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Personal profile

Research Interests

Stem cells and regenerative therapies

Orofacial pain

Minimal intervention dentistry

Oral infections and systemic health

Research Statement

The goal of my research is to develop minimally invasive, biologically based therapies for inflammatory dental diseases. I have particular interest in investigating the link between pain, inflammation and regeneration as well as the implications of dental disease on general health. The current research programmes include:


1-    Exploring potential strategies for optimal differentiation of dental pulp stem cells with particular focus on inflammation and its impact on regeneration


2-    Developing in vitro and in vivo models to study neuronal signalling in inflammatory and neuropathic pain


3-    Investigate potential links between dental infections, systemic inflammation and general heath.

Fingerprint Dive into the research topics where Ikhlas El Karim is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2001 2019

A Comparative Analysis of the Osteogenic Potential of Dental Mesenchymal Stem Cells

Winning, L., El Karim, I. A. & Lundy, F. T., 01 Aug 2019, In : Stem Cells and Development. 28, 15, p. 1050-1058 9 p.

Research output: Contribution to journalArticle

Dental Pulp
Mesenchymal Stromal Cells
Deciduous Tooth
Periodontal Ligament

Current and Future Views on Pulpal Pain and Neurogenesis

Lundy, F., El Karim, I. & Scheven, B., 2019, Clinical Approaches in Endodontic Regeneration, Current and Emerging Therapeutic Perspectives. Springer Nature Switzerland, p. 19-36

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

5 Citations (Scopus)

European Society of Endodontology position statement: Management of deep caries and the exposed pulp: Management of deep caries and the exposed pulp

European Society of Endodontology (ESE) developed by:, 01 Jul 2019, In : International Endodontic Journal. 52, 7, p. 923-934 12 p.

Research output: Contribution to journalArticle

Periapical Periodontitis

Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: A systematic review

Cushley, S., Duncan, H. F., Lappin, M., Tomson, P. L., Lundy, F. T., Cooper, P., Clarke, M. & El Karim, I. A., 20 Jun 2019, In : Journal of Dentistry.

Research output: Contribution to journalReview article

Signs and Symptoms
Dental Pulp Cavity

Activities 2006 2019

ESE Pre-congress symposium: Designing and running Randomised Control Trials and laboratory research projects

Ikhlas El Karim (Invited speaker)
11 Sep 2019

Activity: Talk or presentation typesInvited talk

To RCT or NOT?

Ikhlas El Karim (Invited speaker)
27 Sep 2019

Activity: Talk or presentation typesInvited talk

Identification of novel biomarkers and therapeutic agents for pulpitis using sscMAP

Ikhlas El Karim (Presenter)
04 Sep 2019

Activity: Talk or presentation typesOral presentation

Bioinformatics approach to optimise DPSCs osteo/odontogenic differentiation

Ikhlas El Karim (Keynote speaker)
25 Jul 2018 → …

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

96th General Session & Exhibition of the IADR

Ikhlas El Karim (Organiser)
28 Jul 2018

Activity: Participating in or organising an event typesParticipation in conference


Neuropeptide Y and vasoactive intestinal polypeptide in human dental pulps from carious and non-carious teeth

Author: El Karim, I., 2003

Supervisor: Lundy, F. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy