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Research Output 1997 2019

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Article
2019
2 Citations (Scopus)

A Four-Group Urine Risk Classifier for Predicting Outcome in Prostate Cancer Patients

Movember GAP1 Urine Biomarker Consortium, 20 May 2019, In : BJU International.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Urine
Prostate
RNA
Biopsy
57 Downloads (Pure)

CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation

Itkonen, H. M., Poulose, N., Walker, S. & Mills, I. G., 01 Jul 2019, In : Neoplasia . 21, 7, p. 713-720 8 p.

Research output: Contribution to journalArticle

Open Access
File
Cyclin-Dependent Kinase 9
Prostatic Neoplasms
Fatty Acids
Carnitine
Carnitine O-Palmitoyltransferase
61 Downloads (Pure)

Drivers of AR indifferent anti-androgen resistance in prostate cancer cells

Handle, F., Prekovic, S., Helsen, C., Van den Broeck, T., Smeets, E., Moris, L., Eerlings, R., Kharraz, S. E., Urbanucci, A., Mills, I. G., Joniau, S., Attard, G. & Claessens, F., 24 Sep 2019, In : Scientific Reports. 9, 11 p., 13786.

Research output: Contribution to journalArticle

Open Access
File
Androgen Receptors
Androgens
Prostatic Neoplasms
Castration
docetaxel
1 Citation (Scopus)
61 Downloads (Pure)

High OGT activity is essential for MYC-driven proliferation of prostate cancer cells

Itkonen, H. M., Urbanucci, A., Martin, S. E., Khan, A., Mathelier, A., Thiede, B., Walker, S. & Mills, I. G., 12 Apr 2019, In : Theranostics. 9, 8, p. 2183-2197 15 p.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Host Factor 1 Protein
Chromatin
Chromatin Immunoprecipitation
Androgens
1 Citation (Scopus)
56 Downloads (Pure)
Open Access
File
androgen
Androgen Receptors
Health
Acids
acid
62 Downloads (Pure)

Human blood-based exposure levels of persistent organic pollutant (POP) mixtures antagonise androgen receptor transactivation and translocation

McComb, J., Mills, I., Muller, M., Berntsen, H. F., Elisabeth Zimmer, K., Ropstad, E., Verhaegen, S. & Connolly, L., 27 Aug 2019, In : Environment International. 132, 105083, p. 132 11 p.

Research output: Contribution to journalArticle

Open Access
File
androgen
translocation
blood
assay
gene
16 Citations (Scopus)
141 Downloads (Pure)

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

Sheng, X., Nenseth, H. Z., Qu, S., Kuzu, O. F., Frahnow, T., Simon, L., Greene, S., Zeng, Q., Fazli, L., Rennie, P. S., Mills, I. G., Danielsen, H., Theis, F., Patterson, J. B., Jin, Y. & Saatcioglu, F., 24 Jan 2019, In : Nature Communications. 10, 12 p., 323.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
cancer
Unfolded Protein Response
Chemical activation
Proteins
2 Citations (Scopus)
64 Downloads (Pure)

Low Expression of miR-424-3p is Highly Correlated with Clinical Failure in Prostate Cancer

Richardsen, E., Andersen, S., Al-Saad, S., Rakaee, M., Nordby, Y., Pedersen, M. I., Ness, N., Ingebriktsen, L. M., Fassina, A., Taskén, K. A., Mills, I. G., Donnem, T., Bremnes, R. M. & Busund, L. T., 23 Jul 2019, In : Scientific Reports. 9, 1, p. 10662

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
MicroRNAs
Prostatectomy
Developed Countries
In Situ Hybridization
23 Downloads (Pure)

Methodology for the at-home collection of urine samples for prostate cancer detection

Webb, M., Manley, K., Olivan, M., Guldvik, I., Palczynska, M., Hurst, R., Connell, S. P., Mills, I. G., Brewer, D. S., Mills, R., Cooper, C. S. & Clark, J., 29 Nov 2019, In : BioTechniques.

Research output: Contribution to journalArticle

Open Access
File
Urine Specimen Collection
Prostatic Neoplasms
Genes
Urine
RNA
17 Downloads (Pure)

miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA

Ray, J., Haughey, C., Hoey, C., Jeon, J., Murphy, R., Dura-Perez, L., McCabe, N., Downes, M., Jain, S., Boutros, P. C., Mills, I. G. & Liu, S. K., 23 Dec 2019, In : Cancer Letters.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Radiation
Radiotherapy
Retinoid X Receptor alpha
Recurrence
2 Downloads (Pure)

Putting Prostate Cancer Metabolism into the Right Context

Mills, I. G., Feb 2019, In : Urologic oncology. 2, 1, p. 37-38 2 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
112 Downloads (Pure)

The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance

Hepburn, A. C., Steele, R. E., Veeratterapillay, R., Wilson, L., Kounatidou, E. E., Barnard, A., Berry, P., Cassidy, J. R., Moad, M., El-Sherif, A., Gaughan, L., Mills, I. G., Robson, C. N. & Heer, R., 11 Feb 2019, In : Oncogene.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Neoplasms
Stem Cells
RNA Sequence Analysis
Iodide Peroxidase
6 Downloads (Pure)

The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing

Luxton, H. J., Simpson, B. S., Mills, I. G., Brindle, N. R., Ahmed, Z., Stavrinides, V., Heavey, S., Stamm, S. & Whitaker, H. C., 23 Aug 2019, In : Cancers. 11, 9

Research output: Contribution to journalArticle

Open Access
File
Protein Splicing
Alternative Splicing
Oncogenes
Prostatic Neoplasms
Messenger RNA
1 Citation (Scopus)

The β2-adrenergic receptor is a molecular switch for neuroendocrine transdifferentiation of prostate cancer cells

Braadland, P. R., Ramberg, H., Grytli, H. H., Urbanucci, A., Nielsen, H. K., Guldvik, I. J., Engedal, A., Ketola, K., Wang, W., Svindland, A., Mills, I. G., Bjartell, A. & Tasken, K. A., 08 Aug 2019, In : Molecular cancer research : MCR.

Research output: Contribution to journalArticle

Adrenergic Receptors
Prostatic Neoplasms
Androgens
Down-Regulation
Therapeutics
2018
3 Citations (Scopus)
201 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
99 Downloads (Pure)

A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer

Warren, A. Y., Massie, C. E., Watt, K., Luko, K., Orafidiya, F., Selth, L. A., Mohammed, H., Chohan, B. S., Menon, S., Baridi, A., Zhao, W., Escriu, C., Pungsrinont, T., D'Santos, C., Yang, X., Taylor, C., Qureshi, A., Zecchini, V. R., Shaw, G. L., Dehm, S. M. & 7 others, Mills, I. G., Carroll, J. S., Tilley, W. D., McEwan, I. J., Baniahmad, A., Neal, D. E. & Asim, M., 20 Sep 2018, In : Oncogene. 15 p.

Research output: Contribution to journalArticle

Open Access
File
Androgen Receptors
Prostatic Neoplasms
PDZ-binding kinase
Systems Biology
Proteome
9 Citations (Scopus)
80 Downloads (Pure)

Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer

Carabet, L. A., Lallous, N., Leblanc, E., Ban, F., Morin, H., Lawn, S., Ghaidi, F., Lee, J., Mills, I. G., Gleave, M. E., Rennie, P. S. & Cherkasov, A., 05 Dec 2018, In : European journal of medicinal chemistry. 160, p. 108-119

Research output: Contribution to journalArticle

Open Access
File
Drug Discovery
Prostatic Neoplasms
DNA
Apoptosis
Neoplasms
1 Citation (Scopus)

First Report of Prostate-specific Membrane Antigen-targeted Immunotherapy in Prostate Cancer: The Future is Bright

Lamb, A. D., Bryant, R. J., Mills, I. G. & Hamdy, F. C., May 2018, In : European Urology. 73, 5, p. 653-655

Research output: Contribution to journalArticle

7 Citations (Scopus)

Genetics of lipid metabolism in prostate cancer

Poulose, N., Steele, R. E., Amoroso, F., Singh, R., Ong, C. W. & Mills, I. G., 15 Jan 2018, In : Nature Genetics. p. 1-2

Research output: Contribution to journalArticle

Lipid Metabolism
Prostatic Neoplasms
6 Citations (Scopus)
147 Downloads (Pure)

Identification of shared genetic variants between schizophrenia and lung cancer

Zuber, V., Jönsson, E. G., Frei, O., Witoelar, A., Thompson, W. K., Schork, A. J., Bettella, F., Wang, Y., Djurovic, S., Smeland, O. B., Dieset, I., Fanous, A. H., Desikan, R. S., Küry, S., Bézieau, S., Dale, A. M., Mills, I. G. & Andreassen, O. A., 12 Jan 2018, In : Scientific Reports. 8, 1, p. 674

Research output: Contribution to journalArticle

Open Access
File
Lung Neoplasms
Schizophrenia
Smoking
Neoplasms
Lung
22 Citations (Scopus)
132 Downloads (Pure)

Polygenic hazard score to guide screening for aggressive prostate cancer development and validation in large scale cohorts

Seibert, T. M., Fan, C. C., Wang, Y., Zuber, V., Karunamuni, R., Parsons, J. K., Eeles, R. A., Easton, D. F., Kote-Jarai, ZS., Al Olama, A. A., Garcia, S. B., Muir, K., Grönberg, H., Wiklund, F., Aly, M., Schleutker, J., Sipeky, C., Tammela, T. L., Nordestgaard, B. G., Nielsen, S. F. & 31 others, Weischer, M., Bisbjerg, R., Røder, M. A., Iversen, P., Key, T. J., Travis, R. C., Neal, D. E., Donovan, J. L., Hamdy, F. C., Pharoah, P., Pashayan, N., Khaw, K-T., Maier, C., Vogel, W., Luedeke, M., Herkommer, K., Kibel, A. S., Cybulski, C., Wokolorczyk, D., Kluzniak, W., Cannon-Albright, L., Brenner, H., Cuk, K., Saum, K-U., Park, J. Y., Sellers, T. A., Slavov, C., Kaneva, R., Mitev, V., Mills, I. G. & PRACTICAL Consortium*, 10 Jan 2018, In : British Medical Journal. 360, p. j5757

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Prostate-Specific Antigen
Age of Onset
Genotype
Single Nucleotide Polymorphism
3 Citations (Scopus)
236 Downloads (Pure)

The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer

Forsythe, N., Refaat, A., Javadi, A., Khawaja, H., Weir, J-A., Emam, H., Allen, W. L., Burkamp, F., Popovici, V., Jithesh, P. V., Isella, C., Labonte, M. J., Mills, I. G., Johnston, P. G. & Van Schaeybroeck, S., 26 Feb 2018, In : Molecular Cancer Therapeutics.

Research output: Contribution to journalArticle

Open Access
File
Unfolded Protein Response
Endoplasmic Reticulum Stress
Colorectal Neoplasms
Mitogen-Activated Protein Kinase Kinases
Apoptosis
2017
34 Citations (Scopus)
191 Downloads (Pure)

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer

Urbanucci, A., Barfeld, S. J., Kytölä, V., Itkonen, H. M., Coleman, I. M., Vodák, D., Sjöblom, L., Sheng, X., Tolonen, T., Minner, S., Burdelski, C., Kivinummi, K. K., Kohvakka, A., Kregel, S., Takhar, M., Alshalalfa, M., Davicioni, E., Erho, N., Lloyd, P., Karnes, R. J. & 15 others, Ross, A. E., Schaeffer, E. M., Vander Griend, D. J., Knapp, S., Corey, E., Feng, F. Y., Nelson, P. S., Saatcioglu, F., Knudsen, K. E., Tammela, T. L. J., Sauter, G., Schlomm, T., Nykter, M., Visakorpi, T. & Mills, I. G., 06 Jun 2017, In : Cell Reports. 19, 10, p. 2045-2059 15 p.

Research output: Contribution to journalArticle

Open Access
File
Deregulation
Androgen Receptors
Chromatin
Prostatic Neoplasms
Transcription Factors
9 Citations (Scopus)
110 Downloads (Pure)

Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer

Zuber, V., Bettella, F., Witoelar, A., Andreassen, O. A., Mills, I. G., Urbanucci, A. & PRACTICAL Consortium, 31 Mar 2017, In : BMC Genomics. 18, 1, p. 270

Research output: Contribution to journalArticle

Open Access
File
Disease Susceptibility
Single Nucleotide Polymorphism
Prostatic Neoplasms
Breast Neoplasms
Epigenomics
8 Citations (Scopus)
132 Downloads (Pure)

Calcium Channel Blocker Use and Risk of Prostate Cancer by TMPRSS2:ERG Gene Fusion Status

Geybels, M. S., McCloskey, K., Mills, I. G. & Stanford, J. L., 15 Feb 2017, In : Prostate. 77, 3, p. 282-290 9 p.

Research output: Contribution to journalArticle

Open Access
File
Gene Fusion
Calcium Channel Blockers
Prostatic Neoplasms
Neoplasm Grading
Odds Ratio
24 Citations (Scopus)
160 Downloads (Pure)

c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks

Barfeld, S. J., Urbanucci, A., Itkonen, H. M., Fazli, L., Hicks, J. L., Thiede, B., Rennie, P. S., Yegnasubramanian, S., DeMarzo, A. M. & Mills, I. G., Apr 2017, In : EBioMedicine. 18, p. 83-93

Research output: Contribution to journalArticle

Open Access
File
Gene Regulatory Networks
Androgen Receptors
Prostatic Neoplasms
Genes
Transcription Factors
126 Downloads (Pure)

Correction to Dual transcriptome of the immediate neutrophil and Candida albicans interplay

Niemiec, M. J., Grumaz, C., Ermert, D., Desel, C., Shankar, M., Lopes, J. P., Mills, I. G., Stevens, P., Sohn, K. & Urban, C. F., 13 Nov 2017, In : BMC Genomics. 18, 696, p. 1-2

Research output: Contribution to journalArticle

Open Access
File
Candida albicans
Transcriptome
Neutrophils
Hyphae
Yeasts
9 Citations (Scopus)
152 Downloads (Pure)

Dual transcriptome of the immediate neutrophil and Candida albicans interplay

Niemiec, M. J., Grumaz, C., Ermert, D., Desel, C., Shankar, M., Lopes, J. P., Mills, I. G., Stevens, P., Sohn, K. & Urban, C. F., 06 Sep 2017, In : BMC Genomics. 18, 1, p. 696

Research output: Contribution to journalArticle

Open Access
File
Candida albicans
Transcriptome
Neutrophils
Hyphae
Yeasts
7 Citations (Scopus)
176 Downloads (Pure)

Genetic factors influencing prostate cancer risk in Norwegian men

Chen, H., Ewing, C. M., Zheng, S., Grindedaal, E. M., Cooney, K. A., Wiley, K., Djurovic, S., Andreassen, O. A., Axcrona, K., Mills, I. G., Xu, J., Maehle, L., Fosså, S. D. & Isaacs, W. B., 27 Nov 2017, In : Prostate. 7 p.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Single Nucleotide Polymorphism
Alleles
Norway
Population
8 Citations (Scopus)
146 Downloads (Pure)

Genome-wide analysis of AR binding and comparison with transcript expression in primary human fetal prostate fibroblasts and cancer associated fibroblasts

Nash, C., Boufaied, N., Mills, I. G., Franco, O. E., Hayward, S. W. & Thomson, A. A., 05 May 2017, In : Molecular and Cellular Endocrinology.

Research output: Contribution to journalArticle

Open Access
File
Androgen Receptors
Fibroblasts
Prostatic Neoplasms
Genes
Genome
16 Citations (Scopus)
204 Downloads (Pure)

Lipid degradation promotes prostate cancer cell survival

Itkonen, H. M., Brown, M., Urbanucci, A., Tredwell, G., Ho Lau, C., Barfeld, S. J., Hart, C., Guldvik, I. J., Takhar, M., Heemers, H. V., Erho, N., Bloch, K., Davicioni, E., Derua, R., Waelkens, E., Mohler, J. L., Clarke, N. W., Swinnen, J. V., Keun, H. C., Rekvig, O. P. & 1 others, Mills, I. G., 11 Mar 2017, In : Oncotarget.

