Accepting PhD Students

PhD projects

We are looking for highly motivated and enthusiastic students to embark on a PhD project that addresses questions in the fields of messenger (m)RNA localisation and local translation in the context of angiogenesis. Your work will help to answer how and why particular mRNAs are translated into proteins at the front of endothelial cells as they migrate to form new blood vessels. Your project will be carried out in an exciting and collaborative environment at the Wellcome-Wolfson Institute for Experimental Medicine, where you will work next to worldwide experts in the field of vascular research.

20122020

Research activity per year

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Personal profile

Research Focus

My research focuses on the spatial regulation of gene expression in the context of endothelial biology. I investigate how RNAs are transported in endothelial cells, how protein synthesis is regulated within subcellular domains and how these mechanisms regulate blood vessel development and function.

Research Interests

RNA localisation and localised protein synthesis are fundamental steps between gene transcription and protein activity. This mode of post-transcriptional control of gene expression has major implications in cell behaviour and function. I am interested in understanding how such aspects of RNA biology within endothelial cells regulate blood vessels during development and disease. Thus, I investigate 1) the mechanisms underlying the transport of RNAs to particular subcellular regions in endothelial cells, 2) the role of localised protein translation from targeted messenger RNAs in endothelial cell biology and 3) how VEGF signalling may orchestrate both RNA localisation and local translation. To address these themes, I combine in vitro and in vivo models with imaging and molecular biology approaches that allow testing whether such subcellular events of the RNA life cycle participate in crucial aspects of endothelial function. Ultimately, these studies will contribute to further understanding complex biological processes underpinning blood vessel formation, maintenance and pathology.

Interests

Developmental biology

Vascular biology

RNA localisation

Local protein synthesis

Achievements

2019 Lecturer in Endothelial Biology, Queen’s University Belfast, UK

2017 Dean’s Prize: Early Career Researcher Award, University of Manchester, UK

2011 PhD in Medical Sciences, University of Manchester, UK

Teaching

2018 Academic tutor, Biomedical Sciences, University of Manchester, UK

2017 Fellow of the Higher Education Academy, UK

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