Ian Overton

Research output

Research output per year 2001 2004 2005 2007 2008 2011 2013 2015 2017 2021 2022 2023 2023

• 36 Article
• 1 Chapter
• 1 Conference contribution
• 1 Other contribution

Research output per year

Research output per year

Search results

• 2023

  Investigating the effects of chronic low-dose radiation exposure in the liver of a hypothermic zebrafish model

  Cahill, T., da Silveira, W. A., Renaud, L., Wang, H., Williamson, T., Chung, D., Chan, S., Overton, I. & Hardiman, G., 17 Jan 2023, (Early online date) In: Scientific Reports. 13, 1, 918.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antiapoptotic 100%
  • Radiation Exposure 83%
  • Torpor 83%
  • Zebra Fish 50%
  • Survival 33%
  18 Downloads (Pure)

• Strategies and techniques for quality control and semantic enrichment with multimodal data: a case study in colorectal cancer with eHDPrep

  Toner, T. M., Pancholi, R., Miller, P., Forster, T., Coleman, H. G. & Overton, I. M., 12 May 2023, (Early online date) In: Gigascience. 12, 14 p., giad030.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Quality Control 100%
  • Case Study 100%
  • Patient 100%
  • Colorectal Cancer 100%
  • Semantics 100%
  18 Downloads (Pure)

• Transcriptome profiling reveals enhanced mitochondrial activity as a cold adaptive strategy to hypothermia in zebrafish muscle

  Cahill, T., Chan, S., Overton, I. M. & Hardiman, G., 11 May 2023, In: Cells. 12, 10, 15 p., 1366.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation 100%
  • Gene Expression Profiling 100%
  • Hypothermia 100%
  • Zebra Fish 100%
  • Transcriptome 100%
  22 Downloads (Pure)

• Validation of in vitro trained transcriptomic radiosensitivity signatures in clinical cohorts

  O'Connor, J. D., Overton, I. M. & McMahon, S. J., 05 Jul 2023, In: Cancers. 15, 13, 14 p., 3504.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  25 Downloads (Pure)
• 2022

  Immune cell networks uncover candidate biomarkers of melanoma immunotherapy response

  Vo, D. H. T., McGleave, G. & Overton, I. M., Jun 2022, In: Journal of Personalized Medicine. 12, 6, 20 p., 958.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Immune Checkpoint Inhibitor 100%
  • Combination Therapy 25%
  • Biological Marker 25%
  • Immunocompetent Cell 16%
  • T Cell Proliferation 16%
  34 Downloads (Pure)

• PTEN protein phosphatase activity is not required for tumour suppression in the mouse prostate

  Wise, H. M., Harris, A., Kriplani, N., Schofield, A., Caldwell, H., Arends, M. J., Overton, I. M. & Leslie, N. R., 19 Oct 2022, In: Biomolecules. 12, 10, 15 p., 1511.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein Phosphatase 100%
  • Gene Expression Profiling 33%
  • Mouse 33%
  • Wild Type 16%
  • Electric Potential 16%
  13 Downloads (Pure)

• RadSigBench: a framework for benchmarking functional genomics signatures of cancer cell radiosensitivity

  O'Connor, J. D., Overton, I. M. & McMahon, S. J., 22 Jan 2022, (Early online date) In: Briefings in Bioinformatics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiosensitivity 100%
  • Radioresistance 100%
  • Accuracy 28%
  • Cancer Cell Line 28%
  • Predictor 28%
  134 Downloads (Pure)
• 2021

  Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model

  Cahill, T., da Silveira, W. A., Renaud, L., Williamson, T., Wang, H., Chung, D., Overton, I., Chan, S. S. L. & Hardiman, G., 14 Apr 2021, In: Cells. 10, 4, 26 p., 906.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiation Exposure 100%
  • Oxidative Stress 75%
  • Radiation 75%
  • Gastrointestinal Tract 75%
  • Low Drug Dose 50%
  129 Downloads (Pure)

• Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: Racial, ethnic, and geographical considerations

  Morgan, R., da Silveira, W. A., Kelly, R. C., Overton, I., Allott, E. H. & Hardiman, G., 19 Oct 2021, (Early online date) In: Expert review of molecular diagnostics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Long Untranslated RNA 100%
  • Long Non-Coding RNA 100%
  • Biological Marker 62%
  • Man 50%
  • Diagnosis 50%
  93 Downloads (Pure)

• SynLeGG: analysis and visualization of multiomics data for discovery of cancer ‘Achilles Heels’ and gene function relationships

  Wappett, M., Harris, A., Lubbock, A. L. R., Lobb, I., McDade, S. & Overton, IM., 02 Jul 2021, In: Nucleic Acids Research. 49, W1, p. W613-W618

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SMARCA2 100%
  215 Downloads (Pure)
• 2020

  Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling

  Overton, I. M., Sims, A. H., Owen, J. A., Heale, B. S. E., Ford, M. J., Lubbock, A. L. R., Pairo-Castineira, E. & Essafi, A., 30 Sep 2020, In: Cancers. 12, 10, 34 p., 2823.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cis-Regulatory Module 100%
  1 Citation (Scopus)

  109 Downloads (Pure)
• 2019

  Using Simple PID-inspired Controllers for Online Resilient Resource Management of Distributed Scientific Workflows

  Ferreira da Silva, R., Filgueira, R., Deelman, E., Pairo-Castineira, E., Overton, I. & Atkinson, M., Jun 2019, In: Future Generation Computing Systems. 95, p. 615-628

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  9 Citations (Scopus)

  150 Downloads (Pure)
• 2017

  Overcoming Intratumoural Heterogeneity for Reproducible Molecular Risk Stratification: A Case Study in Advanced Kidney Cancer

  Lubbock, A., Stewart, G., O'Mahony, F. C., Laird, A., Mullen, P., O'Donnell, M., Powles, T., Harrison, D. J. & Overton, I., 26 Jun 2017, In: BMC Medicine. 15, 118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mammalian Target of Rapamycin 100%
  • Nerve Cell Adhesion Molecule 50%
  • Age 50%
  • Cadherin 50%
  • Sampling 40%
  4 Citations (Scopus)

  211 Downloads (Pure)

• Quantitative Shotgun Proteomics Unveils Candidate Novel Esophageal Adenocarcinoma (EAC)-specific Proteins

  O'neill, J. R., Pak, H-S., Pairo-Castineira, E., Save, V., Paterson-Brown, S., Nenutil, R., Vojtěšek, B., Overton, I., Scherl, A. & Hupp, T. R., 01 Mar 2017, In: Molecular and Cellular Proteomics. 16, 6, p. 1138-1150

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein 100%
  • Patient 80%
  • Sample 80%
  • Immunohistochemistry 60%
  • Specific Tumor 40%
  12 Citations (Scopus)

  234 Downloads (Pure)
• 2015

  Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer

  Stewart, G. D., O'Mahony, F. C., Laird, A., Eory, L., Lubbock, A., Mackay, A., Nanda, J., O'Donnell, M., Mullen, P., McNeill, A., Riddick, A., Berney, D., Bex, A., Aitchison, M., Overton, I. M., Harrison, D. J. & Powles, T., 01 Sep 2015, In: Clinical Cancer Research. 21, 18

  Research output: Contribution to journal › Article › peer-review

  • Sunitinib 100%
  • Kidney Cancer 66%
  • Protein 50%
  • Messenger RNA 50%
  • DNA 50%
  25 Citations (Scopus)
• 2014

  Carbonic Anhydrase 9 Expression Increases with Vascular Endothelial Growth Factor-Targeted Therapy and Is Predictive of Outcome in Metastatic Clear Cell Renal Cancer

  Stewart, G. D., O'Mahony, F. C., Laird, A., Rashid, S., Martin, S. A., Eory, L., Lubbock, A. L. R., Nanda, J., O'Donnell, M., Mackay, A., Mullen, P., McNeill, S. A., Riddick, A. C. P., Aitchison, M., Berney, D., Bex, A., Overton, I. M., Harrison, D. J. & Powles, T., Nov 2014, In: European Urology. 66, 5, p. 956–963 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Carbonate Dehydratase IX 100%
  • Carbonic Anhydrase 9 100%
  • Sunitinib 77%
  • Clear Cell 66%
  • Mechanistic Target of Rapamycin 11%
  32 Citations (Scopus)

  221 Downloads (Pure)
• 2013

  The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster

  Li, X., Overton, I. M., Baines, R. A., Keegan, L. P. & O'Connell, M. A., 01 Oct 2013, In: Nucleic Acids Research.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

  O'Mahony, F. C., Nanda, J., Laird, A., Mullen, P., Caldwell, H., Overton, I. M., Eory, L., O'Donnell, M., Faratian, D., Powles, T., Harrison, D. J. & Stewart, G. D., 01 Jan 2013, In: Journal of visualized experiments : JoVE. 71

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• TMA Navigator: network inference, patient stratification and survival analysis with tissue microarray data

  Lubbock, A. L. R., Katz, E., Harrison, D. J. & Overton, I. M., 01 Jul 2013, In: Nucleic Acids Research. 41, W1, p. W562-W568

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)
• 2012

  Addressing statistical biases in nucleotide-derived protein databases for proteogenomic search strategies

  Blakeley, P., Overton, I. M. & Hubbard, S. J., 01 Nov 2012, In: Journal of Proteome Research. 11, 11, p. 5221-34

  Research output: Contribution to journal › Article › peer-review
  55 Citations (Scopus)
• 2011

  Computational approaches to selecting and optimising targets for structural biology

  Overton, I. M. & Barton, G. J., 2011, In: Methods. 55, 1, p. 3-11 9 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus

  Overton, I. M., Graham, S., Gould, K. A., Hinds, J., Botting, C. H., Shirran, S., Barton, G. J. & Coote, P. J., 2011, In: BMC Systems Biology. 5, p. 68 (online only)

  Research output: Contribution to journal › Article › peer-review
  28 Citations (Scopus)

• XANNpred neural nets that predict the propensity of a protein to yield diffraction-quality crystals

  Overton, I. M., Niekerk, C. A. J. & Barton, G. J., 2011, In: Proteins: Structure, Function and Bioinformatics. 79, 4, p. 1027-33

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)
• 2010

  The Scottish Structural Proteomics Facility: targets, methods and outputs

  Oke, M., Carter, L. G., Johnson, K. A., Liu, H., Mcmahon, S. A., Yan, X., Kerou, M., Weikart, N. D., Kadi, N., Sheikh, M. A., Schmelz, S., Dorward, M., Zawadzki, M., Cozens, C., Falconer, H., Powers, H., Overton, I. M., Niekerk, C. A. J., Peng, X., Patel, P., & 11 othersGarrett, R. A., Prangishvili, D., Botting, C. H., Coote, P. J., Dryden, D. T. F., Barton, G. J., Schwarz-linek, U., Challis, G. L., Taylor, G. L., White, M. F. & Naismith, J. H., 01 Jun 2010, In: Journal of Structural and Functional Genomics. 11, 2, p. 167-180 14 p.

  Research output: Contribution to journal › Article › peer-review
  85 Citations (Scopus)
• 2008

  ParCrys: a Parzen window density estimation approach to protein crystallization propensity prediction

  Overton, I. M., Padovani, G., Girolami, M. A. & Barton, G. J., 01 Apr 2008, In: Bioinformatics. 24, 7, p. 901-907 7 p.

  Research output: Contribution to journal › Article › peer-review
  52 Citations (Scopus)

• TarO: a target optimisation system for structural biology

  Overton, I., vanNiekerk, C. A. J., Carter, L., Dawson, A., Martin, D., Cameron, S., McMahon, S., White, M. F., Hunter, W., Naismith, J. H. & Barton, G. J., 2008, In: Nucleic Acids Research. 36, suppl. 2, p. W190-W196

  Research output: Contribution to journal › Article › peer-review
  31 Citations (Scopus)
• 2007

  Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase

  Seetharamappa, J., Oke, M., Liu, H., McMahon, S. A., Johnson, K. A., Carter, L., Dorward, M., Zawadzki, M., Overton, I. M., van Niekirk, C. A. J., Graham, S., Botting, C. H., Taylor, G. L., White, M. F., Barton, G. J., Coote, P. J. & Naismith, J. H., 01 May 2007, In: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 63, Pt 5, p. 452-6

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase

  Seetharamappa, J., Oke, M., Liu, H., McMahon, S. A., Johnson, K. A., Carter, L., Dorward, M., Zawadzki, M., Overton, I. M., van Niekirk, C. A. J., Graham, S., Botting, C. H., Taylor, G. L., White, M. F., Barton, G. J., Coote, P. J. & Naismith, J. H., 01 Jun 2007, In: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 63, Pt 6, p. 488-91

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis

  Yard, B., Carter, L., Johnson, K. A., Overton, I., Dorward, M., Liu, H., McMahon, S., Oke, M., Puech, D., Barton, G. J., Naismith, J. H. & Campopiano, D. J., 2007, In: Journal of Molecular Biology. 370, 5, p. 870-886 17 p.