Research output: Contribution to journalArticle

Open Access
File
Dodecenoyl-CoA Isomerase
Prostatic Neoplasms
Cell Survival
Lipids
Fatty Acids
13 Citations (Scopus)
192 Downloads (Pure)

Mining Human Prostate Cancer Datasets: The "camcAPP" Shiny App

Dunning, M. J., Vowler, S. L., Lalonde, E., Ross-Adams, H., Boutros, P., Mills, I. G., Lynch, A. G. & Lamb, A. D., 02 Mar 2017, In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
181 Downloads (Pure)

Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology

Walker, S. M., Knight, L. A., McCavigan, A. M., Logan, G. E., Berge, V., Sherif, A., Pandha, H., Warren, A. Y., Davidson, C., Uprichard, A., Blayney, J. K., Price, B., Jellema, G. L., Steele, C. J., Svindland, A., McDade, S. S., Eden, C. G., Foster, C., Mills, I. G., Neal, D. E. & 7 others, Mason, M. D., W Kay, E., Waugh, D. J., Harkin, D. P., Watson, R. W., Clarke, N. W. & Kennedy, R. D., 10 Apr 2017, In : European Urology.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Prostatectomy
Recurrence
Cluster Analysis
Gene Expression
32 Citations (Scopus)
186 Downloads (Pure)

Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer

Asim, M., Tarish, F., Ireland-Zecchini, H., Sanjiv, K., Gelali, E., Massie, C. E., Baridi, A., Warren, A. Y., Zhao, W., Ogris, C., McDuffus, L-A., Mascalchi, P., Shaw, G. L., Dev, H., Wadhwa, K., Wijnhoven, P., Forment, J. V., Lyons, S. R., Lynch, A. G., O'Neill, C. & 10 others, Zecchini, V. R., Rennie, P. S., Baniahmad, A., Tavaré, S., Mills, I. G., Galanty, Y., Crosetto, N., Schultz, N., Neal, D. E. & Helleday, T., 29 Aug 2017, In : Nature Communications. 8, 1, p. 374

Research output: Contribution to journalArticle

Open Access
File
lethality
Homologous Recombination
Androgen Receptors
deprivation
Androgens
4 Citations (Scopus)
195 Downloads (Pure)

The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration

Munkley, J., McClurg, U. L., Livermore, K. E., Ehrmann, I., Knight, B., Mccullagh, P., Mcgrath, J., Crundwell, M., Harries, L. W., Leung, H. Y., Mills, I. G., Robson, C. N., Rajan, P. & Elliott, D. J., 12 Jul 2017, In : Scientific Reports. 7, 1, 5249.

Research output: Contribution to journalArticle

Open Access
File
Androgens
Cell Movement
Prostatic Neoplasms
Up-Regulation
Neoplasms
5 Citations (Scopus)
139 Downloads (Pure)

Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy

Jain, S., Lyons, C. A., Walker, S. M., McQuaid, S., Hynes, S., Mitchell, D., Pang, B., Logan, G. E., McCavigan, A. M., O'Rourke, D., McArt, D., McDade, S., Mills, I., Prise, K. M., Knight, L. A., Steele, C. J., Medlow, P. W., Berge, V., Katz, B., Loblaw, D. A. & 5 others, Harkin, D. P., James, J., O'Sullivan, J. M., Kennedy, R. D. & Waugh, D. J., 10 Oct 2017, In : Annals of Oncology.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Radiotherapy
Biopsy
Neoplasm Metastasis
Survival
2016
11 Citations (Scopus)
147 Downloads (Pure)

Cell cycle-coupled expansion of AR activity promotes cancer progression

McNair, C., Urbanucci, A., Comstock, C. E. S., Augello, M. A., Goodwin, J. F., Launchbury, R., Zhao, S. G., Schiewer, M. J., Ertel, A., Karnes, J., Davicioni, E., Wang, L., Wang, Q., Mills, I. G., Feng, F. Y., Li, W., Carroll, J. S. & Knudsen, K. E., 26 Sep 2016, In : Oncogene. 36, p. 1655–1668 14 p.

Research output: Contribution to journalArticle

Open Access
File
Androgen Receptors
Cell Cycle
Neoplasms
Prostatic Neoplasms
Gene Regulatory Networks
11 Citations (Scopus)
148 Downloads (Pure)

Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells

Tekpli, X., Urbanucci, A., Hashim, A., Vågbø, C. B., Lyle, R., Kringen, M. K., Staff, A. C., Dybedal, I., Mills, I. G., Klungland, A. & Staerk, J., 31 May 2016, In : Epigenetics & chromatin. 9, 21, 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cell Differentiation
Hematopoiesis
Blood Cells
Gene Expression Regulation
Epigenomics
16 Citations (Scopus)
238 Downloads (Pure)

Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target

Asim, M., Massie, C. E., Orafidiya, F., Pértega-Gomes, N., Warren, A. Y., Esmaeili, M., Selth, L. A., Zecchini, H. I., Luko, K., Qureshi, A., Baridi, A., Menon, S., Madhu, B., Escriu, C., Lyons, S., Vowler, S. L., Zecchini, V. R., Shaw, G., Hessenkemper, W., Russell, R. & 20 others, Mohammed, H., Stefanos, N., Lynch, A. G., Grigorenko, E., D'Santos, C., Taylor, C., Lamb, A., Sriranjan, R., Yang, J., Stark, R., Dehm, S. M., Rennie, P. S., Carroll, J. S., Griffiths, J. R., Tavaré, S., Mills, I. G., McEwan, I. J., Baniahmad, A., Tilley, W. D. & Neal, D. E., May 2016, In : Journal of the National Cancer Institute. 108, 5, 13 p.

Research output: Contribution to journalArticle

Open Access
File
Choline Kinase
Androgen Receptors
Prostatic Neoplasms
Therapeutics
Heterografts
15 Citations (Scopus)
337 Downloads (Pure)

CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions

Fiorito, E., Sharma, Y., Gilfillan, S., Wang, S., Singh, S. K., Satheesh, S. V., Katika, M. R., Urbanucci, A., Thiede, B., Mills, I. G. & Hurtado, A., 15 Sep 2016, In : Nucleic Acids Research. 15 p.

Research output: Contribution to journalArticle

Open Access
File
Nuclear Lamina
Nuclear Matrix
Estrogen Receptors
Chromatin
Estrogens
1 Citation (Scopus)
339 Downloads (Pure)

Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli

Gerner, L., Munack, S., Temmerman, K., Lawrence-Dörner, A-M., Besir, H., Wilmanns, M., Jensen, J. K., Thiede, B., Mills, I. G. & Morth, J. P., Sep 2016, In : Data in brief. 8, p. 733-40 8 p.

Research output: Contribution to journalArticle

Open Access
File
Calcium-Calmodulin-Dependent Protein Kinases
Calmodulin
Phosphotransferases
Escherichia coli
Calcium-Calmodulin-Dependent Protein Kinase Kinase
42 Citations (Scopus)

Gene regulatory mechanisms underpinning prostate cancer susceptibility

Whitington, T., Gao, P., Song, W., Ross-Adams, H., Lamb, A. D., Yang, Y., Svezia, I., Klevebring, D., Mills, I. G., Karlsson, R., Halim, S., Dunning, M. J., Egevad, L., Warren, A. Y., Neal, D. E., Grönberg, H., Lindberg, J., Wei, G-H. & Wiklund, F., 07 Mar 2016, In : Nature Genetics. 14 p.

Research output: Contribution to journalArticle

Regulator Genes
Prostatic Neoplasms
Androgen Receptors
Single Nucleotide Polymorphism
Genes
25 Citations (Scopus)
164 Downloads (Pure)

Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability

Munkley, J., Vodak, D., Livermore, K. E., James, K., Wilson, B. T., Knight, B., Mccullagh, P., Mcgrath, J., Crundwell, M., Harries, L. W., Leung, H. Y., Robson, C. N., Mills, I. G., Rajan, P. & Elliott, D. J., Jun 2016, In : EBioMedicine. 8, p. 103-16 14 p.

Research output: Contribution to journalArticle

Open Access
File
Glycosylation
Androgens
Prostatic Neoplasms
Cell Survival
Cells
19 Citations (Scopus)
180 Downloads (Pure)

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Ross-Adams, H., Ball, S., Lawrenson, K., Halim, S., Russell, R., Wells, C., Strand, S. H., Ørntoft, T. F., Larson, M., Armasu, S., Massie, C. E., Asim, M., Mortensen, M. M., Borre, M., Woodfine, K., Warren, A. Y., Lamb, A. D., Kay, J., Whitaker, H., Ramos-Montoya, A. & 8 others, Murrell, A., Sørensen, K. D., Fridley, B. L., Goode, E. L., Gayther, S. A., Masters, J., Neal, D. E. & Mills, I. G., 09 Oct 2016, In : Oncotarget. 13 p.

