Research output per year
Research output per year
- 1 - 50 out of 148 results
Search results
-
2023
Development of dissolving microneedles for intradermal delivery of the long-acting antiretroviral drug bictegravir
Zhang, C., Vora, L. K., Tekko, I. A., Volpe-Zanutto, F., Peng, K., Paredes, A. J., McCarthy, H. O. & Donnelly, R. F., 25 Jul 2023, In: International Journal of Pharmaceutics. 642, 14 p., 123108.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Downloads (Pure) -
Development of miR-26a-activated scaffold to promote healing of critical-sized bone defects through angiogenic and osteogenic mechanisms
Sadowska, J. M., Ziminska, M., Ferreira, C., Matheson, A., Balouch, A., Bogle, J., Wojda, S., Redmond, J., Elkashif, A., Dunne, N., McCarthy, H. O., Donahue, S. & O'Brien, F. J., Dec 2023, In: Biomaterials. 303, 14 p., 122398.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Enzyme-triggered L-α/D-peptide hydrogels as a long-acting injectable platform for systemic delivery of HIV/AIDS drugs
Coulter, S. M., Pentlavalli, S., Vora, L. K., An, Y., Cross, E. R., Peng, K., McAulay, K., Schweins, R., Donnelly, R. F., McCarthy, H. O. & Laverty, G., 17 Jul 2023, In: Advanced Healthcare Materials. 12, 8, 17 p., 2203198.Research output: Contribution to journal › Article › peer-review
Open AccessFile67 Downloads (Pure) -
Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for potential treatment of HIV-associated neurocognitive disorder (HAND)
Abbate, M. T. A., Ramöller, I. K., Sabri, A. H., Paredes, A. J., Hutton, A. J., McKenna, P. E., Peng, K., Hollett, J. A., McCarthy, H. O. & Donnelly, R. F., 10 Jun 2023, In: International Journal of Pharmaceutics. 640, 15 p., 123005.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Downloads (Pure) -
Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug
Naser, Y. A., Tekko, I. A., Vora, L. K., Peng, K., Anjani, Q. K., Greer, B., Elliott, C., McCarthy, H. O. & Donnelly, R. F., 13 Mar 2023, (Early online date) In: Journal of controlled release : official journal of the Controlled Release Society. 356, p. 416-433 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Downloads (Pure) -
Hydrogel-forming microarray patch mediated transdermal delivery of tetracycline hydrochloride
Zhao, L., Vora, L. K., Kelly, S. A., Li, L., Larrañeta, E., McCarthy, H. O. & Donnelly, R. F., Apr 2023, In: Journal of Controlled Release. 356, p. 196-204 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile41 Downloads (Pure) -
Metallic microneedles for transdermal drug delivery: applications, fabrication techniques and the effect of geometrical characteristics
Sargioti, N., Levingstone, T. J., O'Cearbhaill, E. D., McCarthy, H. O. & Dunne, N. J., 01 Jan 2023, In: Bioengineering. 10, 1, 24.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Downloads (Pure) -
Microneedle array patches for sustained delivery of fluphenazine: A micron scale approach for the management of schizophrenia
Ershaid, J. M. A., Vora, L. K., Volpe-Zanutto, F., Sabri, A. H., Peng, K., Anjani, Q. K., McKenna, P. E., Ripolin, A., Larrañeta, E., McCarthy, H. O. & Donnelly, R. F., Oct 2023, In: Biomaterials Advances. 153, 16 p., 213526.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Downloads (Pure) -
Multi-objective property optimisation of a phosphoserine-modified calcium phosphate cement for orthopaedic and dental applications using Design of Experiments methodology
Tzagiollari, A., Redmond, J., McCarthy, H. O., Levingstone, T. J. & Dunne, N. J., 23 Nov 2023, (Early online date) In: Acta Biomaterialia.Research output: Contribution to journal › Article › peer-review
Open Access -
Peptide delivery of a multivalent mRNA SARS-CoV-2 vaccine
McCrudden, C. M., Bennie, L., Chambers, P., Wilson, J., Kerr, M., Ziminska, M., Douglas, H., Kuhn, S., Carroll, E., O'Brien, G., Buckley, N., Dunne, N. J. & McCarthy, H. O., Oct 2023, In: Journal of controlled release : official journal of the Controlled Release Society. 362, p. 536-547 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