  Research output: Contribution to journal › Article › peer-review
  86 Citations (Scopus)
• 2006

  A normalised scale for structural genomics target ranking: the OB-Score

  Overton, I. & Barton, G. J., 01 Jul 2006, In: FEBS Letters. 580, 16, p. 4005-4009 5 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)
• 2005

  Structures of three HIV-1 HLA-B* 5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression

  Stewart-Jones, G., Gillespie, G., Overton, I., Kaul, R., Roche, P., McMichael, A. J., Rowland-Jones, S. & Jones, E. Y., 01 Aug 2005, In: Journal of Immunology. 175, 4, p. 2459-2468 10 p.

  Research output: Contribution to journal › Article › peer-review

  57 Citations (Scopus)

• Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags

  Hubbard, S. J., Grafham, D. V., Beattie, K. J., Overton, I. M., McLaren, S. R., Croning, M. D. R., Boardman, P. E., Bonfield, J. K., Burnside, J., Davies, R. M., Farrell, E. R., Francis, M. D., Griffiths-Jones, S., Humphray, S. J., Hyland, C., Scott, C. E., Tang, H., Taylor, R. G., Tickle, C., Brown, W. R. A., & 3 othersBirney, E., Rogers, J. & Wilson, S. A., 01 Jan 2005, In: Genome Research. 15, 1, p. 174-183 10 p.

  Research output: Contribution to journal › Article › peer-review
  73 Citations (Scopus)
• 2004

  A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms

  Wong, G. K-S., Liu, B., Wang, J., Zhang, Z-Y., Yang, X., Zhang, Z., Meng, Q., Zhou, J., Li, D., Zhang, J., Ni, P., Li, S., Ran, L., Li, H., Zhang, J., Li, R., Li, S., Zheng, H., Lin, W., Li, G., & 95 othersWang, X., Zhao, W., Li, J., Ye, C., Dai, M., Ruan, J., Zhou, Y., Li, Y., He, X., Zhang, Y., Wang, J., Huang, X., Tong, W., Chen, J., Ye, J., Chen, C., Wei, N., Li, G., Dong, L., Lan, F., Sun, Y., Zhang, Z., Yang, Z., Yu, Y., Huang, Y., He, D., Xi, Y., Wei, D. Q., Qi, Q., Li, W., Shi, J., Wang, M., Xie, F., Wang, J., Zhang, X., Wang, P., Zhao, Y., Li, N., Yang, N., Dong, W., Hu, S., Zeng, C., Zheng, W., Hao, B., Hillier, L. W., Yang, S-P., Warren, W. C., Wilson, R. K., Brandström, M., Ellegren, H., Crooijmans, R. P. M. A., van der Poel, J. J., Bovenhuis, H., Groenen, M. A. M., Ovcharenko, I., Gordon, L., Stubbs, L., Lucas, S., Glavina, T., Aerts, A., Kaiser, P., Rothwell, L., Young, J. R., Rogers, S., Walker, B. A., van Hateren, A., Kaufman, J., Bumstead, N., Lamont, S. J., Zhou, H., Hocking, P. M., Morrice, D., de Koning, D-J., Law, A., Bartley, N., Burt, D. W., Hunt, H., Cheng, H. H., Gunnarsson, U., Wahlberg, P., Andersson, L., Kindlund, E., Tammi, M. T., Andersson, B., Webber, C., Ponting, C., Overton, I. M., Boardman, P. E., Tang, H., Hubbard, S. J., Wilson, S. A., Yu, J., Wang, J., Yang, H. & Consortium, I. C. P. M., 2004, In: Nature. 432, 7018, p. 717-22 694 p.

  Research output: Contribution to journal › Article › peer-review
  338 Citations (Scopus)

• Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution

  Hillier, L. W., Miller, J. W., Birney, E., Warren, W. C., Hardison, RC., Ponting, CP., Bork, P., Burt, D. W., Groenen, M. A. M., Delany, ME., Dodgson, JB., Chinwalla, AT., Cliften, PF., Clifton, SW., Delehaunty, KD., Fronick, C., Fulton, RS., Graves, TA., Kremitzki, C., Layman, D., & 156 othersMagrini, V., McPherson, JD., Miner, TL., Minx, P., Nash, WE., Nhan, MN., Nelson, JO., Oddy, LG., Pohl, CS., Randall-Maher, J., Smith, SM., Wallis, JW., Yang, SP., Romanov, MN., Rondelli, CM., Paton, B., Smith, J., Morrice, D., Daniels, L., Tempest, HG., Robertson, L., Masabanda, JS., Griffin, DK., Vignal, A., Fillon, V., Jacobbson, L., Kerje, S., Andersson, L. S., Crooijmans, RPM., Aerts, J., van der Poel, JJ., Ellegren, H., Caldwell, RB., Hubbard, S. J., Grafham, DV., Kierzek, AM., McLaren, W. M., Overton, IM., Arakawa, H., Beattie, KJ., Bezzubov, Y., Boardman, P. E., Bonfield, JK., Croning, MDR., Davies, RM., Francis, MD., Humphray, SJ., Scott, CE., Taylor, RG., Tickle, C., Brown, WRA., Rogers, J., Buerstedde, JM., Wilson, SA., Stubbs, L., Ovcharenko, I., Gordon, L., Lucas, G. S., Miller, MM., Inoko, H., Shiina, T., Kaufman, J., Salomonsen, J., Skjoedt, K., Wong, G. K-S., Wang, J., Liu, B., Wang, J., Yu, J., Yang, HM., Nefedov, M., Koriabine, M., deJong, PJ., Goodstadt, L., Webber, C., Dickens, N. J., Letunic, I., Suyama, M., Torrents, D., von Mering, C., Zdobnov, EM., Makova, K., Nekrutenko, A., Elnitski, L., Eswara, P., King, DC., Yang, S., Tyekucheva, S., Radakrishnan, A., Harris, RS., Chiaromonte, F., Taylor, J., He, JB., Rijnkels, M., Griffiths-Jones, S., Ureta-Vidal, A., Hoffman, MM., Severin, J., Searle, SMJ., Law, A. S., Speed, J. D., Waddington, D., Cheng, Z., Tuzun, E., Eichler, E. E., Bao, ZR., Flicek, P., Shteynberg, DD., Brent, MR., Bye, JM., Huckle, EJ., Chatterji, S., Dewey, C., Pachter, L., Kouranov, A., Mourelatos, Z., Hatzigeorgiou, AG., Paterson, AH., Ivarie, R., Brandstrom, M., Axelsson, E., Backstrom, N., Berlin, S., Webster, MT., Pourquie, O., Reymond, A., Ucla, C., Antonarakis, S. E., Long, MY., Emerson, JJ., Betran, E., Dupanloup, N. V., Kaessmann, H., Hinrichs, AS., Bejerano, G., Furey, TS., Harte, RA., Raney, B., Siepel, A., Kent, WJ., Haussler, D., Eyras, E., Castelo, R., Abril, JF., Castellano, S., Camara, F., Nates-Parra, G., Guigo, R., Bourque, G., Tesler, G., Pevzner, PA., Smit, H. A., Fulton, LA., Mardis, E. R., Wilson, RK. & Consortium, I. C. G. S., 01 Dec 2004, In: Nature. 432, 7018, p. 695-716 22 p.

  Research output: Contribution to journal › Article › peer-review
  1984 Citations (Scopus)
• 2002

  A comprehensive collection of chicken cDNAs

  Boardman, P. E., Sanz-Ezquerro, J., Overton, I. M., Burt, D. W., Bosch, E., Fong, W. T., Tickle, C., Brown, W. R. A., Wilson, S. A. & Hubbard, S. J., 2002, In: Current Biology. 12, 22, p. 1965-9 1955 p.

  Research output: Contribution to journal › Article › peer-review
  271 Citations (Scopus)
• 2001

  Translocation portals for the substrates and products of a viral transcription complex: the bluetongue virus core

  Diprose, JM., Burroughs, JN., Sutton, GC., Goldsmith, A., Gouet, P., Malby, R., Overton, I., Zientara, S., Mertens, PPC., Stuart, DI. & Grimes, JM., 01 Dec 2001, In: The EMBO Journal. 20, 24, p. 7229-7239 11 p.

  Research output: Contribution to journal › Article › peer-review
  66 Citations (Scopus)