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PhD projects

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20042019

Research output per year

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Research Output

2019

Determination of In Vivo Interactomes of Dot/Icm Type IV Secretion System Effectors by Tandem Affinity Purification

So, E. C., Mousnier, A., Frankel, G. & Schroeder, G. N., 30 Jan 2019, Methods in Molecular Biology : Legionella . Springer, Vol. 1921. p. 289-303 15 p. (Methods in Molecular Biology ).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

Gomez-Valero, L., Rusniok, C., Carson, D., Mondino, S., Pérez-Cobas, A. E., Rolando, M., Pasricha, S., Reuter, S., Demirtas, J., Crumbach, J., Descorps-Declere, S., Hartland, E. L., Jarraud, S., Dougan, G., Schroeder, G. N., Frankel, G. & Buchrieser, C., 18 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
99 Downloads (Pure)

The Galleria mellonella Infection Model for Investigating the Molecular Mechanisms of Legionella Virulence

Frankel, G. & Schroeder, G. N., 30 Jan 2019, Methods in Molecular Biology : Legionella . Springer, Vol. 1921. p. 333-346 14 p. (Methods in Molecular Biology ).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase

Levanova, N., Mattheis, C., Carson, D., To, K-N., Jank, T., Frankel, G., Aktories, K. & Schroeder, G. N., 22 Feb 2019, In : The Journal of biological chemistry.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
157 Downloads (Pure)
2018
Open Access
File
11 Citations (Scopus)
164 Downloads (Pure)
2017

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

Pearson, J. S., Giogha, C., Mühlen, S., Nachbur, U., Pham, C. L. L., Zhang, Y., Hildebrand, J. M., Oates, C. V., Lung, T. W. F., Ingle, D., Dagley, L. F., Bankovacki, A., Petrie, E. J., Schroeder, G. N., Crepin, V. F., Frankel, G., Masters, S. L., Vince, J., Murphy, J. M., Sunde, M. & 3 others, Webb, A. I., Silke, J. & Hartland, E. L., 13 Jan 2017, In : Nature Microbiology. 2, 16258.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
1470 Downloads (Pure)

Mechanisms regulating collagenolytic and elastolytic activity in M. avium infection

McFetridge, S., Schroeder, G. N., McMullan, R. & O'Kane, C., 15 Dec 2017, In : Thorax. 72, 3 Abstract S18, S18.

Research output: Contribution to journalMeeting abstract

2016

The Rab-binding profiles of bacterial virulence factors during infection

So, E. C., Schroeder, G. N., Carson, D., Mattheis, C., Mousnier, A., Broncel, M., Tate, E. W. & Frankel, G., 11 Mar 2016, In : Journal of Biological Chemistry. 291, 11, p. 5832-5843 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2015

Creating a customized intracellular niche: subversion of host cell signaling by legionella type IV secretion system effectors

So, E. C., Mattheis, C., Tate, E. W., Frankel, G. & Schroeder, G. N., Sep 2015, In : Canadian journal of microbiology. 61, 9, p. 617-635 19 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor

Schroeder, G. N., Aurass, P., Oates, C. V., Tate, E. W., Hartland, E. L., Flieger, A. & Frankel, G., Oct 2015, In : Infection and Immunity. 83, 10, p. 3989-4002 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2014

A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases

Mousnier, A., Schroeder, G. N., Stoneham, C. A., So, E. C., Garnett, J. A., Yu, L., Matthews, S. J., Choudhary, J. S., Hartland, E. L. & Frankel, G., 12 Aug 2014, In : mBio. 5, 4, 10 p., e01148-14.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
189 Downloads (Pure)
2013

LtpD is a novel legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1

Harding, C. R., Mattheis, C., Mousnier, A., Oates, C. V., Hartland, E. L., Frankel, G. & Schroeder, G. N., Nov 2013, In : Infection and Immunity. 81, 11, p. 4261-4270 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

The Dot/Icm Effector SdhA Is Necessary for Virulence of Legionella pneumophila in Galleria mellonella and A/J Mice

Harding, C. R., Stoneham, C. A., Schuelein, R., Newton, H., Oates, C. V., Hartland, E. L., Schroeder, G. N. & Frankel, G., Jul 2013, In : Infection and Immunity. 81, 7, p. 2598-2605 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The Legionella pneumophila Dot/Icm-secreted effector PlcC/CegC1 together with PlcA and PlcB promotes virulence and belongs to a novel zinc metallophospholipase C family present in bacteria and fungi

Aurass, P., Schlegel, M., Metwally, O., Harding, C. R., Schroeder, G. N., Frankel, G. & Flieger, A., 19 Apr 2013, In : Journal of Biological Chemistry. 288, 16, p. 11080-11092 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Use of Galleria mellonella as a model organism to study Legionella pneumophila infection.

