional control of gene expression has major implications in cell behaviour and function. I am interested in understanding how such aspects of RNA biology within endothelial cells regulate blood vessels during development and disease. Thus, I investigate 1) the mechanisms underlying the transport of RNAs to particular subcellular regions in endothelial cells, 2) the role of localised protein translation from targeted messenger RNAs in endothelial cell biology and 3) how VEGF signalling may orchestrate both RNA localisation and local translation. To address these themes, I combine in vitro and in vivo models with imaging and molecular biology approaches that allow testing whether such subcellular events of the RNA life cycle participate in crucial aspects of endothelial function. Ultimately, these studies will contribute to further understanding complex biological processes underpinning blood vessel formation, maintenance and pathology.
Interests
Developmental biology
Vascular biology
RNA localisation
Local protein synthesis
Achievements
2022 Wellcome Trust Career Development Awardee
2019 Lecturer in Endothelial Biology, Queen’s University Belfast, UK
2017 Dean’s Prize: Early Career Researcher Award, University of Manchester, UK
2011 PhD in Medical Sciences, University of Manchester, UK
Teaching
MSc in Experimental Medicine - Advanced Research Skills
MB BCh BAO in Medicine - Fundamentals of Clinical Science and NHS portfolios
BSc in Biomedical Sciences - Cell Signalling, Developmental Biology
Fellow of the Higher Education Academy, UK
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Projects
- 3 Active
-
R2953CEM: Targeting spatial gene expression in angiogenesis on-a-chip models
15/11/2022 → …
Project: Research
-
R1688CEM: mRNA localisation: a subcellular mechanistic target to treat pathological angiogenesis
12/09/2022 → …
Project: Research
-
R2906CEM: Understanding subcellular RNA localisation in blood vessel growth and homeostasis
05/07/2022 → …
Project: Research
-
RNA-binding proteins and translation control in angiogenesis
Smith, M. R. & Costa, G., Dec 2022, In: The FEBS Journal. 289, 24, p. 7788-7809Research output: Contribution to journal › Article › peer-review
-
RAB13 mRNA compartmentalisation spatially orients tissue morphogenesis
Costa, G., Bradbury, J. J., Tarannum, N. & Herbert, S. P., 18 Sep 2020, (Early online date) In: The EMBO Journal. 2020, 39, 20 p., e106003.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)184 Downloads (Pure) -
Sending messages in moving cells: mRNA localization and the regulation of cell migration
Herbert, S. P. & Costa, G., Oct 2019, In: Essays in Biochemistry. 63, 5, p. 595-606 12 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Endothelial cells divide unequally to sprout fairly
Costa, G., Lovegrove, H. & Herbert, S., 10 Mar 2017, In: Cell Cycle . 16, 7, p. 595-596 2 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Asymmetric division coordinates collective cell migration in angiogenesis
Costa, G., Harrington, K., Lovegrove, H., Page, D., Chakravartula, S., Bentley, K. & Herbert, S., 21 Nov 2016, In: Nature Cell Biology. 18, p. 1292–1301 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Citations (Scopus)27 Downloads (Pure)
Prizes
-
Wellcome Trust Career Development Award
Costa, Guilherme (Recipient), Jul 2022
Prize: Fellowship awarded competitively
-
Dean’s Prize: Early Career Researcher Award
Costa, Guilherme (Recipient), Jul 2017
Prize: Fellowship awarded competitively
-
First Prize Winner BSCB/BSDB Joint Spring Meeting – poster presentation
Costa, Guilherme (Recipient), Apr 2016
Prize: Prize (including medals and awards)
-
PhD grant, Portuguese Foundation for Science and Technology
Costa, Guilherme (Recipient), Jan 2007
Prize: Fellowship awarded competitively
-
Ribo-Omics Grant Challenge 2020
Costa, Guilherme (Recipient), Sep 2020
Prize: Prize (including medals and awards)
Activities
-
iENGAGE Summer Student Programme
Guilherme Costa (Participant)
03 Jul 2023 → 11 Aug 2023Activity: Participating in or organising an event types › Participation in workshop, seminar, course
-
eLife (Journal)
Guilherme Costa (Peer reviewer)
Jul 2023Activity: Publication peer-review and editorial work types › Publication peer-review
-
mRNA localisation in endothelial cells
Guilherme Costa (Speaker)
16 Jun 2023Activity: Talk or presentation types › Invited talk
-
EMBO Laboratory Leadership - Laboratory Leadership
Guilherme Costa (Participant)
Apr 2023Activity: Participating in or organising an event types › Participation in workshop, seminar, course
-
Experimental Eye Research (Journal)
Guilherme Costa (Peer reviewer)
Apr 2023Activity: Publication peer-review and editorial work types › Publication peer-review