Research output: Contribution to journalArticle

Open Access
File
Gene Regulatory Networks
Ovarian Neoplasms
Methylation
Prostatic Neoplasms
Epithelial-Mesenchymal Transition
22 Citations (Scopus)
524 Downloads (Pure)

Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism

Itkonen, H. M., Gorad, S. S., Duveau, D. Y., Martin, S. E. S., Barkovskaya, A., Bathen, T. F., Moestue, S. A. & Mills, I. G., 27 Jan 2016, In : Oncotarget.

Research output: Contribution to journalArticle

Open Access
File
Prostatic Neoplasms
Prostate
Epithelium
Cycloserine
Rotenone
3 Citations (Scopus)
103 Downloads (Pure)

Pleiotropic Analysis of Lung Cancer and Blood Triglycerides

Zuber, V., Marconett, C. N., Shi, J., Hua, X., Wheeler, W., Yang, C., Song, L., Dale, A. M., Laplana, M., Risch, A., Witoelar, A., Thompson, W. K., Schork, A. J., Bettella, F., Wang, Y., Djurovic, S., Zhou, B., Borok, Z., van der Heijden, H. F. M., de Graaf, J. & 21 others, Swinkels, D., Aben, K. K., McKay, J., Hung, R. J., Bikeböller, H., Stevens, V. L., Albanes, D., Caporaso, N. E., Han, Y., Wei, Y., Panadero, M. A., Mayordomo, J. I., Christiani, D. C., Kiemeney, L., Andreassen, O. A., Houlston, R., Amos, C. I., Chatterjee, N., Laird-Offringa, I. A., Mills, I. G. & Landi, M. T., 2016, In : Journal of the National Cancer Institute. 108, 12, 4 p.

Research output: Contribution to journalArticle

Open Access
File
Lung Neoplasms
Triglycerides
Genome-Wide Association Study
Lipids
Genetic Loci
22 Citations (Scopus)
207 Downloads (Pure)

Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study

Shi, J., Hua, X., Zhu, B., Ravichandran, S., Wang, M., Nguyen, C., Brodie, S. A., Palleschi, A., Alloisio, M., Pariscenti, G., Jones, K., Zhou, W., Bouk, A. J., Boland, J., Hicks, B., Risch, A., Bennett, H., Luke, B. T., Song, L., Duan, J. & 14 others, Liu, P., Kohno, T., Chen, Q., Meerzaman, D., Marconett, C., Laird-Offringa, I., Mills, I., Caporaso, N. E., Gail, M. H., Pesatori, A. C., Consonni, D., Bertazzi, P. A., Chanock, S. J. & Landi, M. T., 06 Dec 2016, In : PLoS Medicine. 13, 12, 24 p., e1002162.

Research output: Contribution to journalArticle

Open Access
File
Genomics
Retrospective Studies
Mutation
Genes
Mutation Rate
21 Citations (Scopus)
136 Downloads (Pure)

The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer

Shaw, G. L., Whitaker, H., Corcoran, M., Dunning, M. J., Luxton, H., Kay, J., Massie, C. E., Miller, J. L., Lamb, A. D., Ross-Adams, H., Russell, R., Nelson, A. W., Eldridge, M. D., Lynch, A. G., Ramos-Montoya, A., Mills, I. G., Taylor, A. E., Arlt, W., Shah, N., Warren, A. Y. & 1 others, Neal, D. E., Aug 2016, In : European Urology. 70, 2, p. 214-218 5 p.

Research output: Contribution to journalArticle

Open Access
File
Androgens
Castration
Prostatic Neoplasms
Androgen Receptors
Estrogen Receptor alpha
44 Citations (Scopus)
207 Downloads (Pure)

The Importance of DNA methylation in Prostate Cancer development

Massie, C. E., Mills, I. G. & Lynch, A. G., 24 Apr 2016, In : Journal of Steroid Biochemistry and Molecular Biology. 15 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Methylation
Prostatic Neoplasms
Methylation
Mitochondria
Androgen Receptors
27 Citations (Scopus)

The role of glycans in the development and progression of prostate cancer

Munkley, J., Mills, I. G. & Elliott, D. J., 19 Apr 2016, In : Nature reviews. Urology. 13, p. 324–333

Research output: Contribution to journalArticle

Glycosylation
Polysaccharides
Prostatic Neoplasms
Glycoproteins
Biomarkers