Research Output per year
Research Output per year
Dr
Accepting PhD Students
PhD projects
We are looking for highly motivated and enthusiastic students to embark on a PhD project that addresses questions in the fields of messenger (m)RNA localisation and local translation in the context of angiogenesis. Your work will help to answer how and why particular mRNAs are translated into proteins at the front of endothelial cells as they migrate to form new blood vessels. Your project will be carried out in an exciting and collaborative environment at the Wellcome-Wolfson Institute for Experimental Medicine, where you will work next to worldwide experts in the field of vascular research.
Research output per year
My research focuses on the spatial regulation of gene expression in the context of endothelial biology. I investigate how RNAs are transported in endothelial cells, how protein synthesis is regulated within subcellular domains and how these mechanisms regulate blood vessel development and function.
RNA localisation and localised protein synthesis are fundamental steps between gene transcription and protein activity. This mode of post-transcriptional control of gene expression has major implications in cell behaviour and function. I am interested in understanding how such aspects of RNA biology within endothelial cells regulate blood vessels during development and disease. Thus, I investigate 1) the mechanisms underlying the transport of RNAs to particular subcellular regions in endothelial cells, 2) the role of localised protein translation from targeted messenger RNAs in endothelial cell biology and 3) how VEGF signalling may orchestrate both RNA localisation and local translation. To address these themes, I combine in vitro and in vivo models with imaging and molecular biology approaches that allow testing whether such subcellular events of the RNA life cycle participate in crucial aspects of endothelial function. Ultimately, these studies will contribute to further understanding complex biological processes underpinning blood vessel formation, maintenance and pathology.
Developmental biology
Vascular biology
RNA localisation
Local protein synthesis
2019 Lecturer in Endothelial Biology, Queen’s University Belfast, UK
2017 Dean’s Prize: Early Career Researcher Award, University of Manchester, UK
2011 PhD in Medical Sciences, University of Manchester, UK
2018 Academic tutor, Biomedical Sciences, University of Manchester, UK
2017 Fellow of the Higher Education Academy, UK
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Costa, Guilherme (Recipient), Jul 2017
Prize: Fellowship awarded competitively
Costa, Guilherme (Recipient), Apr 2016
Prize: Prize (including medals and awards)
Costa, Guilherme (Recipient), Jan 2007
Prize: Fellowship awarded competitively
Costa, Guilherme (Recipient), Sep 2020
Prize: Prize (including medals and awards)
Costa, Guilherme (Recipient), 2019
Prize: Prize (including medals and awards)
Guilherme Costa (Member)
Activity: Membership types › Membership of network
Guilherme Costa (Presenter)
Activity: Talk or presentation types › Oral presentation
Guilherme Costa (Member)
Activity: Membership types › Membership of network
Guilherme Costa (Presenter)
Activity: Talk or presentation types › Oral presentation
Guilherme Costa (Presenter)
Activity: Talk or presentation types › Oral presentation