Projects per year
Personal profile
Interests
For the last 11 years Prof McCarthy’s research team have focused on the development of non-viral delivery systems for nanomedicine applications. These biomimetic systems are designed to overcome the extra and intracellular barriers, so that the macromolecular payload can be delivered at the destination site in order to exert the optimal therapeutic effect. Helen has designed and patented three delivery systems. Current research projects involve gene therapy for metastatic deposits; miRNA therapeutics for oncology and wound healing applications; mRNA and DNA vaccination strategies; repurposing of bisphosphonates and regeneration of bone by increasing the bioavailability of ceramics. The wide-spread utility of these delivery systems has led to a spin-out company Phion Therapeutics www.phiontx.co.uk. To that end, she has published over 80 scientific publications, edited a book and has given many conference presentations. She has received research grant income from the National Science Foundation, Invest Northern Ireland, Cancer Research UK, Breast Cancer Campaign, Prostate Cancer UK, Royal Pharmaceutical Society of Great Britain, The Royal Society, BBSRC, MRC, EPSRC, Prostate Cancer Research Foundation and Action Cancer. She is also on the editorial board for Cancer Nanotechnology and the Journal of Material Science and is an external examiner at for the Junior Medicine Cycle and Pharmacy at RCSI.
Research Statement
Prof McCarthy's Research interests include:
Cancer Gene Therapy
Bio-inspired Delivery systems
DNA & mRNA Vaccines
Bone Regeneration
Nanotechnology
Macromolecular Delivery
Nitric Oxide
Transcriptional Targeting
Breast Cancer
Prostate Cancer
Current Funding:
MRC
Invest NI
Prostate Cancer UK
The Royal Society
EPSRC
Phion Therapeutics
Teaching
Teaching Administration Associated with the MPharm Degree
2007 - Present Module Co-ordinator PMY3072 Pharmaceutical Biotechnology
2010 - Present Assistant Co-ordinator PMY4005 Project Module
2010 - Present Level 3 Year Co-ordinator
Teaching Contribution within the MPharm Degree
2006-Present PMY1003 Medicines from Concept to Clinic
2007-Present PMY3081 Drug Delivery
2007-Present PMY3072 Pharmaceutical Biotechnology
2007-Present PMY4005 Project Module
2015-Present PMY4107 Advanced Pharmaceutical Care
Teaching Contribution within the BSc Pharm Sci Degree
2015-Present PMY2021 Principles of Drug Action
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Projects 2009 2019
R1007PMY: Anti-inflammatory radiosensitising gold nanoparticles for the treatment of prostate cancer
Coulter, J., Butterworth, K., Jain, S. & McCarthy, H.
25/01/2019 → …
Project: Research
Research Output 1999 2019
Delivery across the blood-brain barrier: nanomedicine for glioblastoma multiforme
Jena, L., McErlean, E. & McCarthy, H., 14 Nov 2019, In : Drug Delivery and Translational Research.Research output: Contribution to journal › Review article
Design, Formulation, and Evaluation of Novel Dissolving Microarray Patches Containing Rilpivirine for Intravaginal Delivery
McCrudden, M., Larrañeta, E., Clark, A., Jarrahian, C., Rein-Weston, A., Creelman, B., Moyo, Y., Lachau-Durand, S., Niemeijer, N., Williams, P., McCarthy, H. O., Zehrung, D. & Donnelly, R. F., 06 Mar 2019, In : Advanced Healthcare Materials. 0, 0, p. 1801510 1 p.Research output: Contribution to journal › Article
DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen
Cole, G., Ali, A. A., McErlean, E., Mulholland, E. J., Short, A., McCrudden, C. M., McCaffrey, J., Robson, T., Kett, V. L., Coulter, J. A., Dunne, N. J., Donnelly, R. F. & McCarthy, H. O., 09 Jul 2019, In : Acta Biomaterialia.Research output: Contribution to journal › Article
Exploring the Potential of MicroRNA Let-7c as a Therapeutic for Prostate Cancer
Mulholland, E. J., Green, W. P., Buckley, N. E. & McCarthy, H. O., 22 Oct 2019, In : Molecular Therapy: Nucleic Acids. 18, p. 927-937 11 p.Research output: Contribution to journal › Review article
FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4
McClements, L., Annett, S., Yakkundi, A., O'Rourke, M., Valentine, A., Moustafa, N., Alqudah, A., Simões, B. M., Furlong, F., Short, A., McIntosh, S. A., McCarthy, H. O., Clarke, R. B. & Robson, T., 11 Apr 2019, In : BMC Cancer. 19, 351.Research output: Contribution to journal › Article
Prizes
All-Ireland Investor Readiness Seedcorn Awards 2017
Helen McCarthy (Recipient), 22 Nov 2017
Prize: Prize (including medals and awards)
Activities 2001 2018
REMEDI
Helen McCarthy (Invited speaker)Activity: Participating in or organising an event types › Participation in conference
Royal College of Surgeons in Ireland
Helen McCarthy (Speaker)Activity: Visiting an external institution types › Research and Teaching at External Organisation
RNAi Therapeutics
Helen McCarthy (Speaker)Activity: Participating in or organising an event types › Participation in conference
PG Recruitment Event
Helen McCarthy (Supervisor)Activity: Other activity types › Hosting a school group or open day
Hunterhouse College
Helen McCarthy (Speaker)Activity: Visiting an external institution types › Research and Teaching at External Organisation
Press / Media
Prostate Cancer UK Innovation Award
01/03/2018
1 item of media coverage
Press/Media: Public Engagement Activities
Northern Ireland Tech Mission
29/01/2018
1 media contribution
Press/Media: Public Engagement Activities
Winner of All Ireland Seedcorn Awards 2017
22/11/2017
1 media contribution
Press/Media: Public Engagement Activities