The osteogenic and angiogenic potential of microRNA-26a delivered via a non-viral delivery peptide for bone repair
Chambers, P., Ziminska, M., Elkashif, A., Wilson, J., Redmond, J., Tzagiollari, A., Ferreira, C., Balouch, A., Bogle, J., Donahue, S. W., Dunne, N. J. & McCarthy, H. O., Oct 2023, In: Journal of controlled release : official journal of the Controlled Release Society. 362, p. 489-501 13 p.Research output: Contribution to journal › Article › peer-review
-
2022
Advancing bone tissue engineering one layer at a time: a layer-by-layer assembly approach to 3D bone scaffold materials
Sahebalzamani, M., Ziminska, M., McCarthy, H. O., Levingstone, T. J., Dunne, N. J. & Hamilton, A. R., 30 Mar 2022, (Early online date) In: Biomaterials Science.Research output: Contribution to journal › Article › peer-review
Open AccessFile52 Downloads (Pure) -
Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone
Tzagiollari, A., McCarthy, H. O., Levingstone, T. J. & Dunne, N. J., 10 Jun 2022, In: Bioengineering. 9, 6, 250.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Downloads (Pure) -
Delivery of a peptide/microRNA blend via electrospun antimicrobial nanofibres for wound repair
Bombin, A. D. J., Dunne, N. & McCarthy, H. O., 03 Nov 2022, (Early online date) In: Acta biomaterialia.Research output: Contribution to journal › Article › peer-review
-
Development and characterisation of 3D collagen-gelatin based scaffolds for breast cancer research
Redmond, J., McCarthy, H. O., Buchanan, P., Levingstone, T. J. & Dunne, N. J., Nov 2022, In: Biomaterials Advances. 142, 213157.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure) -
Development and evaluation of dissolving microarray patches for co-administered and repeated intradermal delivery of long-acting rilpivirine and cabotegravir nanosuspensions for paediatric HIV antiretroviral therapy
Moffatt, K., Tekko, I. A., Vora, L., Volpe-Zanutto, F., Hutton, A. R. J., Mistilis, J., Jarrahian, C., Akhavein, N., Weber, A. D., McCarthy, H. O. & Donnelly, R. F., 12 Oct 2022, (Early online date) In: Pharmaceutical Research. 24 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Downloads (Pure) -
Development of a Spray-Dried Formulation of Peptide-Dna Nanoparticles into a Dry Powder for Pulmonary Delivery Using Factorial Design
Munir, M., Kett, V. L., Dunne, N. J. & McCarthy, H. O., 19 Apr 2022, (Early online date) In: Pharmaceutical Research.Research output: Contribution to journal › Article › peer-review
Open AccessFile159 Downloads (Pure) -
Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer
Abd-El-Azim, H., Tekko, I. A., Ali, A., Ramadan, A., Nafee, N., Khalafallah, N., Rahman, T., Mcdaid, W., Aly, R. G., Vora, L. K., Bell, S. J., Furlong, F., McCarthy, H. O. & Donnelly, R. F., Aug 2022, In: Journal of controlled release : official journal of the Controlled Release Society. 348, p. 849-869Research output: Contribution to journal › Article › peer-review
Open AccessFile63 Downloads (Pure) -
HPLC-MS method for simultaneous quantification of the antiretroviral agents rilpivirine and cabotegravir in rat plasma and tissues
Ramöller, I. K., Abbate, M. T. A., Vora, L. K., Hutton, A. R. J., Peng, K., Volpe-Zanutto, F., Tekko, I. A., Moffatt, K., Paredes, A. J., McCarthy, H. O. & Donnelly, R. F., 10 May 2022, In: Journal of Pharmaceutical and Biomedical Analysis. 213, 114698.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Hydrogel-forming microarray patches with cyclodextrin drug reservoirs for long-acting delivery of poorly soluble cabotegravir sodium for HIV Pre-Exposure Prophylaxis
Volpe-Zanutto, F., Vora, L. K., Tekko, I. A., McKenna, P. E., Permana, A. D., Sabri, A. H., Anjani, Q. K., McCarthy, H. O., Paredes, A. J. & Donnelly, R. F., Aug 2022, In: Journal of Controlled Release. 348, p. 771-785Research output: Contribution to journal › Article › peer-review
Open AccessFile81 Downloads (Pure) -
Nestorone nanosuspension-loaded dissolving microneedles array patch: A promising novel approach for "on-demand" hormonal female-controlled peritcoital contraception
Altuntaş, E., Tekko, I. A., Vora, L. K., Kumar, N., Brodsky, R., Chevallier, O., McAlister, E., Kurnia Anjani, Q., McCarthy, H. O. & Donnelly, R. F., 25 Feb 2022, In: International Journal of Pharmaceutics. 614, 121422.Research output: Contribution to journal › Article › peer-review
-
Novel Bilayer Microarray Patch‐Assisted Long‐Acting Micro‐Depot Cabotegravir Intradermal Delivery for HIV Pre‐Exposure Prophylaxis
Tekko, I. A., Vora, L. K., Volpe-Zanutto, F., Moffatt, K., Jarrahian, C., McCarthy, H. O. & Donnelly, R. F., 23 Feb 2022, In: Advanced Functional Materials. 32, 9, 18 p., 2106999.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)66 Downloads (Pure) -
Nucleic acid vaccination strategies for ovarian cancer
Saha, C., Bojdo, J., Dunne, N. J., Duary, R. K., Buckley, N. E. & McCarthy, H. O., 07 Nov 2022, In: Frontiers in Bioengineering and Biotechnology. 10, 953887.Research output: Contribution to journal › Article › peer-review
Open AccessFile80 Downloads (Pure) -
Systemic delivery of tenofovir alafenamide using dissolving and implantable microneedle patches
Paredes, A. J., Volpe-Zanutto, F., Vora, L. K., Tekko, I. A., Permana, A. D., Picco, C. J., McCarthy, H. O. & Donnelly, R. F., 16 Feb 2022, In: Materials Today Bio. 13, 100217.Research output: Contribution to journal › Article › peer-review
Open AccessFile110 Downloads (Pure) -
2021
Antibiotic Therapy and the Gut Microbiome: Investigating the Effect of Delivery Route on Gut Pathogens
Kelly, S. A., Nzakizwanayo, J., Rodgers, A. M., Zhao, L., Weiser, R., Tekko, I. A., McCarthy, H. O., Ingram, R. J., Jones, B. V., Donnelly, R. F. & Gilmore, B. F., 14 May 2021, In: ACS Infectious Diseases. 7, 5, p. 1283-1296 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Downloads (Pure) -
A Peptide/MicroRNA-31 Nanomedicine within an Electrospun Biomaterial Designed to Regenerate Wounds In Vivo
EJ, M., EM, M., N, D. & HO, M., 17 Nov 2021, (Early online date) In: Acta Biomaterialia.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Downloads (Pure) -
Design of a novel electrospun PVA platform for gene therapy applications using the CHAT peptide
Mulholland, E. J., McErlean, E., Dunne, N. & McCarthy, H., 06 Feb 2021, In: International Journal of Pharmaceutics. 598, p. 120366-77 11 p.Research output: Contribution to journal › Article › peer-review
-
Directly Compressed Tablets: A Novel Drug‐Containing Reservoir Combined with Hydrogel‐Forming Microneedle Arrays for Transdermal Drug Delivery
McAlister, E., Dutton, B., Vora, L. K., Zhao, L., Ripolin, A., Zahari, D. S. Z. B. P. H., Quinn, H. L., Tekko, I. A., Courtenay, A. J., Kelly, S. A., Rodgers, A. M., Steiner, L., Levin, G., Levy-Nissenbaum, E., Shterman, N., McCarthy, H. O. & Donnelly, R. F., 03 Feb 2021, In: Advanced Healthcare Materials. 10, 3, 19 p., 2001256.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections
Peng, K., Vora, L. K., Tekko, I. A., Permana, A. D., Domínguez-Robles, J., Ramadon, D., Chambers, P., McCarthy, H. O., Larrañeta, E. & Donnelly, R. F., 2021, In: Journal of Controlled Release. 339, p. 361-380Research output: Contribution to journal › Article › peer-review
Open AccessFile267 Downloads (Pure) -
Etravirine-loaded dissolving microneedle arrays for long-acting delivery
Rojekar, S., Vora, L. K., Tekko, I. A., Volpe-Zanutto, F., McCarthy, H. O., Vavia, P. R. & Donnelly, R. F., 07 May 2021, (Early online date) In: European Journal of Pharmaceutics and Biopharmaceutics.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)147 Downloads (Pure) -
Exploiting the anticancer effects of a nitrogen bisphosphonate nanomedicine for glioblastoma multiforme
Jena, L. N., Bennie, L. A., McErlean, E. M., Pentlavalli, S., Glass, K., Burrows, J. F., Kett, V. L., Buckley, N. E., Coulter, J. A., Dunne, N. J. & McCarthy, H. O., 04 May 2021, In: Journal of Nanobiotechnology. 19, 1, p. 127Research output: Contribution to journal › Article › peer-review
Open AccessFile98 Downloads (Pure) -
Formulating RALA/Au nanocomplexes to enhance nanoparticle internalisation efficiency, sensitising prostate tumour models to radiation treatment
Bennie, L. A., Feng, J., Emerson, C., Hyland, W. B., Matchett, K. B., McCarthy, H. O. & Coulter, J. A., 19 Sep 2021, In: Journal of Nanobiotechnology. 19, 279 .Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Downloads (Pure) -
Non-viral gene delivery utilizing RALA modulates sFlt-1 secretion, important for preeclampsia
McNally, R., Alqudah, A., McErlean, E. M., Rennie, C., Morshed, N., Short, A., McGrath, K., Shimoni, O., Robson, T., McCarthy, H. O. & McClements, L., Sep 2021, In: Nanomedicine. 16, 22Research output: Contribution to journal › Article › peer-review
-
Rational design and characterisation of an amphipathic cell penetrating peptide for non-viral gene delivery
McErlean, E. M., McCrudden, C. M., McBride, J. W., Cole, G., Kett, V. L., Robson, T., Dunne, N. J. & McCarthy, H. O., 01 Mar 2021, In: International Journal of Pharmaceutics. 596, 13 p., 120223.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)122 Downloads (Pure) -
2020
A novel transdermal protein delivery strategy via electrohydrodynamic coating of PLGA microparticles onto microneedles
Angkawinitwong, U., Courtenay, A. J., Rodgers, A., Larraneta, E., McCarthy, H. O., Brocchini, S., Donnelly, R. F. & Williams, G. R., 18 Feb 2020, (Early online date) In: ACS Applied Materials and Interfaces.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)312 Downloads (Pure) -
A sensitive HPLC-UV method for quantifying vancomycin in biological matrices: Application to pharmacokinetic and biodistribution studies in rat plasma, skin and lymph nodes
Ramadon, D., Courtenay, A. J., Permana, A. D., Tekko, I. A., McAlister, E., McCrudden, M. T. C., McCarthy, H. O. & Donnelly, R., 10 Sep 2020, In: Journal of Pharmaceutical and Biomedical Analysis. 189, 9 p., 113429.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)449 Downloads (Pure) -
Binder jetting additive manufacturing of hydroxyapatite powders: Effects of adhesives on geometrical accuracy and green compressive strength
Zhou, Z., Lennon, A., Buchanan, F., McCarthy, H. O. & Dunne, N., 02 Oct 2020, (Early online date) In: Additive Manufacturing. 11 p., 101645.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)89 Downloads (Pure) -
Collagen/GAG scaffolds activated by RALA-siMMP-9 complexes with potential for improved diabetic foot ulcer healing
Yan, L. P., Castaño, I. M., Sridharan, R., Kelly, D., Lemoine, M., Cavanagh, B. L., Dunne, N. J., McCarthy, H. O. & O'Brien, F. J., Sep 2020, In: Materials Science and Engineering C. 114, 111022.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Development, evaluation, and pharmacokinetic assessment of polymeric microarray patches for transdermal delivery of vancomycin hydrochloride
Ramadon, D., Permana, A. D., Courtenay, A., McCrudden, M., Tekko, I., McAlister, E., Anjani, Q. K., Utomo, E., McCarthy, H. & Donnelly, R., 24 Jul 2020, In: Molecular Pharmaceutics. 17, 9, p. 3353–3368 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)272 Downloads (Pure) -
Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate
Tekko, I. A., Chen, G., Domínguez-Robles, J., Thakur], R. R. S., Hamdan, I. M. N., Vora, L., Larrañeta, E., McElnay, J. C., McCarthy, H. O., Rooney, M. & Donnelly, R. F., 25 Jun 2020, (Early online date) In: International Journal of Pharmaceutics. 1 p., 119580.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)581 Downloads (Pure) -
FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer
Annett, S., Moore, G., Short, A., Marshall, A., McCrudden, C., Yakkundi, A., Das, S., McCluggage, W. G., Nelson, L., Harley, I., Moustafa, N., Kennedy, C. J., deFazio, A., Brand, A., Sharma, R., Brennan, D., O'Toole, S., O'Leary, J., Bates, M., O'Riain, C., & 6 others, 04 Feb 2020, In: British Journal of Cancer. 2020, 126, p. 361Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)181 Downloads (Pure) -
Glucocorticoid Receptor Expression Predicts Good Outcome in response to Taxane-Free, Anthracycline-Based Therapy in Triple Negative Breast Cancer
Elkashif, A., Bingham, V., Haddock, P., Humphries, M., McQuaid, S., Mullan, P., McCarthy, H. & Buckley, N. E., 20 May 2020, In: Journal of Oncology.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)74 Downloads (Pure) -
Hydrogel-forming microneedle arrays as a therapeutic option for transdermal esketamine delivery
Courtenay, A. J., McAlister, E., McCrudden, M. T. C., Vora, L., Steiner, L., Levin, G., Levy-Nissenbaum, E., Shterman, N., Kearney, M-C., McCarthy, H. O. & Donnelly, R. F., 19 Mar 2020, (Early online date) In: Journal of controlled release : official journal of the Controlled Release Society. 322, p. 177-186 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)293 Downloads (Pure) -
Improving the Intercellular Uptake and Osteogenic Potency of Calcium Phosphate via Nanocomplexation with the RALA Peptide
O’Doherty, M., Mulholland, E. J., Chambers, P., Pentlavalli, S., Ziminska, M., Chalanqui, M. J., Pauly, H. M., Sathy, B. N., Donahue, T. H., Kelly, D. J., Dunne, N. & McCarthy, H. O., 07 Dec 2020, In: Nanomaterials. 10, 12, 16 p., 2442.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)58 Downloads (Pure) -
Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: Potential for enhanced treatment of psoriasis
Tekko, I., Permana, A. D., Vora, L., Hatahet, T., McCarthy, H. & Donnelly, R., 01 Sep 2020, In: European Journal of Pharmaceutical Sciences. 152, 1Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)80 Downloads (Pure) -
Microneedle Liquid Injection System Assisted Delivery of Infection Responsive Nanoparticles: A Promising Approach for Enhanced Site-Specific Delivery of Carvacrol against Polymicrobial Biofilms-Infected Wounds
Mir, M., Permana, A., Tekko, I., McCarthy, H., Ahmed, N., Rehman, A. U. & Donnelly, R., 13 Jul 2020, In: International Journal of Pharmaceutics.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery
McErlean, E. M., Ziminska, M., McCrudden, C. M., McBride, J. W., Loughran, S. P., Cole, G., Mulholland, E. J., Kett, V., Buckley, N. E., Robson, T., Dunne, N. J. & McCarthy, H. O., 21 Nov 2020, (Early online date) In: Journal of Controlled Release. 330, p. 1288Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)283 Downloads (Pure) -
Synthesis and Evaluation of a Thermoresponsive Degradable Chitosan-Grafted PNIPAAm Hydrogel as a “Smart” Gene Delivery System
Ziminska, M., Wilson, J. J., McErlean, E., Dunne, N. & McCarthy, H. O., 02 Jun 2020, In: Materials. 13, 11, 22 p., 2530.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)163 Downloads (Pure) -
2019
Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: An innovative angiogenic therapy for wound repair
Mulholland, E., Ali, A., Robson, T., Dunne, N. & McCarthy, H., 28 Dec 2019, In: Journal of Controlled Release. 316, p. 53-65Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)318 Downloads (Pure) -
Design, Formulation, and Evaluation of Novel Dissolving Microarray Patches Containing Rilpivirine for Intravaginal Delivery
McCrudden, M., Larrañeta, E., Clark, A., Jarrahian, C., Rein-Weston, A., Creelman, B., Moyo, Y., Lachau-Durand, S., Niemeijer, N., Williams, P., McCarthy, H. O., Zehrung, D. & Donnelly, R. F., 06 Mar 2019, In: Advanced Healthcare Materials. 0, 0, p. 1801510 1 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)254 Downloads (Pure)