Harding, C. R., Schroeder, G. N., Collins, J. W. & Frankel, G., 2013, In : Journal of visualized experiments : JoVE. 81

Research output: Contribution to journalArticle

43 Citations (Scopus)
2012

Legionella pneumophila pathogenesis in the Galleria mellonella infection model

Harding, C. R., Schroeder, G. N., Reynolds, S., Kosta, A., Collins, J. W., Mousnier, A. & Frankel, G., Aug 2012, In : Infection and Immunity. 80, 8, p. 2780-2790 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2011

BopC is a type III secreted effector protein of Burkholderia pseudomallei

Muangman, S., Korbsrisate, S., Muangsombut, V., Srinon, V., Adler, N. L., Schroeder, G. N., Frankel, G. & Galyov, E. E., Oct 2011, In : FEMS Microbiology Letters. 323, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Salmonella bongori provides insights into the evolution of the salmonellae

Fookes, M., Schroeder, G. N., Langridge, G. C., Blondel, C. J., Mammina, C., Connor, T. R., Seth-Smith, H., Vernikos, G. S., Robinson, K. S., Sanders, M., Petty, N. K., Kingsley, R. A., Bäumler, A. J., Nuccio, S. P., Contreras, I., Santiviago, C. A., Maskell, D., Barrow, P., Humphrey, T., Nastasi, A. & 5 others, Roberts, M., Frankel, G., Parkhill, J., Dougan, G. & Thomson, N. R., Aug 2011, In : PLoS Pathogens. 7, 8, e1002191.

Research output: Contribution to journalArticle

85 Citations (Scopus)
2010

Binding to Na+/H+ exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH

Martinez, E., Schroeder, G. N., Berger, C. N., Lee, S. F., Robinson, K. S., Badea, L., Simpson, N., Hall, R. A., Hartland, E. L., Crepin, V. F. & Frankel, G., Dec 2010, In : Cellular Microbiology. 12, 12, p. 1718-1731 14 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins

Schroeder, G. N., Petty, N. K., Mousnier, A., Harding, C. R., Vogrin, A. J., Wee, B., Fry, N. K., Harrison, T. G., Newton, H. J., Thomson, N. R., Beatson, S. A., Dougan, G., Hartland, E. L. & Frankel, G., Nov 2010, In : Journal of Bacteriology. 192, 22, p. 6001-6016 16 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli

Petty, N. K., Bulgin, R., Crepin, V. F., Cerdeño-Tárraga, A. M., Schroeder, G. N., Quail, M. A., Lennard, N., Corton, C., Barron, A., Clark, L., Toribio, A. L., Parkhill, J., Dougan, G., Frankel, G. & Thomson, N. R., Jan 2010, In : Journal of Bacteriology. 192, 2, p. 525-538 14 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)
2008
321 Citations (Scopus)
2007

Cholesterol is required to trigger caspase-1 activation and macrophage apoptosis after phagosomal escape of Shigella

Schroeder, G. N. & Hilbi, H., Jan 2007, In : Cellular Microbiology. 9, 1, p. 265-278 14 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Intracellular type III secretion by cytoplasmic Shigella flexneri promotes caspase-1-dependent macrophage cell death

Schroeder, G. N., Jann, N. J. & Hilbi, H., Sep 2007, In : Microbiology. 153, 9, p. 2862-2876 15 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2004

Mutational analysis of a type II thioesterase associated with nonribosomal peptide synthesis

Linne, U., Schwarzer, D., Schroeder, G. N. & Marahiel, M. A., Apr 2004, In : European Journal of Biochemistry. 271, 8, p. 1536-1545 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)