• Room 02.004 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr El Karim is accepting PhD applications from individuals with dental and non dental background who are interested in the following research areas: Stem cells and regenerative endodontics Orofacial pain Minimal intervention dentistry Oral infections and systemic health

20012020

Research output per year

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Personal profile

Research Interests

Stem cells and regenerative therapies

Orofacial pain

Minimal intervention dentistry

Oral infections and systemic health

Research Statement

The goal of my research is to develop minimally invasive, biologically based therapies for inflammatory dental diseases. I have particular interest in investigating the link between pain, inflammation and regeneration as well as the implications of dental disease on general health. The current research programmes include:

 

1-    Exploring potential strategies for optimal differentiation of dental pulp stem cells with particular focus on inflammation and its impact on regeneration

 

2-    Developing in vitro and in vivo models to study neuronal signalling in inflammatory and neuropathic pain

 

3-    Investigate potential links between dental infections, systemic inflammation and general heath.

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Research Output

A connectivity mapping approach predicted acetylsalicylic acid (aspirin) to induce osteo/odontogenic differentiation of dental pulp cells

Rankin, R., Lundy, F., Schock, B. C., Zhang, S. D., Al-Natour, B., About, I., Irwin, C., Linden, G. J. & El Karim, I. A., Jun 2020, In : International Endodontic Journal. 53, 6, p. 834-845 12 p.

Research output: Contribution to journalArticle

  • A Comparative Analysis of the Osteogenic Potential of Dental Mesenchymal Stem Cells

    Winning, L., El Karim, I. A. & Lundy, F. T., 01 Aug 2019, In : Stem Cells and Development. 28, 15, p. 1050-1058 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 3 Citations (Scopus)
    9 Downloads (Pure)

    Current and Future Views on Pulpal Pain and Neurogenesis

    Lundy, F., El Karim, I. & Scheven, B., 2019, Clinical Approaches in Endodontic Regeneration, Current and Emerging Therapeutic Perspectives. Springer Nature Switzerland, p. 19-36

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    European Society of Endodontology position statement: Management of deep caries and the exposed pulp: Management of deep caries and the exposed pulp

    European Society of Endodontology (ESE) developed by:, 01 Jul 2019, In : International Endodontic Journal. 52, 7, p. 923-934 12 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 21 Citations (Scopus)
    38 Downloads (Pure)

    Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: A systematic review

    Cushley, S., Duncan, H. F., Lappin, M., Tomson, P. L., Lundy, F. T., Cooper, P., Clarke, M. & El Karim, I. A., 20 Jun 2019, In : Journal of Dentistry.

    Research output: Contribution to journalReview article

    Open Access
    File
  • 2 Citations (Scopus)
    25 Downloads (Pure)

    Activities

    ESE Pre-congress symposium: Designing and running Randomised Control Trials and laboratory research projects

    Ikhlas El Karim (Invited speaker)

    11 Sep 2019

    Activity: Talk or presentation typesInvited talk

    To RCT or NOT?

    Ikhlas El Karim (Invited speaker)

    27 Sep 2019

    Activity: Talk or presentation typesInvited talk

    Identification of novel biomarkers and therapeutic agents for pulpitis using sscMAP

    Ikhlas El Karim (Presenter)

    04 Sep 2019

    Activity: Talk or presentation typesOral presentation

    Bioinformatics approach to optimise DPSCs osteo/odontogenic differentiation

    Ikhlas El Karim (Keynote speaker)

    25 Jul 2018 → …

    Activity: Talk or presentation typesInvited or keynote talk at national or international conference

    Minimally Invasive Endodontics

    Ikhlas El Karim (Invited speaker)

    12 Nov 2018

    Activity: Talk or presentation typesInvited talk

    Thesis

    MRGX1-TRPAI in lnflammatory Pain Signalling

    Author: McMillan, H., Jul 2020

    Supervisor: El Karim, I. (Supervisor), Lundy, F. (Supervisor) & Curtis, T. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Neuropeptide Y and vasoactive intestinal polypeptide in human dental pulps from carious and non-carious teeth

    Author: El Karim, I., 2003

    Supervisor: Lundy, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Peptide Hydrogels as Novel Scaffolds for Dental Pulp Cell Culture

    Author: Afami, M., Jul 2020

    Supervisor: Lundy, F. (Supervisor), Laverty, G. (Supervisor) & El Karim, I. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy