Projects per year
Personal profile
Research Interests
Stem cells and regenerative therapies
Orofacial pain
Minimal intervention dentistry
Oral infections and systemic health
Research Statement
The goal of my research is to develop minimally invasive, biologically based therapies for inflammatory dental diseases. I have particular interest in investigating the link between pain, inflammation and regeneration as well as the implications of dental disease on general health. The current research programmes include:
1- Exploring potential strategies for optimal differentiation of dental pulp stem cells with particular focus on inflammation and its impact on regeneration
2- Developing in vitro and in vivo models to study neuronal signalling in inflammatory and neuropathic pain
3- Investigate potential links between dental infections, systemic inflammation and general heath.
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Projects
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R4826CEM: Endodontic infections and CardiOvascular disease risk (ECO): A prospective study of a possible link?
El Karim, I., Linden, G. & Lundy, F.
08/06/2018 → …
Project: Research
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R2258CII: Mas related gene receptors as novel modules for pain relief
El Karim, I., Curtis, T. & Lundy, F.
16/12/2015 → …
Project: Research
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R2570RED: Molecular mechanisms in detine sensitivity and pain <MEDICI/BIOMED>
El Karim, I., Curtis, T. & Lundy, F.
01/08/2007 → …
Project: Research
Research output
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Odontoblast cell death induces NLRP3 inflammasome-dependent sterile inflammation and regulates dental pulp cell migration, proliferation and differentiation
Al Natour, B., Lundy, F. T., Moynah, P. N., About, I., Jeanneau, C., Irwin, C., Domberoski, Y. & El Karim, I. A., 27 Jan 2021, In: International Endodontic Journal.Research output: Contribution to journal › Article › peer-review
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Outcome measures to assess the effectiveness of endodontic treatment for pulpitis and apical periodontitis for use in the development of European Society of Endodontology (ESE) S3 level clinical practice guidelines: A Protocol
El Karim, I., Duncan, H. F., Nagendrababu, V. & Dummer, P. M. H., 25 Feb 2021, In: International Endodontic Journal.Research output: Contribution to journal › Article › peer-review
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A connectivity mapping approach predicted acetylsalicylic acid (aspirin) to induce osteo/odontogenic differentiation of dental pulp cells
Rankin, R., Lundy, F., Schock, B. C., Zhang, S. D., Al-Natour, B., About, I., Irwin, C., Linden, G. J. & El Karim, I. A., Jun 2020, In: International Endodontic Journal. 53, 6, p. 834-845 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Efficacy of direct pulp capping for management of cariously exposed pulps in permanent teeth: A systematic review and meta-analysis
Cushley, S., Duncan, H. F., Lappin, M. J., Chua, P., Elamin, A. D., Clarke, M. & El-Karim, I. A., 22 Nov 2020, In: International Endodontic Journal.Research output: Contribution to journal › Review article › peer-review
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Natural Antimicrobials in the Dental Pulp
Lundy, F. T., Irwin, C. R., McLean, D. F., Linden, G. J. & El Karim, I. A., 01 Sep 2020, In: Journal of Endodontics. 46, supplement of issue 9, p. S2-S9Research output: Contribution to journal › Article › peer-review
Prizes
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British Endodontic Society Research Poster Prize awarded to Mary McClory (Primary Supervisor Ikhlas El Karim)
El Karim, Ikhlas (Recipient), 2019
Prize: Prize (including medals and awards)
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Dental Health Foundation Award awarded to Mary McClory (primary supervisor Ikhlas El karim)
El Karim, Ikhlas (Recipient), 2021
Prize: Prize (including medals and awards)
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Elected Fellow of the Royal College of Surgeons Edinburgh
El Karim, Ikhlas (Recipient), 2014
Prize: Prize (including medals and awards)
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Fellowship (Ad Eundem) Royal college of Surgeons in Ireland
El Karim, Ikhlas (Recipient), 2016
Prize: Prize (including medals and awards)
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President of the Irish Division of IADR
El Karim, Ikhlas (Recipient), 2020
Prize: Prize (including medals and awards)
Activities
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ESE quality guidelines for endodontic treatment methodology training workshop
Ikhlas El Karim (Member of programme committee)
29 Jan 2021Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Irish Division of IADR virtual meeting
Ikhlas El Karim (Chair)
05 Feb 2021Activity: Participating in or organising an event types › Participation in conference
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PhD Thesis: Tricalcium silicate cements: invitro comparative studies of mechanical and biological characteristics of relevance to regenerative endodontics
Ikhlas El Karim (Examiner)
08 Dec 2020Activity: Examination types › PhD external examination
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Sue H Pavitt
Ikhlas El Karim (Host)
25 Feb 2020Activity: Hosting a visitor types › Hosting an academic visitor
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European Society of Endodontology (External organisation)
Ikhlas El Karim (Advisor)
2020 → …Activity: Membership types › Membership of peer review panel or committee
Thesis
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Neuropeptide Y and vasoactive intestinal polypeptide in human dental pulps from carious and non-carious teeth
Author: El Karim, I., 2003Supervisor: Lundy, F. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy